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2000
Volume 31, Issue 39
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Sleep is the key factor influencing physical and psychological health. Several factors influence sleep, including lifespan, circadian entrainment, diet, stress, and occupation. Pharmacological (for example, histamine type 1 receptor blockers) and non-pharmacological (for example, cognitive-behavioral therapy) therapeutic approaches are used to alleviate sleep disorders. The gut microbiota has an important role in the pathogenesis of sleep-related disorders. Studies suggested that restoring the healthy gut microbiota could improve sleep quality. Hence, related randomized, blinded, controlled studies were reviewed to know the impact of probiotic supplementation on sleep quality. Altered Firmicutes/Bacteroidetes ratio and reduced α-diversity were associated with insomnia, sleep deprivation and rapid eye movement sleep behavior disorder. The literature survey revealed that probiotic supplementation improved healthy subjects' sleep quality and mood states. Probiotic supplementation could improve sleep quality by improving gut microbiota, intestinal integrity, blood-brain barrier function, brain functions and neurotransmitter regulation. The underlying mechanisms through which probiotic supplementation exerts its beneficial effects on sleep disorders remain unclear. Further research involving a variety of probiotic strains, along with long-term follow-up studies, is needed to validate the potential of probiotics as a complementary therapeutic approach for managing sleep disorders and enhancing sleep quality.

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2025-10-25

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References

  1. DavisK.F. ParkerK.P. MontgomeryG.L. Sleep in infants and young children.J. Pediatr. Health Care2004182657110.1016/S0891‑5245(03)00149‑415007289
     [Google Scholar]
  2. RosselotA.E. HongC.I. MooreS.R. Rhythm and bugs.Curr. Opin. Gastroenterol.201632171110.1097/MOG.000000000000022726628099
     [Google Scholar]
  3. IrwinM.R. OppM.R. Sleep Health: Reciprocal regulation of sleep and innate immunity.Neuropsychopharmacology201742112915510.1038/npp.2016.14827510422
     [Google Scholar]
  4. CuestaM. BoudreauP. CermakianN. BoivinD.B. Simulated night shift disrupts circadian rhythms of immune functions in humans.J. Immunol.20161962466247510.4049/jimmunol.150242226873990
     [Google Scholar]
  5. CappuccioF.P. TaggartF.M. KandalaN.B. CurrieA. PeileE. StrangesS. MillerM.A. Meta-analysis of short sleep duration and obesity in children and adults.Sleep200831561962610.1093/sleep/31.5.61918517032
     [Google Scholar]
  6. ItaniO. JikeM. WatanabeN. KaneitaY. Short sleep duration and health outcomes: A systematic review, meta-analysis, and meta-regression.Sleep Med.20173224625610.1016/j.sleep.2016.08.00627743803
     [Google Scholar]
  7. ThangaleelaS. SivamaruthiB.S. KesikaP. MariappanS. RashmiS. ChoeisoongnernT. SittiprapapornP. ChaiyasutC. Neurological insights into sleep disorders in Parkinson’s disease.Brain Sci.2023138120210.3390/brainsci1308120237626558
     [Google Scholar]
  8. AnghelL. CiubarăA. NechitaA. NechitaL. ManoleC. BaroiuL. CiubarăA.B. MușatC.L. Sleep disorders associated with neurodegenerative diseases.Diagnostics (Basel)20231318289810.3390/diagnostics1318289837761265
