Skip to content
2000
Volume 25, Issue 8
  • ISSN: 1566-5240
  • E-ISSN: 1875-5666
file format text download EPUB
file format pdf download PDF
side by side viewer icon HTML

Abstract

Long non-coding RNAs (lncRNAs) refer to a group of RNA molecules that exceed a length of 200 nucleotides and lack the ability to code proteins. Numerous studies suggest that lncRNAs significantly contribute to the onset and progression of various forms of cancers. A specific lncRNA, known as long non-coding RNA 01296 (LINC01296), is extensively expressed in human malignancies. The level of LINC01296 has been shown to correlate with the progression and prognosis of cancers. Moreover, numerous scientific investigations have provided evidence that the dysregulation of LINC01296 functioning as a competitive endogenous RNA (ceRNA) exerts a profound influence on various aspects of cancer cell behavior, including proliferation, apoptosis, invasion, metastasis, and cell cycle progression, by means of regulating target genes and signaling pathways. An increasing body of data strongly suggests that LINC01296 may serve as a valuable biomarker for predicting cancer prognosis and could represent a promising therapeutic target for cancer intervention. In this comprehensive review, we summarize the recent advancements in our understanding of the role, underlying mechanisms, and clinical significance of LINC01296 in malignant tumors. The findings suggest that LINC01296 may be both a reliable biomarker and a potential therapeutic target for cancers.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
Loading

Article metrics loading...

/content/journals/cmm/10.2174/0115665240352933250116050706
2025-01-31
2025-10-25

  • From This Site

    /content/journals/cmm/10.2174/0115665240352933250116050706
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/cmm/25/8/CMM-25-8-07.html?itemId=/content/journals/cmm/10.2174/0115665240352933250116050706&mimeType=html&fmt=ahah

References

  1. CaoM. LiH. SunD. ChenW. Cancer burden of major cancers in China: A need for sustainable actions.Cancer Commun. (Lond.)202040520521010.1002/cac2.12025 32359212
     [Google Scholar]
  2. SiegelR.L. MillerK.D. WagleN.S. JemalA. Cancer statistics, 2023.CA Cancer J. Clin.2023731174810.3322/caac.21763 36633525
     [Google Scholar]
  3. BoshuizenJ. PeeperD.S. Rational Cancer Treatment Combinations: An Urgent Clinical Need.Mol. Cell20207861002101810.1016/j.molcel.2020.05.031 32559422
     [Google Scholar]
  4. WangJ.J. LeiK.F. HanF. Tumor microenvironment: recent advances in various cancer treatments.Eur. Rev. Med. Pharmacol. Sci.2018221238553864 29949179
     [Google Scholar]
  5. BarskiA. CuddapahS. CuiK. High-resolution profiling of histone methylations in the human genome.Cell2007129482383710.1016/j.cell.2007.05.009 17512414
     [Google Scholar]
  6. SlackF.J. ChinnaiyanA.M. The Role of Non-coding RNAs in Oncology.Cell201917951033105510.1016/j.cell.2019.10.017 31730848
     [Google Scholar]
  7. BridgesM.C. DaulagalaA.C. KourtidisA. LNCcation: lncRNA localization and function.J. Cell Biol.20212202e20200904510.1083/jcb.202009045 33464299
     [Google Scholar]
  8. ZhangM. YuX. ZhangQ. SunZ. HeY. GuoW. MIR4435-2HG: A newly proposed lncRNA in human cancer.Biomed. Pharmacother.202215011297110.1016/j.biopha.2022.112971 35447550
     [Google Scholar]
