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2000
Volume 32, Issue 38
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X
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Abstract

Introduction

Melanogenesis, the process responsible for melanin production, is a critical determinant of skin pigmentation. Dysregulation of this process can lead to hyperpigmentation disorders.

Methods

In this study, we identified a novel extract, (1'S, 2'S)-syringyl glycerol 3'-O-β-D-glucopyranoside (compound ), and evaluated its anti-melanogenic potential in zebrafish models and assays. Compound inhibited melanin synthesis by 36.66% ± 14.00% and tyrosinase by 48.26% ± 6.94%, surpassing the inhibitory effects of arbutin. Network pharmacological analysis revealed key targets, including HSP90AA1, HRAS, and PIK3R1, potentially involved in the anti-melanogenic effects of compound .

Results

Molecular docking studies supported the interactions between compound and these targets. Further, gene expression analysis in zebrafish indicated that compound up-regulates , , and , and subsequently down-regulating , , and , critical genes in melanogenesis.

Conclusion

These findings suggest that compound inhibits melanin production PI3K-Akt and Ras-Raf-MEK-ERK signaling pathways, positioning it as a promising candidate for the treatment of hyperpigmentation.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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Phenolic Glycoside Monomer from Reed Rhizome Inhibits Melanin Production via PI3K-Akt and Ras-Raf-MEK-ERK Pathways
Curr. Med. Chem. 32, 8664 (2025); https://doi.org/10.2174/0109298673341645240919072455
/content/journals/cmc/10.2174/0109298673341645240919072455
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  • Article Type:     Research Article
Keyword(s): age spots; anti-melanogenesis; radicals; Reed Rhizome extract; tyrosinase; zebrafish model

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