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Abstract

ABMMA-BMT is a modality that combines innovative complementary and alternative medicine techniques with low-voltage electrical energy, applying it to acupuncture points and meridians to bridge traditional Chinese medicine with modern bioelectric science. This involves the application of microcurrents (10–1000 µA) at acupoints to assess and correct for disrupted energy flow, as determined by electrical resistance measurements. Treatment involves the delivery of weak direct currents, which remove blockages in meridian channels, thereby promoting local blood circulation and tissue repair. Recent research suggests that pulsed electromagnetic fields (PEMFs) and microcurrent stimulation can influence neural signaling, gene expression, and redox balance, thereby benefiting conditions such as chronic pain, soft tissue injury, and functional dysregulation of the immune and endocrine systems. These results suggest that integrating bioelectric principles with traditional acupuncture concepts will support the hypothesis that ABMMA-BMT has the potential to regulate cellular processes and accelerate healing while avoiding invasive procedures. The mechanisms are still not well understood, but preliminary clinical data and experimental studies are good indicators of its therapeutic effect. Future research is needed to standardize treatment parameters and to clinically verify the efficacy of this modality, so that it can be incorporated as a conventional component of healthcare practice.

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2025-08-04
2025-10-28

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References

  1. Matos L.C. Machado J.P. Monteiro F.J. Greten H.J. Perspectives, measurability and effects of non-contact biofield-based practices: A narrative review of quantitative research. Int. J. Environ. Res. Public Health 2021 18 12 6397 10.3390/ijerph18126397 34199174
    [Google Scholar]
  2. Wang G.J. Ayati M.H. Zhang W.B. Meridian studies in China: A systematic review. J. Acupunct. Meridian Stud. 2010 3 1 1 9 10.1016/S2005‑2901(10)60001‑5 20633509
    [Google Scholar]
  3. Robin X. Creixell P. Radetskaya O. Santini C.C. Longden J. Linding R. Personalized network-based treatments in oncology. Clin. Pharmacol. Ther. 2013 94 6 646 650 10.1038/clpt.2013.171 23995267
    [Google Scholar]
  4. Muehsam D. Chevalier G. Barsotti T. Gurfein B.T. An overview of biofield devices. Glob. Adv. Health. Med. 2015 4(1_suppl), gahmj.2015.022.suppl.(Suppl.) 10.7453/gahmj.2015.022.supp 26665041
    [Google Scholar]
  5. Muehsam D. Ventura C. Life rhythm as a symphony of oscillatory patterns: Electromagnetic energy and sound vibration modulates gene expression for biological signaling and healing. Glob. Adv. Health Med. 2014 3 2 40 55 10.7453/gahmj.2014.008 24808981
    [Google Scholar]
  6. Kheifets L. Barnes F.S. Greenebaum B. Handbook of Biological Effects of Electromagnetic Fields - Two Volume Set. Boca Raton CRC Press 2018 10.1201/9781315217734
    [Google Scholar]
  7. Oschman J. Tully L. Energy medicine in therapeutics and human performance. J. Altern. Complement. Med. 2004 10 2 418 10.1089/107555304323062464
    [Google Scholar]
  8. Kanaparthi A. Kesary S.P.R. Pujita C. Gopalaiah H. Bio Electro Magnetic Energy Regulation (BEMER) therapy in myofascial pain dysfunction syndrome: A preliminary study. J. Oral Biol. Craniofac. Res. 2020 10 2 38 42 10.1016/j.jobcr.2020.01.007 32090003
    [Google Scholar]
  9. Guo Y. Wang B. Wang T. Gao L. Yang Z. Wang F. Shang H. Hua R. Xu J. Biological characteristics of IL-6 and related intestinal diseases. Int. J. Biol. Sci. 2021 17 1 204 219 10.7150/ijbs.51362 33390844
    [Google Scholar]
