Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products

D. Sellanes; L. Scarone; G. Mahler; E. Manta; A. Baz; S. Dematteis; J. Saldana; L. Dominguez; P. Wipf; G. Serra

doi:10.2174/157018006775240962

ISSN: 1570-1808
E-ISSN: 1875-628X

Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products
Authors: D. Sellanes¹, L. Scarone², G. Mahler³, E. Manta⁴, A. Baz⁵, S. Dematteis⁶, J. Saldana⁷, L. Dominguez⁸, P. Wipf⁹ and G. Serra¹⁰
View Affiliations Hide Affiliations

¹ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ² Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ³ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ⁴ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ⁵ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ⁶ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ⁷ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ⁸ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ⁹ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay. ¹⁰ Department of Organic Chemistry, Facultad de Quimica, Universidad de la Republica, General Flores 2124, CC 1157, Montevideo, Uruguay.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 1, Feb 2006, p. 35 - 43
DOI: https://doi.org/10.2174/157018006775240962
- Available online: 01 Feb 2006

Abstract

Tandem cyclizations to [2,5'] bis-1,3-azoles provided simplified and stable models of biological active marine natural products. The cytotoxic activity in HCT-15 cells and the effect on the L4 larvae of Nippostrongylus brasiliensis of the heterocycles were evaluated and provided data that serve for the preparation of bioselective new therapeutic agents.

Article metrics loading...

/content/journals/lddd/10.2174/157018006775240962

2006-02-01

2025-09-22

From This Site

/content/journals/lddd/10.2174/157018006775240962

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/lddd/10.2174/157018006775240962

Article Type: Research Article

Keyword(s): anthelmintic; Bengazoles; Bis-1,3-azoles; cytotoxic

Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides

Thermodynamic Aspects of Cancer: Possible Role of Negative Entropy in Tumor Growth, its Relation to Kinetic and Genetic Resistance

Immunomodulatory Properties of Synthetic Imidazolone Derivatives

Design and Prediction of ADME/Tox Properties of Novel Magnolol Derivatives as Anticancer Agents for NSCLC Using 3D-QSAR, Molecular Docking, MOLCAD and MM-GBSA Studies

Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease

Identifying Protein Binding Sites and Optimal Ligands

Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas

Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides

Selection of a Catalytically Active Enzyme In Vivo Via Phage Display of its Product

A Comprehensive Review of the Advancement in Omic Technologies in the Field of Drug Discovery and Development