HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2

Yasutomo Nomura; Hiroyuki Fujiwara; Kohei Ito; Hirobumi Fuchigami; Michihiko Sato; Eiji Takahashi; Yasukazu Hozumi; Kaoru Goto; Zhonggang Feng; Takao Nakamura

doi:10.2174/157018006776286952

ISSN: 1570-1808
E-ISSN: 1875-628X

HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2
Authors: Yasutomo Nomura¹, Hiroyuki Fujiwara², Kohei Ito³, Hirobumi Fuchigami⁴, Michihiko Sato⁵, Eiji Takahashi⁶, Yasukazu Hozumi⁷, Kaoru Goto⁸, Zhonggang Feng⁹ and Takao Nakamura¹⁰
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¹ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ² Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ³ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ⁴ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ⁵ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ⁶ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ⁷ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ⁸ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ⁹ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan. ¹⁰ Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata 992-8510 Japan.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 3, Apr 2006, p. 172 - 174
DOI: https://doi.org/10.2174/157018006776286952
- Available online: 01 Apr 2006

Abstract

Severity of ischemia/reperfusion injury accompanied with generation of reactive oxygen species is reduced by hypoxic preconditioning, the precise mechanisms of which are not completely understood. We found that cobalt-induced hypoxia-inducible factor-1α activity ameliorated suppression of cell growth caused by H2O2 through protecting mitochondrial DNA from oxidative damage.

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2006-04-01

2025-10-15

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Article Type: Research Article

Keyword(s): cell growth; cobalt; DNA damage; H2O2; HIF-1α; mitochondria

HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2

Abstract

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