Skip to content
2000
Volume 32, Issue 30
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Microbes in general, actinomycetes in particular, produce a wide range of antibiotics with various biological activities such as anticancer, antimicrobial, anti-inflammatory, antituberculosis and enzyme inhibition. Actinomycetes are filamentous gram-positive bacteria found in both terrestrial and marine environments. Currently, antibiotics such as Rifamycin, Tetracycline, Kanamycin, Neomycin, Streptomycin and Clavulanic acid derived from actinobacteria are highly useful in the medical field. Out of these biological activities, we need to explore the anticancer activity of various compounds isolated from different actinomycetes since cancer is a deadly disease and it is very common now a day. There are no proper medications for cancer treatment to date. The identification of a drug candidate for cancer treatment will be a striking and lifesaving achievement. Many more research activities must be done in this field. Many molecules have been used as chemotherapeutic agents reported from actinobacteria used for cancer treatment. In this review, various anticancer compounds isolated from the crude extracts of different marine and soil actinomycetes have been reported from 2000-2022. The aim of this review is to summarize and consolidate the anticancer and cytotoxic compounds isolated from the actinomycetes (from different locations) to encourage the scientific community to concentrate more on this field, which will serve good for mankind.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cmc/10.2174/0109298673309904240911080042
2024-12-23
2025-12-13

  • From This Site

    /content/journals/cmc/10.2174/0109298673309904240911080042
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. SudhakarA. History of cancer, ancient and modern treatment methods.J. Cancer Sci. Ther.200912iiv10.4172/1948‑5956.100000e220740081
     [Google Scholar]
  2. SeyfriedT.N. FloresR.E. PoffA.M. D’AgostinoD.P. Cancer as a metabolic disease: Implications for novel therapeutics.Carcinogenesis201435351552710.1093/carcin/bgt48024343361
     [Google Scholar]
  3. DemainA.L. Antibiotics: Natural products essential to human health.Med. Res. Rev.200929682184210.1002/med.2015419291695
     [Google Scholar]
  4. SauravK. KannabiranK. Cytotoxicity and antioxidant activity of 5-(2,4-dimethylbenzyl)pyrrolidin-2-one extracted from marine Streptomyces VITSVK5 spp.Saudi J. Biol. Sci.2012191818610.1016/j.sjbs.2011.07.00323961165
     [Google Scholar]
  5. ZhuX. TianX. YuC. ShenC. YanT. HongJ. WangZ. FangJ.Y. ChenH. A long non-coding RNA signature to improve prognosis prediction of gastric cancer.Mol. Cancer20161516010.1186/s12943‑016‑0544‑027647437
     [Google Scholar]
  6. SubramanianA.P. JaganathanS.K. ManikandanA. PandiarajK.N. NG. SupriyantoE. Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy.RSC Advances2016654482944831410.1039/C6RA07802H
     [Google Scholar]
  7. NakaewN. Pathom-areeW. LumyongS. First record of the isolation, identification and biological activity of a new strain of Spirillospora albida from Thai cave soil.Actinomycetologica20092311710.3209/saj.SAJ230102
     [Google Scholar]
  8. DaighamG.E. MahfouzA.Y. Isolation, characterization, and screening of actinomycetes producing bioactive compounds from Egyptian soil.Egypt. Pharm. J.202019438110.4103/epj.epj_44_20
     [Google Scholar]
  9. BhatM.P NayakaS. KumarR.S. A swamp forest Streptomyces sp. strain KF15 with broad spectrum antifungal activity against chilli pathogens exhibits anticancer activity on HeLa cells.Arch. Microbiol.2022204954010.1007/s00203‑022‑03147‑7
     [Google Scholar]
  10. BahriA. MoazamianE. AzarpiraN. Molecular identification, isolation and evaluation of persian gulf actinomycetes as candidates of cytotoxic metabolites against breast cancer.Multidisciplinary Cancer Investigation201713101410.21859/mci‑01035
     [Google Scholar]
  11. GongB. ChenS. LanW. HuangY. ZhuX. Antibacterial and antitumor potential of actinomycetes isolated from mangrove soil in the Maowei Sea of the southern coast of China.Iran. J. Pharm. Res.20181741339134630568692
     [Google Scholar]
  12. HamedM.M. AbdraboM.A.A. FahmyN.M. AbdelfattahL.S. KelanyM.S. Abd-El latifH.H. El elaG.M.A. Abd-ElnabyH.M. HassanS.W.M. Distribution and characterization of actinomycetes in mangrove habitats (Red Sea, Egypt) with special emphasis on Streptomyces mutabilis M3MT483919.J. Pure Appl. Microbiol.202115124626110.22207/JPAM.15.1.19
     [Google Scholar]
  13. SaviD.C. HaminiukC.W.I. SoraG.T.S. AdamoskiD.M. KenskiJ. WinnischoferS.M.B. GlienkeC. Antitumor, antioxidant and antibacterial activities of secondary metabolites extracted by endophytic actinomycetes isolated from vochysiadivergens.Int. J. Pharm. Chem. Biol. Sci.201551
     [Google Scholar]
  14. OliverosK.M RosanaA.R. MontecilloA.D. OpulenciaR.B. JacildoA.J. ZulaybarT.O. RaymundoA.K. Genomic insights into the antimicrobial and anticancer potential of Streptomyces sp. A1-08 isolated from volcanic soils of Mount Mayon, Philippines.Philipp. J. Sci.20211506A13511377
     [Google Scholar]
  15. QasimB. RisanM.H. Anti-tumor and antimicrobial activity of antibiotic produced by Streptomyces spp.World J. Pharm. Res.20176411612810.20959/wjpr20174‑8121
     [Google Scholar]
  16. YongsmithB. Bioenrichment of Vitamin B 12 in Fermented Foods.Functional Properties of Traditional Foods.Boston, MASpringer2016173710.1007/978‑1‑4899‑7662‑8_3
     [Google Scholar]
