Skip to content
2000
Volume 32, Issue 35
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Background

The potential role of the iroquois homeobox (IRX) genes in tumorigenesis is a subject of interest, yet their specific involvement in lung adenocarcinoma (LUAD) has not been extensively examined.

Objective

This research endeavored to explore the impact of the IRX genes on the onset and progression of LUAD.

Methods

Utilizing data from The Cancer Genome Atlas (TCGA), samples of LUAD were selected for analysis. The influence of the IRX genes was scrutinized through various tools, including Kaplan-Meier Plotter, cBioPortal, and the R programming language (version 3.6.3), with gene expression levels being confirmed in cellular models quantitative real-time polymerase chain reaction (qRT-PCR).

Results

It was observed that the levels of IRX1/2/3/6 were notably diminished in LUAD tissues when juxtaposed with healthy lung tissue. Conversely, the expression of IRX4 was found to be elevated in LUAD. Correlations were identified between IRX gene expression and several clinical parameters such as T stage, smoking history quantified in pack-years, lymph node involvement, patient gender, initial treatment responses, and smoking status. The diminished expression of IRX2/5 emerged as a significant indicator of an unfavorable prognosis in LUAD. The study also highlighted the potential of various IRX genes as diagnostic indicators for LUAD. These genes were implicated in the facilitation of LUAD's growth and spread through a range of biological pathways, encompassing the Ras signaling and more. Additionally, a pronounced link was discovered between the infiltration of immune cells and the expression patterns of the IRX genes. IRX genes were abnormally expressed in LUAD cell lines.

Conclusion

IRX gene family could serve not only as indicators of LUAD prognosis but also as therapeutic targets for LUAD.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cmc/10.2174/0109298673320965240829065919
2024-09-06
2025-10-31

