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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Discovery of AX8312, an N-alkyl-Gly-boro-Pro Derivative that Accelerates Recovery from Neutropenia in the Mouse
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 5, Jul 2008, p. 340 - 345
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- 01 Jul 2008
Abstract
A screen of N-alkyl-Gly-boro-Pro DPP inhibitors using an acute murine model revealed that N-adamantyl and N-cycloalkyl groups greater in size than cyclobutyl significantly induced G-CSF. Treatment of neutropenic mice with the most efficacious compound, AX8312 (N-(1-adamantyl)-Gly-boro-Pro), resulted in a faster and greater neutrophil recovery versus vehicle-treated mice.
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