Lamotrigine Pharmacokinetics During Anticonception and Pregnancy

Lamotrigine (LTG) is a modern, effective and well-tolerated antiepileptic drug (AED) with an expected low teratogenic potential and therefore regarded as a relative safe drug for women of reproductive age. Recent studies, however, have demonstrated that co-administration of LTG and combined oral contraceptives (OC's) and pregnancy interfere with the metabolism of LTG with the risk of therapeutic failure. It is therefore recommended that plasma level of LTG should be closely monitored before and after introduction or discontinuation of OC's and monthly during pregnancy.