Current Science, Engineering and Technology - Volume 5, Issue 1, 2025
Volume 5, Issue 1, 2025
-
-
Research Progress of Magnetic Nanomaterials and Magnetic Field based Chemiresistive Gas Sensors
More LessAuthors: Jiangnan Chang, Yixun Gao, Zhipeng Hou and Yao WangWith the increasing demand for environmental protection and safety monitoring, the development of gas sensors with high sensitivity, fast response and selectivity is imperative. Magnetic field-assisted gas sensing is gradually becoming a research hotspot. This review aims to provide an overview of magnetic-related chemiresistive gas sensing from two segments, including magnetic sensing materials and magnetic field-assisted gas sensing. The type of sensors, the classification and parameters of magnetic materials, and the various materials employed in gas sensing are summarized. The review presents the currently commonly used methods for influencing magnetic structure and properties: chemical doping, defect engineering, and heterostructure construction as well as the application of applied magnetic field in gas sensing. This paper provides the first overview of chemiresistive gas sensors from a magnetic point of view, which is crucial for the development of magnetically correlated gas sensing technology and the subsequent study of the intrinsic mechanisms.
-
-
-
Innovative Approaches in Amphiphilic Small Molecule Design for Inhibiting Monkeypox Virus: Computational and Nanoassembly Approaches
More LessAuthors: Afzal Hussain and Ashfaq HussainThe Monkeypox virus (MPXV) has recently been identified as a new global health concern and, as such, requires new therapeutic approaches. Small molecules that can self-assemble into micelles have been demonstrated to improve solubility, pharmacokinetics, and anti-viral activity. Latest results suggest that amphiphilic small molecules enhance drug delivery and, importantly, can disrupt virus envelopes, which is required for MPXV. Moreover, encapsulating amphiphilic antiviral molecules with various hydrophobic drugs will significantly enhance their therapeutic indexes. This article presents a computational strategy based on molecular docking, dynamics simulations, and drug-mate nano assembly technologies in high antiviral efficiency against MPXV. This study, in fact, proposes new pathways for developing antiviral agents through the identification of key viral proteins as targets and based on insights obtained from already existing research. Safety considerations of amphiphilic molecules in humans have also been discussed. To this end, and through the identification of key viral proteins and the application of drug design principles, we hope to progress the development of novel antiviral agents and potential treatment strategies for MPXV.
-
-
-
Ugi-Trimethylsilylazide Mediated Efficient Synthesis of Tetrazole-Adamantane Hybrids as Anticancer Agents
More LessAuthors: Dharmesh Katariya, Kaushik Pambhar, Amita Vyas and Ranjan C. KhuntAimThis study aimed to synthesize a series of tetrazole-adamantane hybrids using the Ugi-tetrazole four-component reaction and evaluate their anticancer potential.
BackgroundThe search for new, potent, and less toxic anticancer agents has driven the exploration of innovative molecular designs. The Ugi-tetrazole four-component reaction offers an efficient approach to synthesizing tetrazole-containing compounds, which possess bioisosteric properties, combined with the hydrophobic characteristics of adamantane.
MethodsTetrazole-adamantane hybrids (5a-p) were synthesized by reacting an aldehyde, 1-adamantylamine, substituted isocyanides, and trimethylsilylazide in methanol. The compounds were characterized using mass spectrometry (MS), infrared (IR), and nuclear magnetic resonance (NMR) spectroscopy. The anticancer activity was assessed using the National Cancer Institute's 60 human tumor cell line panel (NCI-60) and MTT assays.
ResultsA series of tetrazole-adamantane hybrids (5a-p) were successfully synthesized. Compounds 5e, 5g, 5k, and 5l exhibited significant cytotoxicity against breast (MDA-MB-231, IC50 = 2.1 µM), lung (NCI-H460, IC50 = 1.8 µM), and leukemia (K562, IC50 = 3.0 µM) cell lines.
ConclusionThe Ugi-tetrazole four-component reaction provided a reliable route for synthesizing tetrazole-adamantane hybrids (5a-p) with promising anticancer activity. These hybrids showed potential as novel anticancer agents for treating breast, lung, and leukemia cancers. Further optimization and in vivo studies are warranted to explore their therapeutic potential.