     [Google Scholar]
  9. LinW. LinY.K. YangF.C. ChungC.H. HuJ.M. TsaoC.H. WengZ.X. KoC.A. ChienW.C. Risk of neurodegenerative diseases in patients with sleep disorders: A nationwide population-based case-control study.Sleep Med.202310728929910.1016/j.sleep.2023.05.01437269705
     [Google Scholar]
  10. In brief: What is “normal” sleep?InformedHealth.orgCologne, GermanyInstitute for Quality and Efficiency in Health Care (IQWiG)2006
     [Google Scholar]
  11. SilberM.H. Sleep-related movement disorders.Continuum (Minneap Minn).201319117018410.1212/01.CON.0000427207.13553.6823385700
     [Google Scholar]
  12. SateiaM.J. International classification of sleep disorders-third edition: Highlights and modifications.Chest201414651387139410.1378/chest.14‑097025367475
     [Google Scholar]
  13. BurmanD. Sleep disorders: Sleep-related breathing disorders.FP Essent.2017460112128845957
     [Google Scholar]
  14. XieZ. ChenF. LiW.A. GengX. LiC. MengX. FengY. LiuW. YuF. A review of sleep disorders and melatonin.Neurol. Res.201739655956510.1080/01616412.2017.131586428460563
     [Google Scholar]
  15. AuldF. MaschauerE.L. MorrisonI. SkeneD.J. RihaR.L. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders.Sleep Med. Rev.201734102210.1016/j.smrv.2016.06.00528648359
     [Google Scholar]
  16. SlettenT.L. MageeM. MurrayJ.M. GordonC.J. LovatoN. KennawayD.J. GwiniS.M. BartlettD.J. LockleyS.W. LackL.C. GrunsteinR.R. RajaratnamS.M.W. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.PLoS Med.2018156e100258710.1371/journal.pmed.100258729912983
     [Google Scholar]
  17. HerringW.J. ConnorK.M. SnyderE. SnavelyD.B. MorinC.M. LinesC. MichelsonD. Effects of suvorexant on the insomnia severity index in patients with insomnia: Analysis of pooled phase 3 data.Sleep Med.20195621922310.1016/j.sleep.2018.09.01030522875
     [Google Scholar]
  18. SlowikJ.M. SankariA. CollenJ.F. Obstructive Sleep Apnea.StatPearls.Treasure Island, FLStatPearls Publishing2024
     [Google Scholar]
  19. SchweitzerP.K. RosenbergR. ZammitG.K. GotfriedM. ChenD. CarterL.P. WangH. LuY. BlackJ. MalhotraA. StrohlK.P. BlackmanA. GeorgeC. ShapiroC. ShapiroC. BenesH. FietzeI. MayerG. YoungP. LammersG.J. AhmedM. AjayiA. AndryJ. ArtalR. BastaniB. BoganR. CorserB. DrakeC. EmsellemH. ErmanM. FeldmanN. FoldvaryN. GotfriedM. HudsonJ. KrahnL. LorchD. MalhotraA. MaynardJ. MignotE. NeebM. OjileJ. PerkinsA.T. RosenbergR. RoyA. SahotaP. SangalR.B. SchreiberA. SchweitzerP. SteeleR. SternT. SternT. StolzS. StrohlK. SwickT. SwickT.J. TheinS.G. ThomasR. ThorpyM. WeaverT. WilksK. WinslowD. WylieP. ZammitG. ZeeP. Solriamfetol for excessive sleepiness in obstructive sleep apnea (TONES 3). A randomized controlled trial.Am. J. Respir. Crit. Care Med.2019199111421143110.1164/rccm.201806‑1100OC30521757
     [Google Scholar]
  20. WangJ. YangS. LiX. WangT. XuZ. XuX. GaoH. ChenG. Efficacy and safety of solriamfetol for excessive sleepiness in narcolepsy and obstructive sleep apnea: Findings from randomized controlled trials.Sleep Med.202179404710.1016/j.sleep.2020.12.03933472129
     [Google Scholar]
  21. MalhotraA. ShapiroC. PepinJ.L. HednerJ. AhmedM. Foldvary-SchaeferN. StrolloP.J.Jr MayerG. SarmientoK. BaladiM. ChandlerP. LeeL. SchwabR. Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea.Sleep2020432zsz22010.1093/sleep/zsz22031691827
