Skip to content
2000
Volume 32, Issue 10
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Myricetin, a naturally occurring flavanol, has gained significant attention due to its diverse pharmacological properties, including antioxidant, anti-inflammatory, anticancer, antidiabetic, and neuroprotective effects. Found abundantly in various plant families, such as Myricaceae, Anacardiaceae, and Polygonaceae, Myricetin exerts its therapeutic effects by modulating key cellular pathways, including Nrf2/HO-1, MAPK, and PI3K/Akt signaling. This review systematically evaluates Myricetin’s bioaccessibility, pharmacokinetics, and therapeutic potential, highlighting its role in modulating oxidative stress, inhibiting tumor proliferation, and protecting against neurodegenerative diseases. Despite its promising benefits, Myricetin exhibits limited bioavailability due to poor aqueous solubility and extensive phase II metabolism (glucuronidation and sulfation). Additionally, Myricetin interacts with cytochrome P450 enzymes (CYP3A4, CYP2C9, CYP2D6), potentially altering drug metabolism and increasing the risk of drug interactions. Toxicological studies indicate an LD of 800 mg/kg in mice, with potential hepatic and renal toxicity at high doses, mainly due to redox cycling and quinone formation. While Myricetin shows excellent radical-scavenging properties, it may act as a pro-oxidant in the presence of metal ions, leading to oxidative stress and cellular damage. This review underscores the need for advanced formulation strategies to enhance bioavailability and mitigate toxicity risks. Future clinical investigations are essential to establish optimal therapeutic dosages, assess long-term safety, and validate Myricetin’s potential as a nutraceutical and therapeutic agent in chronic diseases.

© 2026 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cpd/10.2174/0113816128369420250707163438
2025-07-29
2026-03-04

  • From This Site

    /content/journals/cpd/10.2174/0113816128369420250707163438
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. DiasD.A. UrbanS. RoessnerU. A historical overview of natural products in drug discovery.Metabolites20122230333610.3390/metabo2020303 24957513
     [Google Scholar]
  2. MushtaqS. AbbasiB.H. UzairB. AbbasiR. Natural products as reservoirs of novel therapeutic agents.EXCLI J.201817420451 29805348
     [Google Scholar]
  3. ImranM. SalehiB. Sharifi-RadJ. Kaempferol: A key emphasis to its anticancer potential.Molecules20192412227710.3390/molecules24122277 31248102
     [Google Scholar]
  4. Sharifi-RadJ. Sharifi-RadM. SalehiB. In vitro and in vivo assessment of free radical scavenging and antioxidant activities of Veronica persica Poir.Cell. Mol. Biol.2018648576410.14715/cmb/2018.64.8.9 29981684
     [Google Scholar]
  5. ZhuangW.B. LiY.H. ShuX.C. The classification, molecular structure and biological biosynthesis of flavonoids, and their roles in biotic and abiotic stresses.Molecules2023288359910.3390/molecules28083599 37110833
     [Google Scholar]
  6. YaoY. LinG. XieY. Preformulation studies of myricetin: A natural antioxidant flavonoid.Pharmazie20146911926 24601218
     [Google Scholar]
  7. BüchterC. AckermannD. HavermannS. Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF-16.Int. J. Mol. Sci.2013146118951191410.3390/ijms140611895 23736695
     [Google Scholar]
  8. KabraA. MartinsN. SharmaR. KabraR. BaghelU.S. Myrica esculenta buch.-ham. ex d. don: A natural source for health promotion and disease prevention.Plants20198614910.3390/plants8060149
     [Google Scholar]
  9. DhimanN. AhmadG. KhanS.U. Myrica esculenta Buch.-Ham. (ex D. Don): A review on its phytochemistry, pharmacology and nutritional potential.Comb. Chem. High Throughput Screen.202225142372238610.2174/1386207325666220428105255 36330658
