Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression

We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.