  • From This Site

    /content/journals/cmc/10.2174/0109298673320965240829065919
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. HirschF.R. ScagliottiG.V. MulshineJ.L. KwonR. CurranW.J.Jr WuY.L. Paz-AresL. Lung cancer: Current therapies and new targeted treatments.Lancet20173891006629931110.1016/S0140‑6736(16)30958‑827574741
     [Google Scholar]
  2. MengY. SunJ. ZhangG. YuT. PiaoH. Clinical prognostic value of the PLOD gene family in lung adenocarcinoma.Front. Mol. Biosci.2022877072977072910.3389/fmolb.2021.77072935265665
     [Google Scholar]
  3. LiY. GuJ. XuF. ZhuQ. ChenY. GeD. LuC. Molecular characterization, biological function, tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma.Brief. Bioinform.2021224bbaa22510.1093/bib/bbaa22533003204
     [Google Scholar]
  4. JacobsenM.M. SilversteinS.C. QuinnM. WaterstonL.B. ThomasC.A. BenneyanJ.C. HanP.K.J. Timeliness of access to lung cancer diagnosis and treatment: A scoping literature review.Lung Cancer201711215616410.1016/j.lungcan.2017.08.01129191588
     [Google Scholar]
  5. HuW. XinY. ZhangL. HuJ. SunY. ZhaoY. Iroquois Homeodomain transcription factors in ventricular conduction system and arrhythmia.Int. J. Med. Sci.201815880881510.7150/ijms.2514030008591
     [Google Scholar]
  6. GuoX. LiuW. PanY. NiP. JiJ. GuoL. ZhangJ. WuJ. JiangJ. ChenX. CaiQ. LiJ. ZhangJ. GuQ. LiuB. ZhuZ. YuY. Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.Oncogene201029273908392010.1038/onc.2010.14320440264
     [Google Scholar]
  7. JungI.H. JungD.E. ChungY.Y. KimK.S. ParkS.W. Iroquois Homeobox 1 acts as a true tumor suppressor in multiple organs by regulating cell cycle progression.Neoplasia201921101003101410.1016/j.neo.2019.08.00131450023
     [Google Scholar]
  8. WernerS. StammH. PandjaitanM. KemmingD. BrorsB. PantelK. WikmanH. Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells.BMC Cancer201515189610.1186/s12885‑015‑1907‑426560478
     [Google Scholar]
  9. Holmquist MengelbierL. Lindell-MuntherS. YasuiH. JanssonC. EsfandyariJ. KarlssonJ. LauK. HuiC. BexellD. HopyanS. GisselssonD. The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis.J. Pathol.20192471869810.1002/path.517130246301
     [Google Scholar]
  10. ChakmaK. GuZ. AbudurexitiY. HataT. MotoiF. UnnoM. HoriiA. FukushigeS. Epigenetic inactivation of IRX4 is responsible for acceleration of cell growth in human pancreatic cancer.Cancer Sci.2020111124594460410.1111/cas.1464432894817
     [Google Scholar]
  11. LiuD. PattabiramanV. BacanamwoM. AndersonL.M. Iroquois homeobox transcription factor ( Irx5 ) promotes G1/S-phase transition in vascular smooth muscle cells by CDK2-dependent activation.Am. J. Physiol. Cell Physiol.20163112C179C18910.1152/ajpcell.00293.201527170637
     [Google Scholar]
  12. ChenJ. TangH. LiT. JiangK. ZhongH. WuY. HeJ. LiD. LiM. CaiX. Comprehensive analysis of the expression, prognosis, and biological significance of OVOLs in breast cancer.Int. J. Gen. Med.2021143951396010.2147/IJGM.S32640234345183
     [Google Scholar]
  13. VivianJ. RaoA.A. NothaftF.A. KetchumC. ArmstrongJ. NovakA. PfeilJ. NarkizianJ. DeranA.D. Musselman-BrownA. SchmidtH. AmstutzP. CraftB. GoldmanM. RosenbloomK. ClineM. O’ConnorB. HannaM. BirgerC. KentW.J. PattersonD.A. JosephA.D. ZhuJ. ZaranekS. GetzG. HausslerD. PatenB. Toil enables reproducible, open source, big biomedical data analyses.Nat. Biotechnol.201735431431610.1038/nbt.377228398314