  9. KoppF. MendellJ.T. Functional Classification and Experimental Dissection of Long Noncoding RNAs.Cell2018172339340710.1016/j.cell.2018.01.011 29373828
     [Google Scholar]
  10. VanceK.W. PontingC.P. Transcriptional regulatory functions of nuclear long noncoding RNAs.Trends Genet.201430834835510.1016/j.tig.2014.06.001 24974018
     [Google Scholar]
  11. StatelloL. GuoC.J. ChenL.L. HuarteM. Gene regulation by long non-coding RNAs and its biological functions.Nat. Rev. Mol. Cell Biol.20212229611810.1038/s41580‑020‑00315‑9 33353982
     [Google Scholar]
  12. LiuZ. LiuL. WengS. Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer.Nat. Commun.202213181610.1038/s41467‑022‑28421‑6 35145098
     [Google Scholar]
  13. YaoX.T. FengW.P. GongZ.P. LiX.P. Clinical Significance of Long Non-Coding RNA SNHG5 in the Diagnosis and Prognosis of Chronic Obstructive Pulmonary Disease.COPD2024211236363010.1080/15412555.2024.2363630 38973373
     [Google Scholar]
  14. XiaoJ. XuZ. Roles of noncoding RNAs in diabetic retinopathy: Mechanisms and therapeutic implications.Life Sci.202435712309210.1016/j.lfs.2024.123092 39368772
     [Google Scholar]
  15. LihuaC. HuaS. WenzhanW. StandardJ. DenghuiL. Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy loss.Gynecol. Endocrinol.2024401237558210.1080/09513590.2024.2375582 39422994
     [Google Scholar]
  16. DaiC. DaiC. NiH. XuZ. Prognostic value of long non-coding RNA 01296 expression in human solid malignant tumours: a meta-analysis.Postgrad. Med. J.2020961131435210.1136/postgradmedj‑2019‑136684 31444240
     [Google Scholar]
  17. WanY. LiM. HuangP. LINC01296 promotes proliferation, migration, and invasion of HCC cells by targeting miR-122-5P and modulating EMT activity.OncoTargets Ther.2019122193220310.2147/OTT.S197338 30988624
     [Google Scholar]
  18. LiY. ZhangH. GuoJ. Downregulation of LINC01296 suppresses non-small-cell lung cancer via targeting miR-143-3p/ATG2B.Acta Biochim. Biophys. Sin. (Shanghai)202153121681169010.1093/abbs/gmab149 34695177
     [Google Scholar]
  19. ChungC. BoterbergT. LucasJ. Neuroblastoma.Pediatr. Blood Cancer202168S2Suppl. 2e2847310.1002/pbc.28473 33818884
     [Google Scholar]
  20. QinQ.H. YinZ.Q. LiY. WangB.G. ZhangM.F. Long intergenic noncoding RNA 01296 aggravates gastric cancer cells progress through miR-122/MMP-9.Biomed. Pharmacother.20189745045710.1016/j.biopha.2017.10.066 29091895
     [Google Scholar]
  21. BragaE.A. FridmanM.V. MoscovtsevA.A. FilippovaE.A. DmitrievA.A. KushlinskiiN.E. LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms.Int. J. Mol. Sci.20202122885510.3390/ijms21228855 33238475
     [Google Scholar]
  22. ZhangS. WangX. WangD. Long non-coding RNA LINC01296 promotes progression of oral squamous cell carcinoma through activating the MAPK/ERK signaling pathway via the miR-485-5p/PAK4 axis.Arch. Med. Sci.201918378679910.5114/aoms.2019.86805 35591837
     [Google Scholar]
  23. XiaoH. LiY. ZhangY. WangP. Long noncoding RNA LINC01296 regulates the cell proliferation, migration and invasion in neuroblastoma.Metab. Brain Dis.20223741247125810.1007/s11011‑022‑00935‑4 35305236
     [Google Scholar]
  24. ZhangD. LiH. XieJ. Long noncoding RNA LINC01296 promotes tumor growth and progression by sponging miR-5095 in human cholangiocarcinoma.Int. J. Oncol.20185261777178610.3892/ijo.2018.4362 29620172
     [Google Scholar]
