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2000
Volume 1, Issue 1
  • ISSN: 2772-6215
  • E-ISSN: 2772-6223

Abstract

Aim

The current study focused on the development of biocompatible liposomes utilizing a eutectic mixture of thymol and menthol in a 1:1 ratio, serving as an environment friendly alternative to conventional harsh organic solvents.

Introduction

Eczema, also known as atopic dermatitis, is marked by dry and itchy skin, which can result from viral infections, immune system responses, and various other factors. Additionally, thymol and menthol have been noted to alleviate the symptoms associated with atopic eczema.

Objective

The aim of the current study was to develop eco-friendly liposomes loaded with acyclovir, utilizing a eutectic solvent, to achieve a synergistic effect in the management of atopic eczema.

Methods

Eco-friendly liposomes of acyclovir were prepared and assessed for shape and surface morphology, drug entrapment, pH, viscosity, particle size, Zeta potential, drug-excipients interaction, drug permeation, skin irritation and stability.

Results and Discussion

The mean size, Zeta potential and entrapment efficiency of the prepared eco-friendly liposomal vesicles were 798 ± 102 nm, -20 ± 5 mV and 96.06 ± 1.92%, respectively. The pH and viscosity of the optimized formulation were found to be 6.5 and 102 ± 0.8 cps. The prepared eco-friendly liposomal formulation revealed sustained drug release and outcomes stipulated increased permeation of medicament across the egg sheath in comparison to the marketed formulation.

Conclusion

Eco-friendly liposome prepared by a eutectic mixture of thymol and menthol is exceptionally adequate dermal preparation since optimized formulation stipulated no indication of dermal sensitization in mice. Further, the use of eco-friendly eutectic solvent in pharmaceutical formulations releases less toxic hazardous chemical wastes to the atmosphere.

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2025-05-13
2025-10-09

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Eutectic Mixture: Solvent in the Development of Biocompatible Liposome to Manage Dermatitis
Curr Cell Sci 1, E27726215370113 (2025); https://doi.org/10.2174/0127726215370113250509055809
/content/journals/csci/10.2174/0127726215370113250509055809
/content/journals/csci/10.2174/0127726215370113250509055809
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  • Article Type:     Research Article
Keyword(s): atopic eczema; dermatitis; Eco-friendly liposomes; eco-friendly substitute; eutectic mixture; green solvent
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