     [Google Scholar]
  10. NardiniM. GaragusoI. Characterization of bioactive compounds and antioxidant activity of fruit beers.Food Chem.202030512543710.1016/j.foodchem.2019.125437 31499290
     [Google Scholar]
  11. SultanaB. AnwarF. Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants.Food Chem.2008108387988410.1016/j.foodchem.2007.11.053 26065748
     [Google Scholar]
  12. DiasM.C. PintoD.C.G.A. SilvaA.M.S. Plant flavonoids: Chemical characteristics and biological activity.Molecules20212617537710.3390/molecules26175377 34500810
     [Google Scholar]
  13. PathakR ChandraP. Bioactive Compounds from Myrica esculenta: Antioxidant Insights and Docking Studies on H+K+-ATPase and H2 Receptor Targets.United Arab Emirates: Medicinal chemistry (Shariqah202516
     [Google Scholar]
  14. GasparR.S. da SilvaS.A. StapletonJ. Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases pdi and erp5.Front. Pharmacol.202010167810.3389/fphar.2019.01678 32116678
     [Google Scholar]
  15. ParkK.S. ChongY. KimM.K. Myricetin: Biological activity related to human health.Appl. Biolog. Chem.201659225926910.1007/s13765‑016‑0150‑2
     [Google Scholar]
  16. SemwalD. SemwalR. CombrinckS. ViljoenA. Myricetin: A dietary molecule with diverse biological activities.Nutrients2016829010.3390/nu8020090 26891321
     [Google Scholar]
  17. TaheriY. SuleriaH.A.R. MartinsN. Myricetin bioactive effects: Moving from preclinical evidence to potential clinical applications.BMC Complement. Med. Therap.202020124110.1186/s12906‑020‑03033‑z 32738903
     [Google Scholar]
  18. OrtegaJ.T. SuárezA.I. SerranoM.L. BaptistaJ. PujolF.H. RangelH.R. The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro.AIDS Res. Ther.20171415710.1186/s12981‑017‑0183‑6 29025433
     [Google Scholar]
  19. DuH. PanR. HuanW. LiJ. FengL. Theoretical study on the molecular and crystal structures of myricetin.Bull. Chem. Soc. Ethiop.20243851469147810.4314/bcse.v38i5.21
     [Google Scholar]
  20. NanH. MaH. ZhangR. ZhanR. Physiochemical properties of the complex of myricetin and hydroxypropyl-β-cyclodextrin.Trop. J. Pharm. Res.20141311179110.4314/tjpr.v13i11.3
     [Google Scholar]
  21. ChoS. KongB. JungY. Synthesis and physicochemical characterization of acyl myricetins as potential anti-neuroexocytotic agents.Sci. Rep.2023131513610.1038/s41598‑023‑32361‑6 36991086
     [Google Scholar]
  22. GolonkoA. OlichwierA.J. SwislockaR. SzczerbinskiL. LewandowskiW. Why do dietary flavonoids have a promising effect as enhancers of anthracyclines? hydroxyl substituents, bioavailability and biological activity.Int. J. Mol. Sci.202224139110.3390/ijms24010391 36613834
     [Google Scholar]
  23. DangY. LinG. XieY. Quantitative determination of myricetin in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and its absolute bioavailability.Drug Res.20146410516522 24357136
     [Google Scholar]
  24. ImranM. SaeedF. HussainG. Myricetin: A comprehensive review on its biological potentials.Food Sci. Nutr.20219105854586810.1002/fsn3.2513 34646551
     [Google Scholar]
  25. GuptaG. SiddiquiM.A. KhanM.M. Current pharmacological trends on myricetin.Drug Res.2020701044845410.1055/a‑1224‑3625 32877951
     [Google Scholar]
  26. OguC.C. MaxaJ.L. Drug interactions due to cytochrome P450.Proc. Bayl. Univ. Med. Cent.200013442142310.1080/08998280.2000.11927719 16389357
     [Google Scholar]
  27. BhattS. ManhasD. KumarV. Effect of myricetin on cyp2c8 inhibition to assess the likelihood of drug interaction using in silico, in vitro, and in vivo approaches.ACS Omega2022715132601326910.1021/acsomega.2c00726 35474783
     [Google Scholar]
  28. LouD. BaoS. LiY. LinQ. YangS. HeJ. Inhibitory Mechanisms of Myricetin on Human and Rat Liver Cytochrome P450 Enzymes.Eur. J. Drug Metab. Pharmacokinet.201944561161810.1007/s13318‑019‑00546‑y 30825074