     [Google Scholar]
  22. FaulknerS.M. BeeP.E. MeyerN. DijkD.J. DrakeR.J. Light therapies to improve sleep in intrinsic circadian rhythm sleep disorders and neuro-psychiatric illness: A systematic review and meta-analysis.Sleep Med. Rev.20194610812310.1016/j.smrv.2019.04.01231108433
     [Google Scholar]
  23. AhmedM. HaysR. PocetaJS JarosM.J. KimR. ShangG. Effect of gabapentin enacarbil on individual items of the international restless legs study group rating scale and post-sleep questionnaire in adults with moderate-to-severe primary restless legs syndrome: Pooled analysis of 3 randomized trials.Clin. Ther.201638717261737.e110.1016/j.clinthera.2016.05.00827288210
     [Google Scholar]
  24. GaoY. GeL. LiuM. NiuM. ChenY. SunY. ChenJ. YaoL. WangQ. LiZ. XuJ. LiM. HouL. ShiJ. YangK. CaiY. LiL. ZhangJ. TianJ. Comparative efficacy and acceptability of cognitive behavioral therapy delivery formats for insomnia in adults: A systematic review and network meta-analysis.Sleep Med. Rev.20226410164810.1016/j.smrv.2022.10164835759820
     [Google Scholar]
  25. EspieC.A. EmsleyR. KyleS.D. GordonC. DrakeC.L. SiriwardenaA.N. CapeJ. OngJ.C. SheavesB. FosterR. FreemanD. Costa-FontJ. MarsdenA. LuikA.I. Effect of digital cognitive behavioral therapy for insomnia on health, psychological well-being, and sleep-related quality of life: A randomized clinical trial.JAMA Psychiatry2019761213010.1001/jamapsychiatry.2018.274530264137
     [Google Scholar]
  26. GuoF. YiL. ZhangW. BianZ.J. ZhangY.B. Association between z drugs use and risk of cognitive impairment in middle-aged and older patients with chronic insomnia.Front. Hum. Neurosci.20211577514410.3389/fnhum.2021.77514434955792
     [Google Scholar]
  27. EdingerJ.D. ArnedtJ.T. BertischS.M. CarneyC.E. HarringtonJ.J. LichsteinK.L. SateiaM.J. TroxelW.M. ZhouE.S. KazmiU. HealdJ.L. MartinJ.L. Behavioral and psychological treatments for chronic insomnia disorder in adults: An american academy of sleep medicine systematic review, meta-analysis, and grade assessment.J. Clin. Sleep Med.202117226329810.5664/jcsm.898833164741
     [Google Scholar]
  28. SenP. Molinero-PerezA. O’RiordanK.J. McCaffertyC.P. O’HalloranK.D. CryanJ.F. Microbiota and sleep: Awakening the gut feeling.Trends Mol. Med.2021271093594510.1016/j.molmed.2021.07.00434364787
     [Google Scholar]
  29. FuJ. ZhengY. GaoY. XuW. Dietary fiber intake and gut microbiota in human health.Microorganisms20221012250710.3390/microorganisms1012250736557760
     [Google Scholar]
  30. ThangaleelaS. SivamaruthiB.S. KesikaP. BharathiM. ChaiyasutC. Role of the gut–brain axis, gut microbial composition, diet, and probiotic intervention in Parkinson’s disease.Microorganisms2022108154410.3390/microorganisms1008154436013962
     [Google Scholar]
  31. LiJ. JiaH. CaiX. ZhongH. FengQ. SunagawaS. ArumugamM. KultimaJ.R. PriftiE. NielsenT. JunckerA.S. ManichanhC. ChenB. ZhangW. LevenezF. WangJ. XuX. XiaoL. LiangS. ZhangD. ZhangZ. ChenW. ZhaoH. Al-AamaJ.Y. EdrisS. YangH. WangJ. HansenT. NielsenH.B. BrunakS. KristiansenK. GuarnerF. PedersenO. DoréJ. EhrlichS.D. BorkP. WangJ. An integrated catalog of reference genes in the human gut microbiome.Nat. Biotechnol.201432883484110.1038/nbt.294224997786
     [Google Scholar]