  10. Górski F. Buń P. Wichniarek R. Zawadzki P. Hamrol A. Effective design of educational virtual reality applications for medicine using knowledge-engineering techniques. Eurasia J. Math. Sci. Technol. Educ. 2016 13 2 10.12973/eurasia.2017.00623a
    [Google Scholar]
  11. Chang K. Chang W.H.S. Tsai M.T. Shih C. Pulsed electromagnetic fields accelerate apoptotic rate in osteoclasts. Connect. Tissue Res. 2006 47 4 222 228 10.1080/03008200600858783 16987754
    [Google Scholar]
  12. Lohmann C.H. Schwartz Z. Liu Y. Li Z. Simon B.J. Syl V.L. Dean D.D. Bonewald L.F. Donahue H.J. Boyan B.D. Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO‐Y4 osteocyte‐like cells and ROS 17/2.8 osteoblast‐like cells. J. Orthop. Res. 2003 21 2 326 334 10.1016/S0736‑0266(02)00137‑7 12568966
    [Google Scholar]
  13. Shin E.J. Jeong J.H. Kim H.J. Jang C.G. Yamada K. Nabeshima T. Kim H.C. Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. J. Pharmacol. Sci. 2007 105 4 367 371 10.1254/jphs.SC0070348 18094524
    [Google Scholar]
  14. Selvam R. Ganesan K. Narayana Raju K.V.S. Gangadharan A.C. Manohar B.M. Puvanakrishnan R. Low frequency and low intensity pulsed electromagnetic field exerts its antiinflammatory effect through restoration of plasma membrane calcium ATPase activity. Life Sci. 2007 80 26 2403 2410 10.1016/j.lfs.2007.03.019 17537462
    [Google Scholar]
  15. Sakellariou V.I. Badilas N.K. Stavropoulos N.A. Mazis G. Kotoulas H.K. Kyriakopoulos S. Tagkalegkas I. Sofianos I.P. Treatment options for brachial plexus injuries. ISRN Orthop. 2014 2014 1 10 10.1155/2014/314137 24967125
    [Google Scholar]
  16. Frykberg R.G. Banks J. Challenges in the treatment of chronic wounds. Adv. Wound Care (New Rochelle) 2015 4 9 560 582 10.1089/wound.2015.0635 26339534
    [Google Scholar]
  17. Samaan S.S.R.R. Sedhom M.G. Grace M.O. A randomized comparative study between high‐intensity laser vs low‐intensity pulsed ultrasound both combined with exercises for the treatment of knee osteoarthritis. Int. J. Rheum. Dis. 2022 25 8 877 886 10.1111/1756‑185X.14361 35678062
    [Google Scholar]
  18. Borboroglu P.G. Comer S.W. Riffenburgh R.H. Amling C.L. Extensive repeat transrectal ultrasound guided prostate biopsy in patients with previous benign sextant biopsies. J. Urol. 2000 163 1 158 162 10.1016/S0022‑5347(05)67994‑3 10604336
    [Google Scholar]
  19. Gökçe M.I. Yaman O. Erectile dysfunction in the elderly male. Turk. J. Urol. 2017 43 3 247 251 10.5152/tud.2017.70482 28861293
    [Google Scholar]
  20. Adravanti P. Nicoletti S. Setti S. Ampollini A. de Girolamo L. Effect of pulsed electromagnetic field therapy in patients undergoing total knee arthroplasty: A randomised controlled trial. Int. Orthop. 2014 38 2 397 403 10.1007/s00264‑013‑2216‑7 24352823
    [Google Scholar]
  21. Bagnato G.L. Miceli G. Marino N. Sciortino D. Bagnato G.F. Pulsed electromagnetic fields in knee osteoarthritis: A double blind, placebo-controlled, randomized clinical trial. Rheumatology (Oxford) 2016 55 4 755 762 10.1093/rheumatology/kev426 26705327
    [Google Scholar]
  22. Ashar Y.K. Gordon A. Schubiner H. Uipi C. Knight K. Anderson Z. Carlisle J. Polisky L. Geuter S. Flood T.F. Kragel P.A. Dimidjian S. Lumley M.A. Wager T.D. Effect of pain reprocessing therapy vs placebo and usual care for patients with chronic back pain. JAMA Psychiatry 2022 79 1 13 23 10.1001/jamapsychiatry.2021.2669 34586357
    [Google Scholar]
  23. Harrison D.G. Marvar P.J. Titze J.M. Vascular inflammatory cells in hypertension. Front. Physiol. 2012 3 128 10.3389/fphys.2012.00128 22586409
    [Google Scholar]
  24. Han J.S. Acupuncture: Neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci. 2003 26 1 17 22 10.1016/S0166‑2236(02)00006‑1 12495858
    [Google Scholar]
  25. Chen G.S. Erdmann W. Effects of acupuncture on tissue oxygenation of the rat brain. South. Med. J. 1978 71 4 392 395, 398 10.1097/00007611‑197804000‑00015 635615