     [Google Scholar]
  29. ChoiD.H. LiC. ChoiJ.S. Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: Possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin.J. Pharm. Pharmacol.201062790891410.1211/jpp.62.07.0012 20636879
     [Google Scholar]
  30. SinghS.P. DebC.R. AhmedS.U. SaratchandraY. KonwarB.K. Molecular docking simulation analysis of the interaction of dietary flavonols with heat shock protein 90.J. Biomed. Res.2015306774 26423731
     [Google Scholar]
  31. MartemucciG. CostagliolaC. MarianoM. D’andreaL. NapolitanoP. D’AlessandroA.G. Free radical properties, source and targets, antioxidant consumption and health.Oxygen202222487810.3390/oxygen2020006
     [Google Scholar]
  32. Di MeoS. VendittiP. Evolution of the knowledge of free radicals and other oxidants.Oxid. Med. Cell. Longev.2020202013210.1155/2020/9829176 32411336
     [Google Scholar]
  33. Md JaffriJ. Reactive oxygen species and antioxidant system in selected skin disorders.Malays. J. Med. Sci.202330172010.21315/mjms2023.30.1.2 36875194
     [Google Scholar]
  34. LiY.R. TrushM. TrushM.A. Defining ROS in biology and medicine.React Oxyg Spec20161192110.20455/ros.2016.803 29707643
     [Google Scholar]
  35. Aranda-RiveraA.K. Cruz-GregorioA. Arancibia-HernándezY.L. Hernández-CruzE.Y. Pedraza-ChaverriJ. Rons and oxidative stress: An overview of basic concepts.Oxygen20222443747810.3390/oxygen2040030
     [Google Scholar]
  36. PizzinoG. IrreraN. CucinottaM. Oxidative stress: Harms and benefits for human health.Oxid. Med. Cell. Longev.201720171841676310.1155/2017/8416763 28819546
     [Google Scholar]
  37. BhattacharyyaA. ChattopadhyayR. MitraS. CroweS.E. Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases.Physiol. Rev.201494232935410.1152/physrev.00040.2012 24692350
     [Google Scholar]
  38. KurutasE.B. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state.Nutr. J.20151517110.1186/s12937‑016‑0186‑5 27456681
     [Google Scholar]
  39. PathakR. PandeyS.P. ChandraP. Gastroprotective effects of biological macromolecule: Polysaccharides.Macromol. Symp.20244131230012210.1002/masy.202300122
     [Google Scholar]
  40. GhoshR. GirigoswamiK. NADH dehydrogenase subunits are overexpressed in cells exposed repeatedly to H2O2.Mutat. Res.20086381-221021510.1016/j.mrfmmm.2007.08.008 17905312
     [Google Scholar]
  41. HajamY.A. RaniR. GanieS.Y. Oxidative stress in human pathology and aging: Molecular mechanisms and perspectives.Cells202211355210.3390/cells11030552 35159361
     [Google Scholar]
  42. ArfinS. JhaN.K. JhaS.K. Oxidative stress in cancer cell metabolism.Antioxidants202110564210.3390/antiox10050642 33922139
     [Google Scholar]
  43. ChaudharyP. JanmedaP. DoceaA.O. Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases.Front Chem.202311115819810.3389/fchem.2023.1158198 37234200
     [Google Scholar]
  44. SarangarajanR. MeeraS. RukkumaniR. SankarP. AnuradhaG. Antioxidants: Friend or foe?Asian Pac. J. Trop. Med.201710121111111610.1016/j.apjtm.2017.10.017 29268965
     [Google Scholar]
  45. PancheA.N. DiwanA.D. ChandraS.R. Flavonoids: An overview.J. Nutr. Sci.201654710.1017/jns.2016.41 28620474
     [Google Scholar]
  46. UllahA. MunirS. BadshahS.L. Important flavonoids and their role as a therapeutic agent.Molecules20202522524310.3390/molecules25225243 33187049
     [Google Scholar]
  47. Rodríguez-GarcíaC. Sánchez-QuesadaC. GaforioJ.J. Dietary flavonoids as cancer chemopreventive agents: An updated review of human studies.Antioxidants20198513710.3390/antiox8050137 31109072
     [Google Scholar]
  48. AgraharamG. GirigoswamiA. GirigoswamiK. Myricetin: A multifunctional flavonol in biomedicine.Curr. Pharmacol. Rep.202281486110.1007/s40495‑021‑00269‑2 35036292
     [Google Scholar]
