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2000
Volume 32, Issue 34
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Sleep is necessary for long-term health and well-being. Sleep is divided into the rapid eye movement (REM), and non-rapid eye movement (NREM) stages. The normal sleep pattern follows a 90-minute cycle, and within those cycles, the body undergoes a regenerative state, restoring various components used daily. A sleep disorder can be due to multiple factors, , genetic, environmental, and individual factors. Short and long-term effects of sleep deprivation can have harmful effects. The immune system requires sufficient sleep to maintain optimal function, and sleep deprivation leads to the release of proinflammatory cytokines, which dysregulate the function of the immune system. Sleep deprivation affects the central nervous system, resulting in cognitive impairments and diseases related to decreased prefrontal cortex activity. Sleep disturbance affects the hypothalamus, secreting corticotrophin-releasing hormone, which results in the release of adrenocorticotropic hormone. This leads to the secretion of cortisol and catecholamines. Sleep disturbance causes reduced muscle glycogen concentration and gives rise to various gastrointestinal problems. Sleep disturbance affects the cardiovascular system which results in hypertension, cardiac ischemia, congestive cardiac failure, and arrhythmia. Sleep disturbances affect the endocrine system leading to insulin resistance, obesity, and metabolic syndrome. Interestingly, treatment of obstructive sleep apnea with continuous positive airway pressure was found to enhance metabolic status. We discuss the pharmacological, non-pharmacological, and surgical treatment options for sleep disorders. Understanding the mechanism of sleep disturbance and its association with different systems of the body may help in better treatment outcomes.

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References

  1. How Sleep Works - Why is Sleep Important?2022Available from: https://www.nhlbi.nih.gov/health/sleep/why-sleep-important
  2. BuysseD.J. Sleep health: Can we define it? Does it matter?Sleep201437191710.5665/sleep.329824470692
     [Google Scholar]
  3. MemarP. FaradjiF. A novel multi-class EEG-based sleep stage classification system.IEEE Trans. Neural Syst. Rehabil. Eng.2018261849510.1109/TNSRE.2017.277614929324406
     [Google Scholar]
  4. BrinkmanJ.E. ReddyV. SharmaS. Physiology of sleep.StatPearlsStatPearls PublishingTreasure Island (FL)2024
     [Google Scholar]
  5. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem.Washington (DC)National Academies Press (US)2006
     [Google Scholar]
  6. CarskadonM.A. Dement W.C. Chapter 2 – Normal human sleep : An overview.Principles and practice of sleep medicine5th edSt. LouisElsevier Saunders2011162610.1016/B978‑1‑4160‑6645‑3.00002‑5
     [Google Scholar]
  7. BorbA.A. AchermannP. Sleep homeostasis and models of sleep regulation.J. Biol. Rhythms199914655957010.1177/07487309912900089410643753
     [Google Scholar]
  8. DiekelmannS. BornJ. The memory function of sleep.Nat. Rev. Neurosci.201011211412610.1038/nrn276220046194
     [Google Scholar]
  9. FishbeinA.B. KnutsonK.L. ZeeP.C. Circadian disruption and human health.J. Clin. Invest.202113119e14828610.1172/JCI14828634596053
     [Google Scholar]
  10. ZhuL. ZeeP.C. Circadian rhythm sleep disorders.Neurol. Clin.20123041167119110.1016/j.ncl.2012.08.01123099133
     [Google Scholar]
  11. ThorpyM.J. Classification of sleep disorders.Neurotherapeutics20129468770110.1007/s13311‑012‑0145‑622976557
     [Google Scholar]
  12. RiemannD. NissenC. PalaginiL. OtteA. PerlisM.L. SpiegelhalderK. The neurobiology, investigation, and treatment of chronic insomnia.Lancet Neurol.201514554755810.1016/S1474‑4422(15)00021‑625895933
     [Google Scholar]
  13. BonvaletM. OllilaH.M. AmbatiA. MignotE. Autoimmunity in narcolepsy.Curr. Opin. Pulm. Med.201723652252910.1097/MCP.000000000000042628991006
     [Google Scholar]
  14. IranzoA. SantamaríaJ. Severe obstructive sleep apnea/hypopnea mimicking REM sleep behavior disorder.Sleep200528220320610.1093/sleep/28.2.20316171244
     [Google Scholar]
  15. PeppardP.E. YoungT. BarnetJ.H. PaltaM. HagenE.W. HlaK.M. Increased prevalence of sleep-disordered breathing in adults.Am. J. Epidemiol.201317791006101410.1093/aje/kws34223589584
     [Google Scholar]
  16. SackR.L. AuckleyD. AugerR.R. CarskadonM.A. WrightK.P.Jr VitielloM.V. ZhdanovaI.V. American Academy of Sleep Medicine Circadian rhythm sleep disorders: Part I, basic principles, shift work and jet lag disorders. An American academy of sleep medicine review.Sleep200730111460148310.1093/sleep/30.11.146018041480
     [Google Scholar]
  17. OkechukwuC.E. The neurophysiologic basis of the human sleep–wake cycle and the physiopathology of the circadian clock: A narrative review.Egypt. J. Neurol. Psychiat. Neurosurg.20225813410.1186/s41983‑022‑00468‑8
     [Google Scholar]
  18. WangC. HoltzmanD.M. Bidirectional relationship between sleep and Alzheimer’s disease: Role of amyloid, tau, and other factors.Neuropsychopharmacology202045110412010.1038/s41386‑019‑0478‑531408876
     [Google Scholar]
  19. RoennebergT. MerrowM. The circadian clock and human health.Curr. Biol.20162610R432R44310.1016/j.cub.2016.04.01127218855
     [Google Scholar]
  20. MedicG. WilleM. HemelsM. Short- and long-term health consequences of sleep disruption.Nat. Sci. Sleep2017915116110.2147/NSS.S13486428579842
     [Google Scholar]
  21. MeerloP. SgoifoA. SucheckiD. Restricted and disrupted sleep: Effects on autonomic function, neuroendocrine stress systems and stress responsivity.Sleep Med. Rev.200812319721010.1016/j.smrv.2007.07.00718222099
     [Google Scholar]
  22. IrwinM. ThompsonJ. MillerC. GillinJ.C. ZieglerM. Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: Clinical implications.J. Clin. Endocrinol. Metab.19998461979198510.1210/jc.84.6.197910372697
     [Google Scholar]
  23. EkstedtM. ÅkerstedtT. SöderströmM. Microarousals during sleep are associated with increased levels of lipids, cortisol, and blood pressure.Psychosom. Med.200466692593110.1097/01.psy.0000145821.25453.f715564359
     [Google Scholar]
  24. SadehA. GruberR. RavivA. Sleep, neurobehavioral functioning, and behavior problems in school-age children.Child Dev.200273240541710.1111/1467‑8624.0041411949899
     [Google Scholar]
  25. PhillipsB. ManninoD.M. Do insomnia complaints cause hypertension or cardiovascular disease?J. Clin. Sleep Med.20073548949410.5664/jcsm.2691317803012
     [Google Scholar]
  26. NarangI. ManlhiotC. Davies-ShawJ. GibsonD. ChahalN. StearneK. FisherA. DobbinS. McCrindleB.W. Sleep disturbance and cardiovascular risk in adolescents.CMAJ201218417E913E92010.1503/cmaj.11158923027917
     [Google Scholar]
  27. MeisingerC. HeierM. LöwelH. SchneiderA. DöringA. Sleep duration and sleep complaints and risk of myocardial infarction in middle-aged men and women from the general population: The MONICA/KORA Augsburg cohort study.Sleep20073091121112710.1093/sleep/30.9.112117910384
     [Google Scholar]
