Current Nanoscience - Volume 21, Issue 3, 2025
Volume 21, Issue 3, 2025
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Brief Overview of Nanographene Oxide and its Possible Application
More LessAuthors: Srishti Dutta, Dishen Kumar, Abhilash Pandey, Devanand Sahu, Vansikha Sharma and Goutam Kumar PatraIn recent years, graphene oxides have convoked significant attention across various scientific disciplines, including physics, chemistry, and materials science, owing to their extraordinary physical properties, chemical tunability, and vast possibilities for their applications. As a result, our keen interest lies in exploring nanographene oxide and presenting a comprehensive review on this subject. This paper provides a thorough examination of eminently progressive advancements in the synthesis, properties, and performance of graphene oxide. Synthetic chemists venturing into this expanding field of material science and researchers exploring the applications of graphene oxide will find immense value in this review. The comprehensive behavior towards the alchemy of graphene oxide will aid in better apprehension of the current approaches, scope and their limitations in utilizing this remarkable material. Moreover, to promote further research and development in this area, we deliberate on the technical challenges associated with graphene oxide and offer suggestions for several future research directions. This review serves as a valuable resource, encouraging scientific advancements and innovation in the exploration of graphene oxide's potential in various applications. To facilitate further research and development, the technical challenges are discussed, and several future research directions are also suggested in this paper.
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Application of Silicon Nanowires
More LessAuthors: Yang Feng, Shihua Zhao, Ping Liang, Ziwen Xia and Hongyan PengSilicon Nanowires (SiNWs), a novel category of nanomaterials, exhibit several outstanding properties, including superior transistor performance, quantum tunneling effects, and remarkable electrical and optical capabilities. These properties are expected to contribute significantly to the development of future nanodevices, such as sensors and optoelectronic components. The potential for device miniaturization with SiNWs is based on their ease of monocrystallization. This leads to a reduced rate of hole-electron complexes and their extensive specific surface area that promotes boundary effects, thereby diminishing conductivity. Characterized by unique structural attributes, SiNWs hold promise for a wide range of applications in various sectors. To date, multiple methods have been established for SiNW fabrication, including sol-gel, electrochemical, laser ablation, chemical vapor deposition, and thermal vapor deposition techniques. Subsequently, the focus has shifted to the application of SiNWs in electronics, energy, and biomedicine. SiNWs are instrumental in producing high-performance electronic devices, such as field-effect transistors, sensors, and memory units. They also exhibit outstanding photovoltaic properties, making them suitable for high-efficiency solar cell and photocatalyst production. Additionally, SiNWs are poised to make significant contributions to biomedicine, particularly in biosensors, drug delivery systems, and tissue engineering materials. This article provides a concise review of the current status of SiNWs in electronics, sensing devices, and solar cell applications, and their roles in high-performance transistors, biosensors, and solar cells. It concludes with an exploration of the challenges and prospects for SiNWs.
In summary, the unique attributes of SiNWs establish them as a versatile nanomaterial with broad applicability. This review offers a comprehensive overview of SiNW research and theoretical insights that may guide similar studies. The insights into recent SiNW research presented here are intended to inform future applications and investigations involving these nanomaterials.
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A Comprehensive Review of Self-Assembly Techniques Used to Fabricate as DNA Origami, Block Copolymers, and Colloidal Nanostructures
More LessAuthors: Roshan Kumar Dubey, Satyam Shukla, Kamal Shah and Hitesh Kumar DewanganSelf-assembly techniques play a pivotal role in the field of nanotechnology, enabling the spontaneous organization of individual building blocks into ordered nanostructures without external intervention. In DNA origami, the design and synthesis of DNA strands allow for precise folding into complex nanoarchitectures. This technique holds immense promise in nanoelectronics, nanomedicine, and nanophotonics, offering nanoscale precision and versatility in structural design. Block copolymers represent another fascinating self-assembly system, driven by phase separation and microdomain formation. Understanding and controlling the self-assembly behavior of block copolymers enable applications in nanolithography, nanopatterning, and nanofabrication, owing to their ability to generate well-defined nanostructures. Colloidal assembly is a versatile and powerful technique for fabricating ordered nanostructures and materials with precise control over their properties. The process involves the spontaneous arrangement of colloidal particles into well-defined structures at the microscale or larger, driven by interparticle interactions, Brownian motion, and entropic effects. As research and technology continue to progress, colloidal assembly holds promising opportunities for creating novel materials with applications in diverse fields, contributing to advancements in nanotechnology, optics, electronics, and biomedicine. The continuous exploration and development of colloidal assembly techniques will undoubtedly open new avenues for innovation and impact various areas of science and technology in the future. This review article provides a comprehensive overview of various self-assembly techniques used to fabricate nanostructures, focusing on DNA origami, block copolymers, and colloidal assembly. With a focus on DNA origami in particular, its uses in drug administration, biosensing, nanofabrication, and computational storage are introduced. There is also a discussion of the potential and difficulties involved in assembling and using DNA origami.
