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- ISSN: 2213-3461
- E-ISSN: 2213-347X
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Oxone Mediated Oxidation of 2-(aryl/alkyl thio) Quinazolines: A Green Approach
- Source: Current Green Chemistry, Volume 5, Issue 2, Aug 2018, p. 108 - 113
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- 01 Aug 2018
Abstract
Oxidation of 2-(substituted thio) quinazolines in THF and aqueous media using stoichiometric amounts of oxone afforded their corresponding 2-(substituted sulfonyl)quinazolines with excellent selectivity (75-94% yield). This versatile synthetic protocol proved efficient with various substituted thio quinazoline compounds as substrates. All the twelve products were characterized by melting range, infrared, 1H-NMR, 13C-NMR and mass spectrometry.
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