  17. BundaleS. SinghJ. BegdeD. NashikkarN. UpadhyayA. Rare actinobacteria: A potential source of bioactive polyketides and peptides.World J. Microbiol. Biotechnol.20193569210.1007/s11274‑019‑2668‑z31187317
     [Google Scholar]
  18. VidhyashreeN. Yamini Sudha LakshmiS. Screening, isolation, identification, characterisation and applications of silver nanoparticles synthesized from marine actinomycetes (Streptomyces grieseorubens).World J. Pharm. Res.20154818011820
     [Google Scholar]
  19. SelvakumarJ.N. ChandrasekaranS.D. Bio prospecting of marine-derived Streptomyces spectabilis VITJS10 and exploring its cytotoxicity against human liver cancer cell lines.Pharmacognosy Magazine201511Suppl 3S469
     [Google Scholar]
  20. KimJung ParkYoung-Min LimDo-Seon Purification of materials produced by Amylocolatosis sp. and anticancer effect in oral cancer model.J. Dent. Hyg. Sci.2003311114
     [Google Scholar]
  21. SriM. Biosynthesis of silver nanoparticles using Streptomyces griseus pds1 for anticancer activity.IOSR J. Pharm. Biol. Sci.20191261116
     [Google Scholar]
  22. VeluswamyS.C.B. ParimalaG.S.A. Anti-cancer activity of green sporal polyketide from streptomyces sp-jb87 isolated from Jasmonium brevilobum.World J. Pharm. Res.201541118411853
     [Google Scholar]
  23. HuangZ.Y. TangJ.S. GaoH. LiY.J. HongK. LiJ. YaoX.S. Studies on the cytotoxic constituents from marine actinomycete Micromonospora sp.Chin. J. Mar. Drugs2011302933
     [Google Scholar]
  24. DanielK. GuravaiahM. Anticancer activity and ant diabetic activity of Aspergillus stereusaf1.J. Pharm. Res20177212601266
     [Google Scholar]
  25. NakaewN. Pathom-areeW. LumyongS. Generic diversity of rare actinomycetes from Thai cave soils and their possible use as new bioactive compounds.Actinomycetologica2009232212610.3209/saj.SAJ230201
     [Google Scholar]
  26. GozariM. ZaheriA. JahromiS.T. GozariM. KarimzadehR. Screening and characterization of marine actinomycetes from the northern Oman Sea sediments for cytotoxic and antimicrobial activity.Int. Microbiol.201922452153010.1007/s10123‑019‑00083‑331144066
     [Google Scholar]
  27. ChambiyalG. Antibacterial and Anticancer property of bioactive secondary metabolites from Actinomycetes isolated from different regions of Himachal Pradesh.2018
     [Google Scholar]
  28. ArumugamT. Senthil KumarP. Optimization of media components for production of antimicrobial compound by Brevibacillus brevis EGS9 isolated from mangrove ecosystem.J. Microbiol. Methods2017142838910.1016/j.mimet.2017.09.01028923690
     [Google Scholar]
  29. AlmuhayawiM. MohamedM. Abdel-MawgoudM. SelimS. Al JaouniS. AbdElgawadH. Bioactive potential of several actinobacteria isolated from microbiologically barely explored desert habitat, Saudi Arabia.Biology202110323510.3390/biology1003023533808594
     [Google Scholar]
  30. TanL.T.H. SerH.L. YinW.F. ChanK.G. LeeL.H. GohB.H. Investigation of antioxidative and anticancer potentials of Streptomyces sp. MUM256 isolated from Malaysia mangrove soil.Front. Microbiol.20156131610.3389/fmicb.2015.0131626635777
     [Google Scholar]
  31. SubbaiyaR. SaravananM. PriyaA.R. ShankarK.R. SelvamM. OvaisM. BalajeeR. BarabadiH. Biomimetic synthesis of silver nanoparticles from Streptomyces atrovirens and their potential anticancer activity against human breast cancer cells.IET Nanobiotechnol.201711896597210.1049/iet‑nbt.2016.022229155396
     [Google Scholar]
  32. PolapallyR. MansaniM. RajkumarK. BurgulaS. HameedaB. AlhazmiA. BantunF. AlmalkiA.H. HaqueS. El EnshasyH.A. SayyedR.Z. Melanin pigment of Streptomyces puniceus RHPR9 exhibits antibacterial, antioxidant and anticancer activities.PLoS One2022174e026667610.1371/journal.pone.026667635468144
     [Google Scholar]
  33. HongK. GaoA.H. XieQ.Y. GaoH.G. ZhuangL. LinH.P. YuH.P. LiJ. YaoX.S. GoodfellowM. RuanJ.S. Actinomycetes for marine drug discovery isolated from mangrove soils and plants in China.Mar. Drugs200971244410.3390/md701002419370169
     [Google Scholar]
  34. HuangX.L. ZhuangL. LinH.P. LiJ. GoodfellowM. HongK. X. L. Huang Isolation and bioactivity of endophytic filamentous actinobacteria from tropical medicinal plants.Afr. J. Biotechnol.201211419855986410.5897/AJB11.3839
     [Google Scholar]
  35. SangdeeK. Investigation of antibacterial and anti-cancer activities of Streptomyces sp. SRF1 culture filtrate.Trop. J. Pharm. Res.201716112727273410.4314/tjpr.v16i11.21
     [Google Scholar]
  36. FahmyN.M. Abdel-TawabA.M. Isolation and characterization of marine sponge–associated Streptomyces sp. NMF6 strain producing secondary metabolite(s) possessing antimicrobial, antioxidant, anticancer, and antiviral activities.J. Genet. Eng. Biotechnol.202119110210.1186/s43141‑021‑00203‑534264405
     [Google Scholar]
  37. SarikaK. SampathG. Kaveriyappan GovindarajanR. AmeenF. AlwakeelS. Al GwaizH.I. Raja KomuraiahT. RaviG. Antimicrobial and antifungal activity of soil actinomycetes isolated from coal mine sites.Saudi J. Biol. Sci.20212863553355810.1016/j.sjbs.2021.03.02934121898
     [Google Scholar]
  38. AndayaniD.G.S. SukandarU. SukandarE.Y. Ketut AdnyanaI. Antibacterial, antifungal and anticancer activity of five strains of soil microorganisms isolated from tangkuban perahu mountain by fermentation.HAYATI J Biosci2015224186190
     [Google Scholar]
  39. AbdelfattahM.S. ElmallahM.I.Y. HawasU.W. Abou El-KassemaL.T. EidM.A.G. Isolation and characterization of marine-derived actinomycetes with cytotoxic activity from the Red Sea coast.Asian Pac. J. Trop. Biomed.20166865165710.1016/j.apjtb.2016.06.004
     [Google Scholar]