  28. AliT. ChoeJ. AwabA. WagenerT.L. OrrW.C. Sleep, immunity and inflammation in gastrointestinal disorders.World J. Gastroenterol.201319489231923910.3748/wjg.v19.i48.923124409051
     [Google Scholar]
  29. SigurdardottirL.G. ValdimarsdottirU.A. MucciL.A. FallK. RiderJ.R. SchernhammerE. CzeislerC.A. LaunerL. HarrisT. StampferM.J. GudnasonV. LockleyS.W. Sleep disruption among older men and risk of prostate cancer.Cancer Epidemiol. Biomarkers Prev.201322587287910.1158/1055‑9965.EPI‑12‑1227‑T23652374
     [Google Scholar]
  30. SchernhammerE.S. LadenF. SpeizerF.E. WillettW.C. HunterD.J. KawachiI. FuchsC.S. ColditzG.A. Night-shift work and risk of colorectal cancer in the nurses’ health study.J. Natl. Cancer Inst.2003951182582810.1093/jnci/95.11.82512783938
     [Google Scholar]
  31. FilipskiE. KingV.M. LiX. GrandaT.G. MormontM.C. ClaustratB. HastingsM.H. LéviF. Disruption of circadian coordination accelerates malignant growth in mice.Pathol. Biol.200351421621910.1016/S0369‑8114(03)00034‑812852994
     [Google Scholar]
  32. CookeJ.R. Ancoli-IsraelS. Normal and abnormal sleep in the elderly.Handb. Clin. Neurol.20119865366510.1016/B978‑0‑444‑52006‑7.00041‑121056216
     [Google Scholar]
  33. BlackwellT. YaffeK. Ancoli-IsraelS. SchneiderJ.L. CauleyJ.A. HillierT.A. FinkH.A. StoneK.L. Study of Osteoporotic Fractures Group Poor sleep is associated with impaired cognitive function in older women: The study of osteoporotic fractures.J. Gerontol. A Biol. Sci. Med. Sci.200661440541010.1093/gerona/61.4.40516611709
     [Google Scholar]
  34. OhayonM.M. VecchieriniM.F. Normative sleep data, cognitive function and daily living activities in older adults in the community.Sleep200528898198916218081
     [Google Scholar]
  35. DamT.T. EwingS. Ancoli-IsraelS. EnsrudK. RedlineS. StoneK. Osteoporotic Fractures in Men Research Group Association between sleep and physical function in older men: The MrOS sleep study.J. Am. Geriatr. Soc.20085691665167310.1111/j.1532‑5415.2008.01846.x18759758
     [Google Scholar]
  36. StoneK.L. EwingS.K. LuiL.Y. EnsrudK.E. Ancoli-IsraelS. BauerD.C. CauleyJ.A. HillierT.A. CummingsS.R. Self-reported sleep and nap habits and risk of falls and fractures in older women: The study of osteoporotic fractures.J. Am. Geriatr. Soc.20065481177118310.1111/j.1532‑5415.2006.00818.x16913982
     [Google Scholar]
  37. JoffeH. ChangY. DhaliwalS. HessR. ThurstonR. GoldE. MatthewsK.A. BrombergerJ.T. Lifetime history of depression and anxiety disorders as a predictor of quality of life in midlife women in the absence of current illness episodes.Arch. Gen. Psychiatry201269548449210.1001/archgenpsychiatry.2011.157822566580
     [Google Scholar]
  38. FeeleyC.A. Turner-HensonA. ChristianB.J. AvisK.T. HeatonK. LozanoD. SuX. Sleep quality, stress, caregiver burden, and quality of life in maternal caregivers of young children with Bronchopulmonary dysplasia.J. Pediatr. Nurs.2014291293810.1016/j.pedn.2013.08.00123999065
     [Google Scholar]
  39. McCoyJ.G. StreckerR.E. The cognitive cost of sleep lost.Neurobiol. Learn. Mem.201196456458210.1016/j.nlm.2011.07.00421875679
     [Google Scholar]
  40. GroegerJ.A. StanleyN. DeaconS. DijkD.J. Dissociating effects of global SWS disruption and healthy aging on waking performance and daytime sleepiness.Sleep20143761127114210.5665/sleep.377624882908
     [Google Scholar]
  41. TempestaD. De GennaroL. NataleV. FerraraM. Emotional memory processing is influenced by sleep quality.Sleep Med.201516786287010.1016/j.sleep.2015.01.02426008959
     [Google Scholar]
  42. ShochatT. Cohen-ZionM. TzischinskyO. Functional consequences of inadequate sleep in adolescents: A systematic review.Sleep Med. Rev.2014181758710.1016/j.smrv.2013.03.00523806891
     [Google Scholar]
  43. ChungK.F. CheungM.M. Sleep-wake patterns and sleep disturbance among Hong Kong Chinese adolescents.Sleep200831218519410.1093/sleep/31.2.18518274265
     [Google Scholar]
  44. MakK.K. HoS.Y. ThomasG.N. LoW.S. CheukD.K.L. LaiY.K. LamT.H. Smoking and sleep disorders in Chinese adolescents.Sleep Med.201011326827310.1016/j.sleep.2009.07.01720176504
     [Google Scholar]
  45. PérezA. RobertsR.E. SandersonM. ReiningerB. Aguirre-FloresM.I. Disturbed sleep among adolescents living in 2 communities on the Texas-Mexico border, 2000-2003.Prev. Chronic Dis.201072A4020158968
     [Google Scholar]
  46. UmlaufM.G. BollandJ.M. LianB.E. Sleep disturbance and risk behaviors among inner-city African-American adolescents.J. Urban Health20118861130114210.1007/s11524‑011‑9591‑421638116
     [Google Scholar]
  47. MoriokaH. ItaniO. KaneitaY. IkedaM. KondoS. YamamotoR. OsakiY. KandaH. HiguchiS. OhidaT. Associations between sleep disturbance and alcohol drinking: A large-scale epidemiological study of adolescents in Japan.Alcohol201347861962810.1016/j.alcohol.2013.09.04124188738
     [Google Scholar]
  48. PaavonenE.J. Porkka-HeiskanenT. LahikainenA.R. Sleep quality, duration and behavioral symptoms among 5–6-year-old children.Eur. Child Adolesc. Psychiatry2009181274775410.1007/s00787‑009‑0033‑819466475
     [Google Scholar]
  49. SingareddyR. KrishnamurthyV.B. VgontzasA.N. Fernandez-MendozaJ. CalhounS.L. ShafferM.L. BixlerE.O. Subjective and objective sleep and self-harm behaviors in young children: A general population study.Psychiatry Res.2013209354955310.1016/j.psychres.2013.03.03623623452
     [Google Scholar]
  50. DavisK.F. ParkerK.P. MontgomeryG.L. Sleep in infants and young children.J. Pediatr. Health Care2004182657110.1016/S0891‑5245(03)00149‑415007289
     [Google Scholar]
  51. MirmiranM. BaldwinR.B. AriagnoR.L. Circadian and sleep development in preterm infants occurs independently from the influences of environmental lighting.Pediatr. Res.200353693393810.1203/01.PDR.0000061541.94620.1212621096
     [Google Scholar]
  52. AdamsS.M. JonesD.R. EsmailA. MitchellE.A. What affects the age of first sleeping through the night?J. Paediatr. Child Health20044039610110.1111/j.1440‑1754.2004.00317.x15009572
     [Google Scholar]
  53. GallandB.C. TaylorB.J. ElderD.E. HerbisonP. Normal sleep patterns in infants and children: A systematic review of observational studies.Sleep Med. Rev.201216321322210.1016/j.smrv.2011.06.00121784676
     [Google Scholar]
  54. SadehA. MindellJ.A. LuedtkeK. WiegandB. Sleep and sleep ecology in the first 3 years: A web-based study.J. Sleep Res.2009181607310.1111/j.1365‑2869.2008.00699.x19021850
     [Google Scholar]
  55. ThamE. SchneiderN. BroekmanB. Infant sleep and its relation with cognition and growth: A narrative review.Nat. Sci. Sleep2017913514910.2147/NSS.S12599228553151
     [Google Scholar]
  56. YoungT. PeppardP.E. GottliebD.J. Epidemiology of obstructive sleep apnea: A population health perspective.Am. J. Respir. Crit. Care Med.200216591217123910.1164/rccm.210908011991871
     [Google Scholar]
  57. KwonY. TzengW.S. SeoJ. LoganJ.G. TadicM. LinG.M. Martinez-GarciaM.A. PengoM. LiuX. ChoY. DragerL.F. HealyW. HongG.R. Obstructive sleep apnea and hypertension; Critical overview.Clin. Hypertens.20243011910.1186/s40885‑024‑00276‑739090691
     [Google Scholar]
