Eco-friendly and Green Procedure for Iodination of Reactive Aromatics Using PEG 400-I2/HIO3 Combination

Background: Iodination of the organic substrate is an important reaction for the synthesis of pharmacologically active molecules. Methods: In view of these concerns, we reported a convenient procedure for the synthesis of iodo compounds using iodine and iodic acid in PEG-400. We have reported an eco-friendly procedure for the preparation of aromatic iodo compounds using iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400). Results: The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines, and heterocyclic compounds was carried out using iodine, iodic acid, and PEG-400. The synthesized substituted aromatic iodo compounds were confirmed based on the spectral characterization and mixed melting points. Conclusion: The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative yields, and purity of iodo products.