Efficient and Environmentally Benign Diversity Oriented Synthesis of 2, 3- dihydroquinazolin-4(1H)-ones Using GAAS As a Bio-based Green Solvent

An efficient and environmentally benign domino protocol has been presented for the synthesis of structurally diverse 2,3-dihydroquinazolin-4(1H)-one derivatives involving three-component reaction of isatoic anhydride, substituted anilines and aromatic aldehydes in the presence of gluconic acid aqueous solution (50%, wt %). The present protocol offers several advantages such as operational simplicity with easy workup, shorter reaction times, and excellent yields with superior atom economy and environmentally benign reaction conditions with the use of cost-effective, recyclable, non-toxic and bio-degradable GAAS (50%, wt %) as catalyst/solvent.