  58. CalhounD.A. JonesD. TextorS. GoffD.C. MurphyT.P. TotoR.D. WhiteA. CushmanW.C. WhiteW. SicaD. FerdinandK. GilesT.D. FalknerB. CareyR.M. American Heart Association Professional Education Committee Resistant hypertension: Diagnosis, evaluation, and treatment.Circulation200811725e510e52610.1161/CIRCULATIONAHA.108.18914118574054
     [Google Scholar]
  59. CarlsonJ.T. HednerJ. ElamM. EjnellH. SellgrenJ. WallinB.G. Augmented resting sympathetic activity in awake patients with obstructive sleep apnea.Chest199310361763176810.1378/chest.103.6.17638404098
     [Google Scholar]
  60. ShaharE. WhitneyC.W. RedlineS. LeeE.T. NewmanA.B. Javier NietoF. O’ConnorG.T. BolandL.L. SchwartzJ. SametJ.M. Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study.Am. J. Respir. Crit. Care Med.20011631192510.1164/ajrccm.163.1.200100811208620
     [Google Scholar]
  61. DiCaroM.V. LeiK. YeeB. TakT. The effects of obstructive sleep apnea on the cardiovascular system: A comprehensive review.J. Clin. Med.20241311322310.3390/jcm1311322338892933
     [Google Scholar]
  62. SomersV.K. DykenM.E. ClaryM.P. AbboudF.M. Sympathetic neural mechanisms in obstructive sleep apnea.J. Clin. Invest.19959641897190410.1172/JCI1182357560081
     [Google Scholar]
  63. OnatA. CeyhanK. BaşarÖ. ErerB. ToprakS. SansoyV. Metabolic syndrome: Major impact on coronary risk in a population with low cholesterol levels—a prospective and cross-sectional evaluation.Atherosclerosis2002165228529210.1016/S0021‑9150(02)00236‑812417279
     [Google Scholar]
  64. MarinJ.M. CarrizoS.J. VicenteE. AgustiA.G.N. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study.Lancet200536594641046105310.1016/S0140‑6736(05)71141‑715781100
     [Google Scholar]
  65. IpM.S.M. TseH.F. LamB. TsangK.W.T. LamW.K. Endothelial function in obstructive sleep apnea and response to treatment.Am. J. Respir. Crit. Care Med.2004169334835310.1164/rccm.200306‑767OC14551167
     [Google Scholar]
  66. Martínez-GarcíaM.Á. OsculloG. Garcia-OrtegaA. Gómez-OlivasJ.D. BeauperthuyT. OSA and ischemic heart disease in the elderly.Curr. Sleep Med. Rep.20217310511110.1007/s40675‑021‑00208‑z
     [Google Scholar]
  67. YaggiH.K. ConcatoJ. KernanW.N. LichtmanJ.H. BrassL.M. MohseninV. Obstructive sleep apnea as a risk factor for stroke and death.N. Engl. J. Med.2005353192034204110.1056/NEJMoa04310416282178
     [Google Scholar]
  68. KimuraK. YamashitaS. ShibazakiK. Cardioembolic stroke associated with atrial fibrillation.Rinsho Shinkeigaku2013531198999110.5692/clinicalneurol.53.98924291855
     [Google Scholar]
  69. MohamedB. YarlagaddaK. SelfZ. SimonA. RigueiroF. SohooliM. EisenschenkS. DoréS. Obstructive sleep apnea and stroke: Determining the mechanisms behind their association and treatment options.Transl. Stroke Res.202415223933210.1007/s12975‑023‑01123‑x36922470
     [Google Scholar]
  70. RedlineS. YenokyanG. GottliebD.J. ShaharE. O’ConnorG.T. ResnickH.E. Diener-WestM. SandersM.H. WolfP.A. GeraghtyE.M. AliT. LebowitzM. PunjabiN.M. Obstructive sleep apnea-hypopnea and incident stroke: The sleep heart health study.Am. J. Respir. Crit. Care Med.2010182226927710.1164/rccm.200911‑1746OC20339144
     [Google Scholar]
  71. DavisA.P. BillingsM.E. LongstrethW.T.Jr KhotS.P. Early diagnosis and treatment of obstructive sleep apnea after stroke.Neurol. Clin. Pract.20133319220110.1212/CPJ.0b013e318296f27423914326
     [Google Scholar]
  72. BassettiC. AldrichM.S. MichaelS. Sleep apnea in acute cerebrovascular diseases: Final report on 128 patients.Sleep199922221722310.1093/sleep/22.2.21710201066
     [Google Scholar]
  73. JavaheriS. Sleep disorders in systolic heart failure: A prospective study of 100 male patients. The final report.Int. J. Cardiol.20061061212810.1016/j.ijcard.2004.12.06816321661
     [Google Scholar]
  74. BriscoM.A. GoldbergL.R. Sleep apnea in congestive heart failure.Curr. Heart Fail. Rep.20107417518410.1007/s11897‑010‑0033‑520953852
     [Google Scholar]
  75. OldenburgO. LampB. FaberL. TeschlerH. HorstkotteD. TöpferV. Sleep-disordered breathing in patients with symptomatic heart failure A contemporary study of prevalence in and characteristics of 700 patients.Eur. J. Heart Fail.20079325125710.1016/j.ejheart.2006.08.00317027333
     [Google Scholar]
  76. BradleyT.D. LoganA.G. KimoffR.J. SérièsF. MorrisonD. FergusonK. BelenkieI. PfeiferM. FleethamJ. HanlyP. SmilovitchM. TomlinsonG. FlorasJ.S. CANPAP Investigators Continuous positive airway pressure for central sleep apnea and heart failure.N. Engl. J. Med.2005353192025203310.1056/NEJMoa05100116282177
     [Google Scholar]
  77. GamiA.S. HowardD.E. OlsonE.J. SomersV.K. Day-night pattern of sudden death in obstructive sleep apnea.N. Engl. J. Med.2005352121206121410.1056/NEJMoa04183215788497
     [Google Scholar]
  78. LaczayB. FaulxM.D. Obstructive sleep apnea and cardiac arrhythmias: A contemporary review.J. Clin. Med.20211017378510.3390/jcm1017378534501232
     [Google Scholar]
  79. MonahanK. Storfer-IsserA. MehraR. ShaharE. MittlemanM. RottmanJ. PunjabiN. SandersM. QuanS.F. ResnickH. RedlineS. Triggering of nocturnal arrhythmias by sleep-disordered breathing events.J. Am. Coll. Cardiol.200954191797180410.1016/j.jacc.2009.06.03819874994
     [Google Scholar]
  80. GamiA.S. PressmanG. CaplesS.M. KanagalaR. GardJ.J. DavisonD.E. MaloufJ.F. AmmashN.M. FriedmanP.A. SomersV.K. Association of atrial fibrillation and obstructive sleep apnea.Circulation2004110436436710.1161/01.CIR.0000136587.68725.8E15249509
     [Google Scholar]
  81. TaheriS. LinL. AustinD. YoungT. MignotE. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.PLoS Med.200413e6210.1371/journal.pmed.001006215602591
     [Google Scholar]
  82. SpiegelK. TasaliE. PenevP. CauterE.V. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.Ann. Intern. Med.20041411184685010.7326/0003‑4819‑141‑11‑200412070‑0000815583226
     [Google Scholar]
  83. MeyerE.J. WittertG.A. Approach the patient with obstructive sleep apnea and obesity.J. Clin. Endocrinol. Metab.20241093e1267e127910.1210/clinem/dgad57237758218
     [Google Scholar]
  84. MullingtonJ.M. ChanJ.L. Van DongenH.P.A. SzubaM.P. SamarasJ. PriceN.J. Meier-EwertH.K. DingesD.F. MantzorosC.S. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men.J. Neuroendocrinol.200315985185410.1046/j.1365‑2826.2003.01069.x12899679
     [Google Scholar]
  85. SpiegelK. LeproultR. Van CauterE. Impact of sleep debt on metabolic and endocrine function.Lancet199935491881435143910.1016/S0140‑6736(99)01376‑810543671
     [Google Scholar]
  86. HarschI.A. SchahinS.P. Radespiel-TrögerM. WeintzO. JahreißH. FuchsF.S. WiestG.H. HahnE.G. LohmannT. KonturekP.C. FickerJ.H. Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome.Am. J. Respir. Crit. Care Med.2004169215616210.1164/rccm.200302‑206OC14512265
     [Google Scholar]
  87. AlbertiK.G.M.M. EckelR.H. GrundyS.M. ZimmetP.Z. CleemanJ.I. DonatoK.A. FruchartJ.C. JamesW.P.T. LoriaC.M. SmithS.C.Jr. International Diabetes Federation Task Force on Epidemiology and Prevention Hational Heart, Lung, and Blood Institute American Heart Association World Heart Federation International Atherosclerosis Society International Association for the Study of Obesity Harmonizing the metabolic syndrome.Circulation2009120161640164510.1161/CIRCULATIONAHA.109.19264419805654
     [Google Scholar]
