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2000
Volume 32, Issue 9
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Oral diseases represent significant health challenges, with periodontal diseases and dental caries ranking as key preventable infectious diseases worldwide. Oral health affects overall quality of life, and inadequate oral hygiene is associated with chronic diseases. Carvacrol is a monoterpenoid phenol found in essential oils of pepperwort (), thyme (), oregano (), wild bergamot (), and other plants. Carvacrol exhibits numerous biological activities, including antimicrobial, antioxidant, and anticancer effects. Carvacrol demonstrated the ability to inhibit the oral pathogens examined and exhibited properties that prevent biofilm formation on their oral biofilm; thus, it may be used to manage and prevent the colonization of microorganisms, which is particularly important in human oral diseases. Besides, carvacrol protects gingival tissue in periodontal disease. Knowledge of carvacrol's many actions will help develop novel treatment plans, and designing clinical studies will optimize its potential advantages for treating oral diseases.

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2025-07-02
2026-02-27

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References

  1. KumarM. PrakashS. Radha KumariN. PundirA. PuniaS. SaurabhV. ChoudharyP. ChanganS. DhumalS. PradhanP.C. AlajilO. SinghS. SharmaN. IlakiyaT. SinghS. MekhemarM. Beneficial role of antioxidant secondary metabolites from medicinal plants in maintaining oral health.Antioxidants2021107106134209152
     [Google Scholar]
  2. AlsuraimB.S. HanD-H. Effect of globalization on global dental caries trend.Medicine (Baltimore)20209935e2176732871897
     [Google Scholar]
  3. Furquim Dos Santos CardosoV. Amaral RoppaR.H. AntunesC. Silva MoraesA.N. SantiL. KonrathE.L. Efficacy of medicinal plant extracts as dental and periodontal antibiofilm agents: A systematic review of randomized clinical trials.J. Ethnopharmacol.202128111454134416298
     [Google Scholar]
  4. PasupuletiM.K. NagateR.R. AlqahtaniS.M. PenmetsaG.S. GottumukkalaS.N.V.S. RameshK.S.V. Role of medicinal herbs in periodontal therapy: A systematic review.J. Int. Soc. Prev. Community Dent.202313191637153928
     [Google Scholar]
  5. ForouzanfarA. MohammadipourH.S. ForouzanfarF. The potential role of tea in periodontal therapy: an updated review.Curr. Drug Discov. Technol.20211811731985382
     [Google Scholar]
  6. ForouzanfarF. ForouzanfarA. SathyapalanT. OrafaiH.M. SahebkarA. Curcumin for the management of periodontal diseases: A review.Curr. Pharm. Des.202026344277428432400326
     [Google Scholar]
  7. ImranM. AslamM. AlsagabyS.A. SaeedF. AhmadI. AfzaalM. ArshadM.U. AbdelgawadM.A. El-GhorabA.H. KhamesA. ShariatiM.A. AhmadA. HussainM. ImranA. IslamS. Therapeutic application of carvacrol: A comprehensive review.Food Sci. Nutr.202210113544356110.1002/fsn3.299436348778
     [Google Scholar]
  8. DiasC.J. CostaH.A. Alves Dias-FilhoC.A. FerreiraA.C. RodriguesB. IrigoyenM.C. Romão BorgesA.C. de Andadre MartinsV. Branco VidalF.C. RibeiroR.M. FilhoN.S. MostardaC.T. Carvacrol reduces blood pressure, arterial responsiveness and increases expression of MAS receptors in spontaneously hypertensive rats.Eur. J. Pharmacol.202291717471710.1016/j.ejphar.2021.17471734953800
     [Google Scholar]
  9. AristatileB. Al-NumairK.S. VeeramaniC. PugalendiK.V. Effect of carvacrol on hepatic marker enzymes and antioxidant status in d -galactosamine-induced hepatotoxicity in rats.Fundam. Clin. Pharmacol.200923675776510.1111/j.1472‑8206.2009.00721.x19650854