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From Nanomaterials to Well-Defined Structures: Exploring Layer-by-layer Assembly Techniques
More LessAuthors: Yassmen Hamzat, Alaa A. A. Aljabali, Mohamed El-Tanani and Murtaza M. TambuwalaLayered assemblies are essential in materials nanoarchitectonics, which organize nanomaterials into well-defined structures. This overview highlights the significance, advancements, challenges, and future directions of layered assembly. The layer-by-layer (LBL) process relies on electrostatic interactions and self-assembly, which are influenced by factors such as charge, pH, and environmental conditions. Solution-based, vapor-phase, and template-guided methods offer distinct advantages and limitations for tailoring the layered structures. Polymeric, inorganic, and hybrid nanomaterials have diverse functionalities for specific applications. Surface modification, functionalization techniques, templating, and patterning methods play key roles in the customization of layered structures. Integration of stimuli-responsive assemblies enables dynamic control and advanced functionality. Characterization techniques, including spectroscopy and microscopy, provide insights into the structure, morphology, and properties of the layered assemblies. The evaluation of the mechanical and electrical properties enhances the understanding of their behavior and suitability for applications. Layered assemblies find applications in biomaterials, optoelectronics, energy storage, and conversion, promising advances in tissue engineering, optoelectronic devices, and battery technology. Challenges in scalability, stability, and material selection necessitate interdisciplinary collaboration, process standardization, innovation, optimization, and sustainability. Advanced characterization techniques and artificial intelligence (AI) integration hold promise for future advancements in layered assemblies. Layered assemblies have great potential in materials science and technology, offering precise control over the structure and functionality of breakthroughs in various applications. Continued research and collaboration will drive progress in this field and pave the way for innovative materials and technologies. Scientists are encouraged to explore the possibilities of layered assemblies, unlock novel solutions to global challenges, and shape the future of nanomaterial engineering.
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Antibacterial Activities of Copper, Silver, and Zinc-Derived Nanoparticles and their Capacity to Enhance the Antimicrobial Activities of Antibiotics
More LessAuthors: Denise Yancey-Gray, Rogers Nyamwihura, Zikri Arslan and Ifedayo Victor OgungbeNanoparticles derived from copper (Cu), zinc (Zn), and silver (Ag) have bactericidal activities, are biocompatible, and are malleable to different structural designs/shapes, making them attractive as antibacterial agents. The development of new antibacterial agents is particularly important because the emergence of multidrug-resistant (MDR) bacteria driven by overuse, misuse, and abuse of antibiotics has become a global problem. Drug resistance results in higher mortality and morbidity, increase in treatment cost, and longer hospital stays. Unfortunately, over the past three decades, the lack of adequate investments in developing new drugs to replace current and ineffective ones has compounded the problem. This review provides a comprehensive insight into the investigation of nanoparticles derived from Cu, Zn, and Ag as antibacterial agents, especially when combined with antibiotics. It provides mechanistic details about the activities of the nanoparticles and their limited structure-activity relationships. In addition, the effect of doping and its impact on the antibacterial activity of the nanomaterials is discussed, as well as the nanoparticles’ ability to inhibit or reduce bacterial growth on surfaces and prevent the development of antibiotic resistance by biofilms.
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Pharmacological Potential of Argan Oil (Argania spinosa) with a Special Focus on its Chemical Composition and Nanoformulations-based Applications
More LessAuthors: Taniya Paul, Dorji Drakpa, Prasun Mukherjee, Sukriti Chakrabarty, Karma Jigdrel and Jeena GuptaArgan oil is a rich source of bioactive chemicals with potential health advantages and is derived from the kernels of the Argania spinosa tree. Since ancient times, argan oil has been used as a natural cure in traditional medicine. Traditional uses of argan oil include cooking, massaging, healing, and curing skin, nails, and hair ailments. Due to the high concentration of mono- and polyunsaturated fatty acids, antioxidants, polyphenols, and tocopherols, numerous industries are interested in using them in their top-selling products. Studies have evaluated argan oil's exceptional qualities, which include restoring the skin's water-lipid layer, increasing nutrients in skin cells, stimulating intracellular oxygen, neutralizing free radicals, regulating lipid metabolism, lowering blood pressure, and reducing inflammatory indicators. Utilizing argan oil in diet will help to fight ailments like cancer, diabetes, and cardiovascular conditions. In this article, we reviewed the published literature to delineate argan oil's chemical composition, extraction procedures, and pharmacological potential. Furthermore, we also explored the health-beneficial properties of argan oil-based nano-formulations with evidence to prove their effectiveness against various diseases. Underlying argan oil's rich composition and beneficial effects, exploring its favorable qualities and the mechanisms underlying its curative activity will require extensive research.
