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2000
Volume 22, Issue 1
  • ISSN: 1875-6921
  • E-ISSN: 1875-6913

Abstract

Background/Introduction

Dental caries result from the demineralization of enamel or dentin caused by acids produced by cariogenic oral bacteria. The Glutathione S-transferase P1 () is a prominent member of the family, and it exhibits several genetic polymorphisms, with rs1695 being the most common variant.

Aim

Our study is to investigate the relationship between rs1695 polymorphism and the susceptibility to dental caries.

Objective

The study focused on understanding the relationship between rs1695 polymorphisms and susceptibility to dental caries in the Tamil population.

Methods

SNPs in the missense variant rs1695 (A/G) were analysed by PCR RFLP. The study group included 100 dental caries with (DMFT >5) and 100 healthy controls (DMFT=0). Further analysis of the impact of the wild-type gene with the rs1695 variant on mRNA's secondary structure was conducted using prediction tools.

Results and Discussion

The results showed a significant frequency distribution of the heterozygous AG genotype (<0.05). While the genotypic distribution of remained consistent with Hardy-Weinberg equilibrium (HWE) in the control group (-value > 0.05), it deviated from HWE in the caries group. The free energy of the thermodynamic ensemble for the rs1695 variant was calculated to be -186.20 kcal/mol. This lower free energy, compared to the wild-type, indicates that the variant is more stable.

Conclusion

Our findings indicate that rs1695 variants could enhance susceptibility to dental caries by suggesting genetic load as a possible risk factor. However, additional functional research and larger studies are required to confirm these results.

© 2025 Bentham Science Publishers
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2024-12-06
2025-09-02

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GSTP Polymorphism of GSTP1 (rs1695) and its Potential Association with Dental Caries in the Tamil Population
Curr. Pharm. and. Per. Med. 22, E18756921356621 (2025); https://doi.org/10.2174/0118756921356621241125113946
/content/journals/cppm/10.2174/0118756921356621241125113946
/content/journals/cppm/10.2174/0118756921356621241125113946
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  • Article Type:     Research Article
Keyword(s): association; dental caries; DMFT; genotype; GSTP1; oral bacteria; polymorphism

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