  40. KarthikY. KalyaniM.I. Cytotoxic and antimicrobial activities of microbial proteins from mangrove soil actinomycetes of Mangalore, Dakshina Kannada.Biomedicine20204015967
     [Google Scholar]
  41. KhatunM.F. HaqueM.U. IslamM.A.U. Antibacterial and cytotoxic activities of crude ethyl acetate extract of Streptomyces sp. FEAI-1 isolated from soil samples of Rajshahi, Bangladesh.Bangladesh Pharmaceutical Journal201820218819310.3329/bpj.v20i2.37884
     [Google Scholar]
  42. RipaF.A. NikkonF. In vitro antibacterial activity of bioactive metabolite and crude extract from a new Streptomyces sp. Streptomyces rajshahiensis.Int. J. Pharm. Tech. Res.201021644648
     [Google Scholar]
  43. S SP. RudayniH.A. BepariA. NiaziS.K. NayakaS. Green synthesis of Silver nanoparticles using Streptomyces hirsutus strain SNPGA-8 and their characterization, antimicrobial activity, and anticancer activity against human lung carcinoma cell line A549.Saudi J. Biol. Sci.202229122823810.1016/j.sjbs.2021.08.08435002413
     [Google Scholar]
  44. Al-AnsariM. KalaiyarasiM. AlmalkiM.A. VijayaraghavanP. Optimization of medium components for the production of antimicrobial and anticancer secondary metabolites from Streptomyces sp. AS11 isolated from the marine environment.J. King Saud Univ. Sci.20203231993199810.1016/j.jksus.2020.02.005
     [Google Scholar]
  45. Nadar RajivgandhiG. RamachandranG. LiJ.L. YinL. ManoharanN. Rajesh KannanM. Antony Joseph VelanganniA. AlharbiN.S. KadaikunnanS. KhaledJ.M. LiW-J. Molecular identification and structural detection of anti-cancer compound from marine Streptomyces akiyoshiensis GRG 6 (KY457710) against MCF-7 breast cancer cells.J. King Saud Univ. Sci.20203283463346910.1016/j.jksus.2020.10.008
     [Google Scholar]
  46. Abd-ElnabyH.M. Abo-ElalaG.M. Abdel-RaoufU.M. HamedM.M. Antibacterial and anticancer activity of extracellular synthesized silver nanoparticles from marine Streptomyces rochei MHM13.Egypt. J. Aquat. Res.201642330131210.1016/j.ejar.2016.05.004
     [Google Scholar]
  47. Davies-BolorunduroO.F. AdeleyeI.A. AkinleyeM.O. WangP.G. Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment.J. Pharm. Anal.20199320120810.1016/j.jpha.2019.03.00431297298
     [Google Scholar]
  48. PhamHuyen T. NguyenNhue P. PhiTien Q. DangPhuong T. LeHy G. The antibacterial and anticancer activity of marine Actinomycete strain HP411 isolated in the Northern Coast of Vietnam.Actinomycetes20145915
     [Google Scholar]
  49. IzumikawaM. KhanS.T. KomakiH. TakagiM. Shin-yaK. JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge.J. Antibiot.2010631333610.1038/ja.2009.11319927166
     [Google Scholar]
  50. DhaneeshaM. SajeevanT.P. Anticancer activity of sponge associated actinomycetes Streptomyces sp. MCCB267 On lung cancer cell line.Proceedings of 28th Kerala Science CongressUniversity of Calicut, January 2016, pp. 1628-1639.
     [Google Scholar]
  51. KalimuthuK. KumaravelM. HaldarD. PerumalA. Isolation and characterization of marine actinomycetes–bioprospecting for antimicrobial, antioxidant and anticancer properties.Research Square202212110.21203/rs.3.rs‑1546784/v1
     [Google Scholar]
  52. DineshkumarK. AparnaV. MadhuriK.Z. HopperW. Biological activity of sporolides A and B from Salinispora tropica: In silico target prediction using ligand-based pharmacophore mapping and in vitro activity validation on HIV-1 reverse transcriptase.Chem. Biol. Drug Des.201483335036110.1111/cbdd.1225224165098
     [Google Scholar]
  53. HaqueM.U. RahmanM.A. HaqueM.A. SarkerA.K. IslamM.A. Antimicrobial and anticancer activities of ethyl acetate extract of co-culture of Streptomyces sp. ANAM-5 and AIAH-10 isolated from Mangrove Forest of Sundarbans, Bangladesh.J. Appl. Pharm. Sci.20166205105510.7324/JAPS.2016.60207
     [Google Scholar]
  54. DhaneeshaM. Benjamin NamanC. KrishnanK. P. Rupesh Kumar SinhaP. Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products.3 Biotech201771110
     [Google Scholar]
  55. Prieto-DavóA. DiasT. GomesS.E. RodriguesS. Parera-ValadezY. BorralhoP.M. PereiraF. RodriguesC.M.P. Santos-SanchesI. GaudêncioS.P. The Madeira archipelago as a significant source of marine-derived actinomycete diversity with anticancer and antimicrobial potential.Front. Microbiol.20167159410.3389/fmicb.2016.0159427774089
     [Google Scholar]
  56. ElsayedT.R. GalilD.F. SedikM.Z. HassanH.M.M. SadikM.W. Antimicrobial and anticancer activities of actinomycetes isolated from Egyptian soils.Int. J. Curr. Microbiol. Appl. Sci.2020991689170010.20546/ijcmas.2020.909.209
     [Google Scholar]
  57. AhmadM.S. YasserM.M. SholkamyE.N. AliA.M. MehanniM.M. Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1.Int. J. Nanomedicine2015103389340126005349
     [Google Scholar]
  58. OlanoC. MéndezC. SalasJ.A. Antitumor compounds from marine actinomycetes.Mar. Drugs20097221024810.3390/md702021019597582
     [Google Scholar]
  59. NagaseshuP. GayatrideviV. KumarA.B. KumariS. MohanM.G. MallaR. Antioxidant and antiproliferative potentials of marine actinomycetes.Int. J. Pharm. Pharm. Sci.20168277284
     [Google Scholar]
  60. VeenaS. SwethaD. KarthikL. Bhaskara RaoK.V. Assessment of anti-typhoid and antioxidant activity of marine actinobacteria isolated from Chennai marine sediments.Pharm. Lett.201683166172
     [Google Scholar]
  61. RavikumarS. FredimosesM. GnanadesiganM. Anticancer property of sediment actinomycetes against MCF–7 and MDA–MB–231 cell lines.Asian Pac. J. Trop. Biomed.201222929610.1016/S2221‑1691(11)60199‑823569875
     [Google Scholar]
