Current Drug Therapy - Volume 9, Issue 2, 2014

Diluents, also known as fillers, are used to make up the required bulk when the drug dosage is inadequate to produce the bulk of the tablet. In the present study the effect of diluents such as Lactose, Starch and microcrystalline cellulose on the evaluation parameters of curcumin-Hydroxyl Propyl β Cyclodextrin (HPβCD) bioadhesive vaginal tablets containing Carbopol 934P, Hydroxy propyl methyl cellulose (HPMC) and Hydro Read More

Purpose: The objective of the present work was to develop a site specific gastro-retentive floating tablet of Troxipide for the treatment of peptic ulcer. Troxipide is a novel anti-ulcer agent having an elimination half-life of 7.4 hrs and mainly absorbed from the gastrointestinal tract. Methods: 32 factorial design was applied. Dependant variables were swelling index, hardness and % drug release. Pluronic acid F127 and HPMC K 15 Read More

The present work aimed to develop and study the effect of HPMC on compression-coated floating - pulsatile delivery of Bisoprolol. Inner core tablet contains bisoprolol and a super disintegrant. Outer shell contains HPMC K4M and HPMC K100M as erodible layer along with a gas generating agent. Compression-coated tablet of bisoprolol with 120mg HPMC K4M (B2) showed a lag time of 3.40±0.1 hrs with 99.81% drug release. Wher Read More

Contrast induced nephropathy (CIN) is an iatrogenic form of acute kidney injury (AKI) with variable but growing prevalence secondary to increased need for contrast administration during medical investigations such as coronary angiography. The mechanism of CIN is complex and poorly understood but is believed to be secondary to renal medullary hypoxia secondary to direct tubular toxicity from the contrast media and Read More

Acetylcholinesterase inhibitors are regarded as the most promising approach to treat Alzheimer’s disease (AD). However, their anticipated side effects limit their usage. Present investigations involved the incorporation of the newly synthesized 2-naphthol derivatives (PP-81 and PP-84) into solid lipid nanoparticles (SLNs) to improve their accessibility to the brain and enhance the levels of acetylcholine. Drug loaded SLNs of PP Read More

Cyclodextrins (CDs) offer a potential solution to delivery of hydrophobic drugs. Cyclodextrins are capable of hydrophobic drug binding due to their unique property of possessing a hydrophobic interior cavity and a hydrophilic exterior. When hydrophobic drugs are complexed with CD molecules a significant increase has been reported in the bioavailability of those drugs in free solution. The unique characteristics of cyclodextrins f Read More