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A Bird View on the Role of Graphene Oxide Nanosystems in Therapeutic Delivery
More LessAuthors: Sanchit Dhankhar, Nitika Garg, Samrat Chauhan and Monika SainiThe remarkable physicochemical properties of Graphene oxide (GO), a graphene derivative, have made it a material with intriguing medical administration potential. Its 2D allotropic nature is the source of its biological flexibility. The transportation of genes and small molecules are just two of the many biomedical applications of graphene and its composite. Antibacterial use in tooth and bone grafts, biofunctionalization of proteins, and treatment of cancer are among other potential uses. The biocompatibility of the freshly synthesized nanomaterials opens up a world of potential biological and medicinal uses. Furthermore, GO's versatility makes it an ideal component for usage in other drug delivery systems, such as hydrogels, nanoparticles, and micelles. This review aims to compile the existing body of knowledge regarding the use of GO in drug delivery by delving into its many potential uses, obstacles, and future developments.
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Current Application of Nanotechnology to Enhance Cutaneous Permeation of Vitamin C and Derivatives
More LessBackgroundVitamin C (VitC), or L-ascorbic acid in topical formulations acts as an antioxidant, depigmentant, stimulator of stratum corneum renewal and collagen synthesis. VitC is a thermolabile, water-soluble compound, oxidizes when its solution is exposed to air, metals and high pH. Derivative compounds were created to circumvent the instability, poor penetration capacity in the stratum corneum. Furthermore, new drug delivery systems using nanotechnology began to be studied, providing protection against degradation and penetration through the skin.
ObjectiveThe current paper aimed at carrying out a systematic review between 2006 and 2022, seeking innovative topical formulations containing VitC and its derivatives, where the problem of low permeation and instability was circumvented.
MethodsThe search for articles was performed in the Science Direct, Springer and PubMed databases. The largest amount of information was gathered on innovative formulations for topical use for the delivery of VitC and its derivatives, physicochemical characterization data, in vitro and in vivo studies.
ResultsThe search in the databases resulted in a total of 3032 articles, of which 16 studies were selected for the systematic review, as they proved the possibility of carrying the active ingredient in nanosystems, allowing increased stability, better permeation properties and in vitro cutaneous release, enabling the therapeutic function of the active ingredient through the application of formulations to the skin. In vivo studies also proved the clinical efficacy of the compound in liposomes, ethosomes and niosomes.
ConclusionThe most described nanocarriers were nanoparticles and liposomes, and one study involved niosomes and ethosomes. Therefore, even though it is not a newly discovered molecule, VitC continues to be studied in topical formulations ensuring stability, permeation, and effectiveness.
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Biochemical and Preclinical Evaluation with Synthesis and Docking Study of Pyridopyrimidines and Selenium Nanoparticle Drugs for Cancer Targeting
More LessBackgroundUltrasonic irradiation has the remarkable potential to amplify reactivity by a factor of approximately one million. The effects of ultrasound on chemical processes can be categorized as either homogeneous sonochemistry, which takes place in liquids, or heterogeneous sonochemistry, which occurs in liquid-liquid or liquid-solid systems.
ObjectivesPyrimidines are a vital group of compounds known for their anticancer activities. This study delves into investigating the application of ultrasonic irradiation for the synthesis of pyridopyrimidine derivatives.
MethodsIn our study, we utilized pyrimidine derivatives 1, 2a, and 2b as reducing agents during the creation of selenium nanoparticles (Het-SeNPs). The characterization of these nanoparticles was executed through a range of analytical approaches, including ultraviolet-visible spectrometry, dynamic light scattering (DLS, Zeta), and transmission electron microscopy (TEM). Additionally, FTIR and NMR spectroscopic examinations provided proof of the formation of these nanoparticles within the synthesized molecules 1, 2a, and 2b.
ResultsThe impact of the produced heterocyclic derivatives and Het-SeNPs was assessed on various cancer cell lines, including breast cancer (MCF-7), liver cancer (HepG2), and prostate cancer (PC-3) cell lines. All tested substances demonstrated a reasonable level of safety in the HFB4 cell line, which represents normal human skin melanocytes. Noteworthy is the substantial cytotoxicity exhibited by compound 2b against MCF-7 cell lines.