  88. XuH. LiX. AdamsH. KubenaK. GuoS. Etiology of metabolic syndrome and dietary intervention.Int. J. Mol. Sci.201820112810.3390/ijms2001012830602666
     [Google Scholar]
  89. SaklayenM.G. The global epidemic of the metabolic syndrome.Curr. Hypertens. Rep.20182021210.1007/s11906‑018‑0812‑z29480368
     [Google Scholar]
  90. AfshinA. ForouzanfarM.H. ReitsmaM.B. SurP. EstepK. LeeA. MarczakL. MokdadA.H. Moradi-LakehM. NaghaviM. SalamaJ.S. VosT. AbateK.H. AbbafatiC. AhmedM.B. Al-AlyZ. AlkerwiA. Al-RaddadiR. AmareA.T. AmberbirA. AmegahA.K. AminiE. AmrockS.M. AnjanaR.M. ÄrnlövJ. AsayeshH. BanerjeeA. BaracA. BayeE. BennettD.A. BeyeneA.S. BiadgilignS. BiryukovS. BjertnessE. BoneyaD.J. Campos-NonatoI. CarreroJ.J. CecilioP. CercyK. CiobanuL.G. CornabyL. DamtewS.A. DandonaL. DandonaR. DharmaratneS.D. DuncanB.B. EshratiB. EsteghamatiA. FeiginV.L. FernandesJ.C. FürstT. GebrehiwotT.T. GoldA. GonaP.N. GotoA. HabtewoldT.D. HadushK.T. Hafezi-NejadN. HayS.I. HorinoM. IslamiF. KamalR. KasaeianA. KatikireddiS.V. KengneA.P. KesavachandranC.N. KhaderY.S. KhangY.H. KhubchandaniJ. KimD. KimY.J. KinfuY. KosenS. KuT. DefoB.K. KumarG.A. LarsonH.J. LeinsaluM. LiangX. LimS.S. LiuP. LopezA.D. LozanoR. MajeedA. MalekzadehR. MaltaD.C. MazidiM. McAlindenC. McGarveyS.T. MengistuD.T. MensahG.A. MensinkG.B.M. MezgebeH.B. MirrakhimovE.M. MuellerU.O. NoubiapJ.J. ObermeyerC.M. OgboF.A. OwolabiM.O. PattonG.C. PourmalekF. QorbaniM. RafayA. RaiR.K. RanabhatC.L. ReinigN. SafiriS. SalomonJ.A. SanabriaJ.R. SantosI.S. SartoriusB. SawhneyM. SchmidhuberJ. SchutteA.E. SchmidtM.I. SepanlouS.G. ShamsizadehM. SheikhbahaeiS. ShinM.J. ShiriR. ShiueI. RobaH.S. SilvaD.A.S. SilverbergJ.I. SinghJ.A. StrangesS. SwaminathanS. Tabarés-SeisdedosR. TadeseF. TedlaB.A. TegegneB.S. TerkawiA.S. ThakurJ.S. TonelliM. Topor-MadryR. TyrovolasS. UkwajaK.N. UthmanO.A. VaezghasemiM. VasankariT. VlassovV.V. VollsetS.E. WeiderpassE. WerdeckerA. WesanaJ. WestermanR. YanoY. YonemotoN. YongaG. ZaidiZ. ZenebeZ.M. ZipkinB. MurrayC.J.L. GBD 2015 Obesity Collaborators Health effects of overweight and obesity in 195 countries over 25 years.N. Engl. J. Med.20173771132710.1056/NEJMoa161436228604169
     [Google Scholar]
  91. WangY. MiJ. ShanX. WangQ.J. GeK. Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China.Int. J. Obes.200731117718810.1038/sj.ijo.080335416652128
     [Google Scholar]
  92. SliemH. AhmedS. NemrN. El-SherifI. Metabolic syndrome in the Middle East.Indian J. Endocrinol. Metab.2012161677110.4103/2230‑8210.9119322276254
     [Google Scholar]
  93. Al-RiyamiA.A. AfifiM.M. Prevalence and correlates of obesity and central obesity among Omani adults.Saudi Med. J.200324664164612847595
     [Google Scholar]
  94. RiedigerN.D. ClaraI. Prevalence of metabolic syndrome in the Canadian adult population.CMAJ201118315E1127E113410.1503/cmaj.110070
     [Google Scholar]
  95. AguilarM. BhuketT. TorresS. LiuB. WongR.J. Prevalence of the metabolic syndrome in the United States, 2003-2012.JAMA2015313191973197410.1001/jama.2015.426025988468
     [Google Scholar]
  96. Aguilar-SalinasC.A. RojasR. Gómez-PérezF.J. VallesV. Ríos-TorresJ.M. FrancoA. OlaizG. RullJ.A. SepúlvedaJ. High prevalence of metabolic syndrome in Mexico.Arch. Med. Res.2004351768110.1016/j.arcmed.2003.06.00615036804
     [Google Scholar]
  97. VernayM. SalanaveB. de PerettiC. DruetC. MalonA. DeschampsV. HercbergS. CastetbonK. Metabolic syndrome and socioeconomic status in France: The french nutrition and health survey (ENNS, 2006–2007).Int. J. Public Health201358685586410.1007/s00038‑013‑0501‑223999626
     [Google Scholar]
  98. MoebusS. HanischJ. BramlageP. LöschC. HaunerH. WasemJ. JöckelK.H. Regional differences in the prevalence of the metabolic syndrome in primary care practices in Germany.Dtsch. Arztebl. Int.20081051220721310.3238/artzebl.2008.020719629210
     [Google Scholar]
  99. MiccoliR. BianchiC. OdoguardiL. PennoG. CaricatoF. GiovannittiM.G. PucciL. Del PratoS. Prevalence of the metabolic syndrome among Italian adults according to ATP III definition.Nutr. Metab. Cardiovasc. Dis.200515425025410.1016/j.numecd.2004.09.00216054548
     [Google Scholar]
  100. AthyrosV.G. BouloukosV.I. PehlivanidisA.N. PapageorgiouA.A. DionysopoulouS.G. SymeonidisA.N. PetridisD.I. KapousouziM.I. SatsoglouE.A. MikhailidisD.P. MetS-Greece Collaborative Group The prevalence of the metabolic syndrome in Greece: The MetS-Greece multicentre study.Diabetes Obes. Metab.20057439740510.1111/j.1463‑1326.2004.00409.x15955126
     [Google Scholar]
  101. MetelskayaV.A. ShkolnikovaM.A. ShalnovaS.A. AndreevE.M. DeevA.D. JdanovD.A. ShkolnikovV.M. VaupelJ.W. Prevalence, components, and correlates of metabolic syndrome (MetS) among elderly Muscovites.Arch. Gerontol. Geriatr.201255223123710.1016/j.archger.2011.09.00521955584
     [Google Scholar]
  102. Abd ElazizK.M. GabalM.S. AldafrawyO.A. Abou SeifH.A.A. AllamM.F. Prevalence of metabolic syndrome and cardiovascular risk factors among voluntary screened middle-aged and elderly Egyptians.J. Public Health2014374fdu09710.1093/pubmed/fdu09725503580
     [Google Scholar]
  103. OwolabiEO Ter GoonD AdeniyiOV AdedokunAO SeekoeE Prevalence and correlates of metabolic syndrome among adults attending healthcare facilities in Eastern Cape, South Africa.Open Public Health J.20171014815910.2174/1874944501710010148
     [Google Scholar]
  104. Al-RubeaanK. BawazeerN. Al FarsiY. YoussefA.M. Al-YahyaA.A. AlQumaidiH. Al-MalkiB.M. NajiK.A. Al-ShehriK. Al RumaihF.I. Prevalence of metabolic syndrome in Saudi Arabia - A cross sectional study.BMC Endocr. Disord.2018181161610.1186/s12902‑018‑0244‑429506520
     [Google Scholar]
  105. PengpidS. PeltzerK. Prevalence and associated factors of metabolic syndrome among a national population-based sample of 18–108-year-olds in Iraq: Results of the 2015 STEPS survey.Int. J. Diabetes Dev. Ctries.202141342743410.1007/s13410‑020‑00912‑6
     [Google Scholar]
  106. Al-LawatiJ.A. MohammedA.J. Al-HinaiH.Q. JousilahtiP. Prevalence of the metabolic syndrome among Omani adults.Diabetes Care20032661781178510.2337/diacare.26.6.178112766109
     [Google Scholar]
  107. MahmoudI. SulaimanN. Prevalence of metabolic syndrome and associated risk factors in the United Arab Emirates: A cross-sectional population-based study.Front. Public Health2022981100610.3389/fpubh.2021.81100635141192
     [Google Scholar]
  108. Al-ThaniM.H. Al-ThaniA.A.M. CheemaS. SheikhJ. MamtaniR. LowenfelsA.B. Al-ChetachiW.F. AlmalkiB.A. Hassan KhalifaS.A. Haj BakriA.O. MaisonneuveP. Prevalence and determinants of metabolic syndrome in Qatar: results from a National Health Survey.BMJ Open201669e00951410.1136/bmjopen‑2015‑00951427601485
     [Google Scholar]
  109. AliN.S. KhuwajaA.K. Adnan-ur-Rahman NanjiK. Retrospective analysis of metabolic syndrome: Prevalence and distribution in executive population in urban pakistan.Int. J. Family Med.201220121810.1155/2012/64938322988504
     [Google Scholar]
  110. BansalS. PaliwalA. VermaV. ChauhanJ. A study on prevalence of metabolic syndrome in general population in Western Uttar Pradesh, India.Int. J. Res. Med. Sci.201756264110.18203/2320‑6012.ijrms20172462
     [Google Scholar]
