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image of Essential Roles of Macro- and Micro-Minerals in Animal Nutrition: Assessment and Functional Insights

Abstract

Minerals are a key component in the nutrition of animals. The body requires several minerals to maintain its proper functioning. Soft tissues are structurally composed of minerals. These chemical elements are involved in various metabolic reactions in all mammals. These are essential for maintaining osmotic pressure, tissue structures, such as teeth and bone, and acid-base balance for the body's pH neutrality. Minerals influence the productive and reproductive efficiency of almost all species. They account for approximately 5% of total body weight and are involved in most metabolic reactions that occur both inside and outside the cell. Macro-minerals are the major minerals that the body needs in large amounts for bodily functions and metabolic activities. Trace minerals are the micronutrient components that are required for the development, production, and reproduction of animals. Shortages of these minerals can lead to various symptoms and pathological illnesses. Mineral deficits can also cause animal reproductive issues, as minerals are needed for their health and reproduction. The diagnosis of mineral deficiency can be made by recognizing symptoms that cause a decrease in the production and reproduction of animals. An adequate mineral labelplementation as per each mineral's requirement can be beneficial to provide the specific necessary elements, particularly in areas where they are known to be low in forages or soil. This article will help identify specific deficits in animals that may decrease growth or production. Also, it will aid in the formulation of mineral supplements that can alleviate the mineral deficiencies in farm animals.

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2025-10-01
2025-11-13
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References

  1. Malik D. Narayanasamy N. Pratyusha V.A. Thakur J. Sinha N. Inorganic nutrients: Macrominerals. Textbook of nutritional biochemistry. Singapore Springer Nature Singapore 2023 391 446 10.1007/978‑981‑19‑4150‑4_11
    [Google Scholar]
  2. Gupta B. Balakrishna S.L. Singh R.P. Biotechnology in animal nutrition and feed utilization. Emerging issues in climate smart livestock production. Academic Press 2022 339 369 10.1016/B978‑0‑12‑822265‑2.00003‑X
    [Google Scholar]
  3. Nakonechna O. Stetsenko S. Bondareva A. Water-salt and mineral metabolism. urinary function of kidney. normal and pathological components of urine: textbook for students of general medicine and dentistry KhNMU Kharkiv 2020
    [Google Scholar]
  4. Gurung N.K. Rush Jessica Pugh D.G. Feeding and nutrition. Sheep, goat, and cervid medicine. Kansas City Elsevier 2020 P15 P44
    [Google Scholar]
  5. Islam M.R. Akash S. Jony M.H. alam M.N. Nowrin F.T. Rahman M.M. Rauf A. Thiruvengadam M. Exploring the potential function of trace nlms in human health: a therapeutic perspective. Mol. Cell. Biochem. 2023 478 10 2141 2171 10.1007/s11010‑022‑04638‑3 36637616
    [Google Scholar]
  6. Tan M. Macro- and micromineral contents of different quinoa (Chenopodium quinoa Willd.) varieties used as forage by cattle. Turk. J. Agric. For. 2020 44 1 46 53 10.3906/tar‑1904‑10