     [Google Scholar]
  14. HuaH. PanS. DiaoH. CaoY. QianX. ZhangJ. Increased ACSL6 expression predicts a favorable prognosis in triple-negative breast cancer.Curr. Med. Chem.202410.2174/010929867327884623122210342038310395
     [Google Scholar]
  15. LaiF. FangY. ChengC. ZhongX. ZhengW. LanS. PengQ. CaiX. CaoT. ZhongC. GaoY. CDK4 as a prognostic marker of hepatocellular carcinoma and CDK4 inhibitors as potential therapeutics.Curr. Med. Chem.202438231074
     [Google Scholar]
  16. ChenB. GaoC. WangH. SunJ. HanZ. Molecular analysis of prognosis and immune infiltration of ovarian cancer based on Homeobox D genes.Comput. Math. Methods Med.2022202211610.1155/2022/326838636213580
     [Google Scholar]
  17. LiY. LiuZ. ZhangY. Expression and prognostic impact of FZDs in pancreatic adenocarcinoma.BMC Gastroenterol.20212117910.1186/s12876‑021‑01643‑633618667
     [Google Scholar]
  18. LinZ. HuangW. YiY. LiD. XieZ. LiZ. YeM. LncRNA ADAMTS9-AS2 is a prognostic biomarker and correlated with immune infiltrates in lung adenocarcinoma.Int. J. Gen. Med.2021148541855510.2147/IJGM.S34068334849000
     [Google Scholar]
  19. YiW. ShenH. SunD. XuY. FengY. LiD. WangC. Low expression of long noncoding RNA SLC26A4 antisense RNA 1 is an independent prognostic biomarker and correlate of immune infiltrates in breast cancer.Med. Sci. Monit.202127e93452234880202
     [Google Scholar]
  20. LiuJ. LichtenbergT. HoadleyK.A. PoissonL.M. LazarA.J. CherniackA.D. KovatichA.J. BenzC.C. LevineD.A. LeeA.V. OmbergL. WolfD.M. ShriverC.D. ThorssonV. HuH. Caesar-JohnsonS.J. DemchokJ.A. FelauI. KasapiM. FergusonM.L. HutterC.M. SofiaH.J. TarnuzzerR. WangZ. YangL. ZenklusenJ.C. ZhangJ.J. ChudamaniS. LiuJ. LollaL. NareshR. PihlT. SunQ. WanY. WuY. ChoJ. DeFreitasT. FrazerS. GehlenborgN. GetzG. HeimanD.I. KimJ. LawrenceM.S. LinP. MeierS. NobleM.S. SaksenaG. VoetD. ZhangH. BernardB. ChambweN. DhankaniV. KnijnenburgT. KramerR. LeinonenK. LiuY. MillerM. ReynoldsS. ShmulevichI. ThorssonV. ZhangW. AkbaniR. BroomB.M. HegdeA.M. JuZ. KanchiR.S. KorkutA. LiJ. LiangH. LingS. LiuW. LuY. MillsG.B. NgK-S. RaoA. RyanM. WangJ. WeinsteinJ.N. ZhangJ. AbeshouseA. ArmeniaJ. ChakravartyD. ChatilaW.K. de BruijnI. GaoJ. GrossB.E. HeinsZ.J. KundraR. LaK. LadanyiM. LunaA. NissanM.G. OchoaA. PhillipsS.M. ReznikE. Sanchez-VegaF. SanderC. SchultzN. SheridanR. SumerS.O. SunY. TaylorB.S. WangJ. ZhangH. AnurP. PetoM. SpellmanP. BenzC. StuartJ.M. WongC.K. YauC. HayesD.N. ParkerJ.S. WilkersonM.D. AllyA. BalasundaramM. BowlbyR. BrooksD. CarlsenR. ChuahE. DhallaN. HoltR. JonesS.J.M. KasaianK. LeeD. MaY. MarraM.A. MayoM. MooreR.A. MungallA.J. MungallK. RobertsonA.G. SadeghiS. ScheinJ.E. SipahimalaniP. TamA. ThiessenN. TseK. WongT. BergerA.C. BeroukhimR. CherniackA.D. CibulskisC. GabrielS.B. GaoG.F. HaG. MeyersonM. SchumacherS.E. ShihJ. KucherlapatiM.H. KucherlapatiR.S. BaylinS. CopeL. DanilovaL. BootwallaM.S. LaiP.H. MaglinteD.T. Van Den