  49. KleinE. RimarčíkJ. SenajováE. VagánekA. LengyelJ. Deprotonation of flavonoids severely alters the thermodynamics of the hydrogen atom transfer.Comput. Theor. Chem.2016108571710.1016/j.comptc.2016.04.004
     [Google Scholar]
  50. D’AmbrosioM. BigagliE. CinciL. Ethyl acetate extract from Cistus x incanus L. leaves enriched in myricetin and quercetin derivatives, inhibits inflammatory mediators and activates Nrf2/HO-1 pathway in LPS-stimulated RAW 264.7 macrophages.Z. Naturforsch. C J. Biosci.2021761-2798610.1515/znc‑2020‑0053 33027057
     [Google Scholar]
  51. JustinoG.C. VieiraA.J.S.C. Antioxidant mechanisms of Quercetin and Myricetin in the gas phase and in solution – a comparison and validation of semi-empirical methods.J. Mol. Model.201016586387610.1007/s00894‑009‑0583‑1 19779937
     [Google Scholar]
  52. MendesR.A. AlmeidaS.K.C. SoaresI.N. Evaluation of the antioxidant potential of myricetin 3-O-α-L-rhamnopyranoside and myricetin 4′-O-α-L-rhamnopyranoside through a computational study.J. Mol. Model.20192548910.1007/s00894‑019‑3959‑x 30847605
     [Google Scholar]
  53. SajediN. HomayounM. MohammadiF. SoleimaniM. Myricetin exerts its apoptotic effects on MCF-7 breast cancer cells through evoking the BRCA1-GADD45 pathway.Asian Pac. J. Cancer Prev.202021123461346810.31557/APJCP.2020.21.12.3461 33369440
     [Google Scholar]
  54. LiuJ. GuoX. MiaoQ. JiX. LiangY. TongT. Deep eutectic solvent extraction of myricetin and antioxidant properties.RSC Advances20241426181261813510.1039/D4RA01438C 38854824
     [Google Scholar]
  55. GaetkeL.M. Chow-JohnsonH.S. ChowC.K. Copper: Toxicological relevance and mechanisms.Arch. Toxicol.201488111929193810.1007/s00204‑014‑1355‑y 25199685
     [Google Scholar]
  56. PantopoulosK. PorwalS.K. TartakoffA. DevireddyL. Mechanisms of mammalian iron homeostasis.Biochemistry201251295705572410.1021/bi300752r 22703180
     [Google Scholar]
  57. BayramI. LazeA. DeckerE.A. Synergistic mechanisms of interactions between myricetin or taxifolin with α-tocopherol in oil-in-water emulsions.J. Agric. Food Chem.202371249490950010.1021/acs.jafc.3c01226 37279160
     [Google Scholar]
  58. JomováK. HudecovaL. LauroP. A switch between antioxidant and prooxidant properties of the phenolic compounds myricetin, morin, 3′,4′-dihydroxyflavone, taxifolin and 4-hydroxy-coumarin in the presence of copper(II) ions: A spectroscopic, absorption titration and dna damage study.Molecules20192423433510.3390/molecules24234335 31783535
     [Google Scholar]
  59. López-LázaroM. WillmoreE. AustinC.A. The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells.Mutat. Res. Genet. Toxicol. Environ. Mutagen.20106961414710.1016/j.mrgentox.2009.12.01020025993
     [Google Scholar]
  60. ChobotV. HadacekF. Exploration of pro-oxidant and antioxidant activities of the flavonoid myricetin.Redox Rep.201116624224710.1179/1351000211Y.0000000015
     [Google Scholar]
  61. SimunkovaM. BarbierikovaZ. JomovaK. Antioxidant vs. prooxidant properties of the flavonoid, kaempferol, in the presence of Cu(II) Ions: A ROS-scavenging activity, fenton reaction and DNA damage study.Int. J. Mol. Sci.2021224161910.3390/ijms22041619 33562744
     [Google Scholar]
  62. ZhaoJ. HongT. DongM. MengY. MuJ. Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis.Mol. Med. Rep.20137256557010.3892/mmr.2012.1225 23232835
     [Google Scholar]
  63. JiangM. ZhuM. WangL. YuS. Anti-tumor effects and associated molecular mechanisms of myricetin.Biomed. Pharmacother.201912010950610.1016/j.biopha.2019.109506 31586904
     [Google Scholar]
  64. CiY. ZhangY. LiuY. Myricetin suppresses breast cancer metastasis through down‐regulating the activity of matrix metalloproteinase (MMP)‐2/9.Phytother. Res.20183271373138110.1002/ptr.6071 29532526
     [Google Scholar]
  65. TavsanZ. KayaliH.A. Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion.Biomed. Pharmacother.201911610900410.1016/j.biopha.2019.109004 31128404
