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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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The Synthesis and Activity Evaluation of a Bestatin Derivative (LYP) as an Aminopeptidase N Inhibitor
- Source: Letters in Drug Design & Discovery, Volume 6, Issue 6, Sep 2009, p. 420 - 423
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- 01 Sep 2009
Abstract
Aminopeptidase N (APN) is a ubiquitous enzyme overexpressed on the epithelium of tumor and plays an important role in angiogenesis and metastasis of tumor. Bestatin acting as an inhibitor of Aminopeptidase N and B is used in the ancillary treatment of cancer. In this paper, we designed, synthesized a derivative of Bestatin (LYP), and evaluated the activity of it which exhibited better efficacy than Bestain in vitro and vivo.
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