BergD.J. WeisenbergerD.J. AumanJ.T. BaluS. BodenheimerT. FanC. HoadleyK.A. HoyleA.P. JefferysS.R. JonesC.D. MengS. MieczkowskiP.A. MoseL.E. PerouA.H. PerouC.M. RoachJ. ShiY. SimonsJ.V. SkellyT. SolowayM.G. TanD. VeluvoluU. FanH. HinoueT. LairdP.W. ShenH. ZhouW. BellairM. ChangK. CovingtonK. CreightonC.J. DinhH. DoddapaneniH.V. DonehowerL.A. DrummondJ. GibbsR.A. GlennR. HaleW. HanY. HuJ. KorchinaV. LeeS. LewisL. LiW. LiuX. MorganM. MortonD. MuznyD. SantibanezJ. ShethM. ShinbroE. WangL. WangM. WheelerD.A. XiL. ZhaoF. HessJ. AppelbaumE.L. BaileyM. CordesM.G. DingL. FronickC.C. FultonL.A. FultonR.S. KandothC. MardisE.R. McLellanM.D. MillerC.A. SchmidtH.K. WilsonR.K. CrainD. CurleyE. GardnerJ. LauK. MalleryD. MorrisS. PaulauskisJ. PennyR. SheltonC. SheltonT. ShermanM. ThompsonE. YenaP. BowenJ. Gastier-FosterJ.M. GerkenM. LeraasK.M. LichtenbergT.M. RamirezN.C. WiseL. ZmudaE. CorcoranN. CostelloT. HovensC. CarvalhoA.L. de CarvalhoA.C. FregnaniJ.H. Longatto-FilhoA. ReisR.M. Scapulatempo-NetoC. SilveiraH.C.S. VidalD.O. BurnetteA. EschbacherJ. HermesB. NossA. SinghR. AndersonM.L. CastroP.D. IttmannM. HuntsmanD. KohlB. LeX. ThorpR. AndryC. DuffyE.R. LyadovV. PaklinaO. SetdikovaG. ShabuninA. TavobilovM. McPhersonC. WarnickR. BerkowitzR. CramerD. FeltmateC. HorowitzN. KibelA. MutoM. RautC.P. MalykhA. Barnholtz-SloanJ.S. BarrettW. DevineK. FulopJ. OstromQ.T. ShimmelK. WolinskyY. SloanA.E. De RoseA. GiulianteF. GoodmanM. KarlanB.Y. HagedornC.H. EckmanJ. HarrJ. MyersJ. TuckerK. ZachL.A. DeyarminB. HuH. KvecherL. LarsonC. MuralR.J. SomiariS. VichaA. ZelinkaT. BennettJ. IacoccaM. RabenoB. SwansonP. LatourM. LacombeL. TêtuB. BergeronA. McGrawM. StaugaitisS.M. ChabotJ. HibshooshH. SepulvedaA. SuT. WangT. PotapovaO. VoroninaO. DesjardinsL. MarianiO. Roman-RomanS. SastreX. SternM-H. ChengF. SignorettiS. BerchuckA. BignerD. LippE. MarksJ. McCallS. McLendonR. SecordA. SharpA. BeheraM. BratD.J. ChenA. DelmanK. ForceS. KhuriF. MaglioccaK. MaithelS. OlsonJ.J. OwonikokoT. PickensA. RamalingamS. ShinD.M. SicaG. Van MeirE.G. ZhangH. EijckenboomW. GillisA. KorpershoekE. LooijengaL. OosterhuisW. StoopH. van KesselK.E. ZwarthoffE.C. CalatozzoloC. CuppiniL. CuzzubboS. DiMecoF. FinocchiaroG. MatteiL. PerinA. PolloB. ChenC. HouckJ. LohavanichbutrP. HartmannA. StoehrC. StoehrR. TaubertH. WachS. WullichB. KyclerW. MurawaD. WiznerowiczM. ChungK. EdenfieldW.J. MartinJ. BaudinE. BubleyG. BuenoR. De RienzoA. RichardsW.G. KalkanisS. MikkelsenT. NoushmehrH. ScarpaceL. GirardN. AymerichM. CampoE. GinéE. GuillermoA.L. Van BangN. HanhP.T. PhuB.D. TangY. ColmanH. EvasonK. DottinoP.R. MartignettiJ.A. GabraH. JuhlH. AkeredoluT. StepaS. HoonD. AhnK. KangK.J. BeuschleinF. BreggiaA. BirrerM. BellD. BoradM. BryceA.H. CastleE. ChandanV. ChevilleJ. CoplandJ.A. FarnellM. FlotteT. GiamaN. HoT. KendrickM. KocherJ-P. KoppK. MoserC. NagorneyD. O’BrienD. O’NeillB.P. PatelT. PetersenG. QueF. RiveraM. RobertsL. SmallridgeR. SmyrkT. StantonM. ThompsonR.H. TorbensonM. YangJ.D. ZhangL. BrimoF. AjaniJ.A. Angulo GonzalezA.M. BehrensC. BondarukJ. BroaddusR. CzerniakB. EsmaeliB. FujimotoJ. GershenwaldJ. GuoC. LazarA.J. LogothetisC. Meric-BernstamF. MoranC. RamondettaL. RiceD. SoodA. TamboliP. ThompsonT. TroncosoP. TsaoA. WistubaI. CarterC. HayduL. HerseyP. JakrotV. KakavandH. KeffordR. LeeK. LongG. MannG. QuinnM. SawR. ScolyerR. ShannonK. SpillaneA. StretchJ. SynottM. ThompsonJ. WilmottJ. Al-AhmadieH. ChanT.A. GhosseinR. GopalanA. LevineD.A. ReuterV. SingerS. SinghB. TienN.V. BroudyT. MirsaidiC. NairP. DrwiegaP. MillerJ. SmithJ. ZarenH. ParkJ-W. HungN.P. KebebewE. LinehanW.M. MetwalliA.R. PacakK. PintoP.A. SchiffmanM. SchmidtL.S. VockeC.D. WentzensenN. WorrellR. YangH. MoncrieffM. GoparajuC. MelamedJ. PassH. BotnariucN. CaramanI. CernatM. ChemencedjiI. ClipcaA. DorucS. GorincioiG. MuraS. PirtacM. StanculI. TcaciucD. AlbertM. AlexopoulouI. ArnaoutA. BartlettJ. EngelJ. GilbertS. ParfittJ. SekhonH. ThomasG. RasslD.M. RintoulR.C. BifulcoC. TamakawaR. UrbaW. HaywardN. TimmersH. AntenucciA. FaccioloF. GraziG. MarinoM. MerolaR. de