Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives

M. Paula M. Marques; Fernanda Borges; Joana Sousa; Rita Calheiros; Jorge Garrido; Alexandra Gaspar; Carmen Diniz; Paula Fresco

doi:10.2174/157018006777574212

ISSN: 1570-1808
E-ISSN: 1875-628X

Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives
Authors: M. Paula M. Marques¹, Fernanda Borges², Joana Sousa³, Rita Calheiros⁴, Jorge Garrido⁵, Alexandra Gaspar⁶, Carmen Diniz⁷ and Paula Fresco⁸
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¹ Servico de Farmacologia, Faculdade de Farmacia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. ² Servico de Farmacologia, Faculdade de Farmacia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. ³ Servico de Farmacologia, Faculdade de Farmacia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. ⁴ Servico de Farmacologia, Faculdade de Farmacia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. ⁵ Servico de Farmacologia, Faculdade de Farmacia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. ⁶ Servico de Farmacologia, Faculdade de Farmacia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. ⁷ Servico de Farmacologia, Faculdade de Farmacia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. ⁸ Servico de Farmacologia, Faculdade de Farmacia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 5, Jul 2006, p. 316 - 320
DOI: https://doi.org/10.2174/157018006777574212
- Available online: 01 Jul 2006

Abstract

The anticancer (cytotoxicity against human mammary gland adenocarcinoma cells) and antiinflammatory properties (COX-2 inhibition) of the hydroxycinnamic derivatives trans-3-(3,4,5- trihydroxyphenyl)-2-propenoic acid, trans-ethyl(3,4,5-trihydroxyphenyl)-2-propenoate and diethyl 2-(3,4,5- trihydroxy-phenylmethylene)malonate were screened. Data point out a putative correlation between antiinflammatory and anticancer properties and suggest hydroxycinnamic derivatives as promising lead compounds for the development of anti-inflammatory/chemopreventive agents.

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2006-07-01

2025-09-06

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Article Type: Research Article

Keyword(s): anti-inflammatory; anticancer; COX-2; Hydroxycinnamic derivatives; mammary gland adenocarcinoma cells

Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives

Abstract

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