Full text loading...
- ISSN: 1570-1808
- E-ISSN: 1875-628X
-
Molecular Modelling, Design, Synthesis and Biochemical Evaluation of a Range of Non-Steroidal Thiosemicarbazone-Based Inhibitors of Estrone Sulfatase (ES) - A Potential Insight into the Action of a Range of Allosteric Inhibitors of ES
- Source: Letters in Drug Design & Discovery, Volume 8, Issue 9, Nov 2011, p. 889 - 896
-
- 01 Nov 2011
Abstract
Results of the modelling of thiosemicarbazone-based inhibitors of ES suggest that these compounds interact with the calcium ion whilst undergoing hydrogen bonding interaction with the active site - the extent of H-bonding determining the overall inhibitory activity. Novel inhibitors were designed, synthesised and evaluated and found to possess potent inhibitory activity.
© Bentham Science Publishers