    [Google Scholar]
  26. Marshall A.C. Traditional chinese medicine and clinical pharmacology. In: Drug Discovery and Evaluation: Methods in Clinical Pharmacology 1t ed; Springer 2020 455-482 10.1007/978‑3‑319‑68864‑0_60
    [Google Scholar]
  27. Pawitan J.A. Various stem cells in acupuncture meridians and points and their putative roles. J. Tradit. Complement. Med. 2018 8 4 437 442 10.1016/j.jtcme.2017.08.004 30302323
    [Google Scholar]
  28. Yu Z. Neuromechanism of acupuncture regulating gastrointestinal motility. World J. Gastroenterol. 2020 26 23 3182 3200 10.3748/wjg.v26.i23.3182 32684734
    [Google Scholar]
  29. Takano T. Chen X. Luo F. Fujita T. Ren Z. Goldman N. Zhao Y. Markman J.D. Nedergaard M. Traditional acupuncture triggers a local increase in adenosine in human subjects. J. Pain 2012 13 12 1215 1223 10.1016/j.jpain.2012.09.012 23182227
    [Google Scholar]
  30. Naik P.N. Kiran R.A. Yalamanchal S. Kumar V.A. Goli S. Vashist N. Acupuncture: An alternative therapy in dentistry and its possible applications. Med. Acupunct. 2014 26 6 308 314 10.1089/acu.2014.1028 25538815
    [Google Scholar]
  31. Macfelda K. Kapeller B. Holly A. Podesser B.K. Losert U. Brandes K. Goettel P. Mueller J. Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components. ESC Heart Fail. 2017 4 3 291 300 10.1002/ehf2.12169 28772035
    [Google Scholar]
  32. Rosen M. We Are Electric’ delivers the shocking story of bioelectricity. Canongate Books 2023 https://www.sciencenews.org/article/electricity-shocking-book-bioelectricity
    [Google Scholar]
  33. Zhao M. Electrical fields in wound healing: An overriding signal that directs cell migration. Semin. Cell Dev. Biol. 2009 20 6 674 682 10.1016/j.semcdb.2008.12.009 19146969
    [Google Scholar]
  34. Cao L. Wei D. Reid B. Zhao S. Pu J. Pan T. Yamoah E.N. Zhao M. Endogenous electric currents might guide rostral migration of neuroblasts. EMBO Rep. 2013 14 2 184 190 10.1038/embor.2012.215 23328740
    [Google Scholar]
  35. Sundelacruz S. Levin M. Kaplan D.L. Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. PLoS One 2008 3 11 e3737 10.1371/journal.pone.0003737 19011685
    [Google Scholar]
  36. Zhao Z. Watt C. Karystinou A. Roelofs A.J. McCaig C.D. Gibson I.R. De Bari C. Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field. Eur. Cell. Mater. 2011 22 344 358 10.22203/eCM.v022a26 22125259
    [Google Scholar]
  37. Zhao M. Song B. Pu J. Wada T. Reid B. Tai G. Wang F. Guo A. Walczysko P. Gu Y. Sasaki T. Suzuki A. Forrester J.V. Bourne H.R. Devreotes P.N. McCaig C.D. Penninger J.M. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN. Nature 2006 442 7101 457 460 10.1038/nature04925 16871217
    [Google Scholar]
  38. Pai V.P. Lemire J.M. Paré J.F. Lin G. Chen Y. Levin M. Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J. Neurosci. 2015 35 10 4366 4385 10.1523/JNEUROSCI.1877‑14.2015 25762681
    [Google Scholar]
  39. Langevin H.M. Churchill D.L. Fox J.R. Badger G.J. Garra B.S. Krag M.H. Biomechanical response to acupuncture needling in humans. J. Appl. Physiol. 1985 91 6 2471 10.1152/jappl.2001.91.6.2471
    [Google Scholar]
  40. Ahn A.C. Park M. Shaw J.R. McManus C.A. Kaptchuk T.J. Langevin H.M. Electrical impedance of acupuncture meridians: The relevance of subcutaneous collagenous bands. PLoS One 2010 5 7 e11907 10.1371/journal.pone.0011907 20689594
    [Google Scholar]
  41. Cheng R. McKibbin L. Roy B. Pomeranz B. Electroacupuncture elevates blood cortisol levels in naive horses: Sham treatment has no effect. Int. J. Neurosci. 1980 10 2-3 95 97 10.3109/00207458009160487 6245041
    [Google Scholar]
