Full text loading...
- ISSN: 1570-1808
- E-ISSN: 1875-628X
-
Synthesis and Biological Activity of Novel L-Amino Acid Based Analgesic Compounds
- Source: Letters in Drug Design & Discovery, Volume 7, Issue 5, Jun 2010, p. 359 - 364
-
- 01 Jun 2010
Abstract
Synthesis and analgesic activity studies of a series of L-amino acid based compounds were described. These compounds were designed as potential N-type Calcium Channel Blockers and their structures were confirmed by 1H NMR and ESI-MS spectra. Some of the compounds exhibited significant analgesic activity in Mouse Hot-Plate tests. According to the data of pharmacological experiments, we carried out preliminary structure-activity studies and the results indicated that this kind of compounds was useful for the development of new analgesic drugs.
© Bentham Science Publishers