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image of Bioactivities of Secondary Metabolites from Endophytes: A Recent Review

Abstract

Endophytes are symbiotic microbial communities residing within plants and represent a significant source of bioactive secondary metabolites. As integral components of plant microecosystems, endophytes establish stable and mutually beneficial interactions with their hosts, which not only contribute to plant growth and stress resistance but also drive the diversity of their secondary metabolic products through long-term coevolution. These metabolites exhibit diverse biological activities, including anti-inflammatory, antimicrobial, cytotoxic, antiviral, and antioxidant effects, and these bioactive properties make them promising candidates for the development of new agents in multiple fields, including pharmaceuticals, agrochemicals, and functional materials, due to their natural origins and relatively low environmental impact. This review comprehensively summarizes recent advances in understanding the bioactivities of endophyte-derived secondary metabolites, highlighting novel compounds and their pharmacological potential. Alongside traditional approaches, recent technological advancements in separation, purification, and structural identification have further facilitated the discovery and characterization of these metabolites, expanding the pool of potential bioactive molecules for research and application. We also detail common methodologies for investigating endophyte metabolites, such as fermentation optimization and biotransformation, and briefly touch on how these strategies have been widely adopted to enhance metabolite production and explore structural modifications. With the deepening of interdisciplinary research involving microbiology, chemistry, pharmacology, and biotechnology, the exploration of endophyte secondary metabolites has entered a more systematic and in-depth stage. Finally, we discuss current challenges in translating these findings into practical applications, including issues related to resource accessibility, production scalability, and comprehensive efficacy evaluation, and outline promising future research directions for drug discovery in the field of medicine, encompassing the excavation of untapped endophytic resources, the optimization of production processes, and the in-depth evaluation of safety and efficacy, so as to better harness their potential for human health and sustainable development.

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2026-01-12
2026-01-31

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References

  1. Tan R.X. Zou W.X. Endophytes: A rich source of functional metabolites (1987 to 2000). Nat. Prod. Rep. 2001 18 4 448 459 10.1039/b100918o 11548053
    [Google Scholar]
  2. Nisa H. Kamili A.N. Nawchoo I.A. Shafi S. Shameem N. Bandh S.A. Fungal endophytes as prolific source of phytochemicals and other bioactive natural products: A review. Microb. Pathog. 2015 82 50 59 10.1016/j.micpath.2015.04.001 25865953
    [Google Scholar]
  3. Wang Y. Chen N. Deng K. Zhong X. Li Z. Li L. Xu D. Effects and molecular mechanism of endophytic elicitors on the accumulation of secondary metabolites in medicinal plants. Front. Microbiol. 2025 16 1558567 10.3389/fmicb.2025.1558567 40529579
    [Google Scholar]
  4. Guo J. Yang J. Wang P. Guo B. Li H. Zhang D. An F. Gao S. Anti-vibriosis bioactive molecules from Arctic Penicillium sp. Z2230. Bioresour. Bioprocess. 2023 10 1 11 10.1186/s40643‑023‑00628‑5 38647601
    [Google Scholar]
  5. Afzal I. Shinwari Z.K. Sikandar S. Shahzad S. Plant beneficial endophytic bacteria: Mechanisms, diversity, host range and genetic determinants. Microbiol. Res. 2019 221 36 49 10.1016/j.micres.2019.02.001 30825940
    [Google Scholar]
  6. Strobel G. Daisy B. Bioprospecting for microbial endophytes and their natural products. Microbiol. Mol. Biol. Rev. 2003 67 4 491 502 10.1128/MMBR.67.4.491‑502.2003 14665674
    [Google Scholar]
  7. Ancheeva E. Daletos G. Proksch P. Bioactive secondary metabolites from endophytic fungi. Curr. Med. Chem. 2020 27 11 1836 1854 10.2174/0929867326666190916144709 31526342
    [Google Scholar]
  8. Li L. Zhang X. Tan X. Sun B. Wu B. Yu M. Zhang T. Zhang Y. Ding G. Rhinoclactones A-E, resorcylic acid analogs from desert plant endophytic fungus rhinocladiella similis. Molecules 2019 24 7 1405 10.3390/molecules24071405 30974765
    [Google Scholar]
  9. Singh M. Kumar A. Singh R. Pandey K.D. Endophytic bacteria: A new source of bioactive compounds. Biotech 2017 7 5 315 10.1007/s13205‑017‑0942‑z
    [Google Scholar]
  10. Pfannenstiel B.T. Keller N.P. On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi. Biotechnol. Adv. 2019 37 6 107345 10.1016/j.biotechadv.2019.02.001 30738111
    [Google Scholar]
  11. Zheng R. Li S. Zhang X. Zhao C. Biological activities of some new secondary metabolites isolated from endophytic fungi: A review study. Int. J. Mol. Sci. 2021 22 2 959 10.3390/ijms22020959 33478038
    [Google Scholar]
  12. Wang F. Ma H. Hu Z. Jiang J. Zhu H. Cheng L. Yang Q. Zhang H. Zhang G. Zhang Y. Secondary metabolites from Colletotrichum capsici, an endophytic fungus derived from Siegesbeckia pubescens Makino. Nat. Prod. Res. 2017 31 16 1849 1854 10.1080/14786419.2016.1261346 27892688
    [Google Scholar]
  13. Tian H. Li X.P. Zhao J. Gao H.W. Xu Q.M. Wang J.W. Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L. Phytochemistry 2021 185 112682 10.1016/j.phytochem.2021.112682 33582588
    [Google Scholar]
  14. Yang W.Q. Lu Q.P. Chen C.X. Zhu L.P. Zhang X. Xu W. Hu L.S. Chen J. Zhao Z.X. Six undescribed 23-norursane triterpenoids from the biotransformation of ilexgenin a by endophytic fungi and their vascular protective activity. Fitoterapia 2024 176 106053 10.1016/j.fitote.2024.106053 38838828
    [Google Scholar]
  15. Zeng W.L. Li W.K. Han H. Tao Y.Y. Yang L. Wang Z.T. Chen K.X. Microbial biotransformation of gentiopicroside by the endophytic fungus Penicillium crustosum 2T01Y01. Appl. Environ. Microbiol. 2014 80 1 184 192 10.1128/AEM.02309‑13 24141132
    [Google Scholar]
  16. Liu X. Zhou Z.Y. Cui J.L. Wang M.L. Wang J.H. Biotransformation ability of endophytic fungi: From species evolution to industrial applications. Appl. Microbiol. Biotechnol. 2021 105 19 7095 7113 10.1007/s00253‑021‑11554‑x 34499202
    [Google Scholar]
  17. Ma X.D. Zhang X.G. Guo S.J. Ma G.Y. Liu W.J. Wang N. Feng M. Su Y. Application of enzyme-assisted extraction of baicalin from Scutellaria baicalensis Georgi. Prep. Biochem. Biotechnol. 2021 51 3 241 251 10.1080/10826068.2020.1808791 32820988
    [Google Scholar]