     [Google Scholar]
  10. NeopaneD. KushwahaP. Carvacrol in asthma management: A comprehensive review of its therapeutic potential and mechanisms of action.Pharmacol. Rep.202511410.1007/s43440‑025‑00709‑640067636
     [Google Scholar]
  11. GhahremanE. EidiA. MortazaviP. AsghariA. Asle-RoustaM. Carvacrol attenuates varicocele-induced infertility in rats.Eur. J. Pharmacol.202599117730310.1016/j.ejphar.2025.17730339870232
     [Google Scholar]
  12. ShahS. Pushpa TryphenaK. SinghG. KulkarniA. PinjalaP. Kumar KhatriD. Neuroprotective role of Carvacrol via Nrf2/HO-1/NLRP3 axis in Rotenone-induced PD mice model.Brain Res.2024183614895410.1016/j.brainres.2024.14895438649135
     [Google Scholar]
  13. Ezz-EldinY.M. AboseifA.A. KhalafM.M. Potential anti-inflammatory and immunomodulatory effects of carvacrol against ovalbumin-induced asthma in rats.Life Sci.202024211722210.1016/j.lfs.2019.11722231881223
     [Google Scholar]
  14. OliveiraI.S. da SilvaF.V. VianaA.F.S.C. dos SantosM.R.V. Quintans-JúniorL.J. MartinsM.C.C. NunesP.H.M. OliveiraF.A. OliveiraR.C.M. Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents.Naunyn Schmiedebergs Arch. Pharmacol.2012385989990810.1007/s00210‑012‑0771‑x22739789
     [Google Scholar]
  15. AslamH. AlbaqamiF. RehmanN.U. ShahF.A. Carvacrol attenuated myocardial infarction through NLRP3-mediated pyroptosis and mTOR/Nrf2/PPARγ-dependent autophagic signaling.Toxicol. Appl. Pharmacol.202549811728110.1016/j.taap.2025.11728140064378
     [Google Scholar]
  16. ForqaniMA AkbarianM AmirahmadiS KhorramiMB HosseiniM ForouzanfarF Protective effect of carvacrol against oxidative damage in aged rats.Cent Nerv Syst Agents Med Chem2024 Epub ahead of print.10.2174/0118715249303906240729074821
     [Google Scholar]
  17. LeeB. YeomM. ShimI. LeeH. HahmD. Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats.Korean J. Physiol. Pharmacol.2020241273710.4196/kjpp.2020.24.1.2731908572
     [Google Scholar]
  18. BansalA. Saleh-E-InM.M. KarP. RoyA. SharmaN.R. Synthesis of carvacrol derivatives as potential new anticancer agent against lung cancer.Molecules20222714459710.3390/molecules2714459735889476
     [Google Scholar]
  19. ForqaniM.A. AkbarianM. AmirahmadiS. SoukhtanlooM. HosseiniM. ForouzanfarF. Carvacrol improved learning and memory and attenuated the brain tissue oxidative damage in aged male rats.Int. J. Neurosci.20231837694395
     [Google Scholar]
  20. de CarvalhoF.O. SilvaÉ.R. GomesI.A. SantanaH.S.R. do Nascimento SantosD. de Oliveira SouzaG.P. de Jesus SilvaD. MonteiroJ.C.M. de Albuquerque JúniorR.L.C. de Souza AraújoA.A. NunesP.S. Anti-inflammatory and antioxidant activity of carvacrol in the respiratory system: A systematic review and meta-analysis.Phytother. Res.20203492214222910.1002/ptr.668832249518
     [Google Scholar]
  21. SánchezC. AznarR. SánchezG. The effect of carvacrol on enteric viruses.Int. J. Food Microbiol.2015192727610.1016/j.ijfoodmicro.2014.09.02825310265
     [Google Scholar]
  22. SilvaF.V. GuimarãesA.G. SilvaE.R.S. Sousa-NetoB.P. MachadoF.D.F. Quintans-JúniorL.J. ArcanjoD.D.R. OliveiraF.A. OliveiraR.C.M. Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.J. Med. Food2012151198499110.1089/jmf.2012.010222892022
     [Google Scholar]
  23. LimaI.O. PereiraF.O. OliveiraW.A. LimaE.O. MenezesE.A. CunhaF.A. DinizM.F.F.M. Antifungal activity and mode of action of carvacrol against Candida albicans strains.J. Essent. Oil Res.201325213814210.1080/10412905.2012.754728
     [Google Scholar]
  24. MarinelliL. Di StefanoA. CacciatoreI. Carvacrol and its derivatives as antibacterial agents.Phytochem. Rev.201817490392110.1007/s11101‑018‑9569‑x
     [Google Scholar]
