Cytotoxicity and Antiviral Activity of Palladium(II) Quinolylmethylphosphonate Complexes. Synthesis of Acetate Complexes

Ljerka Tusek-Bozic; Vesna Cmrecki; Jan Balzarini; Erik De Clercq

doi:10.2174/157018006778194772

ISSN: 1570-1808
E-ISSN: 1875-628X

Cytotoxicity and Antiviral Activity of Palladium(II) Quinolylmethylphosphonate Complexes. Synthesis of Acetate Complexes
Authors: Ljerka Tusek-Bozic¹, Vesna Cmrecki², Jan Balzarini³ and Erik De Clercq⁴
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¹ Ruder Boskovic Institute, Division of Physical Chemistry, Bijenicka c. 54, HR-10002 Zagreb, Croatia. ² Ruder Boskovic Institute, Division of Physical Chemistry, Bijenicka c. 54, HR-10002 Zagreb, Croatia. ³ Ruder Boskovic Institute, Division of Physical Chemistry, Bijenicka c. 54, HR-10002 Zagreb, Croatia. ⁴ Ruder Boskovic Institute, Division of Physical Chemistry, Bijenicka c. 54, HR-10002 Zagreb, Croatia.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 8, Oct 2006, p. 528 - 533
DOI: https://doi.org/10.2174/157018006778194772
- Available online: 01 Oct 2006

Abstract

Palladium(II) acetate complexes with diethyl 8-quinolylmethylphosphonate (8-dqmp) and monoethyl 2- quinolylmethylphosphonate (2-Hmqmp) were synthesized and evaluated for their cytotoxic and antiviral activity in vitro in different cell lines. Structure-activity relationship studies comprise acetate and chloro complexes of the phosphonate ligands. Cell growth inhibitory effects in micro molar range were observed for the dichloro adduct and acetate bridged dimer of 8-dqmp.

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2006-10-01

2025-09-04

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Article Type: Research Article

Keyword(s): Acetate complex; Antiviral activity; Cytotoxicity; Palladium complex; Phosphonate

Cytotoxicity and Antiviral Activity of Palladium(II) Quinolylmethylphosphonate Complexes. Synthesis of Acetate Complexes

Abstract

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