  62. El-GendyM.M.A.A. ShaymaaM.M. Assessment of the phylogenetic analysis and antimicrobial, antiviral, and anticancer activities of marine endophytic Streptomyces species of the soft coral Sarcophyton convolutum.Int. Microbiol.202225113315210.1007/s10123‑021‑00204‑x34427819
     [Google Scholar]
  63. SabidoE.M. TenebroC.P. TronoD.J.V.L. ViceraC.V.B. LeonidaS.F.L. MaybayJ.J.W.B. Reyes-SalardaR. AmagoD.S. AguaderaA.M.V. OctavianoM.C. SaludesJ.P. DalisayD.S. Insights into the variation in bioactivities of closely related Streptomyces Strains from marine sediments of the Visayan Sea against ESKAPE and ovarian cancer.Mar. Drugs202119844110.3390/md1908044134436280
     [Google Scholar]
  64. OsamaN. BakeerW. RaslanM. SolimanH.A. AbdelmohsenU.R. SebakM. Anti-cancer and antimicrobial potential of five soil Streptomycetes : A metabolomics-based study.R. Soc. Open Sci.20229221150910.1098/rsos.21150935154794
     [Google Scholar]
  65. Saravana KumarP. Al-DhabiN.A. DuraipandiyanV. BalachandranC. Praveen KumarP. IgnacimuthuS. In vitro antimicrobial, antioxidant and cytotoxic properties of Streptomyces lavendulae strain SCA5.BMC Microbiol.201414129110.1186/s12866‑014‑0291‑625433533
     [Google Scholar]
  66. MartinG.D.A. TanL.T. JensenP.R. DimayugaR.E. FairchildC.R. Raventos-SuarezC. FenicalW. Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces.J. Nat. Prod.20077091406140910.1021/np060621r17844998
     [Google Scholar]
  67. ShinH-J. JeongH-S. LeeH-S. ParkS-K. KimH-M. KwonH-J. Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110.J. Microbiol. Biotechnol.20071781403140618051613
     [Google Scholar]
  68. FuP. KongF. WangY. WangY. LiuP. ZuoG. ZhuW. Antibiotic metabolites from the coral-associated actinomycete Streptomyces sp. OUCMDZ-1703.Chin. J. Chem.201331110010410.1002/cjoc.201201062
     [Google Scholar]
  69. Carretero-MolinaD. Ortiz-LópezF.J. MartínJ. Oves- CostalesD. DíazC. de la CruzM. CautainB. VicenteF. GenilloudO. ReyesF. New napyradiomycin analogues from Streptomyces sp. strain CA-271078.Mar. Drugs20191812210.3390/md1801002231888028
     [Google Scholar]
  70. HughesC.C. Prieto-DavoA. JensenP.R. FenicalW. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.Org. Lett.200810462963110.1021/ol702952n18205372
     [Google Scholar]
  71. HughesC.C. MacMillanJ.B. GaudêncioS.P. JensenP.R. FenicalW. The ammosamides: Structures of cell cycle modulators from a marine-derived Streptomyces species.Angew. Chem. Int. Ed.200948472572710.1002/anie.20080489019090514
     [Google Scholar]
  72. LiF. MaskeyR.P. QinS. SattlerI. FiebigH.H. MaierA. ZeeckA. LaatschH. Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045.J. Nat. Prod.200568334935310.1021/np030518r15787434
     [Google Scholar]
  73. MillerE.D. KauffmanC.A. JensenP.R. FenicalW. Piperazimycins: Cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus Streptomyces.J. Org. Chem.200772232333010.1021/jo061064g17221946
     [Google Scholar]
  74. Soria-MercadoI.E. Prieto-DavoA. JensenP.R. FenicalW. Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete.J. Nat. Prod.200568690491010.1021/np058011z15974616
     [Google Scholar]
  75. FarnaesL. La ClairJ.J. FenicalW. Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94.Org. Biomol. Chem.201412341842310.1039/C3OB41355A24292715
     [Google Scholar]
  76. HawasU.W. ShaabanM. ShaabanK.A. SpeitlingM. MaierA. KelterG. FiebigH.H. MeinersM. HelmkeE. LaatschH. Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete.J. Nat. Prod.200972122120212410.1021/np900160g19921834
     [Google Scholar]
  77. KwonH.C. EspindolaA.P.D.M. ParkJ-S. Prieto- DavóA. RoseM. JensenP.R. FenicalW. Nitropyrrolins A−E, cytotoxic farnesyl-α-nitropyrroles from a marine-derived bacterium within the actinomycete family Streptomycetaceae.J. Nat. Prod.201073122047205210.1021/np100622921090803
     [Google Scholar]
  78. ZhangW. LiuZ. LiS. YangT. ZhangQ. MaL. TianX. ZhangH. HuangC. ZhangS. JuJ. ShenY. ZhangC. Spiroindimicins A-D: New bisindole alkaloids from a deep-sea-derived actinomycete.Org. Lett.201214133364336710.1021/ol301343n22694269
     [Google Scholar]
  79. ZhangX. ZhangY. ZhaoJ. LiuC. WangS. YangL. HeH. XiangW. WangX. Nonomuraea fuscirosea sp. nov., an actinomycete isolated from the rhizosphere soil of rehmannia (Rehmannia glutinosa Libosch). Int. J. Syst. Evol. Microbiol.201464211021107
     [Google Scholar]
  80. PanE. OswaldN.W. LegakoA.G. LifeJ.M. PosnerB.A. MacMillanJ.B. Precursor-directed generation of amidine containing ammosamide analogs: Ammosamides E–P.Chem. Sci.20134148248810.1039/C2SC21442C23209870
     [Google Scholar]
  81. Alvarez-MicoX. JensenP.R. FenicalW. HughesC.C. Chlorizidine, a cytotoxic 5H-pyrrolo[2,1-a]isoindol-5-one- containing alkaloid from a marine Streptomyces sp. Org. Lett.201315598899110.1021/ol303374e23405849
     [Google Scholar]
  82. ChengY.B. JensenP.R. FenicalW. Cytotoxic and antimicrobial napyradiomycins from two marine-derived Streptomyces strains.Eur. J. Org. Chem.20132013183751375710.1002/ejoc.20130034924376369
     [Google Scholar]
  83. WuZ. LiS. LiJ. ChenY. SauravK. ZhangQ. ZhangH. ZhangW. ZhangW. ZhangS. ZhangC. Antibacterial and cytotoxic new napyradiomycins from the marine-derived Streptomyces sp. SCSIO 10428.Mar. Drugs20131162113212510.3390/md1106211323771045
     [Google Scholar]
  84. MoonK. AhnC.H. ShinY. WonT. KoK. LeeS. OhK.B. ShinJ. NamS.I. OhD.C. New benzoxazine secondary metabolites from an arctic actinomycete.Mar. Drugs20141252526253810.3390/md1205252624796308
     [Google Scholar]