  18. Xu F. Cao H. Cui X. Guo H. Han C. Optimization of fermentation condition for echinacoside yield improvement with Penicillium sp. H1, an endophytic fungus isolated from Ligustrum lucidum ait using response surface methodology. Molecules 2018 23 10 2586 10.3390/molecules23102586 30308945
    [Google Scholar]
  19. Tironi L.S. Carletto L.B. Silva E.O. Schripsema J. Luiz J.H.H. Endophytic fungi co-culture: An alternative source of antimicrobial substances. Microorganisms 2024 12 12 2413 10.3390/microorganisms12122413 39770616
    [Google Scholar]
  20. Sharma V. Singamaneni V. Sharma N. Kumar A. Arora D. Kushwaha M. Bhushan S. Jaglan S. Gupta P. Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill. Bioorg. Med. Chem. Lett. 2018 28 12 2217 2221 10.1016/j.bmcl.2018.04.018 29759727
    [Google Scholar]
  21. Hewage R.T. Aree T. Mahidol C. Ruchirawat S. Kittakoop P. One strain-many compounds (OSMAC) method for production of polyketides, azaphilones, and an isochromanone using the endophytic fungus Dothideomycete sp. Phytochemistry 2014 108 87 94 10.1016/j.phytochem.2014.09.013 25310919
    [Google Scholar]
  22. Raghav D. Jyoti A. Siddiqui A.J. Saxena J. Plant-associated endophytic fungi as potential bio-factories for extracellular enzymes: Progress, challenges and strain improvement with precision approaches. J. Appl. Microbiol. 2022 133 2 287 310 10.1111/jam.15574 35396804
    [Google Scholar]
  23. Zhao S. Yin R. Zhang M. Zhai Z. Shen Z. Mou Y. Xu D. Zhou L. Lai D. Efficient gene editing in the slow-growing, non-sporulating, melanized, endophytic fungus Berkleasmium sp. Dzf12 using a CRISPR/Cas9 system. World J. Microbiol. Biotechnol. 2024 40 6 176 10.1007/s11274‑024‑03988‑y 38652405
    [Google Scholar]
  24. Yang Q. Wu M. Zhu Y.L. Yang Y.Q. Mei Y.Z. Dai C.C. The disruption of the MAPKK gene triggering the synthesis of flavonoids in endophytic fungus Phomopsis liquidambaris. Biotechnol. Lett. 2021 43 1 119 132 10.1007/s10529‑020‑03042‑5 33128663
    [Google Scholar]
  25. Yayan J. Franke K.J. Berger M. Windisch W. Rasche K. Adhesion, metastasis, and inhibition of cancer cells: A comprehensive review. Mol. Biol. Rep. 2024 51 1 165 10.1007/s11033‑023‑08920‑5 38252369
    [Google Scholar]
  26. Hridoy M. Gorapi M.Z.H. Noor S. Chowdhury N.S. Rahman M.M. Muscari I. Masia F. Adorisio S. Delfino D.V. Mazid M.A. Putative anticancer compounds from plant-derived endophytic fungi: A review. Molecules 2022 27 1 296 10.3390/molecules27010296 35011527
    [Google Scholar]
  27. Hashem A.H. Attia M.S. Kandil E.K. Fawzi M.M. Abdelrahman A.S. Khader M.S. Khodaira M.A. Emam A.E. Goma M.A. Abdelaziz A.M. Bioactive compounds and biomedical applications of endophytic fungi: A recent review. Microb. Cell Fact. 2023 22 1 107 10.1186/s12934‑023‑02118‑x 37280587
    [Google Scholar]
  28. Stierle A. Strobel G. Stierle D. Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 1993 260 5105 214 216 10.1126/science.8097061 8097061
    [Google Scholar]
  29. Zhu L. Chen L. Progress in research on paclitaxel and tumor immunotherapy. Cell. Mol. Biol. Lett. 2019 24 1 40 10.1186/s11658‑019‑0164‑y 31223315
    [Google Scholar]
  30. Li M. Yu R. Bai X. Wang H. Zhang H. Fusarium: A treasure trove of bioactive secondary metabolites. Nat. Prod. Rep. 2020 37 12 1568 1588 10.1039/D0NP00038H 32785347
    [Google Scholar]
  31. Sato S. Sofian F.F. Paulin D.A. Kobayashi S. Koseki T. Shiono Y. Integracide derivatives produced by endophyte Fusarium armeniacum M-3 isolated from Digitaria ciliaris. Nat. Prod. Res. 2024 38 13 2193 2200 10.1080/14786419.2022.2164580 36628994
    [Google Scholar]
  32. Zhang X.L. Lu B.G. Bai J. Li N. Alkaloids isolated from the endophytic fungus Fusarium concentricum. Nat. Prod. Res. 2024 38 9 1517 1523 10.1080/14786419.2022.2154346 36484574
    [Google Scholar]
  33. Tan J.B. Peng W.W. Li M.F. Kang F.H. Zheng Y.T. Xu L. Qin S.Y. Huang Y.T. Zou Z.X. Three new metabolites from the endophyte Fusarium proliferatum T2-10. Nat. Prod. Res. 2025 39 7 1793 1803 10.1080/14786419.2023.2278158 37933750
    [Google Scholar]
  34. Chang S. Yan B. Chen Y. Zhao W. Gao R. Li Y. Yu L. Xie Y. Si S. Chen M. Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp. Front Chem. 2023 10 1106869 10.3389/fchem.2022.1106869 36712984
    [Google Scholar]
  35. Koul M. Singh S. Penicillium spp. Anticancer Drugs 2017 28 1 11 30 10.1097/CAD.0000000000000423 27552492
    [Google Scholar]
  36. Bai Y. Ma X. Ren D. Yu G. Hu J. Hua H. Pan H. Peniapyrones A–I, cytotoxic tricyclic-fused α-Pyrone derivatives from an endophytic Penicillium brefeldianum F4a. J. Nat. Prod. 2024 87 6 1643 1651 10.1021/acs.jnatprod.4c00383 38848113
    [Google Scholar]
  37. Wang Y. Song S.H. Wu L.M. Zhou X. Lu Q.R. Yin A.P. Yin S. Tang G.H. Chemical constituents of Penicillium ferraniaense GE-7 and their cytotoxicities. Nat. Prod. Res. 2025 39 14 3915 3922 10.1080/14786419.2024.2324113 38436324
    [Google Scholar]
  38. Deng M. Pu Y. Wan Z. Xu J. Huang S. Xie J. Zhou X. Nine undescribed oxidized ergosterols from the endophytic fungus Penicillium herquei and their cytotoxic activity. Phytochemistry 2023 212 113716 10.1016/j.phytochem.2023.113716 37156435
    [Google Scholar]
  39. Liu X. Li R. Zhou X. Structurally diverse indole alkaloids with cytotoxicity from Lonicera Japonica -associated endophytic fungus Penicillium ochrochloron YT2022-65. Nat. Prod. Res. 2024 38 22 4071 4075 10.1080/14786419.2023.2272778 37867305
    [Google Scholar]
  40. Song W. Ji L. Zhang Y. Cao L. New cytotoxic indole derivatives with anti-FADU potential produced by the endophytic fungus Penicillium oxalicum 2021CDF-3 through the OSMAC strategy. Front. Microbiol. 2024 15 1400803 10.3389/fmicb.2024.1400803 38873167
    [Google Scholar]
  41. Pang X. Cai G.W. Wang M.Y. Chen X.F. He W.N. Zhao W.L. Zhang T. Yu L.Y. Metabolites from the plant endophytic fungus Penicillium sp. CPCC 401423 and their cytotoxic activity against MIA PaCa-2 cells. J. Asian Nat. Prod. Res. 2023 25 6 528 539 10.1080/10286020.2022.2104719 35920176
    [Google Scholar]
  42. Yu J. Wang J.P. Liu S.F. Yin C.Y. Tang D.Y. Li Y.H. Zhang L.X. 7-Methoxy-13-dehydroxypaxilline: New indole diterpenoid from an endophytic fungus Penicillium sp. Nb 19. Nat. Prod. Res. 2024 38 1 103 111 10.1080/14786419.2022.2107639 35929965
    [Google Scholar]
  43. Frisvad J.C. Larsen T.O. Chemodiversity in the genus Aspergillus. Appl. Microbiol. Biotechnol. 2015 99 19 7859 7877 10.1007/s00253‑015‑6839‑z 26243055
    [Google Scholar]
  44. Ma S. Ge L. Lu H. Yan J. Yang K. Two undescribed compounds from Aspergillus Niger, an endophytic fungus isolated from Camellia flavida. Nat. Prod. Res. 2025 39 15 4239 4246 10.1080/14786419.2024.2334325 38551108
    [Google Scholar]
