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2000
Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Introduction

Accurate early diagnosis and assessment of liver fibrosis are important for patient treatment and prognosis. This study explored the value of Gd-BOPTA-enhanced T1 mapping the B1 inhomogeneity-corrected Variable Flip Angle (VFA) method for staging liver fibrosis in rats.

Methods

Sprague‒Dawley rats were divided into one control group (n = 6) and four carbon tetrachloride-induced liver fibrosis groups (n = 6 each group). T1 mapping B1 inhomogeneity-corrected VFA was performed before and 90 minutes after Gd-BOPTA administration. Precontrast T1 values (T1), postcontrast T1 values (T1), and the reduction rate of T1 values (ΔT1%) were quantified on T1 mapping images. The diagnostic performance was evaluated by the Area Under the Receiver Operating Characteristic Curve (AUC). The correlations between T1, T1, ΔT1% values, and the expression levels of hepatocyte transporters (Oatp1a1 and Mrp2) were evaluated.

Results

T1 and ΔT1% were significantly correlated with liver fibrosis stage (r = 0.832, 0.001; r = −0.798, 0.001, respectively), whereas T1 was not significantly correlated with fibrosis stage (r = 0.357, = 0.062). The AUCs of T1 and ΔT1% were greater than those of postcontrast signal intensity for diagnosing stages F2–F4 (0.936, 0.941 0.791; = 0.043, 0.038, respectively), F3–F4 (0.928, 0.861 0.660; = 0.003, 0.028, respectively) and F4 (0.965, 0.896 0.761; = 0.021, 0.049, respectively). Oatp1a1 and Mrp2 expression levels correlated significantly with T1 (r = −0.859, 0.001; r = −0.697, = 0.017) and ΔT1% (r = 0.891, 0.001; r = 0.685, = 0.020), respectively.

Discussion

T1 and ΔT1% were significantly correlated with liver fibrosis stages, and have good diagnostic performance for staging liver fibrosis. The protein expression levels of Oatp1a1 and Mrp2 correlated significantly with T1 and ΔT1%.

Conclusion

Gd-BOPTA-enhanced T1 mapping the B1 inhomogeneity-corrected VFA shows promise as a potentially accurate and reliable tool for quantifying liver fibrosis stages.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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Quantitative Assessment of Liver Fibrosis: B1 Inhomogeneity-Corrected VFA T1 Mapping on Gadobenate Dimeglumine-Enhanced MRI
Curr. Med. Imaging 21, E15734056393310 (2025); https://doi.org/10.2174/0115734056393310250929071043
/content/journals/cmir/10.2174/0115734056393310250929071043
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  • Article Type:     Research Article
Keyword(s): Gadobenic acid; Liver fibrosis; Magnetic resonance imaging; Organic anion transporters; T1 mapping; Variable Flip Angle

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