  32. HugonP. DufourJ.C. ColsonP. FournierP.E. SallahK. RaoultD. A comprehensive repertoire of prokaryotic species identified in human beings.Lancet Infect. Dis.201515101211121910.1016/S1473‑3099(15)00293‑526311042
     [Google Scholar]
  33. NeroniB. EvangelistiM. RadocchiaG. Di NardoG. PantanellaF. VillaM.P. SchippaS. Relationship between sleep disorders and gut dysbiosis: What affects what?Sleep Med.2021871710.1016/j.sleep.2021.08.00334479058
     [Google Scholar]
  34. SivamaruthiB.S. SuganthyN. KesikaP. ChaiyasutC. The role of microbiome, dietary supplements, and probiotics in autism spectrum disorder.Int. J. Environ. Res. Publ. Heal.2020178264710.3390/ijerph1708264732290635
     [Google Scholar]
  35. ThangaleelaS. SivamaruthiB.S. KesikaP. ChaiyasutC. Role of probiotics and diet in the management of neurological diseases and mood states: A review.Microorganisms20221011226810.3390/microorganisms1011226836422338
     [Google Scholar]
  36. ThangaleelaS. SivamaruthiB.S. KesikaP. BharathiM. ChaiyasutC. Nasal microbiota, olfactory health, neurological disorders and aging: A review.Microorganisms2022107140510.3390/microorganisms1007140535889124
     [Google Scholar]
  37. LiL. LiangT. JiangT. LiY. YangL. WuL. YangJ. DingY. WangJ. ChenM. ZhangJ. XieX. WuQ. Gut microbiota: Candidates for a novel strategy for ameliorating sleep disorders.Crit. Rev. Food Sci. Nutr.20246429107721078810.1080/10408398.2023.222840937477274
     [Google Scholar]
  38. HasanN. YangH. Factors affecting the composition of the gut microbiota, and its modulation.PeerJ20197e750210.7717/peerj.750231440436
     [Google Scholar]
  39. DasriyaV.L. SamtiyaM. RanveerS. DhillonH.S. DeviN. SharmaV. NikamP. PuniyaM. ChaudharyP. ChaudharyV. BehareP.V. DhewaT. VemuriR. RaposoA. PuniyaD.V. KhedkarG.D. VishweswaraiahR.H. VijS. AlarifiS.N. HanH. PuniyaA.K. Modulation of gut-microbiota through probiotics and dietary interventions to improve host health.J. Sci. Food Agric.2024104116359637510.1002/jsfa.1337038334314
     [Google Scholar]
  40. Hotel ACP. Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria. Cordoba, Argentina: Food and Agriculture Organization of the United Nations 2001.
  41. HillC. GuarnerF. ReidG. GibsonG.R. MerensteinD.J. PotB. MorelliL. CananiR.B. FlintH.J. SalminenS. CalderP.C. SandersM.E. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic.Nat. Rev. Gastroenterol. Hepatol.201411850651410.1038/nrgastro.2014.6624912386
     [Google Scholar]
  42. MarottaA. SarnoE. Del CasaleA. PaneM. MognaL. AmorusoA. FelisG.E. FiorioM. Effects of probiotics on cognitive reactivity, mood, and sleep quality.Front. Psychiatry20191016410.3389/fpsyt.2019.0016430971965
     [Google Scholar]
  43. MoloneyG.M. Long-SmithC.M. MurphyA. DorlandD. HojabriS.F. RamirezL.O. MarinD.C. BastiaanssenT.F.S. CusackA.M. BerdingK. FouhyF. AllenA.P. StantonC. ClarkeG. DinanT.G. CryanJ.F. Improvements in sleep indices during exam stress due to consumption of a Bifidobacterium longum. Brain Behav. Immun. Health20211010017410.1016/j.bbih.2020.10017434589719
     [Google Scholar]
  44. MatsudaY. OzawaN. ShinozakiT. WakabayashiK. SuzukiK. KawanoY. OhtsuI. TatebayashiY. Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances.Transl. Psychiatry202010117010.1038/s41398‑020‑0855‑132467627
     [Google Scholar]