  45. Wu B. Xu C. Chen J. Chen G. Rhizoaspergillin A and Rhizoaspergillinol A, including a unique orsellinic acid–ribose–pyridazinone-N-oxide hybrid, from the mangrove endophytic fungus aspergillus sp. A1E3. Mar. Drugs 2023 21 11 598 10.3390/md21110598 37999422
    [Google Scholar]
  46. Wang Y. Chen Y.W. Liu B. Zhang X. Kang Y.N. Lan W. Wang Z.M. Sun Y. Bioactive secondary metabolites from an endophytic fungus Aspergillus sp. CCH-1E from Catharanthus roseus. Zhongguo Zhongyao Zazhi 2024 49 17 4687 4694 10.19540/j.cnki.cjcmm.20240607.202 39307806
    [Google Scholar]
  47. Bo X. Zhao Y. Qin F. Wu F. Tan M. Ju S. Song Z. Li W. He F. Wei Y. Xu H. Huang X. Cytotoxic metabolites from the mangrove endophytic fungus Aspergillus sp. GXNU QG1a. Nat. Prod. Res. 2025 39 9 2572 2579 10.1080/14786419.2024.2303601 38226421
    [Google Scholar]
  48. Zhou J.T. Wu Q. Zhao J.X. Wu L.L. He X.H. Liang L.Q. Zhang G.H. Li J. Xu W.F. Yang R.Y. Sucurchalasins A and B, sulfur-containing heterodimers of a cytochalasan and a macrolide from the endophytic fungus Aspergillus spelaeus GDGJ-286. J. Nat. Prod. 2024 87 9 2327 2334 10.1021/acs.jnatprod.4c00489 39258410
    [Google Scholar]
  49. Takahashi R. Isshiki S.N. Hakozaki M. Kanno Y. Uesugi S. Koseki T. Shiono Y. Altenuene derivatives produced by an endophyte Alternaria alternata. Nat. Prod. Res. 2024 ••• 1 8 10.1080/14786419.2024.2342557 38646834
    [Google Scholar]
  50. Sofian F.F. Suzuki T. Supratman U. Harneti D. Maharani R. Salam S. Abdullah F.F. Yoshida J. Ito Y. Koseki T. Shiono Y. The 2,3-epoxy naphthoquinol produced by endophyte Arthrinium marii M-211. Nat. Prod. Res. 2023 37 7 1060 1066 10.1080/14786419.2021.1998899 34753360
    [Google Scholar]
  51. Zheng Y. Qin S. Xu L. Sang Z. Chen C. Tan J. Huang Y. Li M. Zou Z. Ochrolines A-C, three new indole diketopiperazines from cultures of endophytic fungi Bionectria ochroleuca SLJB-2. Fitoterapia 2024 173 105809 10.1016/j.fitote.2023.105809 38168565
    [Google Scholar]
  52. Wang J. Gao W.B. Liu F.W. Liu Q. Song B. Ye J. Chen Y. Zhao C.L. Dong W. Guo L.N. Song B. Two new furanone derivatives from the endophytic fungus Byssochlamys sp. and their cytotoxic activities. Nat. Prod. Res. 2024 38 23 4292 4296 10.1080/14786419.2023.2275269 37888852
    [Google Scholar]
  53. Gao Z.J. Cao L.L. Ren H.P. Yu H. Wang Y. Novel chlorinated and nitrogenated azaphilones with cytotoxic activities from the marine algal-derived fungus Chaetomium globosum 2020HZ23. Front. Microbiol. 2023 14 1252563 10.3389/fmicb.2023.1252563 37670992
    [Google Scholar]
  54. Parthasarathy R. Chandrika M. Sruthi D. Yashavantha Rao H.C. Jayabaskaran C. Clonostachys rosea, a marine algal endophyte, as an alternative source of chrysin and its anticancer effect. Arch. Microbiol. 2023 205 8 275 10.1007/s00203‑023‑03615‑8 37410212
    [Google Scholar]
  55. Ningsih K.N. Hakim E.H. New indole alkaloid Morucolletotricin from endophytic fungus Colletotrichum queenslandicum associated with Morus australis Poir. Leaf. Nat. Prod Res. 2025 39 1 202 207 10.1080/14786419.2023.2250520 37690000
    [Google Scholar]
  56. Yang L. Wang Q. Ma Q.Y. Xie Q.Y. Gai C.J. Wu Y.G. Dai H.F. Zhao Y.X. Diaporchalasins A–E, new cytochalasins from the endophytic fungus Diaporthe sp. BMX12 isolated from Aquilaria sinensis. Chem. Biodivers. 2024 21 6 e202400567 10.1002/cbdv.202400567 38602253
    [Google Scholar]
  57. Elnaggar M.S. Fayez S. Anwar A. Ebada S.S. Cytotoxic naphtho- and benzofurans from an endophytic fungus Epicoccum nigrum Ann-B-2 associated with Annona squamosa fruits. Sci. Rep. 2024 14 1 4940 10.1038/s41598‑024‑55168‑5 38418706
    [Google Scholar]
  58. Hu J.Y. Yang T. Liu J. Xiao L. Lin L.B. Li Y.C. Ge M.Y. Ji P. Xiao J. Wang X.L. Two new sesquiterpenoids from plant endophytic fungus Flammulina velutipes. J. Asian Nat. Prod. Res. 2023 25 2 156 162 10.1080/10286020.2022.2077199 35616229
    [Google Scholar]
  59. Huang Y. Chen Z. Huang M. Chen K. Liu H. Liang J. Liao Y. Li J. Zhu L. Ding B. Huang H. Tao Y. Cytotoxic tetronic acid derivatives from the mangrove endophytic fungus Hypomontagnella monticulosa YX702. Fitoterapia 2023 170 105656 10.1016/j.fitote.2023.105656 37604245
    [Google Scholar]
  60. Tong S.Y. Ye K. Wang W.X. Ai H.L. Harzianic acids and oxazolidinone from the endophytic fungus Ilyonectria sp. and their cytotoxicity activity. Fitoterapia 2024 175 105941 10.1016/j.fitote.2024.105941 38575089
    [Google Scholar]
  61. Chen Y. Wang N. Ma W. Gu W. Sang Z. Tan H. Zhang W. Liu H. Irpexols A-C, xanthone derivatives from the endophyte fungus Irpex laceratus A878. Fitoterapia 2024 175 105952 10.1016/j.fitote.2024.105952 38614405
    [Google Scholar]
  62. Khruengsai S. Pripdeevech P. Tanapichatsakul C. Sum W.C. Ibrahim M.A.A. Stadler M. Ebada S.S. Lasiodipline G and other diketopiperazine metabolites produced by Lasiodiplodia chiangraiensis. RSC Advances 2023 13 28 19373 19378 10.1039/D3RA03242F 37383691
    [Google Scholar]
  63. Yang X. Wu P. Xue J. Li H. Wei X. Seco-pimarane diterpenoids and androstane steroids from an endophytic Nodulisporium fungus derived from Cyclosorus parasiticus. Phytochemistry 2023 210 113679 10.1016/j.phytochem.2023.113679 37059288
    [Google Scholar]
  64. Chen Y. Liu H. Wang N. Tan H. Zhang W. Pararorine A, isoindolinone alkaloid from the endophytic fungus Paramyrothecium roridum and its anti-tumor activity. Fitoterapia 2024 175 105931 10.1016/j.fitote.2024.105931 38608733
    [Google Scholar]
  65. Duan F. Peng X. Liu L. Meng X. Jin A. Ruan H. Chaepseubakerins A–J, ten undescribed cytotoxic [11]-chaetoglobosins from an endophytic fungus Pseudeurotium bakeri. Phytochemistry 2024 218 113939 10.1016/j.phytochem.2023.113939 38052264
    [Google Scholar]
  66. Gu G. Hou X. Xue M. Jia X. Pan X. Xu D. Dai J. Lai D. Zhou L. Rosellichalasins A–H, cytotoxic cytochalasans from the endophytic fungus Rosellinia sp. Glinf021. Phytochemistry 2024 222 114103 10.1016/j.phytochem.2024.114103 38636686
    [Google Scholar]
  67. Li Z. Zhang B.W. Jiang L. Wang H. Ma Q.Y. Wang H.F. Zhang J. Chen F.L. Zhao Y.X. Luo D.Q. Two new alkaloids from the endophytic fungus Schizophyllum sp. HM230 isolated from Vincetoxicum mongolicum Maxim. Nat. Prod. Res. 2024 38 14 2411 2418 10.1080/14786419.2023.2176493 36762731
    [Google Scholar]
  68. Li H. Li C. Miao C. Shao Y. Huang W. He B. Li W. Undescribed cytotoxic bisabosqual-type meroterpenoids from an endophytic Stachybotryaceae sp. associated with Delphinium yunnanense. Phytochemistry 2024 220 114037 10.1016/j.phytochem.2024.114037 38387725
    [Google Scholar]
  69. Meng Z.K. Rao S.M. Hu Y.K. Zhou X. Yang Q. Tan R.X. Wang Y.S. Discovery of undescribed anthracycline-derived polyketides with cytotoxicity from endophytic Streptomyces chartreusis M7. Phytochemistry 2025 230 114337 10.1016/j.phytochem.2024.114337 39549943