ConclusionMoreover, compound 2b-SeNPs demonstrated even higher cytotoxicity against the MCF-7 cell line compared to compound 2b, where 5-fluorouracil was used as a reference standard. Detailed cell division analysis disclosed significant antiproliferative properties in compounds 2b and 2b-SeNPs, leading to the arrest of the cell cycle at the pre-G1 and G2/M phases..
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Fluorometric Determination of Fe3+ Ions using Carbon Dots Prepared from the Extract of Singapore Cherry
More LessBackground: The development of affordable and ecologically acceptable technologies for heavy metal detection and removal is required due to the rising levels of water and soil pollution. Carbon Dots (CDs) have emerged as a promising nanomaterial for heavy metal detection due to their unique properties. In this study, we report a simple and eco-friendly method to produce CDs using Muntingia calabura fruit extract as a precursor.
MethodsThe hydrothermal method produced a well-defined size, structure, and optical properties of CDs, which were analyzed by using various characterization techniques, including Field Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive X-ray Spectroscopy (EDS), Elemental mapping (E-map), UV-visible spectroscopy, X-ray diffraction (XRD), Fourier Transform Infrared spectroscopy (FT-IR), Photoluminescence (PL) spectroscopy, and Transmission Electron Microscopy (TEM). Additionally, Zeta potential and DLS analysis were used to characterize the CDs.
ResultsAs-synthesized CDs exhibited strong fluorescence emission, making them suitable for the selective determination of Fe3+ ions. The detection limit was found to be 3.6 µM for Fe3+ ions, which highlighted the potential application of as-prepared CDs in environmental monitoring.
ConclusionThe green synthesized CDs from Muntingia calabura fruit extract provided a sustainable approach for developing efficient nanoprobes for detecting Fe3+ ions in environmental and biological samples.
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Fluorometric Determination of Fe3+ Ions using Green Synthesized Carbon Quantum Dots from Damask Rose Flowers
More LessBackgroundCarbon quantum dot synthesis, characterization, and applications have drawn a lot of attention lately. The most effective carbon precursors for creating carbon dots with intriguing chemical and physical characteristics are found in natural materials.
ObjectivesIn this study, we introduced a new approach using a carbon dot system that possesses both absorption and emission capabilities, allowing for the development of a fluorometric assay to detect Fe3+ metal ions.
MethodsHydrothermally, the Damask rose Carbon Quantum Dots (DRCQDs) were synthesized using Damask rose flower petals and various characterisations were performed, such as UV-Vis, FE-SEM, EDS, and Elemental mapping. The fluorescence intensity of carbon quantum dots (CQDs) varies depending on the particular metal ion present in the medium, and the blue fluorescence was selectively quenched.
ResultsFor the purpose of detecting Fe3+ ions at an excitation of 330 nm, CQDs were employed, which produced an extensive emission spectrum between 280 and 400 nm by varying the excitation wavelengths. More than other heavy metals, Fe3+ ions were observed to have a stronger fluorescence quenching effect for the CQDs. According to spectroscopic measurements, the generated CQDs have a detection limit of 1.11 μM and could determine Fe3+ ions in the range of concentrations from 0-80 μM.
ConclusionThis new fluorescent CQD technology offers a promising method for the quick and effective identification of Fe3+ ions, particularly in real-world samples.
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Silver-Coated Waste Rubber Micro-Particles with Low Density, High Stability, and Excellent Electromagnetic Shielding Ability: Design, Preparation, and Characterization
More LessAuthors: Xin-Kun Lv, Qi Zhong, Yong-Kun Li and Jin-Gang YuIntroductionThe electromagnetic radiation caused by the increasing application of electronic devices is associated with environmental hazards and health risks.
MethodsWith the rapid development of science and technology, it is urgent to reduce electromagnetic interference by introducing effective electromagnetic shielding materials. Furthermore, novel electromagnetic shielding materials with increasing stability and decreasing density have become the focus of the current research. Herein, silver (Ag) coated rubber (AR) micro-particles (MPs) were prepared by coating Ag nanoparticles (NPs) onto waste AR MPs.
ResultsThe AR MPs not only exhibited superior electromagnetic shielding performance with the electromagnetic interference (EMI) shielding effectiveness (SE) value of 6.1 dB at 5.8 GHz, but also possessed excellent long-time stability (240 h) in high-temperature (85°C) and high humidity (85% RH) environment. Due to the low density (0.66 g/cm3) of AR-3 MPs, its practical application in lightweight and highly integrated electronic devices is guaranteed.
