Anti-Inflammatory, Analgesic and Anti-Nociceptive Efficacy of Peel of Abelmoschus esculentus Fruits in Laboratory Animal

Objectives: Abelmoschus esculentus is an important medicinal plant for its traditional and folkloric uses against different types of diseases such as headaches, arthritis, abdominal pain, inflammation etc. It also has been reported that root of the Abelmoschus esculentus possesses good CNS depressant activity along with high analgesic activity in Swiss albino mice. So present study investigated the anti-inflammatory, analgesic and anti-nociceptive activities of methanolic and water extracts of the peel of the Abelmoschus esculentus fruits. Methods and Materials: Anti-inflammatory study was done by carrageenan induced inflammation test for anti-inflammation activities while acetic acid induced writhing test and formalin induced pain test was done for analgesic activities and anti-nociceptive activities respectively in Swiss albino mice. Results: The experimental activities of the methanolic and water extracts of the peels of Abelmoschus esculentus fruits showed statistically significant anti-inflammatory activity (50.87% and 40.87%) in carrageenan induced inflammation test, analgesic activity (77.59% and 68.04%) in acetic acid induced writhing test and anti-nociceptive activity (70.06% and 63.40%) in formalin induced pain test in Swiss albino mice for 200mg. Conclusion: Based on the results of the present study, we conclude that the methanolic and water extracts of peels possess strong anti-inflammatory, analgesic and anti-nociceptive activities. However, further studies are necessary to scrutinize underlying mechanisms of anti-inflammatory, analgesic and anti-nociceptive effects and to isolate the active compounds responsible for these pharmacological activities.