Regulation of MMP/TIMP Balance as Therapeutic Target in Pulmonary Diseases

Corinne A.E. Martin-Chouly; Stephanie Guillot; Stephane Jouneau; Sylvie Caulet-Maugendre; Laurent Vernhet; Vincent Lagente; Philippe Delaval

doi:10.2174/157018006776287005

ISSN: 1570-1808
E-ISSN: 1875-628X

Regulation of MMP/TIMP Balance as Therapeutic Target in Pulmonary Diseases
Authors: Corinne A.E. Martin-Chouly¹, Stephanie Guillot², Stephane Jouneau³, Sylvie Caulet-Maugendre⁴, Laurent Vernhet⁵, Vincent Lagente⁶ and Philippe Delaval⁷
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¹ INSERM U620, Universite de Rennes 1, 2 avenue du Pr. Leon Bernard, 35043 Rennes cedex, France. ² INSERM U620, Universite de Rennes 1, 2 avenue du Pr. Leon Bernard, 35043 Rennes cedex, France. ³ INSERM U620, Universite de Rennes 1, 2 avenue du Pr. Leon Bernard, 35043 Rennes cedex, France. ⁴ INSERM U620, Universite de Rennes 1, 2 avenue du Pr. Leon Bernard, 35043 Rennes cedex, France. ⁵ INSERM U620, Universite de Rennes 1, 2 avenue du Pr. Leon Bernard, 35043 Rennes cedex, France. ⁶ INSERM U620, Universite de Rennes 1, 2 avenue du Pr. Leon Bernard, 35043 Rennes cedex, France. ⁷ INSERM U620, Universite de Rennes 1, 2 avenue du Pr. Leon Bernard, 35043 Rennes cedex, France.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 3, Apr 2006, p. 159 - 171
DOI: https://doi.org/10.2174/157018006776287005
- Available online: 01 Apr 2006

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases, regulated by endogenous tissue inhibitors (TIMPs) and inducer (EMMPRIN). The demonstration of a functional role of MMPs in pulmonary diseases raises the possibility of therapeutic intervention targeting MMP/TIMP balance to prevent pathological processes.

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2006-04-01

2025-10-11

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Article Type: Research Article

Keyword(s): EMMPRIN; MMP; Pulmonary diseases; regulation; TIMP

Regulation of MMP/TIMP Balance as Therapeutic Target in Pulmonary Diseases

Abstract

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