    [Google Scholar]
  70. Li J.L. Liu L.L. Lin Z.R. Zeng H.Q. Zhou Z. Long Y.H. Talarindigotin A. A cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041. J. Asian Nat. Prod. Res. 2025 27 4 632 638 10.1080/10286020.2024.2428228 39565810
    [Google Scholar]
  71. Ruan Q.F. He Y. Jiang S.Q. Cui H. Jin J. Zhao Z.X. Cytotoxic indole diterpenoids and rare pyridoxatin atropisomers from the endophytic fungus Tolypocladium sp. SHJJ1. Fitoterapia 2024 175 105983 10.1016/j.fitote.2024.105983 38679297
    [Google Scholar]
  72. Simons V.E. Mándi A. Frank M. van Geelen L. Tran-Cong N. Albrecht D. Coort A. Gebhard C. Kurtán T. Kalscheuer R. Colletodiol derivatives of the endophytic fungus Trichocladium sp. Fitoterapia 2024 175 105914 10.1016/j.fitote.2024.105914 38508500
    [Google Scholar]
  73. Martinez-Klimova E. Rodríguez-Peña K. Sánchez S. Endophytes as sources of antibiotics. Biochem. Pharmacol. 2017 134 1 17 10.1016/j.bcp.2016.10.010 27984002
    [Google Scholar]
  74. Huang J. Zhang C. Yao Y. Gao X. Hou Z. Zhang L. Li O. [Progress in antimicrobial substances of endophytes]. Sheng Wu Gong Cheng Xue Bao 2017 33 2 178 186 10.13345/j.cjb.160277 28956374
    [Google Scholar]
  75. Yadav A.N. Kour D. Kaur T. Devi R. Yadav A. Endophytic fungal communities and their biotechnological implications for agro-environmental sustainability. Folia Microbiol. 2022 67 2 203 232 10.1007/s12223‑021‑00939‑0 35122218
    [Google Scholar]
  76. Elnaggar M.S. Ibrahim N. Elissawy A.M. Anwar A. Ibrahim M.A.A. Ebada S.S. Cytotoxic and antimicrobial mycophenolic acid derivatives from an endophytic fungus Penicillium sp. MNP–HS–2 associated with Macrozamia communis. Phytochemistry 2024 217 113901 10.1016/j.phytochem.2023.113901 37884257
    [Google Scholar]
  77. Li B.C. Lv L.X. Huang L.L. Zhou J.T. Huang X.S. Li J. Yang R.Y. Xu W.F. Cycloaspeptide H, a cyclopentapeptide from the endophytic fungus Penicillium virgatum. Nat. Prod. Res. 2024 38 3 486 492 10.1080/14786419.2022.2128346 36190784
    [Google Scholar]
  78. Wang J.P. Shu Y. Zhang S.Q. Yao L.L. Li B.X. Zhu L. Zhang X. Xiao H. Cai L. Ding Z.T. Polyketides with antimicrobial activities from Penicillium canescens DJJ-1. Phytochemistry 2023 206 113554 10.1016/j.phytochem.2022.113554 36496005
    [Google Scholar]
  79. Yang M. Dong M. Wu Q.Y. Yao S. Pu G. Ma Y.Y. Xiong R.F. Hu Q.F. Wang F. Li Y.K. Three new isoquinoline alkaloids from the fermentation of Aspergillus sp. 0338 and their anti-MRSA activities. Nat. Prod. Res. 2025 39 1 103 109 10.1080/14786419.2023.2254455 37695019
    [Google Scholar]
  80. Deng B.Q. Chen M.Q. Wang H.X. Wang X.X. Zhao H. Li C.H. Qin S.Y. Hu D. Chen G.D. Gao H. Two new alkaloids from a strain of endophytic fungus Aspergillus sp. J. Asian Nat. Prod. Res. 2023 25 10 957 967 10.1080/10286020.2023.2173180 36729489
    [Google Scholar]
  81. Tan Q. Ye X. Fu S. Yin Y. Liu Y. Wu J. Cao F. Wang B. Zhu T. Yang W. She Z. The cytochalasins and polyketides from a mangrove endophytic fungus Xylaria arbuscula QYF. Mar. Drugs 2024 22 9 407 10.3390/md22090407 39330288
    [Google Scholar]
  82. Wei S.S. Lai J.Y. Chen C. Zhang Y.J. Nong X.M. Qiu K.D. Duan F.F. Zou Z.X. Tan H.B. Sesquiterpenes and α-pyrones from an endophytic fungus Xylaria curta YSJ-5. Phytochemistry 2024 220 114011 10.1016/j.phytochem.2024.114011 38367793
    [Google Scholar]
  83. Xu Z.L. Li B.C. Huang L.L. Lv L.X. Luo Y. Xu W.F. Yang R.Y. Two new cytochalasins from the endophytic fungus Xylaria sp. GDGJ-77B. Nat. Prod. Res. 2024 38 9 1503 1509 10.1080/14786419.2022.2153362 36469678
    [Google Scholar]
  84. Lv J. Zhou H. Dong L. Wang H. Yang L. Yu H. Wu P. Zhou L. Yang Q. Liang Y. Luo B. Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity. Nat. Prod. Res. 2024 38 18 3165 3172 10.1080/14786419.2023.2218530 37267595
    [Google Scholar]
  85. Sundar R.D.V. Arunachalam S. Xenomyrothecium tongaense PTS8: A rare endophyte of Polianthes tuberosa with salient antagonism against multidrug-resistant pathogens. Front. Microbiol. 2024 15 1327190 10.3389/fmicb.2024.1327190 38435697
    [Google Scholar]
  86. Zou G. Yang W. Chen T. Liu Z. Chen Y. Li T. Said G. Sun B. Wang B. She Z. Griseofulvin enantiomers and bromine-containing griseofulvin derivatives with antifungal activity produced by the mangrove endophytic fungus Nigrospora sp. QQYB1. Mar. Life Sci. Technol. 2023 6 1 102 114 10.1007/s42995‑023‑00210‑0 38433970
    [Google Scholar]
  87. Zhao S. Jing Z. New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03. Chin. J. Nat. Med. 2024 22 4 356 364 10.1016/S1875‑5364(24)60629‑1 38658098
    [Google Scholar]
  88. Fan Y.Z. Tian C. Tong S.Y. Liu Q. Xu F. Shi B.B. Ai H.L. Liu J.K. The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines. Nat. Prod. Bioprospect. 2023 13 1 43 10.1007/s13659‑023‑00407‑x 37870633
    [Google Scholar]
  89. Morehouse N.J. Flewelling A.J. Liu D.Y. Cavanagh H. Linington R.G. Johnson J.A. Gray C.A. Tolypocaibols: Antibacterial Lipopeptaibols from a Tolypocladium sp. Endophyte of the marine macroalga Spongomorpha arcta. J. Nat. Prod. 2023 86 6 1529 1535 10.1021/acs.jnatprod.3c00233 37313957
    [Google Scholar]
  90. El-Zawawy N.A. Ali S.S. Nouh H.S. Exploring the potential of Rhizopus oryzae AUMC14899 as a novel endophytic fungus for the production of l-tyrosine and its biomedical applications. Microb. Cell Fact. 2023 22 1 31 10.1186/s12934‑023‑02041‑1 36804031
    [Google Scholar]
  91. Chen H.W. Jiang C.X. Ma G.L. Wu X.Y. Jiang W. Li J. Zang Y. Li J. Xiong J. Hu J.F. Unprecedented spirodioxynaphthalenes from the endophytic fungus Phyllosticta ligustricola HDF-L-2 derived from the endangered conifer Pseudotsuga gaussenii. Phytochemistry 2023 211 113687 10.1016/j.phytochem.2023.113687 37105348
    [Google Scholar]
  92. Han L. Zheng W. He Z. Qian S. Ma X. Kang J. Endophytic fungus Biscogniauxia petrensis produces antibacterial substances. PeerJ 2023 11 e15461 10.7717/peerj.15461 37304871
    [Google Scholar]
  93. Han L. Zheng W. Qian S.Y. Yang M.F. Lu Y.Z. He Z.J. Kang J.C. New guaiane-type sesquiterpenoids biscogniauxiaols A–G with anti-fungal and anti-inflammatory activities from the endophytic fungus biscogniauxia petrensis. J. Fungi 2023 9 4 393 10.3390/jof9040393 37108848
    [Google Scholar]
  94. Li W.Y. Hu C.C. Liu J.H. Wang H.J. Lu L.P. Qiao M. Jiang Y.L. Wu R. Botryorhodine J, a new anti-MRSA depsidone isolated from endophytic fungus Alternaria alternata Pas11. Nat. Prod. Res. 2025 39 5 1181 1187 10.1080/14786419.2023.2298727 38148164
    [Google Scholar]
  95. Gu G. Gong X. Xu D. Yang Y. Yin R. Dai J. Zhu K. Lai D. Zhou L. Diphenyl ether derivative rhexocerins and rhexocercosporins from the endophytic Fungus Rhexocercosporidium sp. Dzf14 active against gram-positive bacteria with multidrug-resistance. J. Nat. Prod. 2023 86 8 1931 1938 10.1021/acs.jnatprod.3c00295 37486731