ConclusionThe developed AR MPs have exhibited broad application prospects in the electromagnetic interference (EMI) shielding field due to the good EMI shielding performance, high stability and low density.
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Topical Application of Melatonin in a Grapeseed Oil-based Microemulsion Accelerated Wound Healing in Rat Models
More LessObjectiveMelatonin has been associated with accelerated tissue regeneration and grapeseed oil has abundant unsaturated fatty acids, particularly linoleic acid that makes it a strong antioxidant, having the potential to promote wound healing by enhancing the presence of free radicals at the wound site. The study is aimed to evaluate the potential of a microemulsion gel using grapeseed oil as the organic phase and melatonin encapsulated in the vesicles to exhibit synergistic wound healing in Swiss albino rats.
Materials and MethodsMicroemulsion containing grapeseed oil encapsulating melatonin was developed using the water-titration method. The surfactant and co-surfactant ratio (Smix) were fixed at 1:1. A pseudo-ternary diagram was used to determine the microemulsion zone and the developed microemulsion was further incorporated in carbopol 934P gel. The formulations were evaluated for their physicochemical properties and cytotoxicity assay. The optimized formulation was topically applied to cutaneous wounds of Swiss albino rat models. 30 Swiss albino rats were divided into five groups of 6 animals each: (i) Negative control group, (ii) Standard marketed formulation treated group, (iii) Optimized microemulsion containing Grapeseed oil and melatonin treated group, (iv) Grapeseed oil treated group and (v) Melatonin treated group. All the rats in each group were topically applied with the desired formulations daily for up to 14 days.
ResultsThe treatment with a formulation comprising 10.18% Grapeseed oil, 24.88% water, and 64.94% Smix exhibited the highest entrapment efficiency of 86.65 ± 1.88% with an enhanced in vitro drug release of up to 83.02 ± 1.09%, also demonstrating first-order release kinetics. Furthermore, it did not inhibit L929 mouse fibroblast cell proliferation up to 500 μg/mL and promoted wound closure prior to other groups. Additionally, increased tissue maturation with higher collagen deposition was mostly seen by day 7. Thus demonstrating it is suitable for dermal application and sustained release of melatonin. The in vivo wound healing study and histological investigations on rat models demonstrated comparable results as observed in the marketed formulation of melatonin.
ConclusionThe results showed that GSO oil based microemulsion encapsulating MEL could be a promising wound treatment option to exhibit accelerated wound healing effects.
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Poly-Thionine/SWCNT Nanocomposite Coated Electrochemical Sensor for Determination of Vitamin C
More LessBackgroundThe electrochemical sensors convert biological or chemical information, such as analyte concentration or a biomolecular (biochemical receptor) interaction, into electrical signals. In this paper, we describe the development of a poly-thionine/ single-walled carbon nanotube (P-Th/SWCNT) composite for the electrochemical detection of ascorbic acid (vitamin C).
MethodsTo improve electrochemical performance, we attempted to electro-polymerize the thionine monomers, an essential chemical building block, directly on the surface of single-walled carbon nanotubes (SWCNT).
ResultsField Emission Scanning electron microscopy (FESEM) and energy dispersive spectroscopy (EDS) results revealed that a complex structure of the P-Th/SWCNT was formed. The presence of carbon (C), oxygen (O), nitrogen (N), and sulfur (S) components was confirmed, which indicated the effective fusion of poly-thionine onto SWCNT. Moreover, the X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy confirmed the composite formation. Utilizing cyclic voltammetry, the composite's electrochemical behavior was examined.
ConclusionsExcellent electrocatalytic activity towards the oxidation of ascorbic acid was shown by the P-Th/SWCNT composite. The as-prepared P-Th/SWCNT composite-modified sensor can detect ascorbic acid in food, medical, and pharmaceutical samples.
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Volumes & issues
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Volume 21 (2025)
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Volume 20 (2024)
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Volume 19 (2023)
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Volume 18 (2022)
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Volume 17 (2021)
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Volume 16 (2020)
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Volume 15 (2019)
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Volume 14 (2018)
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Volume 13 (2017)
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Volume 12 (2016)
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Volume 11 (2015)
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Volume 10 (2014)
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Volume 9 (2013)
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Volume 8 (2012)
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Volume 7 (2011)
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Volume 6 (2010)
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Volume 5 (2009)
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Volume 4 (2008)
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Volume 3 (2007)
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Volume 2 (2006)
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Volume 1 (2005)
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