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2000
Volume 25, Issue 14
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Introduction/Objectives

Failures of osseointegrated implants pose significant challenges in the medical field, often due to prolonged osseointegration periods and bacterial infections. Functionalization of Titanium Dioxide Nanotubes (TNTs) has emerged as a promising strategy to improve osseointegration and mitigate infections. This study aims to conduct a bibliometric analysis and review to identify trends, gaps, and advancements in research on the functionalization of TNTs for osseointegration improvement.

Methods

Articles were retrieved from the Web of Science database using the keywords “osseointegration,” “titanium dioxide nanotubes,” and “functionalization.” The inclusion criteria were studies published between 2014 and 2023, written in English, and focusing on the use of TNTs in implant surface modifications. A total of 126 articles were included after screening. Data extraction and analysis were performed using VOS Viewer, Microsoft Excel, and GraphPad Prism.

Results

The review revealed a growing number of publications on TNTs functionalization, with China, the United States, and Brazil leading in contributions. Key findings include the effectiveness of TNTs loaded with bioactive agents (., silver, strontium, hydroxyapatite) in promoting osseointegration and antibacterial activity. Collaborative networks among institutions and authors were mapped, highlighting the Sao Paulo State University and Yong Huang as the most prolific contributors.

Conclusion

The findings underscore the potential of TNTs functionalization to enhance implant performance. However, a gap remains in translating preclinical findings into clinical trials. Future research should focus on clinical validation to bridge this gap and translate laboratory advancements into therapeutic solutions.

© 2025 Bentham Science Publishers
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Osseointegration Process Improving via Functionalization of Titanium Dioxide Nanotubes: A Bibliometric Analysis and Review
Curr. Top. Med. Chem. 25, 1719 (2025); https://doi.org/10.2174/0115680266334190241213101547
/content/journals/ctmc/10.2174/0115680266334190241213101547
/content/journals/ctmc/10.2174/0115680266334190241213101547
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  • Article Type:     Review Article
Keyword(s): antibacterial activity; biocompatibility; Implants; surface modification; titanium

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