  85. AsolkarR.N. SinghA. JensenP.R. AalbersbergW. CartéB.K. FeussnerK.D. SubramaniR. DiPasqualeA. RheingoldA.L. FenicalW. Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete clade MAR4.Tetrahedron201773162234224110.1016/j.tet.2017.03.00328814819
     [Google Scholar]
  86. JiangY.J. LiJ.Q. ZhangH.J. DingW.J. MaZ.J. Cyclizidine-type alkaloids from Streptomyces sp. HNA39.J. Nat. Prod.201881239439910.1021/acs.jnatprod.7b0105529389122
     [Google Scholar]
  87. SongY. YangJ. YuJ. LiJ. YuanJ. WongN.K. JuJ. Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities.J. Antibiot.202073854254710.1038/s41429‑020‑0307‑432332871
     [Google Scholar]
  88. HardtI.H. JensenP.R. FenicalW. Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales).Tetrahedron Lett.200041132073207610.1016/S0040‑4039(00)00117‑9
     [Google Scholar]
  89. FelingR.H. BuchananG.O. MincerT.J. KauffmanC.A. JensenP.R. FenicalW. Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.Angew. Chem. Int. Ed.200342335535710.1002/anie.20039011512548698
     [Google Scholar]
  90. OhD.C. WilliamsP.G. KauffmanC.A. JensenP.R. FenicalW. Cyanosporasides A and B, chloro- and cyano- cyclopenta[a]indene glycosides from the marine actinomycete “Salinispora pacifica”.Org. Lett.2006861021102410.1021/ol052686b16524258
     [Google Scholar]
  91. MaloneyK.N. MacMillanJ.B. KauffmanC.A. JensenP.R. DiPasqualeA.G. RheingoldA.L. FenicalW. Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.Org. Lett.200911235422542410.1021/ol901997k19883103
     [Google Scholar]
  92. SnipesC.E. DuebelbeisD.O. OlsonM. HahnD.R. DentW.H.III GilbertJ.R. WerkT.L. DavisG.E. Lee-LuR. GraupnerP.R. The ansacarbamitocins: Polar ansamitocin derivatives.J. Nat. Prod.200770101578158110.1021/np070275t17892263
     [Google Scholar]
  93. LiJ. LuC. ShenY. Macrolides of the bafilomycin family produced by Streptomyces sp. CS.J. Antibiot.2010631059559910.1038/ja.2010.9520823894
     [Google Scholar]
  94. ZhaoP.J. FanL.M. LiG.H. ZhuN. ShenY.M. Antibacterial and antitumor macrolides from streptomyces sp. Is9131.Arch. Pharm. Res.200528111228123210.1007/BF0297820316350846
     [Google Scholar]
  95. IgarashiY. YanaseS. SugimotoK. EnomotoM. MiyanagaS. TrujilloM.E. SaikiI. KuwaharaS. Lupinacidin C, an inhibitor of tumor cell invasion from Micromonospora lupini.J. Nat. Prod.201174486286510.1021/np100779t21226490
     [Google Scholar]
  96. KimN. ShinJ.C. KimW. HwangB.Y. KimB.S. HongY.S. LeeD. Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi. J. Antibiot.2006591279780010.1038/ja.2006.10517323647
     [Google Scholar]
  97. IgarashiY. MiuraS. FujitaT. FurumaiT. Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus. J. Antibiot.200659319319510.1038/ja.2006.2816724461
     [Google Scholar]
  98. FuP. YangC. WangY. LiuP. MaY. XuL. SuM. HongK. ZhuW. Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strain Streptomyces sp. FMA.Org. Lett.20121492422242510.1021/ol300863822519738
     [Google Scholar]
  99. KumarK.S. AnuradhaS. SarmaG.R. Screening, isolation, taxonomy and fermentation of an antibiotic producer Streptomyces xinghaiensis from soil capable of acting against linezolid resistant strains.Indian J. Exp. Biol.20125010718728
     [Google Scholar]
  100. MohammadipanahF. MomenilandiM. Potential of rare actinomycetes in the production of metabolites against multiple oxidant agents.Pharm. Biol.2018561515910.1080/13880209.2017.141745129275696
     [Google Scholar]
  101. MangamuriU.K. VijayalakshmiM. PodaS. ManavathiB. ChitturiB. Isolation and biological evaluation of N-(4-aminocyclooctyl)-3, 5-dinitrobenzamide, a new semisynthetic derivative from the Mangrove-associated actinomycete Pseudonocardia endophytica VUK-10.3 Biotech201662112
     [Google Scholar]
  102. DingL. MaierA. FiebigH.H. GörlsH. LinW.H. PeschelG. HertweckC. Divergolides A-D from a mangrove endophyte reveal an unparalleled plasticity in ansa-macrolide biosynthesis.Angew. Chem. Int. Ed.20115071630163410.1002/anie.20100616521308920
     [Google Scholar]
  103. AbrahamJ. ChauhanR. Profiling of red pigment produced by Streptomyces sp. JAR6 and its bioactivity.3 Biotech2018811910.1007/s13205‑017‑1044‑7
     [Google Scholar]
  104. ÖzakinS. DavisR.W. UmileT.P. PirincciogluN. KizilM. CelikG. SenA. MinbioleK.P.C. İnceE. The isolation of tetrangomycin from terrestrial Streptomyces sp. CAH29: evaluation of antioxidant, anticancer, and anti-MRSA activity.Med. Chem. Res.201625122872288110.1007/s00044‑016‑1708‑6
     [Google Scholar]
  105. MangroliaU. OsborneW.J. Staphylococcus xylosus VITURAJ10: Pyrrolo [1,2α] pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl) (PPDHMP) producing, potential probiotic strain with antibacterial and anticancer activity.Microb. Pathog.202014710425910.1016/j.micpath.2020.10425932446871
     [Google Scholar]
  106. LimaS.M. MeloJ.G. MilitãoG.C. LimaG.M. do Carmo A LimaM. AguiarJ.S. AraújoR.M. Braz-FilhoR. MarchandP. AraújoJ.M. SilvaT.G. Characterization of the biochemical, physiological, and medicinal properties of Streptomyces hygroscopicus ACTMS-9H isolated from the Amazon (Brazil).Appl. Microbiol. Biotechnol.2017101271172310.1007/s00253‑016‑7886‑927757508
     [Google Scholar]
  107. RatherS.A. ShahA.M. AliS.A. DarR.A. RahB. AliA. HassanQ.P. Isolation and characterization of Streptomyces tauricus from Thajiwas glacier—a new source of actinomycin-D.Med. Chem. Res.20172691897190210.1007/s00044‑017‑1842‑9
     [Google Scholar]
  108. JaroszewiczW. BielańskaP. LubomskaD. Kosznik-KwaśnickaK. GolecP. GrabowskiŁ. WieczerzakE. DróżdżW. GaffkeL. PierzynowskaK. WęgrzynG. WęgrzynA. Antibacterial, antifungal and anticancer activities of compounds produced by newly isolated Streptomyces strains from the Szczelina Chochołowska cave (Tatra Mountains, Poland).Antibiotics20211010121210.3390/antibiotics1010121234680793