  25. XuL. WeiB. HuiH. Positive feedback loop of lncRNA LINC01296/miR‐598/Twist1 promotes non‐small cell lung cancer tumorigenesis.J. Cell. Physiol.201923444563457110.1002/jcp.27235 30240003
     [Google Scholar]
  26. HuX. DuanL. LiuH. ZhangL. Long noncoding RNA LINC01296 induces non-small cell lung cancer growth and progression through sponging miR-5095.Am. J. Transl. Res.2019112895903 30899389
     [Google Scholar]
  27. WangK. LuoQ. ZhangY. LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis.Aging (Albany NY)20221582877289010.18632/aging.204413 36462499
     [Google Scholar]
  28. SunZ. ShaoB. LiuZ. LINC01296/miR-141-3p/ZEB1-ZEB2 axis promotes tumor metastasis via enhancing epithelial-mesenchymal transition process.J. Cancer20211292723273410.7150/jca.55626 33854632
     [Google Scholar]
  29. HasanA. KhanN.A. UddinS. KhanA.Q. SteinhoffM. Deregulated transcription factors in the emerging cancer hallmarks.Semin. Cancer Biol.202498315010.1016/j.semcancer.2023.12.001 38123029
     [Google Scholar]
  30. ZhangY. WangA. ZhangX. WangX. ZhangJ. MaJ. lncRNA LINC01296 Promotes Oral Squamous Cell Carcinoma Development by Binding with SRSF1.BioMed Res. Int.2021202111210.1155/2021/6661520 34195277
     [Google Scholar]
  31. XuJ. ZhangZ. ShenD. ZhangT. ZhangJ. DeW. Long noncoding RNA LINC01296 plays an oncogenic role in colorectal cancer by suppressing p15 expression.J. Int. Med. Res.20214950300060521100441410.1177/03000605211004414 33983053
     [Google Scholar]
  32. YuX. PangL. YangT. LiuP. lncRNA LINC01296 regulates the proliferation, metastasis and cell cycle of osteosarcoma through cyclin D1.Oncol. Rep.20184052507251410.3892/or.2018.6674 30226542
     [Google Scholar]
  33. FuP. ZhengX. FanX. LinA. Role of cytoplasmic lncRNAs in regulating cancer signaling pathways.J. Zhejiang Univ. Sci. B20192011810.1631/jzus.B1800254 30614225
     [Google Scholar]
  34. LiuY. LiuX. LinC. Noncoding RNAs regulate alternative splicing in Cancer.J. Exp. Clin. Cancer Res.20214011110.1186/s13046‑020‑01798‑2 33407694
     [Google Scholar]
  35. WangB. LiuW. SongB. LiY. WangY. TanB. Targeting LINC00665/miR-199b-5p/SERPINE1 axis to inhibit trastuzumab resistance and tumorigenesis of gastric cancer via PI3K/AKt pathway.Noncoding RNA Res.20251015316210.1016/j.ncrna.2024.07.004 39399377
     [Google Scholar]
  36. MiaoW. WangZ. GaoJ. OhnoY. Polyphyllin II inhibits breast cancer cell proliferation via the PI3K/Akt signaling pathway.Mol. Med. Rep.202430622410.3892/mmr.2024.13348 39364737
     [Google Scholar]
  37. WuJ. ChengG. ZhangC. Long noncoding RNA LINC01296 is associated with poor prognosis in prostate cancer and promotes cancer-cell proliferation and metastasis.OncoTargets Ther.2017101843185210.2147/OTT.S129928 28392705
     [Google Scholar]
  38. LiuB. PanS. XiaoY. LiuQ. XuJ. JiaL. LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway.J. Exp. Clin. Cancer Res.201837131610.1186/s13046‑018‑0994‑x 30547804
     [Google Scholar]
  39. ZhouY. XuJ. LuoH. MengX. ChenM. ZhuD. Wnt signaling pathway in cancer immunotherapy.Cancer Lett.2022525849610.1016/j.canlet.2021.10.034 34740608
     [Google Scholar]
  40. ZhangY. WangX. Targeting the Wnt/β-catenin signaling pathway in cancer.J. Hematol. Oncol.202013116510.1186/s13045‑020‑00990‑3 33276800
     [Google Scholar]