  42. Cho Z.H. Chung S.C. Jones J.P. Park J.B. Park H.J. Lee H.J. Wong E.K. Min B.I. RETRACTED: New findings of the correlation between acupoints and corresponding brain cortices using functional MRI. Proc. Natl. Acad. Sci. USA 1998 95 5 2670 2673 10.1073/pnas.95.5.2670 9482945
    [Google Scholar]
  43. Gao X. Zhao Y. Su Y. Liu K. Yu X. Cui C. Yang Z. Shi H. Jing X. Zhu B. β1/2 or M2/3 receptors are required for different gastrointestinal motility responses induced by acupuncture at heterotopic or homotopic acupoints. PLoS One 2016 11 12 e0168200 10.1371/journal.pone.0168200 27978539
    [Google Scholar]
  44. Koizumi K. Iida T. Nakagawa S. Atsumi Y. Imai Y. Okano H. Bioelectrical regulation of cardiomyocyte cycle through the Na+/Ca2+ exchanger 1 (NCX1) dependent Ca2+ influx. J. Physiol. Sci. 2017 67 1 43 54
    [Google Scholar]
  45. Van Campenhout A. Golledge J. Osteoprotegerin, vascular calcification and atherosclerosis. Atherosclerosis 2009 204 2 321 329 10.1016/j.atherosclerosis.2008.09.033 19007931
    [Google Scholar]
  46. McCaig C.D. Song B. Rajnicek A.M. Electrical dimensions in cell science. J. Cell Sci. 2009 122 23 4267 4276 10.1242/jcs.023564 19923270
    [Google Scholar]
  47. Forrester J.V. Lois N. Zhao M. McCaig C. The spark of life: The role of electric fields in regulating cell behaviour using the eye as a model system. Ophthalmic Res. 2007 39 1 4 16 10.1159/000097901 17164572
    [Google Scholar]
  48. Tyler S.E.B. Nature’s electric potential: A systematic review of the role of bioelectricity in wound healing and regenerative processes in animals, humans, and plants. Front. Physiol. 2017 8 627 10.3389/fphys.2017.00627 28928669
    [Google Scholar]
  49. Levin M. Molecular bioelectricity: How endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo. Mol. Biol. Cell 2014 25 24 3835 3850 10.1091/mbc.e13‑12‑0708 25425556
    [Google Scholar]
  50. Tseng A. Levin M. Cracking the bioelectric code: Probing endogenous ionic controls of pattern formation. Commun. Integr. Biol. 2013 6 1 e22595 10.4161/cib.22595 23802040
    [Google Scholar]
  51. Reid B. Song B. McCaig C.D. Zhao M. Wound healing in rat cornea: The role of electric currents. FASEB J. 2005 19 3 379 386 10.1096/fj.04‑2325com 15746181
    [Google Scholar]
  52. McCaig C.D. Rajnicek A.M. Song B. Zhao M. Has electrical growth cone guidance found its potential? Trends Neurosci. 2002 25 7 354 359 10.1016/S0166‑2236(02)02174‑4 12079763
    [Google Scholar]
  53. Armour M. Smith C. Wang L.Q. Naidoo D. Yang G.Y. MacPherson H. Lee M. Hay P. Acupuncture for depression: A systematic review and meta-analysis. J. Clin. Med. 2019 8 8 1140 10.3390/jcm8081140 31370200
    [Google Scholar]
  54. Al-Himdani S. Jessop Z.M. Al-Sabah A. Combellack E. Ibrahim A. Doak S.H. Hart A.M. Archer C.W. Thornton C.A. Whitaker I.S. Tissue-engineered solutions in plastic and reconstructive surgery: Principles and practice. Front. Surg. 2017 4 4 10.3389/fsurg.2017.00004 28280722
    [Google Scholar]
  55. Wu J. Lewis A.H. Grandl J. Touch, tension, and transduction: The function and regulation of piezo ion channels. Trends Biochem. Sci. 2017 42 1 57 71 10.1016/j.tibs.2016.09.004 27743844
    [Google Scholar]
  56. Ahn A.C. Martinsen Ø.G. Electrical characterization of acupuncture points: Technical issues and challenges. J. Altern. Complement. Med. 2007 13 8 817 824 10.1089/acm.2007.7193 17983337
    [Google Scholar]
  57. Smith R.B. Microcurrent therapies: Emerging theories of physiological information processing. NeuroRehabilitation 2002 17 1 3 7 10.3233/NRE‑2002‑17102 12016342
    [Google Scholar]
  58. Han J.S. Acupuncture and endorphins. Neurosci. Lett. 2004 361 1-3 258 261 10.1016/j.neulet.2003.12.019 15135942
    [Google Scholar]
  59. Litscher G. Effects of acupressure, manual acupuncture and Laserneedle® acupuncture on EEG bispectral index and spectral edge frequency in healthy volunteers. Eur. J. Anaesthesiol. 2004 21 1 13 19 10.1097/00003643‑200401000‑00003 14768918