     [Google Scholar]
  109. FuP. WangS. HongK. LiX. LiuP. WangY. ZhuW. Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6.J. Nat. Prod.20117481751175610.1021/np200258h21770434
     [Google Scholar]
  110. KwonY. KimS.H. ShinY. BaeM. KimB.Y. LeeS. OhK.B. ShinJ. OhD.C. A new benzofuran glycoside and indole alkaloids from a sponge-associated rare actinomycete, Amycolatopsis sp.Mar. Drugs20141242326234010.3390/md1204232624759001
     [Google Scholar]
  111. KawaharaT. ItohM. IzumikawaM. KozoneI. SakataN. TsuchidaT. Shin-yaK. New hydroxamate metabolite, MBJ-0003, from Micromonospora sp. 29867.J. Antibiot.201467326126310.1038/ja.2013.12424252811
     [Google Scholar]
  112. LiuD. LinH. ProkschP. TangX. ShaoZ. LinW. Microbacterins A and B, new peptaibols from the deep sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T).Org. Lett.20151751220122310.1021/acs.orglett.5b0017225675340
     [Google Scholar]
  113. SuthindhirK. KannabiranK. Cytotoxic and antimicrobial potential of actinomycete species Saccharopolyspora salina VITSDK4 isolated from the Bay of Bengal Coast of India.Am. J. Infect. Dis.200952909810.3844/ajidsp.2009.90.98
     [Google Scholar]
  114. HolkarS. BegdeD. NashikkarN. KadamT. UpadhyayA. Rhodomycin analogues from Streptomyces purpurascens: isolation, characterization and biological activities.Springerplus2013219310.1186/2193‑1801‑2‑9323419944
     [Google Scholar]
  115. KadiriS. YarlaN.S. VidavalurS. Isolation and identification of a novel aporphine alkaloid SSV, an antitumor antibiotic from fermented broth of marine associated Streptomyces sp. KS1908.J. Mar. Sci. Res. Dev.201334110.4172/2155‑9910.1000137
     [Google Scholar]
  116. SauravK. KannabiranK. Biosorption of Cr(III) and Cr(VI) by Streptomyces VITSVK9 spp.Ann. Microbiol.201161483384110.1007/s13213‑011‑0204‑y
     [Google Scholar]
  117. GorajanaA. KuradaB.V.V.S.N. PeelaS. JangamP. VinjamuriS. PoluriE. ZeeckA. 1-Hydroxy-1-norresistomycin, a new cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.J. Antibiot.200558852652910.1038/ja.2005.7216266126
     [Google Scholar]
  118. FrancoC.M.M. GandhiJ.N. ChatterjeeS. GanguliB.N. Swalpamycin, a new macrolide antibiotic. I. Taxonomy of the producing organism, fermentation, isolation and biological activity.J. Antibiot.198740101361136710.7164/antibiotics.40.13613680001
     [Google Scholar]
  119. NithyaB. PonmuruganP. FredimosesP. 16S rRNA phylogenetic analysis of actinomycetes isolated from Eastern Ghats and marine mangrove associated with antibacterial and anticancerous activities.Afr. J. Biotechnol.201211601237912388
     [Google Scholar]
  120. Al-DhabiN.A. Mohammed GhilanA.K. EsmailG.A. Valan ArasuM. DuraipandiyanV. PonmuruganK. Bioactivity assessment of the Saudi Arabian Marine Streptomyces sp. Al-Dhabi-90, metabolic profiling and its in vitro inhibitory property against multidrug resistant and extended-spectrum beta-lactamase clinical bacterial pathogens.J. Infect. Public Health201912454955610.1016/j.jiph.2019.01.06530755364
     [Google Scholar]
  121. DemainA.L. SanchezS. Microbial drug discovery: 80 years of progress.J. Antibiot.200962151610.1038/ja.2008.1619132062
     [Google Scholar]
  122. ArcamoneF. AnimatiF. CapranicoG. LombardiP. PratesiG. ManziniS. SupinoR. ZuninoF. New developments in antitumor anthracyclines.Pharmacol. Ther.1997761-311712410.1016/S0163‑7258(97)00096‑X9535173
     [Google Scholar]
  123. OsakiT. YokoeI. UtoY. IshizukaM. TanakaT. YamanakaN. KurahashiT. AzumaK. MurahataY. TsukaT. ItoN. ImagawaT. OkamotoY. Bleomycin enhances the efficacy of sonodynamic therapy using aluminum phthalocyanine disulfonate.Ultrason. Sonochem.20162816116810.1016/j.ultsonch.2015.07.01326384895
     [Google Scholar]
  124. SoleckaJ. ZajkoJ. PostekM. RajniszA. Biologically active secondary metabolites from Actinomycetes.Open Life Sci.20127337339010.2478/s11535‑012‑0036‑1
     [Google Scholar]
  125. EleazuC.O. EleazuK.C. ChukwumaS. EssienU.N. Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans.J. Diabetes Metab. Disord.20131216010.1186/2251‑6581‑12‑6024364898
     [Google Scholar]
  126. CriscitielloC. MorgantiS. CuriglianoG. Antibody–drug conjugates in solid tumors: A look into novel targets.J. Hematol. Oncol.20211412010.1186/s13045‑021‑01035‑z33509252
     [Google Scholar]
  127. ZhangH. SunG.Z. LiX. PanH.Y. ZhangY.S. A new geldanamycin analogue from Streptomyces hygroscopicus. Molecules20101531161116710.3390/molecules1503116120335971
     [Google Scholar]
  128. GorajanaA. MV. VinjamuriS. KuradaB.V.V.S.N. PeelaS. JangamP. PoluriE. ZeeckA. Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.Microbiol. Res.2007162432232710.1016/j.micres.2006.01.01216580188
     [Google Scholar]
  129. BhatnagarI. KimS.K. Immense essence of excellence: Marine microbial bioactive compounds.Mar. Drugs20108102673270110.3390/md810267321116414
     [Google Scholar]
  130. ChoJ.Y. WilliamsP.G. KwonH.C. JensenP.R. FenicalW. Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis. J. Nat. Prod.20077081321132810.1021/np070101b17630797
     [Google Scholar]
  131. PérezM. CrespoC. SchleissnerC. RodríguezP. ZúñigaP. ReyesF. TartrolonD. A cytotoxic macrodiolide from the marine-derived actinomycete Streptomyces sp. MDG-04-17-069.J. Nat. Prod.200972122192219410.1021/np900660319968258
     [Google Scholar]
