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2000
Volume 12, Issue 4
  • ISSN: 2213-3461
  • E-ISSN: 2213-347X

Abstract

Paracetamol is one of the most prescribed drugs, which requires a global production of over 200,000 tons/year. The production of paracetamol at the industrial level still relies on multistep methodologies utilizing stoichiometric amounts of oxidizing and reducing agents and corrosive reagents, which demands a sustainable protocol for the synthesis of paracetamol. In this article, we aimed to develop a magnetically retrievable nanohybrid catalyst for the synthesis of paracetamol under mild and green reaction conditions for up to five cycles. FeO nanoparticles were synthesized and Pd(0) particles were embedded into the nanoparticle so that it could be used as a magnetically retrievable catalyst. This hybrid catalyst was successfully utilized in the synthesis of paracetamol in a one-pot reaction with high yield and efficacy within a short time, demonstrating that the nanohybrid catalyst offers advantages in the synthesis of drug leads for industrial purposes.

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2025-02-25
2025-10-21

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Design and Development of Magnetically Retrievable Nanohybrid Catalyst for the Green Synthesis of Paracetamol
Curr Green Chem 12, 419 (2025); https://doi.org/10.2174/0122133461354084250114053952
/content/journals/cgc/10.2174/0122133461354084250114053952
/content/journals/cgc/10.2174/0122133461354084250114053952
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  • Article Type:     Research Article
Keyword(s): green synthesis; industrial level; Magnetic nanoparticle; nanohybrid catalyst; paracetamol production; retrievable catalyst

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