  45. SantiD. DebbiV. CostantinoF. SpaggiariG. SimoniM. GrecoC. CasariniL. Microbiota composition and probiotics supplementations on sleep quality: A systematic review and meta-analysis.Clocks Sleep20235477079210.3390/clockssleep504005038131749
     [Google Scholar]
  46. YamamuraS. MorishimaH. Kumano-goT. SuganumaN. MatsumotoH. AdachiH. SigedoY. MikamiA. KaiT. MasuyamaA. TakanoT. SugitaY. TakedaM. The effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly subjects.Eur. J. Clin. Nutr.200963110010510.1038/sj.ejcn.160289817851460
     [Google Scholar]
  47. HarnettJ.E. PyneD.B. McKuneA.J. PenmJ. PumpaK.L. Probiotic supplementation elicits favourable changes in muscle soreness and sleep quality in rugby players.J. Sci. Med. Sport202124219519910.1016/j.jsams.2020.08.00532847731
     [Google Scholar]
  48. KerksickC.M. MoonJ.M. WaldenK.E. HageleA.M. AllenL.E. GaigeC.J. KriegerJ.M. JägerR. PaneM. MumfordP. Multi-strain probiotic improves subjective sleep quality with no impact on body composition, hemodynamics, and physical activity.Benef. Microbes202415217919410.1163/18762891‑bja0000238350465
     [Google Scholar]
  49. MutohN. MoriyaM. XuC. KatoK. AraiS. IwabuchiN. TanakaM. JinghuaY. ItamuraR. SakataniK. WarisawaS. Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study.Behav. Brain Res.202446011482010.1016/j.bbr.2023.11482038128887
     [Google Scholar]
  50. WestN.P. HughesL. RamseyR. ZhangP. MartoniC.J. LeyerG.J. CrippsA.W. CoxA.J. Probiotics, anticipation stress, and the acute immune response to night shift.Front. Immunol.20211159954710.3389/fimmu.2020.59954733584665
     [Google Scholar]
  51. TakadaM. NishidaK. GondoY. Kikuchi-HayakawaH. IshikawaH. SudaK. KawaiM. HoshiR. KuwanoY. MiyazakiK. RokutanK. Beneficial effects of Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults: A double-blind, randomised, placebo- controlled trial.Benef. Microbes20178215316210.3920/BM2016.015028443383
     [Google Scholar]
  52. WuS.I. WuC.C. TsaiP.J. ChengL.H. HsuC.C. ShanI.K. ChanP.Y. LinT.W. KoC.J. ChenW.L. TsaiY.C. Psychobiotic supplementation of PS128TM improves stress, anxiety, and insomnia in highly stressed information technology specialists: A pilot study.Front. Nutr.2021861410510.3389/fnut.2021.61410533842519
     [Google Scholar]
  53. LeeH.J. HongJ.K. KimJ.K. KimD.H. JangS.W. HanS.W. YoonI.Y. Effects of probiotic NVP-1704 on mental health and sleep in healthy adults: An 8-week randomized, double-blind, placebo-controlled trial.Nutrients2021138266010.3390/nu1308266034444820
     [Google Scholar]
  54. BoehmeM. Rémond-DerbezN. LerondC. LavalleL. KeddaniS. SteinmannM. RytzA. DalileB. VerbekeK. Van OudenhoveL. SteinerP. BergerB. VicarioM. BergonzelliG. Colombo MottazS. HudryJ. Bifidobacterium longum subsp. longum reduces perceived psychological stress in healthy adults: An exploratory clinical trial.Nutrients20231514312210.3390/nu1514312237513541
     [Google Scholar]
  55. MurakamiH. KoT. OuchiH. NambaT. EbiharaS. KobayashiS. Bifidobacterium adolescentis SBT2786 improves sleep quality in Japanese adults with relatively high levels of stress: A randomized, double-blind, placebo-controlled study.Nutrients20241611170210.3390/nu1611170238892634
     [Google Scholar]
  56. LanY. LuJ. QiaoG. MaoX. ZhaoJ. WangG. TianP. ChenW. Bifidobacterium breve CCFM1025 improves sleep quality via regulating the activity of the HPA axis: A randomized clinical trial.Nutrients20231521470010.3390/nu1521470037960353