  132. HohmannC. SchneiderK. BruntnerC. IrranE. NicholsonG. BullA.T. JonesA.L. BrownR. StachJ.E.M. GoodfellowM. BeilW. KrämerM. ImhoffJ.F. SüssmuthR.D. FiedlerH.P. Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937.J. Antibiot.20096229910410.1038/ja.2008.2419198633
     [Google Scholar]
  133. Abdel-MageedW.M. MilneB.F. WagnerM. SchumacherM. SandorP. Pathom-areeW. GoodfellowM. BullA.T. HorikoshiK. EbelR. DiederichM. FiedlerH.P. JasparsM. Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment.Org. Biomol. Chem.20108102352236210.1039/c001445a20448892
     [Google Scholar]
  134. SahaS. MollickS. ZamanS. The uses of bacteria in cancer therapy.PhD diss., Brac University2021
     [Google Scholar]
  135. MotohashiK. TakagiM. Shin-yaK. Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26.J. Nat. Prod.201073475575810.1021/np900740920192240
     [Google Scholar]
  136. MaskeyR.P. LiF.C. QinS. FiebigH.H. LaatschH. Chandrananimycins A approximately C: Production of novel anticancer antibiotics from a marine Actinomadura sp. isolate M048 by variation of medium composition and growth conditions.J. Antibiot.200356762262910.7164/antibiotics.56.62214513905
     [Google Scholar]
  137. GanesanS. VelsamyG. SivasudhaT. ManoharanN. MALDI-TOF mass spectrum profiling, antibacterial and anticancer activity of marine Streptomyces fradiae BDMS1.World J. Pharm. Pharm. Sci.20132651485165
     [Google Scholar]
  138. JensenP.R. MafnasC. Biogeography of the marine actinomycete Salinispora.Environ. Microbiol.20068111881188810.1111/j.1462‑2920.2006.01093.x17014488
     [Google Scholar]
  139. Abd-ElnabyH. Abo-ElalaG. Abdel-RaoufU. Abd-elwahabA. HamedM. Antibacterial and anticancer activity of marine Streptomyces parvus : Optimization and application.Biotechnol. Biotechnol. Equip.201630118019110.1080/13102818.2015.1086280
     [Google Scholar]
  140. Abdel-AzizM.S. HathoutA.S. El-NeleetyA.A. HamedA.A. SabryB.A. AlyS.E. Abdel-WahhabM.A. Molecular identification of actinomycetes with antimicrobial, antioxidant and anticancer properties.Comun. Sci.201910221823110.14295/cs.v10i2.2269
     [Google Scholar]
  141. ZhouW. FangH. WuQ. WangX. LiuR. LiF. XiaoJ. YuanL. ZhouZ. MaJ. WangL. ZhaoW. YouH. JuJ. FengJ. ChenC. Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2.Int. J. Biol. Sci.20191581723173210.7150/ijbs.3528431360114
     [Google Scholar]
  142. FiedlerH.P. BruntnerC. RiedlingerJ. BullA.T. KnutsenG. GoodfellowM. JonesA. MaldonadoL. Pathom-areeW. BeilW. SchneiderK. KellerS. SussmuthR.D. Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora. J. Antibiot.200861315816310.1038/ja.2008.12518503194
     [Google Scholar]
  143. KarpińskiT.M. AdamczakA. Anticancer activity of bacterial proteins and peptides.Pharmaceutics20181025410.3390/pharmaceutics1002005429710857
     [Google Scholar]
  144. El-NaggarN.E.A. DerazS.F. SolimanH.M. El-DeebN.M. El-EwasyS.M. Purification, characterization, cytotoxicity and anticancer activities of L-asparaginase, anti- colon cancer protein, from the newly isolated alkaliphilic Streptomyces fradiae NEAE-82.Sci. Rep.2016613292610.1038/srep3292627605431
     [Google Scholar]
  145. RamalingamV. VarunkumarK. RavikumarV. RajaramR. Production and structure elucidation of anticancer potential surfactin from marine actinomycete Micromonospora marina. Process Biochem.20197816917710.1016/j.procbio.2019.01.002
     [Google Scholar]
  146. YangN. SongF. Bioprospecting of novel and bioactive compounds from marine actinomycetes isolated from South China Sea sediments.Curr. Microbiol.201875214214910.1007/s00284‑017‑1358‑z28918535
     [Google Scholar]
  147. SiddharthS. AswathanarayanJ.B. KuruburuM.G. MadhunapantulaS.R.V. VittalR.R. Diketopiperazine derivative from marine actinomycetes Nocardiopsis sp. SCA30 with antimicrobial activity against MRSA.Arch. Microbiol.2021203106173618110.1007/s00203‑021‑02582‑234632524
     [Google Scholar]
  148. DhaneeshaM. HasinO. SivakumarK.C. RavineshR. NamanC.B. CarmeliS. SajeevanT.P. DNA binding and molecular dynamic studies of polycyclic tetramate macrolactams (PTM) with potential anticancer activity isolated from a sponge-associated Streptomyces zhaozhouensis subsp. mycale subsp. nov.Mar. Biotechnol. (NY)201921112413710.1007/s10126‑018‑9866‑930542952
     [Google Scholar]
  149. DhaneeshaM. UmarM. MerlinT.S. KrishnanK.P. SukumaranV. SinhaR.K. AnasA. FuP. MacMillanJ.B. SajeevanT.P. Pseudonocardia cytotoxica sp. nov., a novel actinomycete isolated from an Arctic fjord with potential to produce cytotoxic compound.Antonie van Leeuwenhoek20211141233510.1007/s10482‑020‑01490‑733230720
     [Google Scholar]
  150. LiuR. CuiC.B. DuanL. GuQ.Q. ZhuW.M. Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.Arch. Pharm. Res.200528121341134410.1007/BF0297789916392666
     [Google Scholar]
  151. RajivgandhiG. MuneeswaranT. MaruthupandyM. RamakritinanC.M. SaravananK. RavikumarV. ManoharanN. Antibacterial and anticancer potential of marine endophytic actinomycetes Streptomyces coeruleorubidus GRG 4 (KY457708) compound against colistin resistant uropathogens and A549 lung cancer cells.Microb. Pathog.201812532533510.1016/j.micpath.2018.09.02530243551
     [Google Scholar]
  152. SudhaS. MasilamaniS.M. Characterization of cytotoxic compound from marine sediment derived actinomycete Streptomyces avidinii strain SU4.Asian Pac. J. Trop. Biomed.201221077077310.1016/S2221‑1691(12)60227‑523569845
     [Google Scholar]
  153. GanM. LiuB. TanY. WangQ. ZhouH. HeH. PingY. YangZ. WangY. XiaoC. Saccharothrixones A–D, tetracenomycin-type polyketides from the marine-derived actinomycete Saccharothrix sp. 10-10.J. Nat. Prod.20157892260226510.1021/acs.jnatprod.5b0057726317881