  41. WangQ. XiaY. ChenH. LINC01296 Regulates Wnt/p-catenin Signaling Pathway and Affects SK-N-SH Cell Proliferation, Apoptosis, Migration and Invasion.Chinese Journal of Cell Biology2019421221162125
     [Google Scholar]
  42. LinF. WuQ. WangR. BoL. Effect of LINC01296 regulating Wnt/β-catenin pathway on cisplatin resistance in ovarian cancer.Modern Oncology2023312037703776
     [Google Scholar]
  43. SegevY. SegevL. SchmidtM. AuslenderR. LavieO. Palliative care in ovarian carcinoma patients—a personalized approach of a team work: a review.Arch. Gynecol. Obstet.2017296469170010.1007/s00404‑017‑4484‑8 28803353
     [Google Scholar]
  44. BaekM.H. ParkE.Y. HaH.I. Secondary Cytoreductive Surgery in Platinum-Sensitive Recurrent Ovarian Cancer: A Meta-Analysis.J. Clin. Oncol.202240151659167010.1200/JCO.21.02085 35188810
     [Google Scholar]
  45. SiegelR.L. MillerK.D. FuchsH.E. JemalA. Cancer Statistics, 2021.CA Cancer J. Clin.202171173310.3322/caac.21654 33433946
     [Google Scholar]
  46. XuH. ZhengJ.F. HouC.Z. LiY. LiuP.S. Up-regulation of long intergenic noncoding RNA 01296 in ovarian cancer impacts invasion, apoptosis and cell cycle distribution via regulating EMT.Cell. Signal.20196210934110.1016/j.cellsig.2019.06.006 31176022
     [Google Scholar]
  47. XuH. MaoH.L. ZhaoX.R. LiY. LiuP.S. MiR-29c-3p, a target miRNA of LINC01296, accelerates tumor malignancy: therapeutic potential of a LINC01296/miR-29c-3p axis in ovarian cancer.J. Ovarian Res.20201313110.1186/s13048‑020‑00631‑w 32192508
     [Google Scholar]
  48. HuangY. XieY. Effect of IncRNA Linc01296 on cisplatin resistance in ovarian cancer cells OVCAR-3 and its relationship with clinicopathological characteristics.Zhongguo Zhongliu Shengwu Zhiliao Zazhi2019263323327
     [Google Scholar]
  49. PapadakosS.P. DedesN. KouroumalisE. TheocharisS. The Role of the NLRP3 Inflammasome in HCC Carcinogenesis and Treatment: Harnessing Innate Immunity.Cancers (Basel)20221413315010.3390/cancers14133150 35804922
     [Google Scholar]
  50. ZhangL. HuJ. HaoM. BuL. Long noncoding RNA Linc01296 promotes hepatocellular carcinoma development through regulation of the miR-26a/PTEN axis.Biol. Chem.2020401340741610.1515/hsz‑2019‑0231 31318685
     [Google Scholar]
  51. ZeineldinM. PatelA.G. DyerM.A. Neuroblastoma: When differentiation goes awry.Neuron2022110182916292810.1016/j.neuron.2022.07.012 35985323
     [Google Scholar]
  52. ZafarA. WangW. LiuG. Molecular targeting therapies for neuroblastoma: Progress and challenges.Med. Res. Rev.2021412961102110.1002/med.21750 33155698
     [Google Scholar]
  53. WangJ. WangZ. YaoW. DongK. ZhengS. LiK. The association between lncRNA LINC01296 and the clinical characteristics in neuroblastoma.J. Pediatr. Surg.201954122589259410.1016/j.jpedsurg.2019.08.032 31522796
     [Google Scholar]
  54. WangJ. WangZ. LinW. LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex.Mol. Ther. Oncolytics20222483484810.1016/j.omto.2022.02.007 35317520
     [Google Scholar]
  55. MorganE. SoerjomataramI. RumgayH. The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020.Gastroenterology20221633649658.e210.1053/j.gastro.2022.05.054 35671803
     [Google Scholar]
  56. ZhaoF. LiZ. DongZ. Exploring the Potential of Exosome-Related LncRNA Pairs as Predictors for Immune Microenvironment, Survival Outcome, and Microbiotain Landscape in Esophageal Squamous Cell Carcinoma.Front. Immunol.20221391815410.3389/fimmu.2022.918154 35880180
