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2000
Volume 32, Issue 5
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Introduction

Nanoceria is a well-known nanomaterial with various properties, including antioxidant, proangiogenic, and therapeutic effects. Despite its potential, there are still aspects that require further exploration, particularly its anti-inflammatory and antimicrobial activities.

Methods

The global demand for novel anti-inflammatory and antimicrobial drugs underscores the significance of understanding nanoceria in both contexts. In this study, we evaluated the effect of nanoceria on macrophage polarization to better understand its anti-inflammatory effects. Additionally, we investigated the mechanism of action of nanoceria against (ATCC 32045), (ATCC 22019), i (ATCC 6258), and .

Results

The results demonstrated that nanoceria can polarize macrophages toward an anti-inflammatory profile, revealing the cellular mechanisms involved in the anti-inflammatory response. Concerning the antimicrobial effect, it was observed that nanoceria have a more pronounced impact on , leading to the formation of pronounced pores on the surface of this species.

Conclusion

Finally, biochemical analysis revealed transitory alterations, mainly in liver enzymes. The data support the use of nanoceria as a potential anti-inflammatory and antimicrobial drug and elucidate some of the mechanisms involved, shedding light on the properties of this nanodrug.

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/content/journals/cmc/10.2174/0109298673285605231229112525
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Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action
Curr. Med. Chem. 32, 1017 (2025); https://doi.org/10.2174/0109298673285605231229112525
/content/journals/cmc/10.2174/0109298673285605231229112525
/content/journals/cmc/10.2174/0109298673285605231229112525
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  • Article Type:     Research Article
Keyword(s): Anti-inflammatory; antimicrobial; antimicrobial resistance; antioxidant; candida; drug delivery

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