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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Structure-Activity Relationship Study of 8-amino-2,8-dideoxy-β -KDO, a Potent CMP-KDO Synthetase Inhibitor
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 5, Jul 2008, p. 336 - 339
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- 01 Jul 2008
Abstract
8-Amino-2,8-dideoxy-β-KDO is a well-known inhibitor of CMP-KDO synthetase involved in the biosynthesis of lipopolysaccharide (LPS), an essential component of the outer membrane of gram-negative bacteria. Chemical modification of the hydroxyl groups of 8-amino-2,8-dideoxy- β-KDO proved that they play a crucial role in CMP-KDO synthetase inhibition.
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