    [Google Scholar]
  96. Cai G. Hu X. Zhang R. Wang J. Fang X. Pang X. Bai J. Zhang T. Zhang T. Lv H. You X. He W. Yu L. Subplenones A–J: Dimeric xanthones with antibacterial activity from the endophytic fungus Subplenodomus sp. CPCC 401465. J. Nat. Prod. 2023 86 11 2474 2486 10.1021/acs.jnatprod.3c00628 37862150
    [Google Scholar]
  97. Liu X.R. Li K.X. Chen H.W. He Y.H. Wang H.Y. Mao Y.C. Li J.Y. Hu J.F. Xiong J. Bioactive polyketides and tryptophol alkaloids from the endophytic fungus Botryosphaeria dothidea LE-07 of Chinese tulip tree. Fitoterapia 2024 179 106229 10.1016/j.fitote.2024.106229 39326797
    [Google Scholar]
  98. Peng W.W. Kuang M. Huang Y.T. Li M.F. Zheng Y.T. Xu L. Tan J.B. Kang F.H. Tan H.B. Zou Z.X. Pseudocercones A-C, three new polyketide derivatives from the endophytic fungus Pseudocercospora sp. TSS-1. Nat. Prod. Res. 2024 38 7 1248 1255 10.1080/14786419.2022.2138874 36308293
    [Google Scholar]
  99. Huang Z. Wu D. Liu X. Liu Q. Han X. Wang W. Yang X. Indole alkaloids from endophytic fungus Robillarda sessilis and their antibacterial activity. Nat. Prod. Res. 2025 39 5 1156 1165 10.1080/14786419.2023.2297853 38299875
    [Google Scholar]
  100. Liang L.Q. He X.H. Wei C.Y. Zhao J.X. Wu Q. Liang M. Li J. Luo Y. Xu W.F. Yang R.Y. Antimicrobial polyketides from an endophytic fungus Arcopilus aureus HJ-7 from Ardisia mamillata Hance. Nat. Prod. Res. 2024 19 1 8 10.1080/14786419.2024.2429119 39560922
    [Google Scholar]
  101. Yang Y. Li G.D. Shao Y.T. Sun Z.W. Li L.W. Li W. Li H.T. Fungal polyketides produced by an endophytic fungus Phoma sp. associated with Gastrodia elata. Fitoterapia 2024 173 105793 10.1016/j.fitote.2023.105793 38158161
    [Google Scholar]
  102. Nakanishi K. The ginkgolides. Pure Appl. Chem. 1967 14 1 89 114 10.1351/pac196714010089 6036635
    [Google Scholar]
  103. Lee C.W. Wang B.Y.H. Wong S.H. Chen Y.F. Cao Q. Hsiao A.W.T. Fung S.H. Chen Y.F. Wu H.H. Cheng P.Y. Chou Z.H. Lee W.Y.W. Tsui S.K.W. Lee O.K.S. Ginkgolide B increases healthspan and lifespan of female mice. Nature Aging 2025 5 2 237 258 10.1038/s43587‑024‑00802‑0 39890935
    [Google Scholar]
  104. Cui Y. Yi D. Bai X. Sun B. Zhao Y. Zhang Y. Ginkgolide B produced endophytic fungus (Fusarium oxysporum) isolated from Ginkgo biloba. Fitoterapia 2012 83 5 913 920 10.1016/j.fitote.2012.04.009 22537641
    [Google Scholar]
  105. Arulselvan P. Fard M.T. Tan W.S. Gothai S. Fakurazi S. Norhaizan M.E. Kumar S.S. Role of antioxidants and natural products in inflammation. Oxid. Med. Cell. Longev. 2016 2016 1 5276130 10.1155/2016/5276130 27803762
    [Google Scholar]
  106. Zhang Y. Kang J. Zhou Q. Chen M. Zhang J. Shi Z. Qiao Y. Qi C. Zhang Y. Discovery of 23,24-diols containing ergosterols with anti-neuroinflammatory activity from Penicillium citrinum TJ507. Bioorg. Chem. 2024 150 107575 10.1016/j.bioorg.2024.107575 38941698
    [Google Scholar]
  107. Lao X.L. Wu M.Z. Zheng T. Chen G.Y. Zheng C.J. Chen Y.L. Zhou J.Q. Feng S. Zhou X.M. Song X.M. [Two new pinophol derivatives from endophytic fungus Penicillium herquei JX4 hosted in Ceriops tagal. Zhongguo Zhongyao Zazhi 2024 49 13 3548 3551 10.19540/j.cnki.cjcmm.20240405.202 39041126
    [Google Scholar]
  108. Wang G. Wu J. Li Z. Chen T. Liu Y. Wang B. Chen Y. She Z. Talaroacids A–D and Talaromarane A, diterpenoids with anti-inflammatory activities from mangrove endophytic fungus Talaromyces sp. JNQQJ-4. Int. J. Mol. Sci. 2024 25 12 6691 10.3390/ijms25126691 38928398
    [Google Scholar]
  109. Zhang J. Tan Z. Chen Y. Li C. Li S. Liu H. Zhang W. Yan H. Secondary metabolites from the endophytic fungus letendraea helminthicola A820 with anti‐inflammatory activity. Chem. Biodivers. 2025 22 2 e202402114 10.1002/cbdv.202402114 39340168
    [Google Scholar]
  110. Wang G. Yuan Y. Li Z. Liu X. Chu Y. She Z. Kang W. Chen Y. Pleosmaranes A–R, isopimarane and 20-nor isopimarane diterpenoids with anti-inflammatory activities from the mangrove endophytic fungus Pleosporales sp. HNQQJ-1. J. Nat. Prod. 2024 87 2 304 314 10.1021/acs.jnatprod.3c00893 38320172
    [Google Scholar]
  111. Yue J.Y. Wang R. Xu T. Wang J.T. Yu Y. Cai B.X. Novel phenolic metabolites isolated from plant endophytic fungus Fusarium guttiforme. Nat. Prod. Res. 2024 38 2 336 340 10.1080/14786419.2022.2116579 36008750
    [Google Scholar]
  112. Jia H. Wu L. Liu R. Li J. Liu L. Chen C. Li J. Zhang K. Liao J. Long Y. Penifuranone A. Penifuranone A. A novel alkaloid from the mangrove endophytic fungus penicillium crustosum SCNU-F0006. Int. J. Mol. Sci. 2024 25 9 5032 10.3390/ijms25095032 38732250
    [Google Scholar]
  113. Wang Y.Y. Pan Y.B. Wan Z.Y. Li J.J. Bao J. Zhang J.S. Zhang H. Anti‐inflammatory polyketides from an endophytic fungus Chaetomium sp. UJN‐EF006 of Vaccinium bracteatum. Chem. Biodivers. 2024 21 4 e202400002 10.1002/cbdv.202400002 38411310
    [Google Scholar]
  114. Zhu X. Liu W. Shi Z. Zhu H. Fan S. Zhang J. Liu W. Xu L.J. Ren Q.J. Feng F. Xu J. Meroterpenoids with divers’ rings systems from Phyllosticta capitalensis and their anti-inflammatory activity. Phytochemistry 2024 217 113918 10.1016/j.phytochem.2023.113918 37952710
    [Google Scholar]
  115. Gao W. Li F. Lin S. Yang B. Wang J. Cao J. Hu Z. Zhang Y. Two new lanostane-type triterpenoids from the fungus Periconia sp. TJ403-rc01. Nat. Prod. Res. 2023 37 7 1154 1160 10.1080/14786419.2021.1998046 34726089
    [Google Scholar]
  116. Bi Y. Yu Y. Yao H. Yuan T. Terpenoids from the endophytic fungus Microdiplodia sp. and their anti-inflammatory activities. Fitoterapia 2023 171 105711 10.1016/j.fitote.2023.105711 37866425
    [Google Scholar]
  117. Yao S. Zhang R. Wang J. Gu L. Hu Z. Zhang Y. A new diketopiperazine-type alkaloid from the endophytic fungus Penicillium expansum. Nat. Prod. Res. 2023 37 21 3716 3721 10.1080/14786419.2022.2099391 35848376
    [Google Scholar]
  118. Zeng Q. Cui H. Yao H. Yuan T. Five sesquiterpenes from Paraconiothyrium sp. and their anti‐inflammatory activity. Chem. Biodivers. 2023 20 6 e202300477 10.1002/cbdv.202300477 37212458
    [Google Scholar]
  119. Feng A. Zhang W. Wang L. Zhou J. Chen J. Xu X. Huang X. Huang J. A new chromone derivative from an endophytic Aspergillus sp. GXNU-B1. Nat. Prod. Res. 2024 38 14 2474 2479 10.1080/14786419.2023.2181805 36815551
    [Google Scholar]
  120. Wang C.Y. Gan D. Shu Y. Mei R.F. Liu J.Q. Li C.Z. Cai L. Zhang S.Q. Zhu L. Zhou H. Cai L. Ding Z.T. Specialized metabolites of the endophyte Annulohypoxylon areolatum hosted by Aconitum carmichaelii. Phytochemistry 2024 228 114251 10.1016/j.phytochem.2024.114251 39178977
    [Google Scholar]