-
-
-
A Relationship between Inflammatory Bowel Diseases and Urinary Lithiasis
More LessObjectiveUlcerative colitis (UC) and Crohn's disease (CD) are two forms of inflammatory bowel disease (IBD) and may be associated with the formation of urinary stones. Urinary lithiasis is a common condition that affects both men and women, and its prevalence is increasing due to dietary and environmental factors. Understanding the association between IBD and urolithiasis is important for the comprehensive treatment of patients. This review aims to evaluate the relationship between IBD and the formation of urinary calculi.
MethodologyPubMed/Medline database was used using the keywords simultaneously: (Inflammatory Bowel Disease) or (Crohn’s Disease) or (Ulcerative Colitis) and (Urolithiasis). After the preliminary search, 61 of 111 studies on the subject were examined. Other studies were included by the authors.
ResultsUrinary lithiasis is more prevalent in patients with Inflammatory Bowel Disease. The latter can be described as a risk factor for the former.
ConclusionPatients with IBD are at increased risk of developing urolithiasis. Despite the limitations of this study, these patients may benefit from early screening, as well as strict control of disease activity, diet, medication and behaviors.
-
-
-
Therapeutic Insights into Sansevieria trifasciata: A Medicinal Powerhouse
More LessAuthors: Romi Rajput, Brijesh Kumar Duvey, Vishnu Mittal, Anjali Sharma, Devkant Sharma and Anurag BhargavaThe snake plant, or Sansevieria trifasciata, is a species that has become well-known for both its remarkable therapeutic qualities and aesthetic appeal. It has long been utilized in traditional medicine to promote fiber formation and wound healing, but more recent research has revealed its full medicinal potential. The botanical characteristics of Sansevieria trifasciata, such as its morphology, taxonomy, ecological and cultural needs, and therapeutic use, are thoroughly examined in this review. Moreover, the presence of vital bioactive substances that underlie the plant’s numerous therapeutic advantages, including triterpenoids, alkaloids, flavonoids, and steroidal saponins, are also explored. Interestingly, seven essential components that are essential to the plant’s medicinal effectiveness, namely beta-d-xylopyranose, sansevierigenin, beta-sitosterol, neoruscogenin, and ruscogenin, are identified. This review emphasizes how unusual these discoveries are and suggests that the chemical components of the plant may provide new ways to treat neurological illnesses, promote wound healing, and manage metabolic diseases like diabetes. Furthermore, the pharmacological properties of these molecules present encouraging opportunities for the creation of natural medicinal medicines. By combining a botanical and pharmacological viewpoint, this review advances our understanding of Sansevieria trifasciata. It also suggests a framework for further research that may uncover more bioactive compounds and increase the plant’s use in conventional and contemporary pharmacotherapy. The culmination of these observations ultimately indicates the enormous unrealized potential of Sansevieria trifasciata in medicinal and pharmaceutical settings, indicating a significant area for further research focused on drug development and health innovation.
-
-
-
Enhancing Quality Standards: A Critical Evaluation of Genuine Cyclodextrin-containing Products in the Post-soviet Market
More LessAuthors: István Puskás, Anna Nebalueva, Anna Botnar, Sergey Shityakov and Anton MuravevThis study addresses suboptimal formulation practices observed in cyclodextrin (CD)-containing medicinal products within the post-Soviet region, particularly in Russia, where CDs are often used in amounts significantly lower than stoichiometric amounts. By analyzing ten products using transparent package inserts, this research underscores the unique transparency observed in the composition information of medicinal products within the post-Soviet region. This study highlights the importance of justifying cyclodextrin quantities in formulations and recommends thorough evaluation by the Ministry of Health for marketing authorization. The exceptional transparency observed in the post-Soviet region enables increased awareness among physicians, patients, and healthcare professionals regarding exposure to inactive ingredients and their functionality. This transparency provides valuable insights into optimizing the use of cyclodextrins in pharmaceutical formulations.
-
Volumes & issues
Most Read This Month