     [Google Scholar]
  57. HoY.T. TsaiY.C. KuoT.B.J. YangC.C.H. Effects of Lactobacillus plantarum PS128 on depressive symptoms and sleep quality in self-reported insomniacs: A randomized, double-blind, placebo- controlled pilot trial.Nutrients2021138282010.3390/nu1308282034444980
     [Google Scholar]
  58. FeiY. WangR. LuJ. PengS. YangS. WangY. ZhengK. LiR. LinL. LiM. Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment.Geriatr. Nurs.20235116717510.1016/j.gerinurse.2023.03.00636990042
     [Google Scholar]
  59. BadrfamR. ZandifarA. HajialigolA. RashidianM. SchmidtN.B. MorabitoD. QorbaniM. ShahrestanakiE. Mehrabani NatanziM. Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: A randomized clinical trial.Psychopharmacology (Berl.)202424171463147610.1007/s00213‑024‑06577‑x38512593
     [Google Scholar]
  60. WuJ. ZhangB. ZhouS. HuangZ. XuY. LuX. ZhengX. OuyangD. Associations between gut microbiota and sleep: A two-sample, bidirectional Mendelian randomization study.Front. Microbiol.202314123684710.3389/fmicb.2023.123684737645227
     [Google Scholar]
  61. WangZ. WangZ. LuT. ChenW. YanW. YuanK. ShiL. LiuX. ZhouX. ShiJ. VitielloM.V. HanY. LuL. The microbiota-gut-brain axis in sleep disorders.Sleep Med. Rev.20226510169110.1016/j.smrv.2022.10169136099873
     [Google Scholar]
  62. HanM. YuanS. ZhangJ. The interplay between sleep and gut microbiota.Brain Res. Bull.202218013114610.1016/j.brainresbull.2021.12.01635032622
     [Google Scholar]
  63. GrosickiG.J. RiemannB.L. FlattA.A. ValentinoT. LustgartenM.S. Self-reported sleep quality is associated with gut microbiome composition in young, healthy individuals: A pilot study.Sleep Med.202073768110.1016/j.sleep.2020.04.01332795890
     [Google Scholar]
  64. ColladoM.C. KatilaM.K. VuorelaN.M. Saarenpää-HeikkiläO. SalminenS. IsolauriE. Dysbiosis in snoring children.J. Pediatr. Gastroenterol. Nutr.201968227227710.1097/MPG.000000000000216130289820
     [Google Scholar]
  65. KoC.Y. FanJ.M. HuA.K. SuH.Z. YangJ.H. HuangL.M. YanF.R. ZhangH.P. ZengY.M. Disruption of sleep architecture in Prevotella enterotype of patients with obstructive sleep apnea-hypopnea syndrome.Brain Behav.2019a95e0128710.1002/brb3.128730957979
     [Google Scholar]
  66. ValentiniF. EvangelistiM. ArpinelliM. Di NardoG. BorroM. SimmacoM. VillaM.P. Gut microbiota composition in children with obstructive sleep apnoea syndrome: A pilot study.Sleep Med.20207614014710.1016/j.sleep.2020.10.01733181474
     [Google Scholar]
  67. LuD. XuS. DaiP. WuL. ZhangH. ZhouB. Gut microbiota in hypertensive patients with versus without obstructive sleep apnea.J. Clin. Hypertens. (Greenwich)202224121598160510.1111/jch.1459836411588
     [Google Scholar]
  68. BikovA. SzaboH. PiroskaM. KunosL. SzilyM. LigetiB. MakraN. SzaboD. TarnokiD.L. TarnokiA.D. Gut microbiome in patients with obstructive sleep apnoea.Appl. Sci. (Basel)2022124200710.3390/app12042007
     [Google Scholar]
  69. BaldanziG. Sayols-BaixerasS. Theorell-HaglöwJ. DekkersK.F. HammarU. NguyenD. LinY.T. AhmadS. HolmJ.B. NielsenH.B. BrunkwallL. BenedictC. CedernaesJ. KoskiniemiS. PhillipsonM. LindL. SundströmJ. BergströmG. EngströmG. SmithJ.G. Orho-MelanderM. ÄrnlövJ. KennedyB. LindbergE. FallT. OSA is associated with the human gut microbiota composition and functional potential in the population-based Swedish cardiopulmonary bioimage study.Chest2023164250351610.1016/j.chest.2023.03.01036925044
