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2000
Volume 31, Issue 33
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background

This study explores the formulation and effectiveness of a phytosomal gel for enhancing wound healing.

Objective

The ethanolic extract of roots, rich in bioactive compounds like alkaloids and flavonoids, was optimized into a phytosomal complex to improve absorption and dermal retention.

Methods

Characterization through GC-MS revealed compounds, such as 2-Heptadecenal and Bicyclo[4.1.0]Heptane and 7-Pentyl. FTIR confirmed the successful encapsulation within the phospholipid bilayer, while SEM showed smooth, spherical particles.

Results

The Box-Behnken design optimized formulation parameters, achieving high yield (92.64%), small particle size (355 nm), and high entrapment efficiency (93.98%). release studies displayed a consistent release profile, aligning with Zero-order and Hixson-Crowell models. evaluation on Wistar rats showed that the phytosomal gel significantly enhanced wound healing, achieving 98.16% wound reduction by day 14, compared to 95.17% for extract and 97.13% for standard treatment. Histopathological analysis demonstrated complete tissue regeneration and well-organized collagen fibers in the phytosomal gel group.

Conclusion

This research highlights the potential of phytosomal gel as an effective wound healing therapy, with future studies suggested for extended stability tests and human skin permeation studies.

© 2025 Bentham Science Publishers
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2025-09-05

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Enhanced Wound Healing with Rhodiola rosea Phytosomal Gel: Extraction, Formulation, and In vivo Evaluation
Curr. Pharm. Des. 31, 2651 (2025); https://doi.org/10.2174/0113816128359150250211053431
/content/journals/cpd/10.2174/0113816128359150250211053431
/content/journals/cpd/10.2174/0113816128359150250211053431
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  • Article Type:     Research Article
Keyword(s): Box-Behnken design; extraction; in vivo evaluation; phytosomal gel; Rhodiola rosea; wound healing

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