    [Google Scholar]
  7. Vlaicu P.A. Untea A.E. Varzaru I. Saracila M. Oancea A.G. Designing nutrition for health incorporating dietary by-products into poultry feeds to create functional foods with insights into health benefits, risks, bioactive compounds, food component functionality and safety regulations. Foods 2023 12 21 4001 10.3390/foods12214001 37959120
    [Google Scholar]
  8. Palomares R.A. Trace minerals supplementation with great impact on beef cattle immunity and health. Animals 2022 12 20 2839 10.3390/ani12202839 36290225
    [Google Scholar]
  9. Shannon M.C. Hill G.M. Trace mineral supplementation for the intestinal health of young monogastric animals. Front. Vet. Sci. 2019 6 73 10.3389/fvets.2019.00073 30918894
    [Google Scholar]
  10. Raje K. Ojha S. Mishra A. Chaudhary S.K. Impact of supplementation of mineral nano particles on growth performance and health status of animals: a review. J. Entomol. Zool. Stud. 2018 6 3 1690 1694
    [Google Scholar]
  11. Silva F.L. Oliveira-Júnior E.S. Silva M.H.M. López-Alonso M. Pierangeli M.A.P. Trace nlms in beef cattle: a review of the scientific approach from one health perspective. Animals 2022 12 17 2254 10.3390/ani12172254 36077974
    [Google Scholar]
  12. Brugger D. Wagner B. Windisch W.M. Schenkel H. Schulz K. Südekum K.H. Berk A. Pieper R. Kowalczyk J. Spolders M. Review: Bioavailability of trace nlms in farm animals: definition and practical considerations for improved assessment of efficacy and safety. Animal 2022 16 8 100598 10.1016/j.animal.2022.100598 35952480
    [Google Scholar]
  13. Fadlalla I.M.T. Omer S.A. Atta M. Determination of some serum macronlm minerals levels at different lactation stages of dairy cows and their correlations. Sci. Afr. 2020 8 e00351 10.1016/j.sciaf.2020.e00351
    [Google Scholar]
  14. Saha S.K. Pathak N.N. Mineral nutrition. Fundamentals of animal nutrition. Singapore Springer Singapore 2021 113 131 10.1007/978‑981‑15‑9125‑9_9
    [Google Scholar]
  15. Hoque M. Emon K. Malo P.C. Roshed M.M. Comprehensive guide to vitamin and mineral sources with their requirements. Ind. J. Agric. Life Sci. 2023 3 6 23 31
    [Google Scholar]
  16. Stapay P.V. Stakhiv N.P. Salyha Y.T. Mineral elements in sheep nutrition and wool processes Publishing House Baltija Publishing 2023 327 349 10.30525/978‑9934‑26‑316‑3‑16
    [Google Scholar]
  17. Bjørklund G. Shanaida M. Gontova T. Gheorghe E. Kassym L. Kussainova A. Voloshyn V. Semenova Y. Lysiuk R. Voloshyn O. Shanaida V. Hangan T. Minerals and trace nlms: Key protectors of skin health and defenders against skin disorders. Curr. Med. Chem. 2025 32 35 7804 7830 10.2174/0109298673348175250214054101 40045862
    [Google Scholar]
  18. Keen C.L. Teratogenic effects of essential trace metals: deficiencies and excesses. Toxicology of Metals. CRC Press 2023 Vol. I 977 1001
    [Google Scholar]
  19. Velladurai C. Selvaraju M. Napolean R.E. Effects of macro and micro minerals on reproduction in dairy cattle a review. Int. J. Sci. Res. Sci. Technol. 2016 2 1 68 70
    [Google Scholar]
  20. Lambert H Hakim O Lanham-New S Major minerals: Calcium and magnesium. Science Trove Oxford University Press 2024 10.1093/hesc/9780198866671.003.0011