     [Google Scholar]
  57. WangB. LiangT. LiJ. Long noncoding RNA LINC01296 is associated with poor prognosis in ESCC and promotes ESCC cell proliferation, migration and invasion.Eur. Rev. Med. Pharmacol. Sci.2018221445244531 30058683
     [Google Scholar]
  58. WangL. MengD. WangY. HuJ. Long non-coding RNA LINC01296 promotes esophageal squamous cell carcinoma cell proliferation and invasion by epigenetic suppression of KLF2.Am. J. Cancer Res.201881020202029 30416853
     [Google Scholar]
  59. LiangH. ZhaoQ. ZhuZ. ZhangC. ZhangH. Long noncoding RNA LINC00958 suppresses apoptosis and radiosensitivity of colorectal cancer through targeting miR-422a.Cancer Cell Int.202121147710.1186/s12935‑021‑02188‑0 34496838
     [Google Scholar]
  60. SungH. FerlayJ. SiegelR.L. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.CA Cancer J. Clin.202171320924910.3322/caac.21660 33538338
     [Google Scholar]
  61. DongS. LiangS. ChengZ. ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.J. Exp. Clin. Cancer Res.20224111510.1186/s13046‑021‑02229‑6 34998404
     [Google Scholar]
  62. MiniE. LapucciA. PerroneG. RNA sequencing reveals PNN and KCNQ1OT1 as predictive biomarkers of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy.Int. J. Cancer201914592580259310.1002/ijc.32326 30973654
     [Google Scholar]
  63. ZhangX. ZhangH. ShenB. SunX.F. Novel MicroRNA Biomarkers for Colorectal Cancer Early Diagnosis and 5-Fluorouracil Chemotherapy Resistance but Not Prognosis: A Study from Databases to AI-Assisted Verifications.Cancers (Basel)202012234110.3390/cancers12020341 32028703
     [Google Scholar]
  64. QiuJ. YanJ. Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer.Tumour Biol.20153697175718310.1007/s13277‑015‑3448‑5 25894381
     [Google Scholar]
  65. MiyamotoD.T. MouwK.W. FengF.Y. ShipleyW.U. EfstathiouJ.A. Molecular biomarkers in bladder preservation therapy for muscle-invasive bladder cancer.Lancet Oncol.20181912e683e69510.1016/S1470‑2045(18)30693‑4 30507435
     [Google Scholar]
  66. SongQ. ZhouR. ShuF. FuW. Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer.Front. Immunol.20221395836810.3389/fimmu.2022.958368 35990642
     [Google Scholar]
  67. WangX. WangL. GongY. Long noncoding RNA LINC01296 promotes cancer-cell proliferation and metastasis in urothelial carcinoma of the bladder.OncoTargets Ther.201812758510.2147/OTT.S192809 30588032
     [Google Scholar]
  68. SeitzA.K. ChristensenL.L. ChristensenE. Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer.Sci. Rep.20177139510.1038/s41598‑017‑00327‑0 28341852
     [Google Scholar]
  69. SiegelR.L. MillerK.D. FuchsH.E. JemalA. Cancer statistics, 2022.CA Cancer J. Clin.202272173310.3322/caac.21708 35020204
     [Google Scholar]
  70. TianX. GuT. LeeM.H. DongZ. Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer.Biochim. Biophys. Acta Rev. Cancer20221877118864510.1016/j.bbcan.2021.188645 34793897
     [Google Scholar]
  71. XiaD. XuL. ChaiB. GuoJ. SunQ. LiY. Research on the promotion of non-small cell lung cancer progression by LINC01296/miR-1255b-5p.Translational Medicine Journal2021105281286
     [Google Scholar]
  72. DaiY. WangX. GazinaT. Relationship between long-chain non-coding RNA-LINC01296 and epithelial-mesenchymal transformation of lung cancer cells.Xinjiang Yike Daxue Xuebao2022459953957