  25. HocaM. BecerE. VatanseverH.S. Carvacrol is potential molecule for diabetes treatment.Arch. Physiol. Biochem.20231838019023
     [Google Scholar]
  26. BalefS.S.H. HosseiniS.S. AsgariN. SohrabiA. MortazaviN. The inhibitory effects of carvacrol, nystatin, and their combination on oral candidiasis isolates.BMC Res. Notes202417110410.1186/s13104‑024‑06767‑y38605312
     [Google Scholar]
  27. CiandriniE. CampanaR. FedericiS. MantiA. BattistelliM. FalcieriE. PapaS. BaffoneW. In vitro activity of Carvacrol against titanium-adherent oral biofilms and planktonic cultures.Clin. Oral Investig.20141882001201310.1007/s00784‑013‑1179‑924458367
     [Google Scholar]
  28. Fernández-BabianoI. Navarro-PérezM.L. Pérez-GiraldoC. Fernández-CalderónM.C. Antibacterial and antibiofilm activity of carvacrol against oral pathogenic bacteria.Metabolites20221212125510.3390/metabo1212125536557293
     [Google Scholar]
  29. KhanS.T. KhanM. AhmadJ. WahabR. Abd-ElkaderO.H. MusarratJ. AlkhathlanH.Z. Al-KedhairyA.A. Thymol and carvacrol induce autolysis, stress, growth inhibition and reduce the biofilm formation by Streptococcus mutans.AMB Express2017714928233286
     [Google Scholar]
  30. Maquera HuachoP.M. Rodriguez HerreroE. VerspechtT. PauwelsM. MarcantonioE.Jr Palomari SpolidorioD.M. TeughelsW. Terpinen-4-ol and carvacrol affect multi-species biofilm composition.Biofouling201935556157231282200
     [Google Scholar]
  31. Maquera-HuachoP.M. TononC.C. CorreiaM.F. FrancisconiR.S. BordiniE.A.F. MarcantonioÉ. SpolidorioD.M.P. In vitro antibacterial and cytotoxic activities of carvacrol and terpinen-4-ol against biofilm formation on titanium implant surfaces.Biofouling201834669970910.1080/08927014.2018.148589230187780
     [Google Scholar]
  32. MasocattoDC MatsumotoMA CoelhoTMK JardimECG de MendonçaJCG da SilvaJCL Comparison of antimicrobial activity of thymol and carvacrol to chlorhexidine in surgery. Archives202110710.33448/rsd‑v10i7.16310
     [Google Scholar]
  33. NemodaM NikolićB VukotićT RakaševićD MarkovićD JovičićM Antibacterial and antibiofilm potential of carvacrol against oral Streptococcus spp. isolates.Lekovite sirovine202343110.61652/leksir2343e177N
     [Google Scholar]
  34. Safa LarijaniK. Moghhaddam NiaA.A. Bozorgi MakraniA. AbouHosseini TabariM. KhodadadiE. Antimicrobial activity of carvacrol against Lactobacillus acidophilus and Lactobacillus casei, An in-vitro study.J. Research. Appl. Basic Medical Sciences.202174172178
     [Google Scholar]
  35. SahinZ. OzerN.E. CalıA. Biofilm inhibition of denture cleaning tablets and carvacrol on denture bases produced with different techniques.Clin. Oral Investig.202428741310.1007/s00784‑024‑05810‑338965139
     [Google Scholar]
  36. WalczakM. Michalska-SionkowskaM. OlkiewiczD. TarnawskaP. WarżyńskaO. Potential of carvacrol and thymol in reducing biofilm formation on technical surfaces.Molecules2021269272334066411
     [Google Scholar]
  37. BotelhoM.A. MartinsJ.G. RuelaR.S. iR. SantosJ.A. SoaresJ.B. FrançaM.C. MontenegroD. RuelaW.S. BarrosL.P. QueirozD.B. AraujoR.S. SampioF.C. Protective effect of locally applied carvacrol gel on ligature-induced periodontitis in rats: A tapping mode AFM study.Phytother. Res.200923101439144819274705
     [Google Scholar]
  38. BotelhoM.A. RaoV.S. MontenegroD. BandeiraM.A.M. FonsecaS.G.C. NogueiraN.A.P. RibeiroR.A. BritoG.A. Effects of a herbal gel containing carvacrol and chalcones on alveolar bone resorption in rats on experimental periodontitis.Phytother. Res.200822444244918338370
     [Google Scholar]