    [Google Scholar]
  21. Selmi H Bahri A Rouissi H Nutrition for lactation of dairy sheep. Lactation in farm animals - biology, physiological basis, nutritional requirements, and modelization IntechOpen 2020 10.5772/intechopen.85344
    [Google Scholar]
  22. Rout P. K. Behera B. K. Rout P. K. Behera B. K. Goat and sheep farming. Sustainability in ruminant livestock: Management and marketing Springer 2021 33 76 10.1007/978‑981‑33‑4343‑6 978-981-33-4342-9
    [Google Scholar]
  23. Dominguez LJ Farruggia M Veronese N Barbagallo M Vitamin D sources, metabolism, and deficiency: Available compounds and guidelines for its treatment. Metabolites 2021 11 4 255 10.3390/metabo11040255 33924215 PMC8074587
    [Google Scholar]
  24. Babazadeh D. Razavi S.A. Abd El-Ghany W.A. F Cotter P. Vitamin D deficiency in farm animals: a review. Farm Animal Health and Nutrition 2022 1 1 10 16 10.58803/fahn.v1i1.7
    [Google Scholar]
  25. Bukar BA Mabu IM Common diseases of goats, treatment and preventive measures. Goat science - From keeping to precision production IntechOpen 2023 10.5772/intechopen.1001377
    [Google Scholar]
  26. Luna M.A.E. Roldan M.S.T. Reyes L.A. Ronquillo J.C.C. Importance of minerals in the diet of cattle in the tropical climate of Mexico. Landraces-its productive conservation in animals and plants. IntechOpen 2023 10.5772/intechopen.110491
    [Google Scholar]
  27. Jackson D. Dixon R.M. Quigley S.P. Callaghan M.J. Phosphorus management of beef cattle in northern Australia. Meat & Livestock Australia 2023 17 24
    [Google Scholar]
  28. Grünberg W. Phosphorus lnsition. Vet. Clin. North Am. Food Anim. Pract. 2023 39 2 261 274 10.1016/j.cvfa.2023.02.002 37032293
    [Google Scholar]
  29. McAllister T.A. Ribeiro G. Stanford K. Wang Y. Moore K.J. Collins M. Nelson C.J. Redfearn D.D. Forages. Science of Grassland Agriculture 2020 2 839 860 10.1002/9781119436669.ch47
    [Google Scholar]
  30. Sager B. Van Saun R.J. Trace mineral supplementation for beef cows: Dry range environment. Vet. Clin. North Am. Food Anim. Pract. 2023 39 3 471 489 10.1016/j.cvfa.2023.08.012 37684112
    [Google Scholar]
  31. Unny M.N. Zarina A. Beena V. Fluid and electrolyte balance. Textbook of veterinary physiology. Singapore Springer Nature Singapore 2023 193 211 10.1007/978‑981‑19‑9410‑4_8
    [Google Scholar]
  32. Costa R.G. Freire R.M.B. de Araújo G.G.L. Queiroga R.C.R.E. Paiva G.N. Ribeiro N.L. Oliveira R.L. Domínguez R. Lorenzo J.M. Effect of increased salt water intake on the production and composition of dairy goat milk. Animals 2021 11 9 2642 10.3390/ani11092642 34573608
    [Google Scholar]
  33. Boland T.M. Brophy P.O. Callan J.J. Quinn P.J. Nowakowski P. Crosby T.F. The effects of mineral supplementation to ewes in late pregnancy on colostrum yield and immunoglobulin G absorption in their lambs. Livest. Prod. Sci. 2005 97 2-3 141 150 10.1016/j.livprodsci.2005.03.004
    [Google Scholar]
  34. Wu G. Management of metabolic disorders (including metabolic diseases) in ruminant and non-ruminant animals. Animal agriculture. Academic Press 2020 471 491 10.1016/B978‑0‑12‑817052‑6.00027‑6
    [Google Scholar]
  35. Rayisyan M. Zakharova N. Babaskina L. Complexions therapy and severe intoxication by Thallium salts. J. Environ. Sci. Health Part A Tox. Hazard. Subst. Environ. Eng. 2021 56 4 445 453 10.1080/10934529.2021.1885905 33573452