  111. MainuddinA. ChoudhuryK. AhmedK. AkterS. IslamN. The metabolic syndrome: Comparison of newly proposed IDF, modified ATP III and WHO criteria and their agreements.Cardiovasc J.201361172210.3329/cardio.v6i1.16110
     [Google Scholar]
  112. AekplakornW. ChongsuvivatwongV. TatsanavivatP. SuriyawongpaisalP. Prevalence of metabolic syndrome defined by the international diabetes federation and national cholesterol education program criteria among Thai adults.Asia Pac. J. Public Health201123579280010.1177/101053951142448221984495
     [Google Scholar]
  113. ZainuddinL.R. IsaN. MudaW.M. MohamedH.J. The prevalence of metabolic syndrome according to various definitions and hypertriglyceridemic-waist in malaysian adults.Int. J. Prev. Med.20112422923722174962
     [Google Scholar]
  114. GuD. ReynoldsK. WuX. ChenJ. DuanX. ReynoldsR.F. WheltonP.K. HeJ. InterASIA Collaborative Group Prevalence of the metabolic syndrome and overweight among adults in China.Lancet200536594681398140510.1016/S0140‑6736(05)66375‑115836888
     [Google Scholar]
  115. ParkH.S. ParkC.Y. OhS.W. YooH.J. Prevalence of obesity and metabolic syndrome in Korean adults.Obes. Rev.20089210410710.1111/j.1467‑789X.2007.00421.x17986177
     [Google Scholar]
  116. HidakaT. HayakawaT. KakamuT. KumagaiT. HirutaY. HataJ. TsujiM. FukushimaT. Prevalence of metabolic syndrome and its components among Japanese workers by clustered business category.PLoS One2016114e015336810.1371/journal.pone.015336827082961
     [Google Scholar]
  117. CameronA.J. MaglianoD.J. ZimmetP.Z. WelbornT. ShawJ.E. The metabolic syndrome in Australia: Prevalence using four definitions.Diabetes Res. Clin. Pract.200777347147810.1016/j.diabres.2007.02.00217350710
     [Google Scholar]
  118. KareemO. TanvirM. BaderG.N. Obstructive sleep apnea and metabolic syndrome.Sleep Vigil.202261859910.1007/s41782‑022‑00204‑5
     [Google Scholar]
  119. VgontzasA.N. LegroR.S. BixlerE.O. GrayevA. KalesA. ChrousosG.P. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: Role of insulin resistance.J. Clin. Endocrinol. Metab.200186251752010.1210/jcem.86.2.718511158002
     [Google Scholar]
  120. TasaliE. Van CauterE. EhrmannD.A. EhrmannD.A. Polycystic ovary syndrome and obstructive sleep apnea.Sleep Med. Clin.200831374610.1016/j.jsmc.2007.11.00119255602
     [Google Scholar]
  121. ZhaoJ. ChenQ. XueX. Relationship between sleep disorders and female infertility among US reproductive-aged women.Sleep Breath.20232751875188210.1007/s11325‑023‑02802‑736877353
     [Google Scholar]
  122. FogelR.B. MalhotraA. PillarG. PittmanS.D. DunaifA. WhiteD.P. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.J. Clin. Endocrinol. Metab.20018631175118010.1210/jc.86.3.117511238505
     [Google Scholar]
  123. GohilA. EugsterE. Growth hormone deficiency and excessive sleepiness: A case report and review of the literature.Pediatr. Endocrinol. Rev.2019171414610.17458/per.vol17.2019.ge31599135
     [Google Scholar]
  124. HayashiM. ShimohiraM. SaishoS. ShimozawaK. IwakawaY. Sleep disturbance in children with growth hormone deficiency.Brain Dev.199214317017410.1016/S0387‑7604(12)80259‑21445594
     [Google Scholar]
  125. Lo BueA. SalvaggioA. InsalacoG. Obstructive sleep apnea in developmental age. A narrative review.Eur. J. Pediatr.2020179335736510.1007/s00431‑019‑03557‑831940071
     [Google Scholar]
  126. BonuckK.A. FreemanK. HendersonJ. Growth and growth biomarker changes after adenotonsillectomy: Systematic review and meta-analysis.Arch. Dis. Child.2008942839110.1136/adc.2008.14119218684748
     [Google Scholar]
  127. GozalD. WangM. PopeD.W.Jr. Objective sleepiness measures in pediatric obstructive sleep apnea.Pediatrics2001108369369710.1542/peds.108.3.69311533338
     [Google Scholar]
  128. PekerY. KraicziH. HednerJ. LöthS. JohanssonÅ. BendeM. An independent association between obstructive sleep apnoea and coronary artery disease.Eur. Respir. J.199914117918410.1034/j.1399‑3003.1999.14a30.x10489848
     [Google Scholar]
  129. FletcherE.C. DeBehnkeR.D. LovoiM.S. GorinA.B. Undiagnosed sleep apnea in patients with essential hypertension.Ann. Intern. Med.1985103219019510.7326/0003‑4819‑103‑2‑1904014900
     [Google Scholar]
  130. SharmaB. McSharryD. MalhotraA. Sleep disordered breathing in patients with heart failure: Pathophysiology and management.Curr. Treat. Options Cardiovasc. Med.201113650651610.1007/s11936‑011‑0145‑621894522
     [Google Scholar]
  131. LvR. LiuX. ZhangY. DongN. WangX. HeY. YueH. YinQ. Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome.Signal Transduct. Target. Ther.20238121810.1038/s41392‑023‑01496‑337230968
     [Google Scholar]
  132. SchizaS. SchwarzE.I. BonsignoreM.R. McNicholasW.T. PatakaA. BouloukakiI. Co-existence of OSA and respiratory diseases and the influence of gender.Expert Rev. Respir. Med.202317121221123510.1080/17476348.2024.230406538198636
     [Google Scholar]
  133. InoueD. Obstructive sleep apnea syndrome(OSAS)and bone.Clin. Calcium201626101399140627666686
     [Google Scholar]
  134. VitaleK.C. OwensR. HopkinsS.R. MalhotraA. Sleep hygiene for optimizing recovery in athletes: Review and recommendations.Int. J. Sports Med.201940853554310.1055/a‑0905‑310331288293
     [Google Scholar]
  135. KurinM. ShibliF. KitayamaY. KimY. FassR. Sorting out the relationship between gastroesophageal reflux disease and sleep.Curr. Gastroenterol. Rep.20212391510.1007/s11894‑021‑00815‑434338891
     [Google Scholar]
  136. TarquiniB. CecchettinM. CariddiA. Serum gastrin and pepsinogen in shift workers.Int. Arch. Occup. Environ. Health19865829910310.1007/BF003807603744572
     [Google Scholar]
  137. AlghamdiA.A. AlghamdiA.M. AlshareefM.A. AlGhamdiA.A. AlghamdiR.A. AlAmriA.A. AlzahraniG.T. Assessment of sleep quality among adolescents and adults with self-diagnosed irritable bowel syndrome, in Jeddah, Saudi Arabia.Cureus2023157e4277810.7759/cureus.4277837663979
     [Google Scholar]
  138. GombertM. Carrasco-LunaJ. Pin-ArboledasG. Codoñer-FranchP. The connection of circadian rhythm to inflammatory bowel disease.Transl. Res.201920610711810.1016/j.trsl.2018.12.00130615844
     [Google Scholar]
  139. MesarwiO.A. LoombaR. MalhotraA. Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease.Am. J. Respir. Crit. Care Med.2019199783084110.1164/rccm.201806‑1109TR30422676
     [Google Scholar]
  140. RasmussenM.K. MestreH. NedergaardM. The glymphatic pathway in neurological disorders.Lancet Neurol.201817111016102410.1016/S1474‑4422(18)30318‑130353860
     [Google Scholar]
  141. LysenT.S. DarweeshS.K.L. IkramM.K. LuikA.I. IkramM.A. Sleep and risk of parkinsonism and Parkinson’s disease: A population-based study.Brain201914272013202210.1093/brain/awz11331038176
     [Google Scholar]
  142. BraleyT.J. BoudreauE.A. Sleep disorders in multiple sclerosis.Curr. Neurol. Neurosci. Rep.2016165505010.1007/s11910‑016‑0649‑227068547
     [Google Scholar]
  143. McDermottM. BrownD.L. ChervinR.D. Sleep disorders and the risk of stroke.Expert Rev. Neurother.201818752353110.1080/14737175.2018.148923929902391
     [Google Scholar]
  144. St LouisE.K. Sleep and epilepsy: Strange bedfellows no more.Minerva Pneumol.201150315917623539488
     [Google Scholar]
