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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor
- Source: Letters in Drug Design & Discovery, Volume 8, Issue 9, Nov 2011, p. 884 - 888
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- 01 Nov 2011
Abstract
4, 5, 6, 7-Tetrahydropravastatin and its sodium salt as the hydrogenated derivatives of pravastatin were evaluated as HMG-CoA reductase inhibitor in vitro and in vivo, and they exhibited similar antihyperlipidaemic activity to pravastatin. The results could be regarded as a particular case to the reported SARs of statins up to now.
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