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image of HIV Co-infected with Asymptomatic Visceral Leishmaniasis Exhibited a High Prevalence of the B type HBV Genotype

Abstract

Background

Multiple organisms infect the host simultaneously in the case of co-infection. This study intended to determine the prevalence of viral hepatitis B in HIV/Asymptomatic VL co-infected patients and to identify the HBV genotype circulating in these patients in Bihar, India.

Methods

There were 96 archived samples with co-infection with HIV and asymptomatic VL-positivity included in this study. A real-time PCR test was performed to measure the load of HBV DNA, and a chemiluminescent immunoassay was performed to determine the level of HBsAg.

Results

Our study evaluated HIV and AVL co-infected patients with two coexisting genotypes of HBV and observed the expression of the B, C, and D genotypes. HBsAg levels correlated directly with HBV DNA levels in almost every case.

Conclusion

For a better understanding of this disease, authors need approaches and strategies for improving the current diagnostic techniques, as well as studies focusing on vector control procedures and other operational tools.

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2025-06-23
2025-09-19

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References

  1. Huang C.C. Kuo T.M. Yeh C.T. Hu C. Chen Y.L. Tsai Y.L. Chen M.L. Chou Y.C. Chang C. One single nucleotide difference alters the differential expression of spliced RNAs between HBV genotypes A and D. Virus Res. 2013 174 1-2 18 26 10.1016/j.virusres.2013.02.004 23501362
    [Google Scholar]
  2. Biswas A. Panigrahi R. Pal M. Chakraborty S. Bhattacharya P. Chakrabarti S. Chakravarty R. Shift in the hepatitis B virus genotype distribution in the last decade among the HBV carriers from eastern India: Possible effects on the disease status and hbv epidemiology. J. Med. Virol. 2013 85 8 1340 1347 10.1002/jmv.23628 23765773
    [Google Scholar]
  3. Sarma M.P. Bhattacharjee M. Kar P. Medhi S. Detection of HBV Genotype C in Hepatocellular Carcinoma Patients from North East India: A Brief Report. Asian Pac. J. Cancer Prev. 2018 19 7 1741 1746 30049181
    [Google Scholar]
  4. Prevention of hepatitis B in India: An overview. In: Technical Report. Geneva, Switzerland World Health Organization 2002
    [Google Scholar]
  5. Murhekar M.V. Murhekar K.M. Das D. Arankalle V.A. Sehgal S.C. Prevalence of hepatitis B infection among the primitive tribes of Andaman & Nicobar Islands. Indian J. Med. Res. 2000 111 199 203 10969487
    [Google Scholar]
  6. Murhekar M.V. Murhekar K.M. Sehgal S.C. Alarming prevalence of hepatitis‐B infection among the Jarawas – a primitive Negrito tribe of Andaman and Nicobar Islands, India. J. Viral Hepat. 2003 10 3 232 233 10.1046/j.1365‑2893.2003.00419.x 12753343
    [Google Scholar]
  7. India H. IV Estimates. New Delhi, India National AIDS Control Organisation 2019
    [Google Scholar]
  8. Burza S. Mahajan R. Sanz M.G. Sunyoto T. Kumar R. Mitra G. Lima M.A. HIV and visceral leishmaniasis coinfection in Bihar, India: An underrecognized and underdiagnosed threat against elimination. Clin. Infect. Dis. 2014 59 4 552 555 10.1093/cid/ciu333 24814660
    [Google Scholar]
  9. Mahajan R. Owen S.I. Kumar S. Pandey K. Kazmi S. Kumar V. Adams E.R. Harshana A. Burza S. Prevalence and determinants of asymptomatic Leishmania infection in HIV-infected individuals living within visceral leishmaniasis endemic areas of Bihar, India. PLoS Negl. Trop. Dis. 2022 16 8 0010718 10.1371/journal.pntd.0010718 36040931
