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Abstract

Accurate prediction of Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) is a key component in using the drug as a therapeutic. Traditionally many and techniques are used for ADMET profiling in pre-clinical studies. Due to the absence of all cellular parameters and inter-species variability, the obtained pre-clinical study results were not reproducible in clinical trials. As a result, both industry and academic researchers find drug discovery and development to be a daunting task due to several constraints. A reliable and simple approach is, therefore, needed for PK-PD studies. The new ray of hope in this field is the Organ-on-a-Chip (OoC) technique. On one side, it is an technique, and on another side, it can reliably produce reliable PK/PD results. In this review, we primarily focused on the application and scope of OoC technology in the field of PK/PD studies. We believe this review will be helpful for future researchers in this domain.

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2025-03-07
2025-10-01

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/content/journals/dmbl/10.2174/0118723128377867250225073257
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Navigating Drug Dynamics: Unleashing On-Chip Pharmacokinetics and Pharmacodynamics
Bentham Science Publishers ; https://doi.org/10.2174/0118723128377867250225073257
/content/journals/dmbl/10.2174/0118723128377867250225073257
/content/journals/dmbl/10.2174/0118723128377867250225073257
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  • Article Type:     Review Article
Keywords: microphysiological systems ; PK-PD parameters ; Organ-on-a-chip ; multi-organ chip ; inter-species variability ; drug discovery

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