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image of Synthetic Approaches and Reactivity of 3-Aminothieno[2,3-b]pyridine Derivatives Review

Abstract

The synthesis and chemical reactivity of 3-aminothieno[2,3-b]pyridine derivatives have been extensively studied due to their importance in medicinal chemistry and material sciences. This review focuses on the various synthetic strategies employed for their preparation, including reactions involving 1,2-dihydro-2-thioxopyridine-3-carbonitrile derivatives, phase-transfer catalysis, and Thorpe-Ziegler cyclization. Additionally, the chemical reactivity of these compounds is explored, highlighting transformations, such as cyclizations, functional group modifications, and coupling reactions. These advancements underline the versatility of 3-aminothieno[2,3-b]pyridines as valuable intermediates in organic synthesis and their potential for further functionalization in diverse chemical frameworks.

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2025-06-05
2025-09-05

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/content/journals/coc/10.2174/0113852728388904250520104218
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Synthetic Approaches and Reactivity of 3-Aminothieno[2,3-b]pyridine Derivatives Review
Bentham Science Publishers ; https://doi.org/10.2174/0113852728388904250520104218
/content/journals/coc/10.2174/0113852728388904250520104218
/content/journals/coc/10.2174/0113852728388904250520104218
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  • Article Type:     Review Article
Keywords: Thienopyridine ; functional transformations ; cyclization reactions ; 3-aminothieno derivatives ; phase-transfer catalysis ; synthetic strategies

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