  145. RaymondK. ChenW.H. BracherM. FosterA. LovleyA. SaucierC. JacksonK. McDermottE.J. A concept elicitation study to understand the relationship between sleep and pain in rheumatoid arthritis and axial spondyloarthritis.Qual. Life Res.202433237338510.1007/s11136‑023‑03524‑937889386
     [Google Scholar]
  146. ChoiM.Y. MalspeisS. SparksJ.A. CuiJ. YoshidaK. CostenbaderK.H. Association of sleep deprivation and the risk of developing systemic lupus erythematosus among women.Arthritis Care Res.20237561206121210.1002/acr.2501736094865
     [Google Scholar]
  147. PoggiogalleE. JamshedH. PetersonC.M. Circadian regulation of glucose, lipid, and energy metabolism in humans.Metabolism201884112710.1016/j.metabol.2017.11.01729195759
     [Google Scholar]
  148. AliT. Sleep and inflammatory bowel disease.Gastroenterol. Hepatol.2014101174875128435412
     [Google Scholar]
  149. RaultC. SangaréA. DiazV. RagotS. FratJ.P. RauxM. SimilowskiT. RobertR. ThilleA.W. DrouotX. Impact of sleep deprivation on respiratory motor output and endurance. A physiological study.Am. J. Respir. Crit. Care Med.2020201897698310.1164/rccm.201904‑0819OC31810378
     [Google Scholar]
  150. JacksonC. StewartI.D. PlekhanovaT. CunninghamP.S. HazelA.L. Al-ShekllyB. AulR. BoltonC.E. ChalderT. ChalmersJ.D. ChaudhuriN. DochertyA.B. DonaldsonG. EdwardsonC.L. ElneimaO. GreeningN.J. HanleyN.A. HarrisV.C. HarrisonE.M. HoL.P. Houchen-WolloffL. HowardL.S. JolleyC.J. JonesM.G. LeavyO.C. LewisK.E. LoneN.I. MarksM. McAuleyH.J.C. McNarryM.A. PatelB.V. Piper-HanleyK. PoinasamyK. RamanB. RichardsonM. Rivera-OrtegaP. Rowland-JonesS.L. RowlandsA.V. SaundersR.M. ScottJ.T. SerenoM. ShahA.M. ShikotraA. SingapuriA. StanelS.C. ThorpeM. WoottonD.G. YatesT. Gisli JenkinsR. SinghS.J. ManW.D.C. BrightlingC.E. WainL.V. PorterJ.C. ThompsonA.A.R. HorsleyA. MolyneauxP.L. EvansR.A. JonesS.E. RutterM.K. BlaikleyJ.F. JacksonC. StewartI.D. PlekhanovaT. CunninghamP.S. HazelA.L. Al-ShekllyB. AulR. BoltonC.E. ChalderT. ChalmersJ.D. ChaudhuriN. DochertyA.B. DonaldsonG. EdwardsonC.L. ElneimaO. GreeningN.J. HanleyN.A. HarrisV.C. HarrisonE.M. HoL-P. Houchen-WolloffL. HowardL.S. JolleyC.J. JonesM.G. LeavyO.C. LewisK.E. LoneN.I. MarksM. McAuleyH.J.C. McNarryM.A. PatelB. Piper-HanleyK. PoinasamyK. RamanB. RichardsonM. Rivera-OrtegaP. Rowland-JonesS.L. RowlandsA.V. SaundersR.M. ScottJ.T. SerenoM. ShahA.M. ShikotraA. SingapuriA. StanelS.C. ThorpeM. WoottonD.G. YatesT. JenkinsG. SinghS.J. ManW.D-C. BrightlingC.E. WainL.V. PorterJ.C. ThompsonR. HorsleyA. MolyneauxP.L. EvansR.A. JonesS.E. RutterM.K. BlaikleyJ.F. AbelK. AdamaliH. AdeloyeD. AdeyemiO. AdregoR. Aguilar JimenezL.A. AhmadS. Ahmad HaiderN. AhmedR. AhwirengN. AinsworthM. Al-ShekllyB. AlamoudiA. AliM. AljaroofM. AllA.M. AllanL. AllenR.J. AllertonL. AllsopL. AlmeidaP. AltmannD. Alvarez CorralM. AmoilsS. AndersonD. AntoniadesC. ArbaneG. AriasA. ArmourC. ArmstrongL. ArmstrongN. ArnoldD. ArnoldH. AshishA. AshworthA. AshworthM. AslaniS. Assefa-KebedeH. AtkinC. AtkinP. AungH. AustinL. AvramC. AyoubA. BaboresM. BaggottR. BagshawJ. BaguleyD. BaileyL. BaillieJ.K. BainS. BakaliM. BakauM. BaldryE. BaldwinD. BaldwinM. BallardC. BanerjeeA. BangB. BarkerR.E. BarmanL. BarrattS. BarrettF. BasireD. BasuN. BatesM. BatesA. BatterhamR. BaxendaleH. BayesH. BeadsworthM. BeckettP. BeggsM. BegumM. BeirneP. BellD. BellR. BennettK. BeranovaE. BermperiA. BerridgeA. BerryC. BettsS. BevanE. BhuiK. BinghamM. BirchallK. BishopL. BisnauthsingK. BlaikelyJ. BlossA. BolgerA. BonningtonJ. BotkaiA. BourneC. BourneM. BramhamK. BrearL. BreenG. BreezeJ. BriggsA. BrightE. BrillS. BrindleK. BroadL. BroadleyA. BrookesC. BroomeM. BrownA. BrownJ. BrownJ.S. BrownM. BrownV. BrughaT. BrunskillN. BuchM. BuckleyP. BulargaA. BullmoreE. BurdenL. BurdettT. BurnD. BurnsG. BurnsA. BusbyJ. ButcherR. ButtA. ByrneS. CairnsP. CalderP.C. CalveloE. CarbornH. CardB. CarrC. CarrL. CarsonG. CarterP. CaseyA. CassarM. CavanaghJ. ChablaniM. ChambersR.C. ChanF. ChannonK.M. ChapmanK. CharalambouA. CheckleyA. ChenJ. ChengY. ChethamL. ChildsC. ChilversE.R. ChinoyH. ChiribiriA. Chong-JamesK. ChoudhuryG. ChoudhuryN. ChowienczykP. ChristieC. ChrystalM. ClarkD. ClarkC. ClarkeJ. ClohiseyS. CoakleyG. CoburnZ. CoetzeeS. ColeJ. ColemanC. ConnehF. ConnellD. ConnollyB. ConnorL. CookA. CooperB. CooperJ. CooperS. CopelandD. CosierT. CouldingM. CouplandC. CoxE. CraigT. CrispP. CristianoD. CrooksM.G. CrossA. CruzI. CullinanP. CuthbertsonD. DainesL. DaltonM. DalyP. DanielsA. DarkP. DasginJ. DavidA. DavidC. DaviesE. DaviesF. DaviesG. DaviesG.A. DaviesK. DaviesM.J. DawsonJ. DaynesE. De SoyzaA. DeakinB. DeansA. DeasC. DeeryJ. DefresS. DellA. DempseyK. DennenyE. DennisJ. DewarA. DharmagunawardenaR. Diar-BakerlyN. DickensC. DipperA. DiverS. DiwanjiS.N. DixonM. DjukanovicR. DobsonH. DobsonS.L. DonaldsonA. DongT. DormandN. DoughertyA. DowlingR. DrainS. DraxlbauerK. DruryK. DulawanP. DunleavyA. DunnS. DupontC. EarleyJ. EasomN. EchevarriaC. EdwardsS. EdwardsonC. El-TaweelH. ElliottA. ElliottK. EllisY. ElmerA. EvansD. EvansH. EvansJ. EvansR. EvansR.I. EvansT. EvendenC. EvisonL. FabbriL. FairbairnS. FairmanA. FallonK. FaluyiD. FavagerC. FayzanT. FeatherstoneJ. FeltonT. FinchJ. FinneyS. FinniganJ. FinniganL. FisherH. FletcherS. FlocktonR. FlynnM. FootH. FooteD. FordA. FortonD. FraileE. FrancisC. FrancisR. FrancisS. FrankelA. FraserE. FreeR. FrenchN. FuX. FuldJ. FurnissJ. GarnerL. GautamN. GeddesJ.R. GeorgeJ. GeorgeP.M. GibbonsM. GillM. GilmourL. GleesonF. GlossopJ. GloverS. GoodmanN. GoodwinC. GooptuB. GordonH. GorsuchT. GreatorexM. GreenhaffP.L. GreenhalfW. GreenhalghA. GreenwoodJ. GregoryH. GregoryR. GrieveD. GriffinD. GriffithsL. GuerdetteA-M. Guillen GuioB. GummadiM. GuptaA. GurramS. GuthrieE. GuyZ. HensonH. HadleyK. HaggarA. HaineyK. HairsineB. HaldarP. HallI. HallL. Halling-BrownM. HamilR. HancockA. HancockK. HaqS. HardwickH.E. HardyE. HardyT. HargadonB. HarringtonK. HarrisE. HarrisonP. HartN. HarveyA. HarveyM. HarvieM. HaslamL. Havinden-WilliamsM. HawkesJ. HawkingsN. HaworthJ. HaydayA. HaynesM. HazeldineJ. HazeltonT. HeaneyL.G. HeeleyC. HeeneyJ.L. HeightmanM. HellerS. HendersonM. HesseldenL. HewittM. HighettV. HillmanT. HiwotT. HoL-P. HoareA. HoareM. HockridgeJ. HogarthP. HolbournA. HoldenS. HoldsworthL. HolgateD. HollandM. HollowayL. HolmesK. HolmesM. Holroyd-HindB. HoltL. HormisA. HosseiniA. HotopfM. HowardK. HowellA. HuftonE. HughesA.D. HughesJ. HughesR. HumphriesA. HunekeN. HurditchE. HurstJ. HusainM. HussellT. HutchinsonJ. IbrahimW. IlyasF. InghamJ. IngramL. IonitaD. IsaacsK. IsmailK. JacksonT. JacobJ. JamesW.Y. JangW. JarmanC. JarroldI. JarvisH. JastrubR. JayaramanB. JenkinsR.G. JezzardP. JiwaK. JohnsonC. JohnsonS. JohnstonD. JonesD. JonesG. JonesH. JonesI. JonesL. JonesM.G. JonesS. JoseS. KabirT. KaltsakasG. KamwaV. KanellakisN. KaprowskaS. KausarZ. KeenanN. KellyS. KempG. KerrS. KerslakeH. KeyA.L. KhanF. KhuntiK. KilroyS. KingB. KingC. KinghamL. KirkJ. KitterickP. KlenermanP. KnibbsL. KnightS. KnightonA. KonO. KonS. KonS.S. KoprowskaS. KorszunA. KoychevI. KuraszC. KurupatiP. LaingC. LamlumH. LandersG. LangenbergC. LassersonD. Lavelle-LanghamL. LawrieA. LawsonC. LaytonA. LeaA. LeeD. LeeJ-H. LeeE. LeitchK. LenaghR. LewisD. LewisJ. LewisV. Lewis-BurkeN. LiX. LightT. LightstoneL. LilaonitkulW. LimL. LinfordS. Lingford-HughesA. LipmanM. LiyanageK. LloydA. LoganS. LomasD. LoosleyR. LordJ.M. LotaH. LovegroveW. LuceyA. LukaschukE. LyeA. LynchC. MacDonaldS. MacGowanG. MachariaI. MackieJ. MacliverL. MadathilS. MadzambaG. MageeN. MagtotoM.M. MairsN. MajeedN. MajorE. MaleinF. MalimM. MallisonG. MandalS. MangionK. ManistyC. ManleyR. MarchK. MarciniakS. MarinoP. MarivelesM. MarouzetE. MarshS. MarshallB. MarshallM. MartinJ. MartineauA. MartinezL.M. MaskellN. MatilaD. Matimba-MupayaW. MatthewsL. MbuyisaA. McAdooS. McAllister-WilliamsH. McArdleA. McArdleP. McAulayD. McCannG.P. McCormickJ. McCormickW. McCourtP. McGarveyL. McGheeC. McgeeK. McGinnessJ. McGlynnK. McGovernA. McGuinnessH. McInnesI.B. McIntoshJ. McIvorE. McIvorK. McLeaveyL. McMahonA. McMahonM.J. McMorrowL. McnallyT. McNarryM. McNeillJ. McQueenA. McShaneH. MearsC. MegsonC. MegsonS. MehtaP. MeiringJ. MellingL. MenciasM. MenziesD. Merida