     [Google Scholar]
  73. MumtazM. BijnsdorpI.V. BöttgerF. Secreted protein markers in oral squamous cell carcinoma (OSCC).Clin. Proteomics2022191410.1186/s12014‑022‑09341‑5 35130834
     [Google Scholar]
  74. SiegelR.L. MillerK.D. JemalA. Cancer statistics, 2018.CA Cancer J. Clin.201868173010.3322/caac.21442 29313949
     [Google Scholar]
  75. IshidaK. TomitaH. NakashimaT. Current mouse models of oral squamous cell carcinoma: Genetic and chemically induced models.Oral Oncol.201773162010.1016/j.oraloncology.2017.07.028 28939069
     [Google Scholar]
  76. LiangK.Y. Chun-Yu HoD. YangH.P. LINC01296 promotes cancer stemness traits in oral carcinomas by sponging miR-143.J. Dent. Sci.202318281482110.1016/j.jds.2023.01.008 37021272
     [Google Scholar]
  77. YangK. LiL. ChenY. The role of long non-coding RNA LINC01296 in oral squamous cell carcinoma: a study based on bioinformatics analysis and in vitro validation.J. Cancer202213377578310.7150/jca.60417 35154446
     [Google Scholar]
  78. JiangM. XiaoY. LiuD. LuoN. GaoQ. GuanY. Overexpression of long noncoding RNA LINC01296 indicates an unfavorable prognosis and promotes tumorigenesis in breast cancer.Gene201867521722410.1016/j.gene.2018.07.004 29981416
     [Google Scholar]
  79. WuJ. ChenH. LiJ. LiX. CaoJ. QiM. Long non-coding RNA LINC01296 acts as a migration and invasion promoter in head and neck squamous cell carcinoma and predicts poor prognosis.Bioengineered20211215607561910.1080/21655979.2021.1967033 34515611
     [Google Scholar]
  80. YuanQ. ZhangY. FengL. JiangY. Upregulated long noncoding RNA LINC01296 indicates a dismal prognosis for pancreatic ductal adenocarcinoma and promotes cell metastatic properties by affecting EMT.J. Cell. Biochem.2019120155256110.1002/jcb.27411 30203487
     [Google Scholar]
  81. DongX. YangJ. WenY. ZhaoL. Expression and clinical significance of LINC01296 in renal clear cell carcinoma.Hainan Med J2022331113951398
     [Google Scholar]
  82. PassaroA. Al BakirM. HamiltonE.G. Cancer biomarkers: Emerging trends and clinical implications for personalized treatment.Cell202418771617163510.1016/j.cell.2024.02.041 38552610
     [Google Scholar]
  83. HallC. ClarkeL. PalA. A Review of the Role of Carcinoembryonic Antigen in Clinical Practice.Ann. Coloproctol.201935629430510.3393/ac.2019.11.13 31937069
     [Google Scholar]
  84. ScaràS. BottoniP. ScatenaR. CA 19-9: Biochemical and Clinical Aspects.Adv. Exp. Med. Biol.201586724726010.1007/978‑94‑017‑7215‑0_15 26530370
     [Google Scholar]
  85. YangS. MaR. WuJ. The diagnostic value of combining preoperative serum CA19-9, ALBI score, and 18F-FDG PET/CT imaging in preoperative resectability of pancreatic cancer.Nucl. Med. Commun.202445121061106810.1097/MNM.0000000000001910 39363633
     [Google Scholar]
  86. ButzH. PatócsA. IgazP. Circulating non-coding RNA biomarkers of endocrine tumours.Nat. Rev. Endocrinol.2024201060061410.1038/s41574‑024‑01005‑8 38886617
     [Google Scholar]
  87. ReisE.M. Verjovski-AlmeidaS. Perspectives of long non-coding RNAs in cancer diagnostics.Front. Genet.201233210.3389/fgene.2012.00032 22408643
     [Google Scholar]
  88. LiuX. MaZ. ZhangX. LiS. AnJ. LuoZ. Research Progress of Long Non-coding RNA-ZFAS1 in Malignant Tumors.Cell Biochem. Biophys.20248243145315610.1007/s12013‑024‑01441‑3 39060915
     [Google Scholar]