KrijgerR. Gimenez-RoqueploA-P. PichéA. ChevalierS. McKercherG. BirsoyK. BarnettG. BrewerC. FarverC. NaskaT. PennellN.A. RaymondD. SchileroC. SmolenskiK. WilliamsF. MorrisonC. BorgiaJ.A. LiptayM.J. PoolM. SederC.W. JunkerK. OmbergL. DinkinM. ManikhasG. AlvaroD. BragazziM.C. CardinaleV. CarpinoG. GaudioE. CheslaD. CottinghamS. DubinaM. MoiseenkoF. DhanasekaranR. BeckerK-F. JanssenK-P. Slotta-HuspeninaJ. Abdel-RahmanM.H. AzizD. BellS. CebullaC.M. DavisA. DuellR. ElderJ.B. HiltyJ. KumarB. LangJ. LehmanN.L. MandtR. NguyenP. PilarskiR. RaiK. SchoenfieldL. SenecalK. WakelyP. HansenP. LechanR. PowersJ. TischlerA. GrizzleW.E. SextonK.C. KastlA. HendersonJ. PortenS. WaldmannJ. FassnachtM. AsaS.L. SchadendorfD. CouceM. GraefenM. HulandH. SauterG. SchlommT. SimonR. TennstedtP. OlabodeO. NelsonM. BatheO. CarrollP.R. ChanJ.M. DisaiaP. GlennP. KelleyR.K. LandenC.N. PhillipsJ. PradosM. SimkoJ. Smith-McCuneK. VandenBergS. RogginK. FehrenbachA. KendlerA. SifriS. SteeleR. JimenoA. CareyF. ForgieI. MannelliM. CarneyM. HernandezB. CamposB. Herold-MendeC. JungkC. UnterbergA. von DeimlingA. BosslerA. GalbraithJ. JacobusL. KnudsonM. KnutsonT. MaD. MilhemM. SigmundR. GodwinA.K. MadanR. RosenthalH.G. AdebamowoC. AdebamowoS.N. BoussioutasA. BeerD. GiordanoT. Mes-MassonA-M. SaadF. BocklageT. LandrumL. MannelR. MooreK. MoxleyK. PostierR. WalkerJ. ZunaR. FeldmanM. ValdiviesoF. DhirR. LuketichJ. Mora PineroE.M. Quintero-AguiloM. CarlottiC.G.Jr Dos SantosJ.S. KempR. SankarankutyA. TirapelliD. CattoJ. AgnewK. SwisherE. CreaneyJ. RobinsonB. ShelleyC.S. GodwinE.M. KendallS. ShipmanC. BradfordC. CareyT. HaddadA. MoyerJ. PetersonL. PrinceM. RozekL. WolfG. BowmanR. FongK.M. YangI. KorstR. RathmellW.K. Fantacone-CampbellJ.L. HookeJ.A. KovatichA.J. ShriverC.D. DiPersioJ. DrakeB. GovindanR. HeathS. LeyT. Van TineB. WesterveltP. RubinM.A. LeeJ.I. AredesN.D. MariamidzeA. An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics.Cell20181732400416.e1110.1016/j.cell.2018.02.05229625055
     [Google Scholar]
  21. LiM. WangX. LiuJ. MaoX. LiD. WangZ. TangY. WuS. Identification of core prognosis-related candidate genes in chinese gastric cancer population based on integrated bioinformatics.BioMed Res. Int.2020202011410.1155/2020/885982633381592
     [Google Scholar]
  22. YangY. GuX. LiZ. ZhengC. WangZ. ZhouM. ChenZ. LiM. LiD. XiangJ. Whole-exome sequencing of rectal cancer identifies locally recurrent mutations in the Wnt pathway.Aging (Albany NY)20211319232622328310.18632/aging.20361834642262
     [Google Scholar]
  23. HänzelmannS. CasteloR. GuinneyJ. GSVA: Gene set variation analysis for microarray and RNA-Seq data.BMC Bioinformatics2013141710.1186/1471‑2105‑14‑723323831
     [Google Scholar]
  24. YangD. LiuM. JiangJ. LuoY. WangY. ChenH. LiD. WangD. YangZ. ChenH. Comprehensive analysis of DMRT3 as a potential biomarker associated with the immune infiltration in a pan-cancer analysis and validation in lung adenocarcinoma.Cancers (Basel)20221424622010.3390/cancers1424622036551704