     [Google Scholar]
  66. ZhangS. WangL. LiuH. ZhaoG. MingL. Enhancement of recombinant myricetin on the radiosensitivity of lung cancer A549 and H1299 cells.Diagn. Pathol.2014916810.1186/1746‑1596‑9‑68 24650056
     [Google Scholar]
  67. SharmaV. JanmedaP. Extraction, isolation and identification of flavonoid from Euphorbia neriifolia leaves.Arab. J. Chem.201710450951410.1016/j.arabjc.2014.08.019
     [Google Scholar]
  68. KnickleA. FernandoW. GreenshieldsA.L. RupasingheH.P.V. HoskinD.W. Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide.Food Chem. Toxicol.201811815416710.1016/j.fct.2018.05.005 29742465
     [Google Scholar]
  69. ZangW. WangT. WangY. Myricetin exerts anti-proliferative, anti-invasive, and pro-apoptotic effects on esophageal carcinoma EC9706 and KYSE30 cells via RSK2.Tumour Biol.20143512125831259210.1007/s13277‑014‑2579‑4 25192723
     [Google Scholar]
  70. YeC. ZhangC. HuangH. The natural compound myricetin effectively represses the malignant progression of prostate cancer by inhibiting PIM1 and disrupting the PIM1/CXCR4 interaction.Cell. Physiol. Biochem.20184831230124410.1159/000492009 30045021
     [Google Scholar]
  71. LiM. ChenJ. YuX. Myricetin suppresses the propagation of hepatocellular carcinoma via down-regulating expression of YAP.Cells20198435810.3390/cells8040358 30999669
     [Google Scholar]
  72. HuangH. ChenA. YeX. Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway.Int. J. Oncol.20154741494150210.3892/ijo.2015.3133 26315556
     [Google Scholar]
  73. WangL. LeeI.M. ZhangS.M. BlumbergJ.B. BuringJ.E. SessoH.D. Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women.Am. J. Clin. Nutr.200989390591210.3945/ajcn.2008.26913 19158208
     [Google Scholar]
  74. RajendranP. MaheshwariU. MuthukrishnanA. Myricetin: Versatile plant based flavonoid for cancer treatment by inducing cell cycle arrest and ROS–reliant mitochondria-facilitated apoptosis in A549 lung cancer cells and in silico prediction.Mol. Cell. Biochem.20214761576810.1007/s11010‑020‑03885‑6 32851589
     [Google Scholar]
  75. SalvamaniS. GunasekaranB. ShaharuddinN.A. AhmadS.A. ShukorM.Y. Antiartherosclerotic effects of plant flavonoids.BioMed Res. Int.2014201411110.1155/2014/480258 24971331
     [Google Scholar]
  76. QiuY. CongN. LiangM. WangY. WangJ. Systems pharmacology dissection of the protective effect of myricetin against acute ischemia/reperfusion-induced myocardial injury in isolated rat heart.Cardiovasc. Toxicol.201717327728610.1007/s12012‑016‑9382‑y 27484498
     [Google Scholar]
  77. LiaoH. ZhangN. MengY. Myricetin alleviates pathological cardiac hypertrophy via TRAF6/TAK1/MAPK and Nrf2 signaling pathway.Oxid. Med. Cell. Longev.2019201911410.1155/2019/6304058 31885808
     [Google Scholar]
  78. LescanoC.H. Freitas de LimaF. Mendes-SilvérioC.B. Effect of polyphenols from Campomanesia adamantium on platelet aggregation and inhibition of cyclooxygenases: Molecular docking and in vitro analysis.Front. Pharmacol.2018961710.3389/fphar.2018.00617 29946259
     [Google Scholar]
  79. DainoG.L. FrauA. SannaC. Identification of Myricetin as an Ebola Virus VP35–Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay.Biochemistry201857446367637810.1021/acs.biochem.8b00892 30298725
     [Google Scholar]
  80. KeumY.S. JeongY.J. Development of chemical inhibitors of the SARS coronavirus: Viral helicase as a potential target.Biochem. Pharmacol.201284101351135810.1016/j.bcp.2012.08.012 22935448
     [Google Scholar]
  81. LiW. XuC. HaoC. Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway.Antiviral Res.202017710471410.1016/j.antiviral.2020.104714 32165083
     [Google Scholar]
  82. ManiJ.S. JohnsonJ.B. SteelJ.C. Natural product-derived phytochemicals as potential agents against coronaviruses: A review.Virus Res.202028419798910.1016/j.virusres.2020.197989 32360300