  89. NadhanR. IsidoroC. SongY.S. DhanasekaranD.N. LncRNAs and the cancer epigenome: Mechanisms and therapeutic potential.Cancer Lett.202460521729710.1016/j.canlet.2024.217297 39424260
     [Google Scholar]
  90. FengW. ZhaiC. ShiW. Clinicopathological and prognostic value of LINC01296 in cancers: a meta-analysis.Artif. Cells Nanomed. Biotechnol.20194713315332110.1080/21691401.2019.1648284 31385542
     [Google Scholar]
  91. ZhangY. ChenC. ZhangM. JiangG. Study on relationship between lneRNA LINC01296 and prognosis in patients with non-small cell lung cancer.Journal of Clinical Lung201924814931497
     [Google Scholar]
  92. PanX. LiC. FengJ. The role of LncRNAs in tumor immunotherapy.Cancer Cell Int.20232313010.1186/s12935‑023‑02872‑3 36810034
     [Google Scholar]
  93. Chandra GuptaS. Nandan TripathiY. Potential of long non‐coding RNAs in cancer patients: From biomarkers to therapeutic targets.Int. J. Cancer201714091955196710.1002/ijc.30546 27925173
     [Google Scholar]
  94. RoknabadiN. BorgheiY.S. SeifezadehS.S. SoltaniB.M. MowlaS.J. Selective Naked-Eye Detection of Lung Squamous Cell Carcinoma Mediated by lncRNA SOX2OT Targeted Nanoplasmonic Probe.ACS Omega2024935372053721210.1021/acsomega.4c04565 39246497
     [Google Scholar]
  95. LiX. HuangH. LiuM. LuoH. Tumor Suppressor LncRNA on Chromosome 8p12 (TSLNC8): A Concise Review in Human Malignancies.J. Cancer202314152867287710.7150/jca.87801 37781073
     [Google Scholar]
  96. KadianL.K. VermaD. LohaniN. Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy.Mol. Cell. Biochem.2024479123229325410.1007/s11010‑024‑04933‑1 38413478
     [Google Scholar]
  97. DavodabadiF. Farasati FarB. SargaziS. Nanomaterials-Based Targeting of Long Non-Coding RNAs in Cancer: A Cutting-Edge Review of Current Trends.ChemMedChem2024198e20230052810.1002/cmdc.202300528 38267373
     [Google Scholar]
  98. SarkarS. MoitraP. BeraS. BhattacharyaS. Antisense Oligonucleotide Embedded Context Responsive Nanoparticles Derived from Synthetic Ionizable Lipids for lncRNA Targeted Therapy of Breast Cancer.ACS Appl. Mater. Interfaces20241635458714588710.1021/acsami.4c04893 39163516
     [Google Scholar]
  99. S ZibittM HartfordCCR LalA. Interrogating lncRNA functions via CRISPR/Cas systems.RNA Biol.202118122097210610.1080/15476286.2021.1899500 33685382
     [Google Scholar]
  100. ChangJ.Y. NeugebauerC. Mues genannt Koers A, ’t Hart P. Small molecule WDR5 inhibitors down-regulate lncRNA expression.RSC Med. Chem.202415263664010.1039/D3MD00605K 38389889
     [Google Scholar]
  101. MahatoR.K. BhattacharyaS. KhullarN. Targeting long non-coding RNAs in cancer therapy using CRISPR-Cas9 technology: A novel paradigm for precision oncology.J. Biotechnol.20243799811910.1016/j.jbiotec.2023.12.003 38065367
     [Google Scholar]
/content/journals/cmm/10.2174/0115665240352933250116050706
Loading
The Emerging Role of Long Non-coding RNA 01296 in Human Malignancies
Current Molecular Medicine 25, 1010 (2025); https://doi.org/10.2174/0115665240352933250116050706
/content/journals/cmm/10.2174/0115665240352933250116050706
/content/journals/cmm/10.2174/0115665240352933250116050706
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): Cancer; LINC01296; long non-coding RNA; molecular mechanisms; prognostic biomarker; therapeutic target

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test