Skip to content
2000
Volume 23, Issue 2
  • ISSN: 1871-5257
  • E-ISSN: 1875-6182

Abstract

Background

Coronary collaterals are the feeding bridges between the main epicardial arteries, and research has shown that this collateral development plays a crucial role in myocardial performance, especially in patients with coronary artery disease. However, the evolution of these collaterals has not been fully explained.

Objectives

In this study, we aimed to reveal the effect of CD31 on coronary collateral development.

Methods

As a result of coronary angiography performed in our clinic, 89 patients with coronary artery disease and 90 patients with normal coronary arteries were included in the study. Collateral development degrees were recorded from the angiographic images of the subjects. CD31 values were compared between the group with coronary artery disease and the control group. In addition, the coronary artery disease group was divided into subgroups according to the collateral development in terms of good collateral development and poor collateral development, and the factors that may affect the collateral development were tried to be determined.

Results

CD31 levels were significantly higher in the group with coronary artery disease compared to the control group ( <0.001). In addition, CD31 levels in the subgroup with good collateral were significantly higher than in the group with weak collateral ( <0.001). In the correlation analysis, a significant positive correlation was found between serum CD31 level and SYNTAX score, age, glucose, and rentrop grade. Multivariate logistic regression analysis showed CD31 to be an independent predictor of good coronary collateral development.

Conclusion

CD31, a marker of angiogenesis, may be involved in coronary collateral development.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/chamc/10.2174/0118715257300068240819071920
2025-06-01
2025-09-16

