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2000
Volume 2, Issue 6
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Methionine aminopeptidase type 2 catalyzes the removal of the amino-terminal methionine from newly translated polypeptides and has been shown to be a promising target for anti-angiogenesis and anticancer drugs. We describe a novel μARCS HTS method to identify inhibitors of this target utilizing porous matrices to introduce reagents throughout the assay. A library of 250,000 compounds was screened and compounds with IC50 values of less than 10μM were identified. These compounds may serve as initial lead molecules for further medicinal chemistry optimization.

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/content/journals/lddd/10.2174/1570180054771518
2005-09-01
2024-11-07
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/content/journals/lddd/10.2174/1570180054771518
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  • Article Type: Research Article
Keyword(s): aminopeptidase; arcs; cancer; membranes; metap2; methionine
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