     [Google Scholar]
  83. GoyalA. SikarwarO. VermaA. Unveiling myricetin’s pharmacological potency: A comprehensive exploration of the molecular pathways with special focus on PI3K/AKT and Nrf2 signaling.J. Biochem. Mol. Toxicol.20243862373910.1002/jbt.23739 38769721
     [Google Scholar]
  84. AgrawalP.K. AgrawalC. BlundenG.J.N.P.C. Antiviral and possible prophylactic significance of myricetin for COVID-19.Nat. Prod. Communicat20231841610.1177/1934578X231166283
     [Google Scholar]
  85. PasettoS. PardiV. MurataR.M. Anti-HIV-1 activity of flavonoid myricetin on HIV-1 infection in a dual-chamber in vitro model.PLoS One201491211532310.1371/journal.pone.0115323 25546350
     [Google Scholar]
  86. JoS. KimS. ShinD.H. KimM.S. Inhibition of African swine fever virus protease by myricetin and myricitrin.J. Enzyme Inhib. Med. Chem.20203511045104910.1080/14756366.2020.1754813 32299265
     [Google Scholar]
  87. LimH. NguyenT.T.H. KimN.M. ParkJ.S. JangT.S. KimD. Inhibitory effect of flavonoids against NS2B-NS3 protease of ZIKA virus and their structure activity relationship.Biotechnol. Lett.201739341542110.1007/s10529‑016‑2261‑6 27885509
     [Google Scholar]
  88. ZouM. LiuH. LiJ. Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection.Biochem. Pharmacol.202017711396210.1016/j.bcp.2020.113962 32272109
     [Google Scholar]
  89. XiaoT. CuiM. ZhengC. Myricetin inhibits SARS-CoV-2 viral replication by targeting Mpro and ameliorates pulmonary inflammation.Front. Pharmacol.20211266964210.3389/fphar.2021.669642 34220507
     [Google Scholar]
  90. LeeY.S. ChoiE.M. Myricetin inhibits IL-1β-induced inflammatory mediators in SW982 human synovial sarcoma cells.Int. Immunopharmacol.201010781281410.1016/j.intimp.2010.04.010 20403460
     [Google Scholar]
  91. DomitrovićR. RashedK. CvijanovićO. Vladimir-KneževićS. ŠkodaM. VišnićA. Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice.Chem. Biol. Interact.2015230212910.1016/j.cbi.2015.01.030 25656916
     [Google Scholar]
  92. LeeD.H. LeeC.S. Flavonoid myricetin inhibits TNF-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-κB pathways in human keratinocytes.Eur. J. Pharmacol.201678416417210.1016/j.ejphar.2016.05.02527221774
     [Google Scholar]
  93. YangL. GaoY. WangH. ZhongW. GongJ. FaragM.A. Myricetin attenuates the inflammatory bowel disease in prediabetic mice via inflammation inhibition and gut microbiota modulation.Food Saf Health202422303317
     [Google Scholar]
  94. KumarS. SwamyN. TuliH.S. Myricetin: A potential plant-derived anticancer bioactive compound—an updated overview.Naunyn Schmiedebergs Arch. Pharmacol.2023396102179219610.1007/s00210‑023‑02479‑5 37083713
     [Google Scholar]
  95. SethiyaN.K. GhiloriaN. SrivastavA. Therapeutic potential of myricetin in the treatment of neurological, neuropsychiatric, and neurodegenerative disorders.CNS Neurol. Disord. Drug Targets2024237865882 37461364
     [Google Scholar]
  96. BorieroD. Carcereri de PratiA. AntoniniL. The anti‐STAT1 polyphenol myricetin inhibits M1 microglia activation and counteracts neuronal death.FEBS J.202128872347235910.1111/febs.15577 32981207
     [Google Scholar]
  97. WangL. TangZ. LiB. Myricetin ameliorates cognitive impairment in 3×Tg Alzheimer’s disease mice by regulating oxidative stress and tau hyperphosphorylation.Biomed. Pharmacother.202417711696310.1016/j.biopha.2024.116963 38889642
     [Google Scholar]
  98. JoshiV. MishraR. UpadhyayA. Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation.J. Cell. Physiol.201923411209002091410.1002/jcp.28695 31004355
     [Google Scholar]
  99. ShimmyoY. KiharaT. AkaikeA. NiidomeT. SugimotoH. Multifunction of myricetin on Aβ: Neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases.J. Neurosci. Res.200886236837710.1002/jnr.21476 17722071