  121. Chen J.Q. Li S. Fan R.Z. Sun Z.H. Zhu X.Y. Yin A.P. Tang G.H. Yin S. Talaesthanes A–C, three new meroterpenoids from the endophytic fungus Talaromyces primulinus H21. Fitoterapia 2024 177 106085 10.1016/j.fitote.2024.106085 38901806
    [Google Scholar]
  122. Li Y.C. Yang J. Zhao Y.Z. Ma Q.D. Liu B.G. Sun J.L. Cytochalasans from the endophytic fungus Aspergillus sp. LE2: Their structures, antibacterial and NO production inhibitory activities. J. Fungi 2023 9 3 374 10.3390/jof9030374 36983542
    [Google Scholar]
  123. Pal P.P. Begum S.A. Basha A.S. Araya H. Fujimoto Y. A new lignan (Polonilignan) and inhibitors of nitric oxide production from penicillium polonicum, an endophytic fungi of Piper nigrum. Chem. Biodivers. 2023 20 3 e202200840 10.1002/cbdv.202200840 36662670
    [Google Scholar]
  124. Zhang D. Wang X. Liu B. Li S. Wang Y. Guo T. Sun Y. Petrelli R. New dipyrroloquinones from a plant-derived endophytic fungus Talaromyces sp. Molecules 2023 28 23 7847 10.3390/molecules28237847 38067576
    [Google Scholar]
  125. Lu X. Qi J. Tang X. Wang X. Ye C. Bai J. Tang C. Xi Y. Wu B. Wan X. Feng B. Polyketides with anti-inflammatory activity isolated from Rhodiola tibetica endophytic fungus Penicillium sp. HJT-A-10. Fitoterapia 2023 164 105361 10.1016/j.fitote.2022.105361 36435487
    [Google Scholar]
  126. Hossain U. Das A.K. Ghosh S. Sil P.C. An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications. Food Chem. Toxicol. 2020 145 111738 10.1016/j.fct.2020.111738 32916220
    [Google Scholar]
  127. Akıncıoğlu H. Gülçin İ. Potent acetylcholinesterase inhibitors: Potential drugs for Alzheimer’s disease. Mini Rev. Med. Chem. 2020 20 8 703 715 10.2174/1389557520666200103100521 31902355
    [Google Scholar]
  128. Ma Q. Zhong Y. Huang P. Li A. Jiang T. Jiang L. Yang H. Wang Z. Wu G. Huang X. Pu H. Liu J. Bioactive naphthoquinone and phenazine analogs from the endophytic Streptomyces sp. PH9030 as α-Glucosidase inhibitors. Molecules 2024 29 15 3450 10.3390/molecules29153450 39124856
    [Google Scholar]
  129. Wang D. Zhuang X. Yin Y. Wu D. He W. Zhu W. Xu Y. Zuo M. Wang L. Indole diterpene derivatives from the Aspergillus flavus GZWMJZ-288, an endophytic fungus from Garcinia multiflora. Molecules 2023 28 23 7931 10.3390/molecules28237931 38067659
    [Google Scholar]
  130. Zhang Y. Liu H. Chen Y. Liu Z. Qiu K. Wei S. Zhang W. Tan H. Alkyl aromatic derivatives from the endophytic fungus Cytospora rhizophorae. J. Antibiot. 2023 76 3 121 130 10.1038/s41429‑022‑00591‑x 36575311
    [Google Scholar]
  131. Li J. Li Z. Chen T. Ye G. Qiu L. Long Y. New azaphilones from mangrove endophytic fungus Penicillium sclerotiorin SCNU-F0040. Nat. Prod. Res. 2023 37 2 296 304 10.1080/14786419.2021.1959580 34498957
    [Google Scholar]
  132. Wang Z. Ma Q. Wu G. Zhong Y. Feng B. Huang P. Li A. Tang G. Huang X. Pu H. Bioactive α-Pyrone analogs from the endophytic fungus Diaporthe sp. CB10100: α-Glucosidase inhibitory activity, molecular docking, and molecular dynamics studies. Molecules 2024 29 8 1768 10.3390/molecules29081768 38675588
    [Google Scholar]
  133. Jiang T.T. Zhai L.L. Wang Z.J. Wang X.Y. Li J.N. Zhai Y.J. Li D. Han W.B. Polyketides with α-glucosidase inhibitory and neuroprotective activities from Aspergillus versicolor associated with Pedicularis sylvatica. Org. Biomol. Chem. 2024 22 20 4179 4189 10.1039/D4OB00316K 38716654
    [Google Scholar]
  134. Zhao X. Hu Q. Wang X. Li C. Chen X. Zhao D. Qiu Y. Xu H. Wang J. Ren L. Zhang N. Li S. Gong P. Hou Y. Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer’s disease. Eur. J. Med. Chem. 2024 279 116810 10.1016/j.ejmech.2024.116810 39243456
    [Google Scholar]
  135. Chen H. Zheng H. Cai C. Wang H. Gai C. Tan Z. Dai H. Mei W. New indole derivatives from endophytic fungus Colletotruchum sp. HK-08 originated from leaves of Nerium indicum. Chin. Herb. Med. 2024 16 2 235 238 10.1016/j.chmed.2023.07.004 38706824
    [Google Scholar]
  136. Liu Y. Xue X. Zhou L. Yang W. She Z. Liao Q. Feng Y. Chen X. Zhang Y. Quinolinones alkaloids with AChE inhibitory activity from mangrove endophytic fungus Penicillium citrinum YX‐002. Chem. Biodivers. 2023 20 8 e202300735 10.1002/cbdv.202300735 37423890
    [Google Scholar]
  137. Dwibedi V. Mishra S.S. George N. Joshi M. Kaur G. Gupta M. Rath S.K. Purification of ursolic acid and β-sitosterol from endophytic Alternaria alternata for their alpha-amylase inhibitory activity. J. Biomol. Struct. Dyn. 2024 42 13 6688 6699 10.1080/07391102.2023.2236717 37477594
    [Google Scholar]
  138. Li H. Yang R. Xie F. Xie T. Tang L. Zhou H. Ding Z. Multioxidized polyketides from an endophytic Penicillium sp. YUD17006 associated with Gastrodia elata. Chin. J. Nat. Med. 2024 22 11 1057 1064 10.1016/S1875‑5364(24)60724‑7 39510638
    [Google Scholar]
  139. Liu Y. Chen K.L. Zhao J.Y. Yang C.Y. Jia X.B. Niu Y.W. Tian Y.N. Yang Y. Liu Y.B. A derivative of trihydroxynaphthalenone and a pyrone metabolite from the endophytic fungus Talaromyces purpurpgenus. J. Asian Nat. Prod. Res. 2024 26 5 555 561 10.1080/10286020.2024.2333359 38563409
    [Google Scholar]
  140. Sana T. Khan M. Jabeen A. Shams S. Hadda T.B. Begum S. Siddiqui B.S. Urease and carbonic anhydrase inhibitory effect of xanthones from Aspergillus nidulans, an endophytic fungus of Nyctanthes arbor-tristis. Planta Med. 2023 89 4 377 384 10.1055/a‑1908‑0935 36626924
    [Google Scholar]
  141. Li X. Gong Y.X. Feng L. Wang X.J. Wang J.W. Zhang A.X. Tan N.H. Wang Z. Neuropyrones A–E, five undescribed α-pyrone derivatives with tyrosinase inhibitory activity from the endophytic fungus Neurospora dictyophora WZ-497. Phytochemistry 2023 207 113579 10.1016/j.phytochem.2022.113579 36586529
    [Google Scholar]
  142. Ren J.L. Li C.M. Shen L. Wu J. A new terrein dimer and a new meroterpene from the mangrove endophytic fungus Lichtheimia sp. J. Asian Nat. Prod. Res. 2023 25 11 1068 1075 10.1080/10286020.2023.2197596 37042744
    [Google Scholar]
  143. Huang G. Mei X. Hu J. The antioxidant activities of natural polysaccharides. Curr. Drug Targets 2017 18 11 1296 1300 10.2174/1389450118666170123145357 28117001
    [Google Scholar]
  144. Zou G. Li T. Yang W. Sun B. Chen Y. Wang B. Ou Y. Yu H. She Z. Antioxidative indenone and benzophenone derivatives from the mangrove-derived fungus Cytospora heveae NSHSJ-2. Mar. Drugs 2023 21 3 181 10.3390/md21030181 36976230
    [Google Scholar]
  145. Guo X.W. Yu Z.Q. Xi J. Ren H. Xiang X.Y. Wu J. Fang J. Wu Q.X. Isolation and identification of novel antioxidant polyketides from an endophytic fungus Ophiobolus cirsii LZU-1509. J. Agric. Food Chem. 2023 71 3 1593 1606 10.1021/acs.jafc.2c07386 36634077
    [Google Scholar]