  • From This Site

    /content/journals/chamc/10.2174/0118715257300068240819071920
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. ElaydaM.A. MathurV.S. HallR.J. MassumiG.A. GarciaE. de CastroC.M. Collateral circulation in coronary artery disease.Am. J. Cardiol.1985551586010.1016/0002‑9149(85)90299‑13966400
     [Google Scholar]
  2. MeierP. HemingwayH. LanskyA.J. KnappG. PittB. SeilerC. The impact of the coronary collateral circulation on mortality: A meta-analysis.Eur. Heart J.201233561462110.1093/eurheartj/ehr30821969521
     [Google Scholar]
  3. HennekensC.H. Increasing burden of cardiovascular disease: Current knowledge and future directions for research on risk factors.Circulation199897111095110210.1161/01.CIR.97.11.10959531257
     [Google Scholar]
  4. MeiningerC.J. SchellingM.E. GrangerH.J. Adenosine and hypoxia stimulate proliferation and migration of endothelial cells.Am. J. Physiol.19882553 Pt 2H554H5623414822
     [Google Scholar]
  5. SchaperW. Angiogenesis in the adult heart.Basic Res. Cardiol.199186Suppl. 251561719953
     [Google Scholar]
  6. NewmanP.J. BerndtM.C. GorskiJ. WhiteG.C.II LymanS. PaddockC. MullerW.A. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.Science199024749471219122210.1126/science.16904531690453
     [Google Scholar]
  7. DeLisserH.M. Christofidou-SolomidouM. StrieterR.M. BurdickM.D. RobinsonC.S. WexlerR.S. KerrJ.S. GarlandaC. MerwinJ.R. MadriJ.A. AlbeldaS.M. Involvement of endothelial PECAM-1/CD31 in angiogenesis.Am. J. Pathol.199715136716779284815
     [Google Scholar]
  8. Peter RentropK. CohenM. BlankeH. PhillipsR.A. Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects.J. Am. Coll. Cardiol.19855358759210.1016/S0735‑1097(85)80380‑63156171
     [Google Scholar]
  9. FarooqV. BrugalettaS. SerruysP.W. The SYNTAX score and SYNTAX-based clinical risk scores.Semin. Thorac. Cardiovasc. Surg.20112329910510.1053/j.semtcvs.2011.08.00122041038
     [Google Scholar]
  10. SchillerN.B. AcquatellaH. PortsT.A. DrewD. GoerkeJ. RingertzH. SilvermanN.H. BrundageB. BotvinickE.H. BoswellR. CarlssonE. ParmleyW.W. Left ventricular volume from paired biplane two-dimensional echocardiography.Circulation197960354755510.1161/01.CIR.60.3.547455617
     [Google Scholar]
  11. TepperO.M. CaplaJ.M. GalianoR.D. CeradiniD.J. CallaghanM.J. KleinmanM.E. GurtnerG.C. Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow–derived cells.Blood200510531068107710.1182/blood‑2004‑03‑105115388583
     [Google Scholar]
  12. HansenJ.F. Coronary collateral circulation: Clinical significance and influence on survival in patients with coronary artery occlusion.Am. Heart J.1989117229029510.1016/0002‑8703(89)90771‑02916404
     [Google Scholar]
  13. KoerselmanJ. van der GraafY. de JaegereP.P.T. GrobbeeD.E. Coronary collaterals.Circulation2003107192507251110.1161/01.CIR.0000065118.99409.5F12756191
     [Google Scholar]
  14. WustmannK. ZbindenS. WindeckerS. MeierB. SeilerC. Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?Circulation2003107172213222010.1161/01.CIR.0000066321.03474.DA12707241
     [Google Scholar]
  15. FultonW.F.M. The time factor in the enlargement of anastomoses in coronary artery disease.Scott. Med. J.196491182310.1177/00369330640090010414103801
     [Google Scholar]
  16. KurmusO. AslanT. EkiciB. Baglan UzungetS. KaraarslanS. TanindiA. ErkanA.F. Akgul ErcanE. KervancıogluC. Impact of admission blood glucose on coronary collateral flow in patients with ST-elevation myocardial infarction.Cardiol. Res. Pract.201820181510.1155/2018/405954229721336
     [Google Scholar]
  17. KadiH. CeyhanK. KarayakaliM. CelikA. OzturkA. KocF. OnalanO. Effects of prediabetes on coronary collateral circulation in patients with coronary artery disease.Coron. Artery Dis.201122423323710.1097/MCA.0b013e328345241b21358541
     [Google Scholar]
  18. YetkinE. TopalE. ErguzelN. SenenK. HeperG. WaltenbergerJ. Diabetes mellitus and female gender are the strongest predictors of poor collateral vessel development in patients with severe coronary artery stenosis.Angiogenesis201518220120710.1007/s10456‑015‑9460‑y25680403
     [Google Scholar]
  19. YaylalıY.T. KaftanA. Influence of clinical characteristics on coronary collaterals.Pamukkale Med. J.2012525762
     [Google Scholar]
  20. TascanovM.B. TanriverdiZ. GungorenF. BesliF. ErkusM.E. GonelA. KoyuncuI. DemirbagR. Association between the no-reflow phenomenon and soluble CD40 ligand level in patients with acute ST-segment elevation myocardial infarction.Medicina201955737610.3390/medicina5507037631311177
     [Google Scholar]
  21. MatsumuraT. WolffK. PetzelbauerP. Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin.J. Immunol.199715873408341610.4049/jimmunol.158.7.34089120301
     [Google Scholar]
  22. YangS. GrahamJ. KahnJ.W. SchwartzE.A. GerritsenM.E. Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels.Am. J. Pathol.1999155388789510.1016/S0002‑9440(10)65188‑710487846
     [Google Scholar]
  23. NewmanP.J. NewmanD.K. Signal transduction pathways mediated by PECAM-1: New roles for an old molecule in platelet and vascular cell biology.Arterioscler. Thromb. Vasc. Biol.200323695396410.1161/01.ATV.0000071347.69358.D912689916
     [Google Scholar]
  24. ToprakK. YılmazR. KaplangorayM. MemioğluT. İnanırM. AkyolS. ÖzenK. BiçerA. DemirbağR. Comparison of the effect of uric acid/albumin ratio on coronary colleteral circulation with other inflammation-based markers in stable coronary artery disease patients.Perfusion20230267659123120210510.1177/0267659123120210537674333
     [Google Scholar]
/content/journals/chamc/10.2174/0118715257300068240819071920
Loading
The Effect of CD31 on Coronary Collateral Development
Cardiovasc. Hematol. Agents Med. Chem. 23, 137 (2025); https://doi.org/10.2174/0118715257300068240819071920
/content/journals/chamc/10.2174/0118715257300068240819071920
/content/journals/chamc/10.2174/0118715257300068240819071920
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): Angiogenesis; CD31; coronary angiography; coronary artery disease; coronary collateral; epicardial arteries

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test