    [Google Scholar]
  36. Yadav S. Yadav J. Kumar S. Singh P. Metabolism of macro-elements (calcium, magnesium, sodium, potassium, chloride and phosphorus) and associated disorders. Clinical applications of biomolecules in disease diagnosis: A comprehensive guide to biochemistry and metabolism Springer Nature Singapore 2024 177 203
    [Google Scholar]
  37. Kao P.T. Darch T. McGrath S.P. Kendall N.R. Buss H.L. Warren H. Lee M.R.F. Factors influencing nlmal micronutrient supply from pasture systems for grazing ruminants. Adv. Agron. 2020 164 161 229 10.1016/bs.agron.2020.06.004
    [Google Scholar]
  38. Ali R. Gul H. Rauf M. Arif M. Hamayun M. Husna Khilji S.A. Ud-Din A. Sajid Z.A. Lee I.J. Growth-promoting endophytic fungus (Stemphyliumlycopersici) ameliorates salt stress tolerance in maize by balancing ionic and metabolic status. Front. Plant Sci. 2022 13 890565 10.3389/fpls.2022.890565 35898220
    [Google Scholar]
  39. Wilkens M.R. Muscher-Banse A.S. Review: Regulation of gastrointestinal and renal transport of calcium and phosphorus in ruminants. Animal 2020 14 S1 s29 s43 10.1017/S1751731119003197 32024566
    [Google Scholar]
  40. Yue O. Wang X. Xie L. Bai Z. Zou X. Liu X. Biomimetic Exogenous Tissue Batteries as artificial power sources for implantable bioelectronic devices manufacturing. Adv. Sci. 2024 11 11 2307369 10.1002/advs.202307369 38196276
    [Google Scholar]
  41. Pinotti L. Manoni M. Ferrari L. Tretola M. Cazzola R. Givens I. The contribution of dietary magnesium in farm animals and human nutrition. Nutrients 2021 13 2 509 10.3390/nu13020509 33557151
    [Google Scholar]
  42. Preuss H.G. Sodium, chloride, and potassium. Present knowledge in nutrition. Academic Press 2020 467 484 10.1016/B978‑0‑323‑66162‑1.00028‑7
    [Google Scholar]
  43. Van Saun R. J. Feeding and nutrition. Medicine and surgery of camelids John Wiley & Sons, Inc. 2022 55 107 9781119583240 9781119583295 10.1002/9781119583295
    [Google Scholar]
  44. Affan A.A. Salleh A. Zamri-Saad M. Jayanegara A. Hassim H.A. Clinical signs and blood variables of pregnancy toxemia goats during late gestation and postpartum. Trop. Anim. Sci. J. 2022 45 1 84 90 10.5398/tasj.2022.45.1.84
    [Google Scholar]
  45. Vas L.C. Chronic pain: Out-of-the-box treatments that cure. CRC Press 2024
    [Google Scholar]
  46. Adil M. Iqbal M. Kanwal S. Abbas G. Toxicity and adverse effects of veterinary pharmaceuticals in animals. Pharmaceuticals in aquatic environments. CRC Press 2024 141 159
    [Google Scholar]
  47. Wang C. Zhang J. Guo G. Huo W. Xia C.Q. Chen L. Zhang Y. Pei C. Liu Q. Effects of folic acid and riboflavin on growth performance, nutrient digestion and rumen fermentation in Angus bulls. Br. J. Nutr. 2023 129 1 1 9 10.1017/S0007114522000630 35225178
    [Google Scholar]
  48. Nipane S.F. Roupesh G. Kawitkar S.B. Lende S.R. Nutritional Strategy in Goat. Indian J Livestock Vet Res 2023 3 1
    [Google Scholar]
  49. Askar A.R. Salama R. El-Shaer H.M. Raef O. Effects of supplementary feeding level on digestion and energy utilization by sheep and goats grazing arid-area rangelands. Anim. Feed Sci. Technol. 2021 271 114695 10.1016/j.anifeedsci.2020.114695