MorillasM. MichaelA. MillerC. MilliganL. MillsC. MillsG. MillsN.L. MilnerL. MisraS. MitchellJ. MohamedA. MohamedN. MohammedS. MonteiroW. MorieraS. MorleyA. MorrisonL. MorrissR. MorrowA. MossA.J. MossP. MotohashiK. MsimangaN. Mukaetova-LadinskaE. MunawarU. MuriraJ. NandaU. NassaH. NasseriM. NealA. NeedhamR. NeillP. NeubauerS. NewbyD.E. NewellH. NewmanT. NewmanJ. Newton-CoxA. NicholsonT. NicollD. NikolaidisA. NolanC.M. NoonanM.J. NormanC. NovotnyP. NunagJ. NwaforL. NwangumaU. NyabokoJ. O’BrienC. O’DonnellK. O’ReganD. O’BrienL. OdellN. OggG. OlaosebikanO. OliverC. OmarZ. OpenshawP.J.M. Orriss-DibL. OsborneL. OsbourneR. OstermannM. OvertonC. OwenJ. OxtonJ. PackJ. PacpacoE. PaddickS. PainterS. PakzadA. PalmerS. PapineniP. PaquesK. ParadowskiK. PareekM. ParekhD. ParfreyH. ParianteC. ParkerS. ParkesM. ParmarJ. PataleS. PatelM. PatelS. PattenadkD. PavlidesM. PayneS. PearceL. PearlJ.E. PeckhamD. PendleburyJ. PengY. PenningtonC. PeraltaI. PerkinsE. PeterkinZ. PetoT. PetousiN. PetrieJ. PfefferP. PhippsJ. PimmJ. PiusR. PlantH. PleinS. PlowrightM. PolgarO. PollL. PorterJ. PortukhayS. PowellN. PrabhuA. PrattJ. PriceA. PriceC. PriceD. PriceL. PrickettA. PropescuJ. ProsperS. PugmireS. QuaidS. QuigleyJ. QuintJ. QureshiH. QureshiI.N. RadhakrishnanK. RahmanN.M. RalserM. RamosA. RamosH. RangeleyJ. RangelovB. RatcliffeL. RavencroftP. ReddingtonA. ReddyR. ReddyA. RedfearnH. RedwoodD. ReedA. ReesM. ReesT. ReganK. ReynoldsW. RibeiroC. RichardsA. RichardsonE. RobertsK. RobertsonE. RobinsonE. RobinsonL. RocheL. RoddisC. RodgerJ. RossA. RossG. RossdaleJ. RostronA. RoweA. RowlandA. RowlandJ. RowlandM.J. Rowland-JonesS.L. RoyK. RoyM. RudanI. RussellR. RussellE. SaalminkG. SabitR. SageE.K. SamakomvaT. SamaniN. SampsonC. SamuelK. SamuelR. SandersonA. SapeyE. SaralayaD. SargentJ. SarginsonC. SassT. SattarN. SaundersK. SaundersP. SaundersL.C. SavillH. SaxonW. SayerA. SchronceJ. SchwaebleW. ScottK. SelbyN. SempleM.G. SewellT.A. ShahK. ShahP. Shankar-HariM. SharmaM. SharpeC. SharpeM. ShashaaS. ShawA. ShawK. ShawV. SheikhA. SheltonS. ShentonL. ShevketK. ShortJ. SiddiqueS. SiddiquiS. SidebottomJ. SigfridL. SimonsG. SimpsonJ. SimpsonN. SinghC. SinghS.J. SissonsD. SkeemerJ. SlackK. SmithA. SmithD. SmithS. SmithJ. SmithL. SoaresM. SolanoT.S. SollyR. SolsticeA.R. SoulsbyT. SouthernD. SowterD. SpearsM. SpencerL.G. SperanzaF. StadonL. StanelS. SteeleN. SteinerM. StenselD. StephensG. StephensonL. SternM. StimpsonR. StockdaleS. StockleyJ. StokerW. StoneR. StorrarW. StorrieA. StortonK. StringerE. Strong-SheldrakeS. StroudN. SubbeC. SudlowC.L. SuleimanZ. SummersC. SummersgillC. SutherlandD. SykesD.L. SykesR. TalbotN. TanA.L. TarusanL. TavoukjianV. TaylorA. TaylorC. TaylorJ. TeA. TeddH. TeeC.J. TeixeiraJ. TenchH. TerryS. Thackray-NoceraS. ThaivalappilF. ThamuB. ThickettD. ThomasC. ThomasD.C. ThomasS. ThomasA.K. Thomas-WoodsT. ThompsonT. ThompsonA A R. ThorntonT. ThwaitesR.S. TilleyJ. TinkerN. TiongsonG.F. TobinM. TomlinsonJ. TongC. ToshnerM. TouyzR. TrippK.A. TunnicliffeE. TurnbullA. TurnerE. TurnerS. TurnerV. TurnerK. TurneyS. TurtleL. TurtonH. UgojiJ. UgwuokeR. UpthegroveR. ValabhjiJ. VenturaM. VereJ. VickersC. VinsonB. WadeE. WadeP. WainwrightT. WajeroL.O. WalderS. WalkerS. WallE. WallisT. WalmsleyS. WalshJ.A. WalshS. WarburtonL. WardT.J.C. WarwickK. WassallH. WatersonS. WatsonE. WatsonL. WatsonJ. Weir McCallJ. WelchC. WelchH. WelshB. WesselyS. WestS. WestonH. WheelerH. WhiteS. WhiteheadV. WhitneyJ. WhittakerS. WhittamB. WhitworthV. WightA. WildJ.M. WilkinsM. WilkinsonD. WilliamsB. WilliamsN. WilliamsJ. Williams-HowardS.A. WillicombeM. WillisG. WilloughbyJ. WilsonA. WilsonD. WilsonI. WindowN. WithamM. Wolf-RobertsR. WoodC. WoodheadF. WoodsJ. WormleightonJ. WorsleyJ. WraithD. Wrey BrownC. WrightC. WrightL. WrightS. WylesJ. WynterI. XuM. YasminN. YasminS. YipK.P. YoungB. YoungS. YoungA. YousufA.J. ZawiaA. ZeidanL. ZhaoB. ZhengB. ZongoO. PHOSP-COVID Study Collaborative Group Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: A prospective multicentre cohort study.Lancet Respir. Med.202311867368410.1016/S2213‑2600(23)00124‑837072018
     [Google Scholar]
  151. DáttiloM. AntunesH.K.M. GalbesN.M.N. Mônico-NetoM. Effects of sleep deprivation on acute skeletal muscle recovery after exercise.Med. Sci. Sports Exerc.202052250751410.1249/MSS.000000000000213731469710
     [Google Scholar]
  152. OrrW.C. FassR. SundaramS.S. ScheimannA.O. The effect of sleep on gastrointestinal functioning in common digestive diseases.Lancet Gastroenterol. Hepatol.20205661662410.1016/S2468‑1253(19)30412‑132416862
     [Google Scholar]
  153. VerniaF. Di RuscioM. CicconeA. ViscidoA. FrieriG. StefanelliG. LatellaG. Sleep disorders related to nutrition and digestive diseases: A neglected clinical condition.Int. J. Med. Sci.202118359360310.7150/ijms.4551233437194
     [Google Scholar]
  154. VoigtR.M. ForsythC.B. KeshavarzianA. Circadian rhythms: A regulator of gastrointestinal health and dysfunction.Expert Rev. Gastroenterol. Hepatol.201913541142410.1080/17474124.2019.159558830874451
     [Google Scholar]
  155. SempleJ.I. NewtonJ.L. WestleyB.R. MayF.E.B. Dramatic diurnal variation in the concentration of the human trefoil peptide TFF2 in gastric juice.Gut200148564865510.1136/gut.48.5.64811302963
     [Google Scholar]
  156. BelliniM. GemignaniA. GambacciniD. TotiS. MenicucciD. StasiC. CostaF. MumoloM.G. RicchiutiA. BediniR. de BortoliN. MarchiS. Evaluation of latent links between irritable bowel syndrome and sleep quality.World J. Gastroenterol.201117465089509610.3748/wjg.v17.i46.508922171143
     [Google Scholar]
  157. Indah Kusumawati NoorL. BakriA. SoejadhiR. KesumaY. Association between irritable bowel syndrome and sleep disturbance in adolescents.Adolesc. Health Med. Ther.202011737710.2147/AHMT.S24871132607040
     [Google Scholar]
  158. LoganR.W. McClungC.A. Rhythms of life: Circadian disruption and brain disorders across the lifespan.Nat. Rev. Neurosci.2019201496510.1038/s41583‑018‑0088‑y30459365
     [Google Scholar]
  159. KillgoreW.D.S. Effects of sleep deprivation on cognition.Prog. Brain Res.201018510512910.1016/B978‑0‑444‑53702‑7.00007‑521075236
     [Google Scholar]
  160. YiT. GaoP. ZhuT. YinH. JinS. Glymphatic system dysfunction: A novel mediator of sleep disorders and headaches.Front. Neurol.20221388502010.3389/fneur.2022.88502035665055
