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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines
- Source: Letters in Drug Design & Discovery, Volume 1, Issue 3, Jul 2004, p. 217 - 223
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- 01 Jul 2004
Abstract
Detailed SAR examination and DIStance COmparison (DISCO) computation were used for identification and superposition of common structural features of 2,3-benzodiazepines with high affinity to an allosteric AMPA binding site. Two similar 4-point models were identified; both contained 2 donor sites, a donor atom and a hydrophobic centre. At one of the donor sites a characteristic difference between the two models was observed.
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