  146. Cao H.Y. Sun S. Yi C. Yang C. Chen K. Zhang X. Liu Y.B. Muyocoxanthones O–S: Undescribed xanthones with antioxidative damage bioactivity to cardiomyocytes from the endophytic fungus Muyocopron laterale. Phytochemistry 2023 209 113625 10.1016/j.phytochem.2023.113625 36858338
    [Google Scholar]
  147. Parkin J. Cohen B. An overview of the immune system. Lancet 2001 357 9270 1777 1789 10.1016/S0140‑6736(00)04904‑7 11403834
    [Google Scholar]
  148. Wu J. Ye J. Cen J. Chen Y. Xu J. Induction of three new secondary metabolites by the co-culture of endophytic fungi Phomopsis asparagi DHS-48 and Phomopsis sp. DHS-11 isolated from the Chinese mangrove Plant Rhizophora mangle. Mar. Drugs 2024 22 8 332 10.3390/md22080332 39195448
    [Google Scholar]
  149. Chang J.L. Pei J. Zhou Y.H. Ouyang Q.X. Qin C.L. Hu J.Y. Meng X.G. Ruan H.L. Diaporaustalides A–L, austalide meroterpenoids from a plant endophytic Diaporthe sp. J. Nat. Prod. 2024 87 1 141 151 10.1021/acs.jnatprod.3c00986 38128907
    [Google Scholar]
  150. Liu J.Q. Zhang S.Q. Wu X.H. Liu S.X. Yang R.D. Deng L. Cai L. A new benzophenone derivative from Aspergillus fumigatus WJ-131. Nat. Prod. Res. 2025 39 2 223 232 10.1080/14786419.2023.2260071 37732607
    [Google Scholar]
  151. Kumari R. Sharma S.D. Kumar A. Ende Z. Mishina M. Wang Y. Falls Z. Samudrala R. Pohl J. Knight P.R. Sambhara S. Antiviral approaches against influenza virus. Clin. Microbiol. Rev. 2023 36 1 e00040 e22 10.1128/cmr.00040‑22 36645300
    [Google Scholar]
  152. Lacerda Í.C.S. Polonio J.C. Golias H.C. Endophytic fungi as a source of antiviral compounds – A review. Chem. Biodivers. 2022 19 6 e202100971 10.1002/cbdv.202100971 35426966
    [Google Scholar]
  153. Zhang R. Wang Y. Cai G. Wang J. Zhao J. Bai J. Zhang T. Cen S. He W. Yu L. Verbalide A~F: New phthalide derivatives from the endophytic fungus Preussia sp. CPCC 400972. J. Antibiot. 2023 76 10 613 617 10.1038/s41429‑023‑00640‑z 37402885
    [Google Scholar]
  154. Yang Z. Wu K. Ji W. Yin Y. Wang X. Shao L. Ge M. Xu Y. A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410. J. Antibiot. 2023 76 4 239 243 10.1038/s41429‑022‑00586‑8 36806196
    [Google Scholar]
  155. Li J. Chen T. Yu J. Jia H. Chen C. Long Y. New sorbicillinoids from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042. Mar. Drugs 2023 21 8 442 10.3390/md21080442 37623722
    [Google Scholar]
  156. Fan Z.Y. Peng J. Lou J.Q. Chen Y. Wu X.M. Tan R. Tan R.X. Neuroprotective α-pyrones from Nigrospora oryzae, an endophytic fungus residing in Taxus chinensis var. mairei. Phytochemistry 2023 216 113873 10.1016/j.phytochem.2023.113873 37769958
    [Google Scholar]
  157. Gu C.C. Zeng J. Peng X.P. Sun Y.J. Yuan S.Z. Wang X.N. Zhang R.S. Lou H.X. Li G. Cytochalasans with inhibitory activity against NPC1L1 from the endophytic fungus chaetomium nigricolor F5. J. Org. Chem. 2023 88 5 3185 3192 10.1021/acs.joc.2c02983 36812072
    [Google Scholar]
  158. Kuncharoen N. Bunbamrung N. Intaraudom C. Choowong W. Thawai C. Tanasupawat S. Pittayakhajonwut P. Antimalarial and antimicrobial substances isolated from the endophytic actinomycete, Streptomyces aculeolatus MS1-6. Phytochemistry 2023 207 113568 10.1016/j.phytochem.2022.113568 36565946
    [Google Scholar]
  159. Zhang X.Q. Lu Z.H. Tang G.M. Duan L.P. Wang Z.H. Guo Z.Y. Proksch P. Prunolactones A-G, proangiogenic isocoumarin derivatives with an unusual 6/6/6/6/6 spiropentacyclic skeleton from the endophytic fungus Phomopsis prunorum. Bioorg. Chem. 2023 141 106898 10.1016/j.bioorg.2023.106898 37801783
    [Google Scholar]
  160. Qin F. Luo L. Liu Y.C. Bo X.L. Wu F.R. Wang F.F. Tan M.J. Wei Y.Q. Dou X.B. Wang C.Y. Huang X.S. Wang H.S. Diisoprenyl-cyclohexene-type meroterpenoids from a mangrove endophytic fungus Aspergillus sp. GXNU-Y65 and their anti-nonalcoholic steatohepatitis activity in AML12 cells. Phytochemistry 2024 218 113955 10.1016/j.phytochem.2023.113955 38128773
    [Google Scholar]
  161. Kemkuignou B.M. Lambert C. Schmidt K. Schweizer L. Anoumedem E.G.M. Kouam S.F. Stadler M. Stradal T. Marin-Felix Y. Unreported cytochalasins from an acid-mediated transformation of cytochalasin J isolated from Diaporthe cf. ueckeri. Fitoterapia 2023 166 105434 10.1016/j.fitote.2023.105434 36681097
    [Google Scholar]
  162. Gao S. Lin X. Shi Y. Zhou H. Zheng X. Li M. Lin T. A new hypoglycemic prenylated indole alkaloid N-Oxide from endophytic fungus pallidocercospora crystalline. Int. J. Mol. Sci. 2023 24 10 8767 10.3390/ijms24108767 37240113
    [Google Scholar]
  163. Yin Y. Wang D. Wu D. He W. Zuo M. Zhu W. Xu Y. Wang L. Two new 4-Hydroxy-2-pyridone alkaloids with antimicrobial and cytotoxic activities from Arthrinium sp. GZWMJZ-606 endophytic with Houttuynia cordata Thunb. Molecules 2023 28 5 2192 10.3390/molecules28052192 36903438
    [Google Scholar]
  164. Wang C. Wang F. Tao P. Shao Y. Li Q. Gu M. Liao Z. Qin F. New meroterpenoids and α-Pyrone derivatives isolated from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85. Mar. Drugs 2024 22 6 277 10.3390/md22060277 38921588
    [Google Scholar]
  165. Wang F.F. Huang G.B. Lu C.H. Chen L.J. Chen H.Z. Luo M.Q. Tao P.F. Tan M.X. Qin F. A new isoprenyl-phenol-type meroterpenoid from mangrove endophytic fungus Aspergillus sp. GXNU-Y65. Nat. Prod. Res. 2024 1-5 1 5 10.1080/14786419.2024.2390614 39126707
    [Google Scholar]
  166. Qin F. Song Z.S. Luo L. Bo X.L. Wu F.R. Tan M.J. Wang F.F. Huang X.S. Wang H.S. Diisoprenyl cyclohexene-type meroterpenoids with cytotoxic activity from a mangrove endophytic fungus Aspergillus sp. GXNU-Y85. Mar. Drugs 2024 22 2 58 10.3390/md22020058 38393029
    [Google Scholar]
  167. Shi B.B. Tian C. Lv X. Schinnerl J. Ye K. Guo H. Xu F. He Y. Ai H.L. Liu J.K. Boerelasins A–D, four unprecedented cytochalasins from the endophytic fungus Boeremia Exigua. J. Org. Chem. 2023 88 19 13926 13933 10.1021/acs.joc.3c01515 37728955
    [Google Scholar]
  168. Khan B. Li Y. Wei W. Liu G. Xiao C. He B. Zhang C. Rajput N.A. Ye Y. Yan W. Chemical investigation of endophytic Diaporthe unshiuensis YSP3 reveals new antibacterial and cytotoxic agents. J. Fungi 2023 9 2 136 10.3390/jof9020136 36836251
    [Google Scholar]
  169. Yuan Y. Wang G. She Z. Chen Y. Kang W. Metabolites isolated from the mangrove endophytic fungus Didymella sp. CYSK-4 and their cytotoxic activities. Fitoterapia 2023 171 105692 10.1016/j.fitote.2023.105692 37757921
    [Google Scholar]
  170. Wang X.Q. Liu B. Wang Z.M. Zhao S.N. Weng X.G. Guo S.Y. Sun Y. [Active secondary metabolites from an endophytic fungus Fusarium solani MBM-5 of Datura arborea. Zhongguo Zhongyao Zazhi 2024 49 10 2722 2727 10.19540/j.cnki.cjcmm.20240311.201 38812172
    [Google Scholar]
  171. Wang Y. Liu C. Yang Y. Li C. Pei Y. A new tetracyclic triterpenoid from endophytic fungus Fusarium sporotrichioides. Chin. Herb. Med. 2024 16 2 231 234 10.1016/j.chmed.2022.10.007 38706828