     [Google Scholar]
  161. GoldsteinA.N. WalkerM.P. The role of sleep in emotional brain function.Annu. Rev. Clin. Psychol.201410167970810.1146/annurev‑clinpsy‑032813‑15371624499013
     [Google Scholar]
  162. Shokri-KojoriE. WangG.J. WiersC.E. DemiralS.B. GuoM. KimS.W. LindgrenE. RamirezV. ZehraA. FreemanC. MillerG. ManzaP. SrivastavaT. De SantiS. TomasiD. BenvenisteH. VolkowN.D. β-Amyloid accumulation in the human brain after one night of sleep deprivation.Proc. Natl. Acad. Sci. USA2018115174483448810.1073/pnas.172169411529632177
     [Google Scholar]
  163. BesedovskyL. LangeT. BornJ. Sleep and immune function.Pflugers Arch.2012463112113710.1007/s00424‑011‑1044‑022071480
     [Google Scholar]
  164. GarbarinoS. LanteriP. BragazziN.L. MagnavitaN. ScodittiE. Role of sleep deprivation in immune-related disease risk and outcomes.Commun. Biol.202141130410.1038/s42003‑021‑02825‑434795404
     [Google Scholar]
  165. BalboM. LeproultR. Van CauterE. Impact of sleep and its disturbances on hypothalamo-pituitary-adrenal axis activity.Int. J. Endocrinol.20102010111610.1155/2010/75923420628523
     [Google Scholar]
  166. IrwinM.R. WangM. RibeiroD. ChoH.J. OlmsteadR. BreenE.C. Martinez-MazaO. ColeS. Sleep loss activates cellular inflammatory signaling.Biol. Psychiatry200864653854010.1016/j.biopsych.2008.05.00418561896
     [Google Scholar]
  167. LvY.N. CuiY. ZhangB. HuangS.M. Sleep deficiency promotes Alzheimer’s disease development and progression.Front. Neurol.202213105394210.3389/fneur.2022.105394236588906
     [Google Scholar]
  168. FluyauD. PonnarasuS. PatelP. Temazepam.StatPearls.Treasure Island, FLStatPearls Publishing2024
     [Google Scholar]
  169. ChungC. Valtoco (diazepam) dosing, indications, interactions, adverse effects, and more.Available from: https://reference.medscape.com/drug/valium-valtoco-diazepam-342902
  170. LerchenfeldtS. RosenfeldG.C. BRS pharmacology.7th edPhiladelphiaWolters Kluwer2020
     [Google Scholar]
  171. Ambien, Ambien CR (zolpidem) dosing, indications, interactions, adverse effects, and more.Available from: https://reference.medscape.com/drug/ambien-cr-zolpidem-342931
  172. Lunesta (eszopiclone) dosing, indications, interactions, adverse effects, and more.Available from: https://reference.medscape.com/drug/lunesta-eszopiclone-342927
  173. MogaveroM.P. SilvaniA. LanzaG. DelRossoL.M. Ferini-StrambiL. FerriR. Targeting orexin receptors for the treatment of insomnia: From physiological mechanisms to current clinical evidence and recommendations.Nat. Sci. Sleep202315173810.2147/NSS.S20199436713640
     [Google Scholar]
  174. KatzungB.G. VanderahT.W. Basic & clinical pharmacology.Fifteenth edMcGraw-HillNew York Chicago San Francisco Athens London Madrid Mexico City Milan New Delhi Singapore Sydney Toronto20211311
     [Google Scholar]
  175. Cruz-SanabriaF CarmassiC BrunoS BazzaniA CarliM ScarselliM FaragunaU. Melatonin as a chronobiotic with sleep-promoting properties.Curr. Neuropharmacol.202321495198710.2174/1570159X20666220217152617
     [Google Scholar]
  176. KuriyamaA. HondaM. HayashinoY. Ramelteon for the treatment of insomnia in adults: A systematic review and meta-analysis.Sleep Med.201415438539210.1016/j.sleep.2013.11.78824656909
     [Google Scholar]
  177. TuftC. MatarE. Menczel SchrireZ. GrunsteinR.R. YeeB.J. HoyosC.M. Current insights into the risks of using melatonin as a treatment for sleep disorders in older adults.Clin. Interv. Aging202318495910.2147/CIA.S36151936660543
     [Google Scholar]
  178. ThakkarM.M. Histamine in the regulation of wakefulness.Sleep Med. Rev.2011151657410.1016/j.smrv.2010.06.00420851648
     [Google Scholar]
  179. SicariV. ZabboC.P. Diphenhydramine.StatPearls.Treasure Island, FLStatPearls Publishing2024
     [Google Scholar]
  180. WichniakA. WierzbickaA. WalęckaM. JernajczykW. Effects of antidepressants on sleep.Curr. Psychiatry Rep.20171996310.1007/s11920‑017‑0816‑428791566
     [Google Scholar]
  181. JafferK.Y. ChangT. VanleB. DangJ. SteinerA.J. LoeraN. AbdelmessehM. DanovitchI. IshakW.W. Trazodone for insomnia: A systematic review.Innov. Clin. Neurosci.2017147-8243429552421
     [Google Scholar]
  182. ShefflerZ.M. PatelP. AbdijadidS. Antidepressants.StatPearls.Treasure Island, FLStatPearls Publishing2024
     [Google Scholar]
  183. GandotraK. ChenP. JaskiwG.E. KonickiP.E. StrohlK.P. Effective treatment of insomnia with mirtazapine attenuates concomitant suicidal ideation.J. Clin. Sleep Med.201814590190210.5664/jcsm.7142
     [Google Scholar]
  184. KrystalA.D. DurrenceH.H. ScharfM. JochelsonP. RogowskiR. LudingtonE. RothT. Efficacy and safety of Doxepin 1 mg and 3 mg in a 12-week sleep laboratory and outpatient trial of elderly subjects with chronic primary insomnia.Sleep201033111553156110.1093/sleep/33.11.155321102997
     [Google Scholar]
  185. AlmasiA. PatelP. MezaC.E. Doxepin.StatPearls.Treasure Island, FLStatPearls Publishing2024
     [Google Scholar]
  186. CohrsS. RodenbeckA. GuanZ. PohlmannK. JordanW. MeierA. RütherE. Sleep-promoting properties of quetiapine in healthy subjects.Psychopharmacology2004174342142910.1007/s00213‑003‑1759‑515029469
     [Google Scholar]
  187. Khaledi-PavehB. MaazinezhadS. RezaieL. KhazaieH. Treatment of chronic insomnia with atypical antipsychotics: Results from a follow-up study.Sleep Sci.2021141273210.5935/1984‑0063.2019014934104334
     [Google Scholar]
  188. RossmanJ. Cognitive-behavioral therapy for insomnia: An effective and underutilized treatment for insomnia.Am. J. Lifestyle Med.201913654454710.1177/155982761986767731662718
     [Google Scholar]
  189. BaranwalN. YuP.K. SiegelN.S. Sleep physiology, pathophysiology, and sleep hygiene.Prog. Cardiovasc. Dis.202377596910.1016/j.pcad.2023.02.00536841492
     [Google Scholar]
  190. LovatoN. LackL. The role of bright light therapy in managing insomnia.Sleep Med. Clin.20138335135910.1016/j.jsmc.2013.06.003
     [Google Scholar]
  191. EpsteinL.J. KristoD. StrolloP.J.Jr FriedmanN. MalhotraA. PatilS.P. RamarK. RogersR. SchwabR.J. WeaverE.M. WeinsteinM.D. Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults.J. Clin. Sleep Med.20095326327610.5664/jcsm.2749719960649
     [Google Scholar]
  192. Sleep Disorder Treatments - Sleep Disorder Treatments.Available from: https://www.nhlbi.nih.gov/health/sleep-disorder-treatments
  193. PetersB. Sleep apnea surgery: Overview.Available from: https://www.verywellhealth.com/surgery-options-for-obstructive-sleep-apnea-3015238
  194. Sleep foundation.2021Available from: https://www.sleepfoundation.org/sleep-apnea/surgery-for-sleep-apnea
/content/journals/cmc/10.2174/0109298673350476250331181123
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Sleep Disturbances Associated with Different Systems of the Body: Underlying Mechanisms Involved and Consequences
Curr. Med. Chem. 32, 7624 (2025); https://doi.org/10.2174/0109298673350476250331181123
/content/journals/cmc/10.2174/0109298673350476250331181123
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  • Article Type:     Review Article
Keyword(s): cardiac ischemia; hormones; hypertension; insulin; metabolism; Sleep

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