    [Google Scholar]
  50. Teklebrhan T. Tan Z. Diet supplementation with sulfur amino acids modulated fermentation metabolome and gut microbiome in goats. Front. Microbiol. 2022 13 870385 10.3389/fmicb.2022.870385 35694302
    [Google Scholar]
  51. Li G.D. Conyers M.K. Refshauge G. Ataollahi F. Hayes R.C. Long-term liming changes pasture mineral profile. Sci. Rep. 2024 14 1 3539 10.1038/s41598‑024‑53908‑1 38347031
    [Google Scholar]
  52. Malyugina S. The importance of sulfur in ruminant nutrition. Lucr. Stiint. Zooteh. Biotehnol. 2023 56 2 20 24
    [Google Scholar]
  53. Mitchell S.C. Nutrition and sulfur. Adv. Food Nutr. Res. 2021 96 123 174 10.1016/bs.afnr.2021.02.014 34112351
    [Google Scholar]
  54. Yatoo M.I. Saxena A. Deepa P.M. Habeab B.P. Devi S. Jatav R.S. Dimri U. Role of trace nlms in animals: a review. Vet. World 2013 6 12 963 967 10.14202/vetworld.2013.963‑967
    [Google Scholar]
  55. Jomova K. Makova M. Alomar S.Y. Alwasel S.H. Nepovimova E. Kuca K. Rhodes C.J. Valko M. Essential metals in health and disease. Chem. Biol. Interact. 2022 367 110173 10.1016/j.cbi.2022.110173 36152810
    [Google Scholar]
  56. López-Alonso M. Miranda M. Copper supplementation, a challenge in cattle. Animals 2020 10 10 1890 10.3390/ani10101890 33076570
    [Google Scholar]
  57. Maji C Biswas S Kaur J Nutritional deficiency diseases in goats. Principles of goat disease and prevention John Wiley & Sons, Inc. 2023 221 236 10.1002/9781119896142
    [Google Scholar]
  58. Arthington J.D. Ranches J. Trace mineral nutrition of grazing beef cattle. Animals 2021 11 10 2767 10.3390/ani11102767 34679788
    [Google Scholar]
  59. Rizwan H.M. Abbas H. Sajid M.S. Jones M.K. Preventive management of the parasitic diseases through trace nlms. Veterinary Pathobiology and Public Health. Pakistan Unique Scientific Publishers 2021 190 202
    [Google Scholar]
  60. Wallig M.A. Usborne A. Keenan K.P. Nutritional toxicologic pathology. Haschek and Rousseauxs handbook of toxicologic pathology. Academic Press 2023 Vol. 3 105 180 10.1016/B978‑0‑443‑16153‑7.00003‑4
    [Google Scholar]
  61. Thorndyke M.P. Guimaraes O. Kistner M.J. Wagner J.J. Engle T.E. Influence of molybdenum in drinking water or feed on copper metabolism in cattlea review. Animals 2021 11 7 2083 10.3390/ani11072083 34359210
    [Google Scholar]
  62. Abbott K.A. Clinical aspects of trace nlm and vitamin nutrition. Sheep veterinary practice. CRC Press 2024 73 110 10.1201/9781003344346‑4
    [Google Scholar]
  63. Bourke C.A. Molybdenum deficiency produces motor nervous effects that are consistent with amyotrophic lateral sclerosis. Front. Neurol. 2016 7 28 10.3389/fneur.2016.00028 27014182
    [Google Scholar]
  64. Dyrek N. Wikarek A. Niemiec M. KoceBak P. Selected musculoskeletal disorders in patients with thyroid dysfunction, diabetes, and obesity. Reumatologia 2023 61 4 305 317 10.5114/reum/170312 37745138
    [Google Scholar]
  65. Rao L.N. Rani N.L. Enzootic ataxia in goat kids. Intas Polivet 2020 21 2 440 442
    [Google Scholar]
  66. Swecker WS Van Saun RJ Vitamins and trace minerals in ruminants, an issue of veterinary clinics of North America: Food animal practice, E-Book Elsevier Health Sciences 2023 39
    [Google Scholar]
