Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of [2,5']Bis-1,3-Azole Analogs of Bengazoles

Using different heterocycle formation methodologies (Deoxo-Fluor, DAST, POCl3, TosMIC), [2,5']bis-1,3- azoles were prepared as stable analogs of bengazoles, a family of potent anthelmintic marine natural products. The cytotoxic activity of these heterocycles and their precursors on HCT-15 cells and the effect on the L4 larvae of Nippostrongylus brasiliensis were evaluated.