     [Google Scholar]
  25. ChenY.C. LiD.B. WangD.L. PengH. Comprehensive analysis of distal-less homeobox family gene expression in colon cancer.World J. Gastrointest. Oncol.20231561019103510.4251/wjgo.v15.i6.101937389108
     [Google Scholar]
  26. HanQ. CuiZ. WangQ. PangF. LiD. WangD. Upregulation of OTX2-AS1 is associated with immune infiltration and predicts prognosis of gastric cancer.Technol. Cancer Res. Treat.2023221533033823115409110.1177/1533033823115409136740995
     [Google Scholar]
  27. LiangW. LuY. PanX. ZengY. ZhengW. LiY. NieY. LiD. WangD. Decreased expression of a novel lncRNA FAM181A-AS1 is associated with poor prognosis and immune infiltration in lung adenocarcinoma.Pharm. Genomics Pers. Med.20221598599810.2147/PGPM.S38490136482943
     [Google Scholar]
  28. BindeaG. MlecnikB. TosoliniM. KirilovskyA. WaldnerM. ObenaufA.C. AngellH. FredriksenT. LafontaineL. BergerA. BrunevalP. FridmanW.H. BeckerC. PagèsF. SpeicherM.R. TrajanoskiZ. GalonJ. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.Immunity201339478279510.1016/j.immuni.2013.10.00324138885
     [Google Scholar]
  29. KüsterM.M. SchneiderM.A. RichterA.M. RichtmannS. WinterH. KriegsmannM. PullamsettiS.S. StieweT. SavaiR. MuleyT. DammannR.H. Epigenetic inactivation of the tumor suppressor IRX1 occurs frequently in lung adenocarcinoma and its silencing is associated with impaired prognosis.Cancers (Basel)20201212352810.3390/cancers1212352833256112
     [Google Scholar]
  30. MarcinkiewiczK.M. GudasL.J. Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.Exp. Cell Res.2014320112814310.1016/j.yexcr.2013.09.01124076275
     [Google Scholar]
  31. ZhuQ. WuY. YangM. WangZ. ZhangH. JiangX. ChenM. JinT. WangT. IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathway.Mol. Carcinog.201958112065207610.1002/mc.2309831432570
     [Google Scholar]
  32. HeB. ChenJ. SongW. BaiY. miR-646/TET1 mediated demethylation of IRX1 promoter upregulates HIST2H2BE and promotes the progression of invasive ductal carcinoma.Genomics202111331469148110.1016/j.ygeno.2020.12.04433667646
     [Google Scholar]
  33. WuD. LiZ. ZhaoS. YangB. LiuZ. Downregulated microRNA-150 upregulates IRX1 to depress proliferation, migration, and invasion, but boost apoptosis of gastric cancer cells.IUBMB Life202072347649110.1002/iub.221431846199
     [Google Scholar]
  34. LiuX. ZhangJ. LiuL. JiangY. JiJ. YanR. ZhuZ. YuY. Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes to tumorigenicity and metastasis of gastric cancer.Biochim. Biophys. Acta Mol. Basis Dis.2018186492835284410.1016/j.bbadis.2018.05.01529802960
     [Google Scholar]
  35. MatsumotoK. NishiharaS. KamimuraM. ShiraishiT. OtoguroT. UeharaM. MaedaY. OguraK. LumsdenA. OguraT. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation.Nat. Neurosci.20047660561210.1038/nn124915133517
     [Google Scholar]
  36. JiaZ. ZhangY. YanA. WangM. HanQ. WangK. WangJ. QiaoC. PanZ. ChenC. HuD. DingX. 1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.Cell Death Dis.202011867010.1038/s41419‑020‑02908‑w32820157
     [Google Scholar]
  37. Ha NguyenH. TakataR. AkamatsuS. ShigemizuD. TsunodaT. FurihataM. TakahashiA. KuboM. KamataniN. OgawaO. FujiokaT. NakamuraY. NakagawaH. IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.Hum. Mol. Genet.20122192076208510.1093/hmg/dds02522323358
     [Google Scholar]