  67. Sandali R. Sadhana H.S.S.S. Danushika M.C. Cobalt and copper deficiency and molybdenosis. Medical Geology. Enroute to one health. 2023 235 52 10.1002/9781119867371.ch15
    [Google Scholar]
  68. Silva W.J. Guizelini C.C. Franco G.L. Veiga R.C.P. Arruda W.G. Nascimento V.A. Melo E.S.P. Lemos R.A.A. Cobalt deficiency in cattle and its impact on production. Pesqui. Vet. Bras. 2020 40 11 837 841 10.1590/1678‑5150‑pvb‑6770
    [Google Scholar]
  69. Wijesekera K Dissanayake AS Lady gardeners: Seeds, roots, propagation, from England to the wider world. Orestano Francesca Vickers Michael Chemistry of natural products: Phytochemistry and pharmacognosy of medicinal plants Archaeopress Oxford (UK) 2023
    [Google Scholar]
  70. Khosla I. 4Gs Of good health: Dont diet, know whats right for your body. Penguin Random House India Private Limited 2022
    [Google Scholar]
  71. González-Montaña J.R. Escalera-Valente F. Alonso A.J. Lomillos J.M. Robles R. Alonso M.E. Relationship between vitamin B12 and cobalt metabolism in domestic ruminant: an update. Animals 2020 10 10 1855 10.3390/ani10101855 33053716
    [Google Scholar]
  72. Konieczny K. Pomorska-Mól M. A literature review of selected bacterial diseases in alpacas and llamas epidemiology, clinical signs and diagnostics. Animals 2023 14 1 45 10.3390/ani14010045 38200776
    [Google Scholar]
  73. Hartwig A. Arand M. Commission M.A.K. Tricresyl phosphate, sum of all ortho isomers. MAK Collect. Occup. Health Saf. 2023 8 3 Doc060
    [Google Scholar]
  74. Pisoschi A.M. Pop A. Iordache F. Stanca L. Predoi G. Serban A.I. Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status. Eur. J. Med. Chem. 2021 209 112891 10.1016/j.ejmech.2020.112891 33032084
    [Google Scholar]
  75. Costa M.I. Sarmento-Ribeiro A.B. Gonçalves A.C. Zinc: from biological functions to therapeutic potential. Int. J. Mol. Sci. 2023 24 5 4822 10.3390/ijms24054822 36902254
    [Google Scholar]
  76. GaBska E. WrzeciDska M. Kowalczyk A. Araujo J.P. Reproductive consequences of electrolyte disturbances in domestic animals. Biology 2022 11 7 1006 10.3390/biology11071006 36101387
    [Google Scholar]
  77. Molín J. Mendonça F.S. Henderson E.E. Nyaoke A.C. Ramírez G.A. Navarro M.A. Uzal F.A. Asín J. Toxic wasting disorders in sheep. Animals 2021 11 1 229 10.3390/ani11010229 33477688
    [Google Scholar]
  78. Ensley S. Evaluating mineral status in ruminant livestock. Vet. Clin. North Am. Food Anim. Pract. 2020 36 3 525 546 10.1016/j.cvfa.2020.08.009 32943305
    [Google Scholar]
  79. Conte F. van Buuringen N. Voermans N.C. Lefeber D.J. Galactose in human metabolism, glycosylation and congenital metabolic diseases: Time for a closer look. Biochim. Biophys. Acta, Gen. Subj. 2021 1865 8 129898 10.1016/j.bbagen.2021.129898 33878388
    [Google Scholar]
  80. Budinger D. Barral S. Soo A.K.S. Kurian M.A. The role of manganese dysregulation in neurological disease: emerging evidence. Lancet Neurol. 2021 20 11 956 968 10.1016/S1474‑4422(21)00238‑6 34687639
    [Google Scholar]
  81. Amin Y. Mahmoud A. Ali R. Fouad S. Shanab O. Ibrahim R. Farrag F. Shukry M. Ibrahim S. Fericean L. Mohamed R. Treatment of inactive ovaries of Holstein dairy cows by epidural injection of gnrh analogue (receptal) and its impact on the reproductive hormones, oxidant/antioxidant profile and micro and macro-nlms profile. Animals 2023 13 4 653 10.3390/ani13040653 36830440