     [Google Scholar]
  154. FuP. MacMillanJ.B. Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.J. Nat. Prod.201578354855110.1021/np500929z25584783
     [Google Scholar]
  155. DuncanK.R. HaltliB. GillK.A. CorreaH. BerruéF. KerrR.G. Exploring the diversity and metabolic potential of actinomycetes from temperate marine sediments from Newfoundland, Canada.J. Ind. Microbiol. Biotechnol.2015421577210.1007/s10295‑014‑1529‑x25371290
     [Google Scholar]
  156. MullowneyM. Ó hAinmhireE. TanouyeU. BurdetteJ. PhamV. MurphyB. A pimarane diterpene and cytotoxic angucyclines from a marine-derived Micromonospora sp. in Vietnam’s east sea.Mar. Drugs20151395815582710.3390/md1309581526389922
     [Google Scholar]
  157. ZhangX.M. ZhangD.F. LiW.J. LuC.H. Pseudonocardides A - G, new γ -butyrolactones from marine-derived pseudonocardia sp. YIM M13669.Helv. Chim. Acta201699319119610.1002/hlca.201500109
     [Google Scholar]
  158. YeX. AnjumK. SongT. WangW. YuS. HuangH. LianX.Y. ZhangZ. A new curvularin glycoside and its cytotoxic and antibacterial analogues from marine actinomycete Pseudonocardia sp. HS7.Nat. Prod. Res.201630101156116110.1080/14786419.2015.104777526119337
     [Google Scholar]
  159. FukudaT. TakahashiM. NagaiK. HarunariE. ImadaC. TomodaH. Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1.J. Antibiot.201770559059410.1038/ja.2016.15227999443
     [Google Scholar]
  160. ZhangX.M. SunM.W. ShiH. LuC.H. α-pyrone derivatives from a marine actinomycete Nocardiopsis sp. YIM M13066.Nat. Prod. Res.201731192245224910.1080/14786419.2017.129973028281379
     [Google Scholar]
  161. Sarmiento-VizcaínoA. BrañaA. Pérez-VictoriaI. MartínJ. De PedroN. CruzM. DíazC. VicenteF. AcuñaJ. ReyesF. GarcíaL. BlancoG. Paulomycin G, a new natural product with cytotoxic activity against tumor cell lines produced by deep-sea sediment derived Micromonosporamatsumotoense M-412 from the Avilés Canyon in the Cantabrian Sea.Mar. Drugs201715927110.3390/md1509027128846627
     [Google Scholar]
  162. SunM. ChenX. LiW. LuC. ShenY. New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066.J. Antibiot.201770679579710.1038/ja.2017.4628377635
     [Google Scholar]
  163. BhatM.P. NayakaS. Cave soil Streptomyces sp. strain YC69 antagonistic to chilli fungal pathogens exhibits in vitro anticancer activity against human cervical cancer cells.Appl. Biochem. Biotechnol.2023195106232625510.1007/s12010‑023‑04388‑y36853440
     [Google Scholar]
  164. MathH.H. NayakaS. RudrappaM. KumarR.S. AlmansourA.I. PerumalK. KantliG.B. Isolation, characterization of pyraclostrobin derived from soil actinomycete Streptomyces sp. HSN-01 and its antimicrobial and anticancer activity.Antibiotics2023127121110.3390/antibiotics1207121137508307
     [Google Scholar]
  165. KanchanasinP. SripreechasakP. SuriyachadkunC. SupongK. PittayakhajonwutP. SomphongA. TanasupawatS. PhongsopitanunW. Streptomyces macrolidinus sp. nov., a novel soil actinobacterium with potential anticancer and antimalarial activity.Int. J. Syst. Evol. Microbiol.202373100568210.1099/ijsem.0.00568236748587
     [Google Scholar]
  166. Al-TuwaijriM. Phylogenetic analysis and bioactivity of soil-derived nocardiopsis species: Antibacterial and anticancer potentials against MCF7 and HCT16 cell.J. Biosci. Appl. Res.2023010211410.21608/jbaar.2023.314704
     [Google Scholar]
  167. IbrahimW.M. OlamaZ.A. Abou-elelaG.M. RamadanH.S. HegazyG.E. El BadanD.E.S. Exploring the antimicrobial, antiviral, antioxidant, and antitumor potentials of marine Streptomyces tunisiensis W4MT573222 pigment isolated from Abu-Qir sediments, Egypt.Microb. Cell Fact.20232219410.1186/s12934‑023‑02106‑137147660
     [Google Scholar]
  168. HamedA.A. Abdel-RazikG.G. BattahM.G. HassanM. Bioactive metabolites from Streptomyces sp. RSE with potential anticancer and antioxidant activity.Egypt. J. Chem.2024674115125
     [Google Scholar]
  169. ShaabanM.T. MohamedB.S. ZayedM. El-SabbaghS.M. Antibacterial, antibiofilm, and anticancer activity of silver-nanoparticles synthesized from the cell-filtrate of Streptomyces enissocaesilis. BMC Biotechnol.2024241810.1186/s12896‑024‑00833‑w38321442
     [Google Scholar]
  170. do Nascimento ChavesK.R. de Andrade FrançaM.L.T. MendesA.L.O. CardosoP.P. VasconcelosK.B.P. de SantanaR.C.F. LotufoL.V.C. Antibacterial, antioxidant and anticancer activities of the streptomyces PML5 strain isolated from carbonate rocksin the amazon.Research Square2024
     [Google Scholar]
  171. SomphongA. WeeraphanT. PoengsungnoenV. SuriyachadkunC. SripreechasakP. ChaothamC. TanasupawatS. PhongsopitanunW. Actinoplanes pyxinae sp. nov., a new lichen-derived rare actinobacterium exhibiting antimicrobial and anticancer activity.Int. J. Syst. Evol. Microbiol.202474100621510.1099/ijsem.0.00621538180333
     [Google Scholar]
  172. MestaS.C. OnkarappaR. Anticancer property of l-glutaminase producing actinomycete Streptomyces albogriseolus isolated from estuary of uttara kannada district against hela and HepG2 cell lines.J. Adv. Zool.2024453
     [Google Scholar]
/content/journals/cmc/10.2174/0109298673309904240911080042
Loading
Actinomycetes: A Source of Anticancer Metabolites
Curr. Med. Chem. 32, 6517 (2025); https://doi.org/10.2174/0109298673309904240911080042
/content/journals/cmc/10.2174/0109298673309904240911080042
/content/journals/cmc/10.2174/0109298673309904240911080042
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): actinomycetes; antibiotics; anticancer compounds; cancer treatment; cytotoxicity; Microbes

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test