Drug Metabolism and Bioanalysis Letters - Online First
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A Physiologically-Based Pharmacokinetic Model to Characterize Dasotraline Pharmacokinetics and CYP-mediated Drug-Drug Interactions
Available online: 27 June 2025More LessIntroduction Dasotraline is an investigational inhibitor of dopamine and norepinephrine reuptake transporters that has completed pivotal studies in Attention Deficit and Hyperactivity Disorder (ADHD) and Binge Eating Disorder (BED). Preclinical studies show dasotraline is well absorbed, well distributed, and highly metabolized in animal models, though absorption is prolonged with slow overall elimination in humans. Dasotralin Read More
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Advancing Pediatric Drug Safety: The Potential of Physiologically Based Pharmacokinetic Modeling
Available online: 11 June 2025More LessPhysiologically Based Pharmacokinetic (PBPK) modeling represents an advanced computational model that bridges the gap between theoretical pharmacology and clinical practice. These advanced mathematical frameworks integrate complex physiological parameters with absorption, distribution, metabolism, and excretion (ADME) processes to create dynamic simulations of drug behavior in biological systems. By provi Read More
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Navigating the Medicinal Benefits of Cubosome in Medicated Cosmetics for Potent Dermal Drug Delivery
Authors: Sumedha Saxena, Amol Kumar and Rashmi Saxena PalAvailable online: 19 May 2025More LessCubosomes, nanoscale liquid crystalline particles, represent a groundbreaking advancement in dermal drug delivery for medicated cosmetics. These innovative structures feature a three-dimensional cubic lattice formed through the self-assembly of lipid molecules, which possess both hydrophilic and hydrophobic domains. This unique composition allows cubosomes to form stable, water-dispersible nanoparticles, makin Read More
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`3-Hydroxy-6H,7H-chromeno [3,4-c]chromene-6,7-dione as a Substrate for Studying Glucuronidation, Sulfonation and Lactone Hydrolysis
Available online: 25 April 2025More LessIntroduction/Objective Glucuronidation and sulfonation enzymes conjugate compounds containing a hydroxyl group, while paraoxonase enzymes hydrolyze lactone-containing compounds. 3-Hydroxy-6H,7H-chromeno [3,4-c]chromene-6,7-dione (3-hydroxy-V-coumarin) contains both a hydroxyl substituent and two lactone substructures and is strongly fluorescent. This study evaluates glucuronidation, sulfonation and hydrolysis of Read More
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Development and Validation of HPLC Method for Metformin and Canagliflozin in Bulk and Pharmaceutical Dosage Form Using the QbD Approach
Authors: Ansari Sajjad Husain Mumtaz Ahmad and Sunita S. DeoreAvailable online: 23 April 2025More LessIntroduction A simple, precise, robust, and accurate high-performance liquid chromatography (HPLC) technique has been devised and validated for the simultaneous quantification of canagliflozin (CAN) and metformin (MET) in the dose form of combination tablets. Methods The significance and interaction effects of independent variables on the response factors were evaluated using 32 factorial design. Analysis of variance (ANO Read More
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Bioanalytical Method Development and Validation for the Estimation of Metformin and Vildagliptin in K3EDTA Human Plasma Using HPLC-ESI-MS/MS
Authors: Binit Patel, Shalin Parikh, Ravi Patel, Khushbu Patel, Pinak Patel, Pravinkumar Darji, Archita Patel and Samir PatelAvailable online: 19 March 2025More LessObjective A unique liquid chromatography-tendon mass spectrometric technique for the determination of metformin and vildagliptin in K3EDTA human plasma was developed and verified as per the USFDA guidelines of bioanalysis. Methods The chromatographic separation was achieved using a Cosmosil CN (150 x 4.6 mm, 5 µm) column with an isocratic elution pattern using 10 mM ammonium formate (pH 5.0) and meth Read More
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Recent Advances and Opportunities in Cancer Cell Targeting by Surface Decoration: A Review
Available online: 19 March 2025More LessRecently, polymeric systems have emerged as the most practical and adaptable delivery method for targeted cancer therapy. Surface functionalization of polymers is one of the delivery methods of targeted drugs. For instance, to increase the selectivity and affinity of polymers for cancer cells, targeting moieties are covalently bonded on their surface. The surface decoration of polymers with a particular tumor-hom Read More
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Understanding DNA and PARP in Cancer: Tackling Inhibitor Resistance
Available online: 13 March 2025More LessDeoxyribonucleic acid (DNA) is the crucial molecule that stores and transmits genetic information in living organisms. DNA can incur damage from various sources, necessitating efficient DNA repair mechanisms to maintain genomic stability. Cells employ multiple repair pathways, including single-strand repair and double-strand break repair, each involving specific proteins and enzymes. PARPs play a fundamental role in the Read More
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A Novel Stability-Indicating HPLC Method with Kinetics Study for the Concurrent Analysis of Anti‐Hypertensive Drug Combination of Atenolol and Indapamide
Authors: Vibhuti A. Rabadiya, Nehal Shah and Ashok H. AkabariAvailable online: 13 March 2025More LessBackground Stability-indicating methods are essential in pharmaceutical analysis to ensure the efficacy and safety of drugs throughout their shelf life. Atenolol and indapamide, both widely prescribed for hypertension, require robust analytical methods for the detection and quantification of their degradation products. Ensuring their stability is vital to maintaining therapeutic efficacy and safety, necessitating thorough analytic Read More
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Navigating Drug Dynamics: Unleashing On-Chip Pharmacokinetics and Pharmacodynamics
Available online: 07 March 2025More LessAccurate prediction of Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) is a key component in using the drug as a therapeutic. Traditionally many in vitro and in vivo techniques are used for ADMET profiling in pre-clinical studies. Due to the absence of all cellular parameters and inter-species variability, the obtained pre-clinical study results were not reproducible in clinical trials. As a result, both industry and a Read More
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A Review on Pharmaceutical and Bio-Allied Applications of Infrared Spectroscopy
Authors: Muskan1, Bhawna Chopra, Sakshi Bhardwaj and Ashwani K. DhingraAvailable online: 26 February 2025More LessInfrared spectroscopy has emerged as a powerful analytical technique with diverse applications in the pharmaceutical and bio-allied domains. This article provides an in-depth exploration of the method's utility in pharmaceutical applications, including identification, moisture content determination, and assay of pharmaceutical compounds. Additionally, it delves into the extensive role of infrared spectroscopy in bio-alli Read More
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Sphingolipids in Cancer: Metabolism, Signaling, and Clinical Implications
Authors: Sharav A. Desai, Sandip D. Nagare, Vipul P. Patel, Nishant B. Pagare and Tejas C. JangamAvailable online: 26 February 2025More LessSphingolipids are bioactive lipids that are essential for cellular functions like signaling, apoptosis, and proliferation. They are also important in the biology of cancer. The complex dynamics of sphingolipid metabolism and its consequences for the advancement of cancer are examined in this review. It highlights the regulatory functions of important enzymes such as ceramide kinase (CERK) and sphingosine kinases (SPHKs) in Read More
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