Enhancement of Drug Cytotoxicity by Silicon Containing Groups

Jose M. Padron; Osvaldo J. Donadel; Leticia G. Leon; Tomas Martin; Victor S. Martin

doi:10.2174/157018006775240944

ISSN: 1570-1808
E-ISSN: 1875-628X

Enhancement of Drug Cytotoxicity by Silicon Containing Groups
Authors: Jose M. Padron¹, Osvaldo J. Donadel², Leticia G. Leon³, Tomas Martin⁴ and Victor S. Martin⁵
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¹ Instituto Canario de Investigacion del Cancer, Unidad de Investigacion, Hospital Universitario NS de Candelaria, Ctra. del Rosario s/n, 38010 S/C de Tenerife, Spain. ² Instituto Canario de Investigacion del Cancer, Unidad de Investigacion, Hospital Universitario NS de Candelaria, Ctra. del Rosario s/n, 38010 S/C de Tenerife, Spain. ³ Instituto Canario de Investigacion del Cancer, Unidad de Investigacion, Hospital Universitario NS de Candelaria, Ctra. del Rosario s/n, 38010 S/C de Tenerife, Spain. ⁴ Instituto Canario de Investigacion del Cancer, Unidad de Investigacion, Hospital Universitario NS de Candelaria, Ctra. del Rosario s/n, 38010 S/C de Tenerife, Spain. ⁵ Instituto Canario de Investigacion del Cancer, Unidad de Investigacion, Hospital Universitario NS de Candelaria, Ctra. del Rosario s/n, 38010 S/C de Tenerife, Spain.
Source: Letters in Drug Design & Discovery, Volume 3, Issue 1, Feb 2006, p. 29 - 34
DOI: https://doi.org/10.2174/157018006775240944
- Available online: 01 Feb 2006

Abstract

Enantiomerically pure (2R,3S)-disubstituted tetrahydropyrans with diverse functional groups were synthesized. These derivatives were used as a model to study the influence of the tert-butyl dimethyl silyl group in the anticancer activity. The in vitro cytotoxicity was evaluated against a panel of six human cancer cells from diverse origin (MCF7, T-47D, HeLa, SW1573, WiDr and A2780). The structure-activity relationship study shows the relevant role of the silyl protecting group in the enhancement of the observed cytotoxic activity.

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2006-02-01

2025-09-22

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Article Type: Research Article

Keyword(s): antitumor agents; drug design; lipophilicity; Silyl ethers; structure-activity relationships

Enhancement of Drug Cytotoxicity by Silicon Containing Groups

Abstract

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