     [Google Scholar]
  100. GuS.C. XieZ.G. GuM.J. Myricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson’s disease.Sci. Rep.20241411510710.1038/s41598‑024‑62910‑6 38956066
     [Google Scholar]
  101. GiglioR.V. PattiA.M. CiceroA.F.G. Polyphenols: Potential use in the prevention and treatment of cardiovascular diseases.Curr. Pharm. Des.201824223925810.2174/1381612824666180130112652 29384050
     [Google Scholar]
  102. AngeloneT. PasquaT. Di MajoD. Distinct signalling mechanisms are involved in the dissimilar myocardial and coronary effects elicited by quercetin and myricetin, two red wine flavonols.Nutr. Metab. Cardiovasc. Dis.201121536237110.1016/j.numecd.2009.10.011 20096547
     [Google Scholar]
  103. BhatiaG. KhannaA.K. SonkarR. MishraS.K. SrivastavaS. LakshmiV. Lipid lowering and antioxidant activity of flavones in triton treated hyperlipidemic rats.Med. Chem. Res.20112091622162610.1007/s00044‑010‑9444‑9
     [Google Scholar]
  104. TiwariR. MohanM. KastureS. MaxiaA. BalleroM. Cardioprotective potential of myricetin in isoproterenol‐induced myocardial infarction in wistar rats.Phytother. Res.200923101361136610.1002/ptr.2688 19306480
     [Google Scholar]
  105. ScarabelliT.M. MariottoS. Abdel-AzeimS. Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion‐induced injury.FEBS Lett.2009583353154110.1016/j.febslet.2008.12.037 19116149
     [Google Scholar]
  106. HagenackerT. HillebrandI. WissmannA. BüsselbergD. SchäfersM. Anti‐allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38 and protein kinase C mediated modulation of Ca2+ channels.Eur. J. Pain2010141099299810.1016/j.ejpain.2010.04.005 20471878
     [Google Scholar]
  107. TongY. ZhouX.M. WangS.J. YangY. CaoY.L. Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves.Arch. Pharm. Res.200932452753310.1007/s12272‑009‑1408‑6 19407970
     [Google Scholar]
  108. BordeP. MohanM. KastureS. Effect of myricetin on deoxycorticosterone acetate (DOCA)-salt-hypertensive rats.Nat. Prod. Res.201125161549155910.1080/14786410903335190 21391110
     [Google Scholar]
  109. YangZ. ZhangJ. ShiB. QianJ. GuoH.J.A.A. Antihyperlipidemic activity of myricetin.Acta Aliment.202453229230410.1556/066.2024.00068
     [Google Scholar]
  110. MoghadamS. EbrahimiS. SalehiP. Moridi FarimaniM. HamburgerM. JabbarzadehE. Wound healing potential of chlorogenic acid and myricetin-3-o-β-rhamnoside isolated from parrotia persica.Molecules2017229150110.3390/molecules22091501 28885580
     [Google Scholar]
  111. JungS.K. LeeK.W. KimH.Y. Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.Biochem. Pharmacol.201079101455146110.1016/j.bcp.2010.01.004 20093107
     [Google Scholar]
  112. ZhangN. YangY. WangX. ShiT. LvP. LiQ.X. Myricetin inhibits photodegradation of profenofos in water: Pathways and mechanisms.Agronomy202414239910.3390/agronomy14020399
     [Google Scholar]
  113. KimW. YangH.J. YounH. YunY.J. SeongK.M. YounB. Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes.J. Radiat. Res. (Tokyo)201051328529610.1269/jrr.09141 20339252
     [Google Scholar]
  114. KumamotoT. FujiiM. HouD.X. Akt is a direct target for myricetin to inhibit cell transformation.Mol. Cell. Biochem.20093321-2334110.1007/s11010‑009‑0171‑9 19504174
     [Google Scholar]
  115. NieN. LiZ. LiW. HuangX. JiangZ. ShenY. Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting MCP-1 expression.Eur. J. Pharmacol.202394217554910.1016/j.ejphar.2023.175549 36708976
     [Google Scholar]
  116. ZhuS. YangC. ZhangL. Development of M10, myricetin-3-O-β-d-lactose sodium salt, a derivative of myricetin as a potent agent of anti-chronic colonic inflammation.Eur. J. Med. Chem.201917491510.1016/j.ejmech.2019.04.031 31022552
     [Google Scholar]
