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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Analysis of Brostallicin Effect on Different Human Gastrointestinal Cancer Cell Lines
- Source: Letters in Drug Design & Discovery, Volume 3, Issue 8, Oct 2006, p. 524 - 527
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- 01 Oct 2006
Abstract
Brostallicin, a specific adenine-thymine minor groove binder belonging to a new class of distamycin A-derivatives, proved to be active in vitro against a panel of human tumor cell lines. We demonstrated here the cytotoxic and apoptotic potential of this compound on gastric and colon cancer cell lines with either wt or mutated p53.
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