    [Google Scholar]
  10. Adam A.O.A. Dafalla M.M.M. Mohammed H.A.A. Elamin M.Y. Younis B.M. Elfaki M.E.E. Musa A.M. Elhassan A.M. Khalil E.A.G. Visceral leishmaniasis-hepatitis B/C coinfections: A rising necessity to triage patients for treatment. Ann. Saudi Med. 2014 34 2 143 146 10.5144/0256‑4947.2014.143 24894783
    [Google Scholar]
  11. Naito H. Hayashi S. Abe K. Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers. J. Clin. Microbiol. 2001 39 1 362 364 10.1128/JCM.39.1.362‑364.2001 11136801
    [Google Scholar]
  12. Abass E. Haroun A. Jomaa M. Serological screening of HIV and viral hepatitis revealed low prevalence among visceral leishmaniosis patients in Sudan. Ann. Parasitol. 2020 66 2 135 141 10.17420/ap6602.248 32530590
    [Google Scholar]
  13. Burza S. Mahajan R. Sinha P.K. van Griensven J. Pandey K. Lima M.A. Sanz M.G. Sunyoto T. Kumar S. Mitra G. Kumar R. Verma N. Das P. Visceral leishmaniasis and HIV co-infection in Bihar, India: Long-term effectiveness and treatment outcomes with liposomal amphotericin B (AmBisome). PLoS Negl. Trop. Dis. 2014 8 8 3053 10.1371/journal.pntd.0003053 25101665
    [Google Scholar]
  14. Kay A. Zoulim F. Hepatitis B virus genetic variability and evolution. Virus Res. 2007 127 2 164 176 10.1016/j.virusres.2007.02.021 17383765
    [Google Scholar]
  15. Cao G.W. Clinical relevance and public health signifcance of hepatitisB virus genomic variations. World J. Gastroenterol. 2009 15 46 5761 5769 10.3748/wjg.15.5761 19998495
    [Google Scholar]
  16. Tanaka Y. Mizokami M. Genetic diversity of hepatitis B virus as an important factor associated with differences in clinical outcomes. J. Infect. Dis. 2007 195 1 1 4 10.1086/509898 17152002
    [Google Scholar]
  17. Norder H. Couroucé A.M. Coursaget P. Echevarria J.M. Lee S.D. Mushahwar I.K. Robertson B.H. Locarnini S. Magnius L.O. Genetic diversity of hepatitis B virus strains derived worldwide: Genotypes, subgenotypes, and HBsAg subtypes. Intervirology 2004 47 6 289 309 10.1159/000080872 15564741
    [Google Scholar]
  18. Kuang S.Y. Jackson P.E. Wang J.B. Lu P.X. Muñoz A. Qian G.S. Kensler T.W. Groopman J.D. Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proc. Natl. Acad. Sci. USA 2004 101 10 3575 3580 10.1073/pnas.0308232100 14990795
    [Google Scholar]
  19. Maksoud S. El Hokayem J. The cytokine/chemokine response in Leishmania/HIV infection and co-infection. Heliyon 2023 9 4 15055 10.1016/j.heliyon.2023.e15055 37082641
    [Google Scholar]
  20. Maksoud S. Ortega J.T. Hidalgo M. Rangel H.R. Leishmania donovani and HIV co-infection in vitro: Identification and characterization of main molecular players. Acta Trop. 2022 228 106248 10.1016/j.actatropica.2021.106248 34822851
    [Google Scholar]
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HIV Co-infected with Asymptomatic Visceral Leishmaniasis Exhibited a High Prevalence of the B type HBV Genotype
Bentham Science Publishers ; https://doi.org/10.2174/0113892010310175250618134149
/content/journals/cpb/10.2174/0113892010310175250618134149
/content/journals/cpb/10.2174/0113892010310175250618134149
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  • Article Type:     Research Article
Keywords: B type HBV genotype ; Visceral Leishmaniasis ; Asymptomatic VL ; qPCR ; HIV co-infection ; HBsAg

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