    [Google Scholar]
  82. Chao H.H. Zhang Y. Dong P.Y. Gurunathan S. Zhang X.F. Comprehensive review on the positive and negative effects of various important regulators on male spermatogenesis and fertility. Front. Nutr. 2023 9 1063510 10.3389/fnut.2022.1063510 36726821
    [Google Scholar]
  83. Xiang Y. Wang L. Wei Y. Zhang H. Emu Q. Excessive manganese alters serum biochemical indices, induces histopathological alterations, and activates apoptosis in liver and cerebrum of Jianzhou Daer goat (Capra hircus). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2022 252 109241 10.1016/j.cbpc.2021.109241 34752896
    [Google Scholar]
  84. Kalarani I.B. Veerabathiran R. Impact of iodine intake on the pathogenesis of autoimmune thyroid disease in children and adults. Ann. Pediatr. Endocrinol. Metab. 2022 27 4 256 264 10.6065/apem.2244186.093 36567462
    [Google Scholar]
  85. Rigutto-Farebrother J. Optimizing growth: the case for iodine. Nutrients 2023 15 4 814 10.3390/nu15040814 36839172
    [Google Scholar]
  86. Abruzzese G.A. Arbocco F.C.V. Ferrer M.J. Motta A.B. Role of hormones during gestation and early development: pathways involved in developmental programming. Advances in maternal-fetal biomedicine: Cellular and molecular mechanisms of pregnancy pathologies. Cham Springer International Publishing 2023 31 70 10.1007/978‑3‑031‑32554‑0_2
    [Google Scholar]
  87. Ankit P.S. Prakash C.M. Chapter 32 - Perinatal diseases in goats. Rana Tanmoy Trends in clinical diseases, production and management of goats Academic Press 2024 429 448 9780443154850 10.1016/B978‑0‑443‑23697‑6.00011‑1
    [Google Scholar]
  88. Masoudi A.T. Hojati S.F. The efficacy of iodinated ethyl esters of safflower seed oil (Carthamus tinctorius L.) in the control of iodine deficiency in sheep. Small Rumin. Res. 2023 226 107043 10.1016/j.smallrumres.2023.107043
    [Google Scholar]
  89. Winder M. KosztyBa Z. Boral A. KoceBak P. Chudek J. The impact of iodine concentration disorders on health and cancer. Nutrients 2022 14 11 2209 10.3390/nu14112209 35684009
    [Google Scholar]
  90. Kurt OB Ozdemir S Selenium in food chain in relation to human and animal nutrition and health. Selenium and nano-selenium in environmental stress management and crop quality improvement. Sustainable plant nutrition in a changing world 2022; (pp: 383- 436) Springer Cham 10.1007/978‑3‑031‑07063‑1_19
    [Google Scholar]
  91. Kwentoh I. Daniel S. Atiku E.S. Daniel S.G. Cocaine-induced kidney, liver, lung, and muscle injury (C-KLM), presenting With foot drop: A case report. Cureus 2023 15 12 e50745 10.7759/cureus.50745 38239537
    [Google Scholar]
  92. Hernández-García F.I. Matías J. López-Parra M. García-Gudiño J. Barraso C. Garrido N. García-Calvo A.M. Izquierdo M. Effects of agronomical selenium biofortification of Iberian pig diet on quality and antioxidant capacity of pork. Livest. Sci. 2024 281 105413 10.1016/j.livsci.2024.105413
    [Google Scholar]
  93. Takci A. Ekici M. Kivrak M.B. The effect of vitamin and mineral supplementation in different forms on placenta and birth weight and reproductive performance in kangal sheep. Van Veterinary Journal 2023 34 2 168 173 10.36483/vanvetj.1297898