  117. AbidovM. RamazanovA. Jimenez Del RioM. ChkhikvishviliI. Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: Double-blind, placebo controlled clinical study.Georgian Med. News20061416672 17261891
     [Google Scholar]
  118. AhrensM.J. ThompsonD.L. Effect of emulin on blood glucose in type 2 diabetics.J. Med. Food201316321121510.1089/jmf.2012.0069 23444965
     [Google Scholar]
  119. PathakR. SachanN. ChandraP. Mechanistic approach towards diabetic neuropathy screening techniques and future challenges: A review.Biomed. Pharmacother.202215011302510.1016/j.biopha.2022.113025 35658222
     [Google Scholar]
  120. BabotăM. FrumuzachiO. TanaseC. MocanA. Efficacy of myricetin supplementation on glucose and lipid metabolism: A systematic review and meta-analysis of in vivo mice studies.Nutrients20241621373010.3390/nu16213730 39519561
     [Google Scholar]
  121. DeviK.P. RajavelT. HabtemariamS. NabaviS.F. NabaviS.M. Molecular mechanisms underlying anticancer effects of myricetin.Life Sci.2015142192510.1016/j.lfs.2015.10.004 26455550
     [Google Scholar]
  122. KnektP. KumpulainenJ. JärvinenR. Flavonoid intake and risk of chronic diseases.Am. J. Clin. Nutr.200276356056810.1093/ajcn/76.3.560 12198000
     [Google Scholar]
  123. GatesM.A. TworogerS.S. HechtJ.L. De VivoI. RosnerB. HankinsonS.E. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer.Int. J. Cancer2007121102225223210.1002/ijc.22790 17471564
     [Google Scholar]
  124. BobeG. WeinsteinS.J. AlbanesD. Flavonoid intake and risk of pancreatic cancer in male smokers (Finland).Cancer Epidemiol. Biomarkers Prev.200817355356210.1158/1055‑9965.EPI‑07‑2523 18349272
     [Google Scholar]
  125. TangN.P. ZhouB. WangB. YuR.B. MaJ. Flavonoids intake and risk of lung cancer: A meta-analysis.Jpn. J. Clin. Oncol.200939635235910.1093/jjco/hyp028 19351659
     [Google Scholar]
  126. ZernT.L. WoodR.J. GreeneC. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress.J. Nutr.200513581911191710.1093/jn/135.8.1911 16046716
     [Google Scholar]
  127. YangY. ChoiJ. JungC. SNARE-wedging polyphenols as small molecular botox.Planta Med.201278323323610.1055/s‑0031‑1280385 22109835
     [Google Scholar]
  128. ChenY.H. YangZ.S. WenC.C. Evaluation of the structure–activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae.Food Chem.2012134271772410.1016/j.foodchem.2012.02.166 23107683
     [Google Scholar]
  129. KimJ.D. LiuL. GuoW. MeydaniM. Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion.J. Nutr. Biochem.200617316517610.1016/j.jnutbio.2005.06.006 16169200
     [Google Scholar]
  130. CanadaA.T. WatkinsW.D. NguyenT.D. The toxicity of flavonoids to guinea pig enterocytes.Toxicol. Appl. Pharmacol.198999235736110.1016/0041‑008X(89)90018‑5 2734797
     [Google Scholar]
  131. PreetG. Haj HasanA. RamlaganP. FawdarS. BoulleF. JasparsM. Anti-neurodegenerating activity: Structure-activity relationship analysis of flavonoids.Molecules20232820718810.3390/molecules28207188 37894669
     [Google Scholar]
  132. ŠimunkováM. ValkoM. BučinskýL. MalčekM. Structure functionality relationship of flavonoids (myricetin, morin, taxifolin and 3′,4′-dihydroxyflavone). A computational study via the cupric ion probe.J. Mol. Struct.2020122212892310.1016/j.molstruc.2020.128923
     [Google Scholar]
/content/journals/cpd/10.2174/0113816128369420250707163438
Loading
Unveiling the Health Potential of Myricetin: Bio-accessibility, Safety Considerations, and Therapeutic Mechanisms
Curr. Pharm. Des. 32, 742 (2026); https://doi.org/10.2174/0113816128369420250707163438
/content/journals/cpd/10.2174/0113816128369420250707163438
/content/journals/cpd/10.2174/0113816128369420250707163438
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): Alzheimer; anticancer; biological activity; flavonoid; Myricetin; preserving agent

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test