     [Google Scholar]
  70. LiY. ZhangB. ZhouY. WangD. LiuX. LiL. WangT. ZhangY. JiangM. TangH. AmselL.V. FanF. HovenC.W. Gut microbiota changes and their relationship with inflammation in patients with acute and chronic insomnia.Nat. Sci. Sleep20201289590510.2147/NSS.S27192733177907
     [Google Scholar]
  71. NishiwakiH. HamaguchiT. ItoM. IshidaT. MaedaT. KashiharaK. TsuboiY. UeyamaJ. ShimamuraT. MoriH. KurokawaK. KatsunoM. HirayamaM. OhnoK. Short-chain fatty acid-producing gut microbiota is decreased in Parkinson’s disease but not in rapid-eye-movement sleep behavior disorder.mSystems202056e00797-2010.1128/mSystems.00797‑2033293403
     [Google Scholar]
  72. LiuZ. WeiZ.Y. ChenJ. ChenK. MaoX. LiuQ. SunY. ZhangZ. ZhangY. DanZ. TangJ. QinL. ChenJ.H. LiuX. Acute sleep-wake cycle shift results in community alteration of human gut microbiome.MSphere202051e00914-1910.1128/mSphere.00914‑1932051239
     [Google Scholar]
  73. WangZ. ChenW.H. LiS.X. HeZ.M. ZhuW.L. JiY.B. WangZ. ZhuX.M. YuanK. BaoY.P. ShiL. MengS.Q. XueY.X. XieW. ShiJ. YanW. WeiH. LuL. HanY. Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation.Mol. Psychiatry202126116277629210.1038/s41380‑021‑01113‑133963281
     [Google Scholar]
  74. KoC.Y. LiuQ.Q. SuH.Z. ZhangH.P. FanJ.M. YangJ.H. HuA.K. LiuY.Q. ChouD. ZengY.M. Gut microbiota in obstructive sleep apnea–hypopnea syndrome: Disease-related dysbiosis and metabolic comorbidities.Clin. Sci. (Lond.)2019133790591710.1042/CS2018089130957778
     [Google Scholar]
  75. LiuB. LinW. ChenS. XiangT. YangY. YinY. XuG. LiuZ. LiuL. PanJ. XieL. Gut Microbiota as an objective measurement for auxiliary diagnosis of insomnia disorder.Front. Microbiol.201910177010.3389/fmicb.2019.0177031456757
     [Google Scholar]
  76. ZhangQ. YunY. AnH. ZhaoW. MaT. WangZ. YangF. Gut microbiome composition associated with major depressive disorder and sleep quality.Front. Psychiatry20211264504510.3389/fpsyt.2021.64504534093266
     [Google Scholar]
  77. HuaX. ZhuJ. YangT. GuoM. LiQ. ChenJ. LiT. The gut microbiota and associated metabolites are altered in sleep disorder of children with autism spectrum disorders.Front. Psychiatry20201185510.3389/fpsyt.2020.0085532982808
     [Google Scholar]
  78. Heintz-BuschartA. PandeyU. WickeT. Sixel-DöringF. JanzenA. Sittig-WiegandE. TrenkwalderC. OertelW.H. MollenhauerB. WilmesP. The nasal and gut microbiome in Parkinson’s disease and idiopathic rapid eye movement sleep behavior disorder.Mov. Disord.2018331889810.1002/mds.2710528843021
     [Google Scholar]
/content/journals/cpd/10.2174/0113816128370349250413163229
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The Impact of Probiotic Supplementation on the Sleep Quality of Humans: A Review of Results of Randomized, Blinded, Controlled Studies
Curr. Pharm. Des. 31, 3128 (2025); https://doi.org/10.2174/0113816128370349250413163229
/content/journals/cpd/10.2174/0113816128370349250413163229
/content/journals/cpd/10.2174/0113816128370349250413163229
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  • Article Type:     Review Article
Keyword(s): Gut microbiota; insomnia; probiotics; rapid eye movement; sleep; sleep deprivation

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