    [Google Scholar]
  94. Milewski S. Sobiech P. BBa|ejak-Grabowska J. Wójcik R. {arczyDska K. MiciDski J. Zbek K. The efficacy of a long-acting injectable selenium preparation administered to pregnant ewes and lambs. Animals 2021 11 4 1076 10.3390/ani11041076 33918972
    [Google Scholar]
  95. Briguglio M. Hrelia S. Malaguti M. Lombardi G. Riso P. Porrini M. Perazzo P. Banfi G. The central role of iron in human nutrition: from folk to contemporary medicine. Nutrients 2020 12 6 1761 10.3390/nu12061761 32545511
    [Google Scholar]
  96. de Arruda M.C.G. Santos Torres R.N. Rozza D.B. Chardulo L.A.L. Baldassini W.A. Curi R.A. Pereira G.L. de Farias I.M.S.C. Porcionato M.A. Neto O.R.M. Effects of the inclusion of a rumen-protected B-vitamin blend and hydroxy trace minerals in the diets of confined Nellore cattle on performance and cecal and ruminal histology. Anim. Feed Sci. Technol. 2025 328 116448 10.1016/j.anifeedsci.2025.116448
    [Google Scholar]
  97. Asín J. Ramírez G.A. Navarro M.A. Nyaoke A.C. Henderson E.E. Mendonça F.S. Molín J. Uzal F.A. Nutritional wasting disorders in sheep. Animals 2021 11 2 501 10.3390/ani11020501 33671862
    [Google Scholar]
  98. Neda F. Bahareh H.T. Swati R. Zahra S. Zahra D. Asgari Lajayer Behnam van Hullebusch Eric D. Toxicity of nanoparticles onto plants: Overview of the biochemical and molecular mechanisms. Nanomaterial-Plant Interactions, Toxicity of Nanoparticles in Plants Academic Press 2022 5 69 94 9780323907743 10.1016/B978‑0‑323‑90774‑3.00002‑7
    [Google Scholar]
  99. Wysocka D Snarska A Sobiech P 2020 Iron in cattle health. Journal of nlmology 25 3 1175 1185 10.5601/jelem.2020.25.2.1960
    [Google Scholar]
  100. Ayobami R.K. Afisu B. Oladimeji Raji R.L. Ayoade O.I. Chapter 13 - Productive performance of goat. Rana Tanmoy Trends in clinical diseases, production and management of goats Academic Press 2024 163 177 9780443154850 10.1016/B978‑0‑443‑23696‑9.00001‑8
    [Google Scholar]
  101. Yadav S. Dubey S.K. Singh S.K. Singh R. Yemul S.N. Singh M. Singh S.K. Srivastava A.K. Singh S. Farmer participatory assessment of nutritional interventions for productivity and profitability enhancement of dairy animals at small farms. Indian J. Anim. Sci. 2025 95 3 262 269 10.56093/ijans.v95i3.149438
    [Google Scholar]
  102. der Poel A.F.B. Abdollahi M.R. Cheng H. Colovic R. den Hartog L.A. Miladinovic D. Page G. Sijssens K. Smillie J.F. Thomas M. Wang W. Yu P. Hendriks W.H. Future directions of animal feed technology research to meet the challenges of a changing world. Anim. Feed Sci. Technol. 2020 270 114692 10.1016/j.anifeedsci.2020.114692
    [Google Scholar]
  103. Verma A.K. Rajkumar V. Kumar R. Gururaj K. Singh T.P. Kushwah T. Chatli M.K. Impact of dietary mineral and vitamin supplementation on meat quality and nutritional profile and gene expression in goats. Eur. J. Lipid Sci. Technol. 2025 127 3 e70005 10.1002/ejlt.70005
    [Google Scholar]
/content/journals/cnf/10.2174/0115734013420390250919112151
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  • Article Type:
    Review Article
Keywords: food supplements ; essential minerals ; nutrition ; Macro-minerals ; deficiency ; proteins
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