    [Google Scholar]
  60. Mao J.J. Liou K.T. Baser R.E. Bao T. Panageas K.S. Romero S.A.D. Li Q.S. Gallagher R.M. Kantoff P.W. Effectiveness of electroacupuncture or auricular acupuncture vs usual care for chronic musculoskeletal pain among cancer survivors. JAMA Oncol. 2021 7 5 720 727 10.1001/jamaoncol.2021.0310 33734288
    [Google Scholar]
  61. Alsaqqa S. Sawalha S. Abdel-Nabi H. Agile software development: Methodologies and trends. Int. J. Interact. Mob Technol 2020 14 11 246 10.3991/ijim.v14i11.13269
    [Google Scholar]
  62. Meng D. Mao Y. Song Q. Yan C. Zhao Q. Yang M. Xiang G. Song Y. Efficacy and Safety of Transcutaneous Electrical Acupoint Stimulation (TEAS) for postoperative pain in laparoscopy: A systematic review and meta-analysis of randomized controlled trials. Evid. Based Complement. Alternat. Med. 2022 2022 1 17 10.1155/2022/9922879 35075367
    [Google Scholar]
  63. Garcia M.K. McQuade J. Haddad R. Patel S. Lee R. Yang P. Palmer J.L. Cohen L. Systematic review of acupuncture in cancer care: A synthesis of the evidence. J. Clin. Oncol. 2013 31 7 952 960 10.1200/JCO.2012.43.5818 23341529
    [Google Scholar]
  64. Dong Y. Guo T. Xu L. Wang C. Wen G. Zhao Z. Duan L. Zou M. Xiang Y. Wang S. Cervicogenic headache treated by acupuncture based on jin theory: Study protocol for a randomized controlled trial. Trials 2019 20 1 418 10.1186/s13063‑019‑3478‑1 31291977
    [Google Scholar]
  65. Heo I. Shin B.C. Kim Y.D. Hwang E.H. Han C.W. Heo K.H. Acupuncture for spinal cord injury and its complications: A systematic review and meta-analysis of randomized controlled trials. Evid. Based Complement. Alternat. Med. 2013 2013 1 18 10.1155/2013/364216 23476688
    [Google Scholar]
  66. Napadow V. Makris N. Liu J. Kettner N.W. Kwong K.K. Hui K.K.S. Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Hum. Brain Mapp. 2005 24 3 193 205 10.1002/hbm.20081 15499576
    [Google Scholar]
  67. Sandberg M. Lundeberg T. Lindberg L.G. Gerdle B. Effects of acupuncture on skin and muscle blood flow in healthy subjects. Eur. J. Appl. Physiol. 2003 90 1-2 114 119 10.1007/s00421‑003‑0825‑3 12827364
    [Google Scholar]
  68. Min S. Lee H. Kim S.Y. Park J.Y. Chae Y. Lee H. Park H.J. Local changes in microcirculation and the analgesic effects of acupuncture: A laser Doppler perfusion imaging study. J. Altern. Complement. Med. 2015 21 1 46 52 10.1089/acm.2013.0442 25354241
    [Google Scholar]
  69. Torres-Rosas R. Yehia G. Peña G. Mishra P. del Rocio Thompson-Bonilla M. Moreno-Eutimio M.A. Arriaga-Pizano L.A. Isibasi A. Ulloa L. Dopamine mediates vagal modulation of the immune system by electroacupuncture. Nat. Med. 2014 20 3 291 295 10.1038/nm.3479 24562381
    [Google Scholar]
  70. Napadow V. Liu J. Li M. Kettner N. Ryan A. Kwong K.K. Hui K.K.S. Audette J.F. Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture. Hum. Brain Mapp. 2007 28 3 159 171 10.1002/hbm.20261 16761270
    [Google Scholar]
  71. Registration 2023 ANZCTR. Available from:https://www.anzctr. org.au/Trial/Registration/TrialReview.aspx?id=385065&isReview=true
    [Google Scholar]
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A Comprehensive Mini-Review on the Understanding of Electrotherapy for Pain Management: An Introduction to ABMMA-BMT
Bentham Science Publishers ; https://doi.org/10.2174/0113892010364814250730111524
/content/journals/cpb/10.2174/0113892010364814250730111524
/content/journals/cpb/10.2174/0113892010364814250730111524
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  • Article Type:     Review Article
Keywords: micron stimulation ; channels ; energy medicine ; Bioelectricity ; CAM ; traditional Chinese medicine

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