    [Google Scholar]
  172. Jin Y. Tian S. Xue J. Isolation and structure determination of a new bisabolane-type sesquiterpenoid with cytotoxicity from Penicillium oxalicum MZY-202312-521. Nat. Prod. Res. 2024 39 14 4193 4197 10.1080/14786419.2024.2356651 38824430
    [Google Scholar]
  173. Yu X. Müller W.E.G. Frank M. Gao Y. Guo Z. Zou K. Proksch P. Liu Z. Caryophyllene-type sesquiterpenes from the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach. Front. Microbiol. 2024 14 1248896 10.3389/fmicb.2023.1248896 38274753
    [Google Scholar]
  174. Dong F. Jiang Z. Wu P. Duan F. Xue J. Tan H. Wei X. Bioactive ambuic acid congeners from endophytic fungus Pestalotiopsis trachicarpicola SC-J551. J. Antibiot. 2024 77 1 21 29 10.1038/s41429‑023‑00674‑3 37957338
    [Google Scholar]
  175. Wu J.W. Chen D.D. Li Q. Feng T. Xu J. Metabolomics-Guided discovery of new dimeric xanthones from co-cultures of mangrove endophytic fungi DHS-48 and Phomopsis sp. DHS-11. Mar. Drugs 2024 22 3 102 10.3390/md22030102 38535443
    [Google Scholar]
  176. Guo Z. Chen B. Chen D. Deng X. Yuan J. Zhang S. Xiong Z. Xu J. new isocoumarin and pyrone derivatives from the chinese mangrove plant Rhizophora mangle-Associated Fungus Phomopsis sp. DHS-11. Molecules 2023 28 9 3756 10.3390/molecules28093756 37175165
    [Google Scholar]
  177. Li H. Lin C. Chen K. Zhou Z. Chen Z. Ding B. Huang H. Tao Y. New polyketides and cytotoxic alkaloids from the mangrove endophytic fungus Talaromyces sp. SAF14. Nat. Prod. Res. 2025 39 15 4497 4501 10.1080/14786419.2024.2367239 38885344
    [Google Scholar]
  178. Zhang X. Fan Y. Ye K. Pan X. Ma X. Ai H. Shi B. Liu J. Six unprecedented cytochalasin derivatives from the potato endophytic fungus Xylaria curta E10 and their cytotoxicity. Pharmaceuticals 2023 16 2 193 10.3390/ph16020193 37259342
    [Google Scholar]
  179. Xu Z. Feng T. Wen Z. Li Q. Chen B. Liu P. Xu J. New naphthalene derivatives from the mangrove endophytic fungus Daldinia eschscholzii MCZ-18. Mar. Drugs 2024 22 6 242 10.3390/md22060242 38921554
    [Google Scholar]
  180. Yin Y. Yang W. Chen T. Tan Q. Zou G. Zang Z. Li J. Wang B. She Z. Cytosporones W and X: Two mutually converting epimers from a mangrove endophytic fungus Diaporthe sp. ZJHJYZ-1. ACS Omega 2023 8 29 26628 26634 10.1021/acsomega.3c03862 37521628
    [Google Scholar]
  181. Chen H.W. Wu X.Y. Zhao Z.Y. Huang Z.Q. Lei X.S. Yang G.X. Li J. Xiong J. Hu J.F. Terricoxanthones A–E, unprecedented dihydropyran-containing dimeric xanthones from the endophytic fungus Neurospora terricola HDF-Br-2 associated with the vulnerable conifer Pseudotsuga gaussenii. Phytochemistry 2024 219 113963 10.1016/j.phytochem.2023.113963 38171409
    [Google Scholar]
  182. Wang B. Li H. Chen T. Wei W. Liu G. Huang W. He B. Ye Y. Yan W. Two new sesquiterpene derivatives, dendocarbin B and bisaborosaol C with antifungal activity from the endophytic fungus Nigrospora chinensis GGY-3. Nat. Prod. Res. 2024 38 9 1478 1486 10.1080/14786419.2022.2151011 36451585
    [Google Scholar]
  183. Chen H.W. Yan L.H. Wang X.J. Zhao Z.Y. Wu X. Li J. Lei X.S. Xiong J. Hu J.F. Undescribed polyketides from endophytes associated with the critically endangered conifer Abies beshanzuensis. Fitoterapia 2024 177 106104 10.1016/j.fitote.2024.106104 38950637
    [Google Scholar]
  184. Zhu S. Xu T.C. Huang R. Gao Y. Wu S.H. Four new polyketides from an endophytic fungus Talaromyces muroii. Fitoterapia 2024 177 106073 10.1016/j.fitote.2024.106073 38897246
    [Google Scholar]
  185. Zhu L. Wang J.P. Hao F. Gan D. Zhang X.R. Li C.Z. Wang C.Y. Zhang L. Cai L. A new cyclopentenone derivative from Trichoderma atroviride HH-01. Nat. Prod. Res. 2023 37 7 1205 1211 10.1080/14786419.2021.1984912 34585648
    [Google Scholar]
  186. Yin Y. Tan Q. Wu J. Chen T. Yang W. She Z. Wang B. The polyketides with antimicrobial activities from a mangrove endophytic fungus trichoderma lentiforme ML-P8-2. Mar. Drugs 2023 21 11 566 10.3390/md21110566 37999390
    [Google Scholar]
  187. Rajendran S. Robertson L.P. Kosgahakumbura L. Fernando C. Göransson U. Wang H. Hettiarachchi C. Gunasekera S. Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens. Fitoterapia 2023 167 105496 10.1016/j.fitote.2023.105496 36990291
    [Google Scholar]
  188. Zhang W. Hao L. Qin X. Huang J. Yang R. Li J. Huang X. A new lactone from mangrove endophytic fungus Aspergillus sp. GXNU-A9. Nat. Prod. Res. 2023 37 3 417 423 10.1080/14786419.2021.1977298 34937443
    [Google Scholar]
  189. Wu F. Zhang W. Bo X. Feng Q. Tan M. Ju S. Song Z. Li J. Huang X. A new sulphur-containing metabolite from a mangrove endophytic fungus Aspergillus sp. GXNU-MA. Nat. Prod. Res. 2025 39 8 2074 2079 10.1080/14786419.2023.2288685 38037915
    [Google Scholar]
  190. Liu W.B. Tang J. Li J.L. Chen C. Wu L. Li J.S. Long Y.H. A new chromone from Kandelia candel endophytic fungus Aspergillus sp. ZJ-68. J. Asian Nat. Prod. Res. 2023 25 11 1125 1131 10.1080/10286020.2023.2197226 37042704
    [Google Scholar]
  191. Ma W. Shao Z. Chen Y. Li S. Liu H. Zhang W. Gao X. Cytospotones A-D, four new polyketones from the endophytic fungus Cytospora sp. A879. Fitoterapia 2024 173 105751 10.1016/j.fitote.2023.105751 37977303
    [Google Scholar]
  192. Zhai L.L. Jiang T.T. Zhang R. Li J.N. Zhai Y.J. Zhang Q. Li D. Han W.B. Ergostane-type sterols and sesquiterpenes with anti-neuroinflammatory activity from a Nigrograna species associated with Clematis shensiensis. Phytochemistry 2023 211 113690 10.1016/j.phytochem.2023.113690 37150432
    [Google Scholar]
  193. Wang G. Yuan Y. Li Z. Zhu J. She Z. Chen Y. Cytosporones with anti-inflammatory activities from the mangrove endophytic fungus Phomopsis sp. QYM-13. Mar. Drugs 2023 21 12 631 10.3390/md21120631 38132952
    [Google Scholar]
  194. Ying Y. Lei P. Xu Y. Lin Y. Yang N. Han Y. Zhang Z. Shan W. Rao G. Wang J. Secondary metabolites from Penicillium sp. HS-11, a fungal endophyte of Huperzia serrata. Fitoterapia 2024 175 105943 10.1016/j.fitote.2024.105943 38575090
    [Google Scholar]
/content/journals/cpb/10.2174/0113892010415786251029061350
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Bioactivities of Secondary Metabolites from Endophytes: A Recent Review
Bentham Science Publishers ; https://doi.org/10.2174/0113892010415786251029061350
/content/journals/cpb/10.2174/0113892010415786251029061350
/content/journals/cpb/10.2174/0113892010415786251029061350
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  • Article Type:     Review Article
Keywords: novel bioactive compounds ; isolation ; secondary metabolites ; Endophytes ; bioactivity ; natural products

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