  39. KuoP.J. HungT.F. LinC.Y. HsiaoH.Y. FuM.W. HongP.D. ChiuH.C. FuE. Carvacrol ameliorates ligation-induced periodontitis in rats.J. Periodontol.2017887e120e12810.1902/jop.2017.16061828387609
     [Google Scholar]
  40. LauritanoD. PazziD. IapichinoA. GaudioR.M. Di MuzioM. Lo RussoL. PezzettiF. Evaluation of the efficacy of a new oral gel containing carvacrol and thymol for home oral care in the management of chronic periodontitis using PCR analysis: A microbiological pilot study.J. Biol. Regul. Homeost. Agents2016302Suppl. 112913427469559
     [Google Scholar]
  41. Potra CicalăuG.I. CiavoiG. ScrobotăI. MarcuA.O. RomanulI. MarianE. VicașL.G. GaneaM. Assessing the antioxidant benefits of topical carvacrol and magnolol periodontal hydrogel therapy in periodontitis associated with diabetes in wistar rats.Dent. J.2023111228438132422
     [Google Scholar]
  42. Potra CicalăuG.I. MarcuO.A. GhiteaT.C. CiavoiG. IurcovR.C. BeiusanuC. TrifanD.F. VicașL.G. GaneaM. Study of Periodontal bacteria in diabetic wistar rats: Assessing the anti-inflammatory effects of carvacrol and magnolol hydrogels.Biomedicines2024127144510.3390/biomedicines1207144539062018
     [Google Scholar]
  43. DaiW. SunC. HuangS. ZhouQ. Carvacrol suppresses proliferation and invasion in human oral squamous cell carcinoma.OncoTargets Ther.201692297230410.2147/OTT.S9887527143925
     [Google Scholar]
  44. YuC.C. HsiehP.L. ChaoS.C. LiaoY.W. YuC.H. ChuehP.J. PengC.Y. LeeS.S. Carvacrol inhibits the progression of oral submucous fibrosis via downregulation of PVT1/miR-20a-5p-mediated pyroptosis.J. Cell. Mol. Med.20242818e7011210.1111/jcmm.7011239320020
     [Google Scholar]
  45. PalomboE.A. Traditional medicinal plant extracts and natural products with activity against oral bacteria: Potential application in the prevention and treatment of oral diseases.Evid. Based Complement. Alternat. Med.20112011168035410.1093/ecam/nep06719596745
     [Google Scholar]
  46. MohammadipourH.S. ForouzanfarF. ForouzanfarA. The role of type 2 fibroblast growth factor in periodontal therapy.Curr. Drug Targets202122331031710.2174/138945012199920110515263933153420
     [Google Scholar]
  47. JangidA. SharmaS. Overview of herbal nanoparticles: A patent review.Curr. Nanomed.20251510.2174/0124681873332177250117100927
     [Google Scholar]
  48. SouzaR.L. DantasA.G.B. MeloC.O. FelícioI.M. OliveiraE.E. Nanotechnology as a tool to improve the biological activity of carvacrol: A review.J. Drug Deliv. Sci. Technol.20227610383410.1016/j.jddst.2022.103834
     [Google Scholar]
  49. GhoraniV. AlavinezhadA. RajabiO. MohammadpourA.H. BoskabadyM.H. Safety and tolerability of carvacrol in healthy subjects: A phase I clinical study.Drug Chem. Toxicol.202144217718910.1080/01480545.2018.153823330486682
     [Google Scholar]
  50. SuntresZ.E. CoccimiglioJ. AlipourM. The bioactivity and toxicological actions of carvacrol.Crit. Rev. Food Sci. Nutr.201555330431810.1080/10408398.2011.65345824915411
     [Google Scholar]
  51. TzimasK. AntoniadouM. VarzakasT. VoidarouC.C. Plant-derived compounds: A promising tool for dental caries prevention.Curr. Issues Mol. Biol.20244665257529010.3390/cimb4606031538920987
     [Google Scholar]
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Role of Carvacrol in Oral Health: An Overview
Curr. Pharm. Des. 32, 688 (2026); https://doi.org/10.2174/0113816128386169250616124712
/content/journals/cpd/10.2174/0113816128386169250616124712
/content/journals/cpd/10.2174/0113816128386169250616124712
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  • Article Type:     Review Article
Keyword(s): antimicrobial; Carvacrol; medicinal plants; oral biofilm; oral health; periodontitis

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