  38. LvY. LinW. Comprehensive analysis of the expression, prognosis, and immune infiltrates for CHDs in human lung cancer.Discover Oncology2022131292910.1007/s12672‑022‑00489‑y35467222
     [Google Scholar]
  39. MyrthueA. RademacherB.L.S. PittsenbargerJ. Kutyba-BrooksB. GantnerM. QianD.Z. BeerT.M. The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells.Clin. Cancer Res.200814113562357010.1158/1078‑0432.CCR‑07‑464918519790
     [Google Scholar]
  40. CoelhoM.A. de Carné TrécessonS. RanaS. ZecchinD. MooreC. Molina-ArcasM. EastP. Spencer-DeneB. NyeE. BarnouinK. SnijdersA.P. LaiW.S. BlackshearP.J. DownwardJ. Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA.Immunity201747610831099.e610.1016/j.immuni.2017.11.01629246442
     [Google Scholar]
  41. TanJ. YuC.Y. WangZ.H. ChenH.Y. GuanJ. ChenY.X. FangJ.Y. Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer.Sci. Rep.201551847310.1038/srep0847325683757
     [Google Scholar]
  42. ChenP.H. CaiL. HuffmanK. YangC. KimJ. FaubertB. BoroughsL. KoB. SudderthJ. McMillanE.A. GirardL. ChenD. PeytonM. ShieldsM.D. YaoB. ShamesD.S. KimH.S. TimmonsB. SekineI. BrittR. WeberS. ByersL.A. HeymachJ.V. ChenJ. WhiteM.A. MinnaJ.D. XiaoG. DeBerardinisR.J. Metabolic diversity in human non-small cell lung cancer cells.Mol. Cell2019765838851.e510.1016/j.molcel.2019.08.02831564558
     [Google Scholar]
  43. JohanssonD. BergströmP. HenrikssonR. GrankvistK. JohanssonA. Behnam-MotlaghP. Adenylate cyclase toxin from Bordetella pertussis enhances cisplatin-induced apoptosis to lung cancer cells in vitro .Oncol. Res.200515942343010.3727/09650400577656827316555548
     [Google Scholar]
  44. WangH. ChenS. KangW. DingB. CuiS. ZhouL. ZhangN. LuoH. WangM. ZhangF. ZhaoZ. GuoZ. WangC. LiL. WangZ. ChenX. WangY. High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer. Discover. Oncology20231412536996352
     [Google Scholar]
  45. SymmansW.F. Interpreting the complex landscape of immune–tumor interface.Clin. Cancer Res.202127205446544810.1158/1078‑0432.CCR‑21‑220834389608
     [Google Scholar]
  46. Nebot-BralL. BrandaoD. VerlingueL. RouleauE. CaronO. DesprasE. El-DakdoukiY. ChampiatS. AoufouchiS. LearyA. MarabelleA. MalkaD. ChaputN. KannoucheP.L. Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine.Eur. J. Cancer20178429030310.1016/j.ejca.2017.07.02628846956
     [Google Scholar]
  47. WangH. LiuY. ZhuX. ChenC. FuZ. WangM. LinD. ChenZ. LuC. YangH. Multistage cooperative nanodrug combined with PD-L1 for enhancing antitumor chemoimmunotherapy.Adv. Healthc. Mater.20211021210119910.1002/adhm.20210119934382363
     [Google Scholar]
/content/journals/cmc/10.2174/0109298673320965240829065919
Loading
Expression Profile and Prognostic Values of IRX Family Members in Lung Adenocarcinoma
Curr. Med. Chem. 32, 7906 (2025); https://doi.org/10.2174/0109298673320965240829065919
/content/journals/cmc/10.2174/0109298673320965240829065919
/content/journals/cmc/10.2174/0109298673320965240829065919
Loading

Data & Media loading...

Supplements

Supplementary material is available on the publisher’s website along with the published article.

file format download Download

  • Article Type:     Research Article
Keyword(s): biomarker; immune infiltration; Iroquois homeobox; lung adenocarcinoma; prognosis; therapeutic target

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test