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2000
Volume 20, Issue 9
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903

Abstract

Background

Interpenetrating Polymeric Networks (IPN) are cross-linked polymeric alloys developed when two or more cross-linked polymers inter-penetratingly entangle. Interpenetrating polymeric networks possess several benefits including stability, biocompatibility, biodegradability, high swelling ability, and modified release efficiency.

Aim

The aim of this study is to design stable, control-released montelukast sodium-loaded IPN hydrogel beads as a promising approach toward drug delivery.

Objective

The goal of the present work was to develop Chitosan (swellable polymer) and glutaraldehyde (cross-linker) based modified (controlled) released montelukast sodium IPN hydrogel beads.

Methods

The montelukast sodium IPN hydrogel beads were prepared via the precipitation method, and the final batch of IPN hydrogel beads was based on particle size, percent entrapment efficiency, area of swelling, and cumulative percent drug release using an overlay plot in Box-Behnken design. Compatibility studies (DSC, FT-IR) and microscopical observation (SEM) confirmed the compatibility and sphericity of the formulations.

Results

The optimized (comprising 2.01% chitosan and 0.48% glutaraldehyde) IPN hydrogel beads having satisfactory particle size (817.76±54.49 µm), good entrapment efficiency (71.36±3.04%), and area of swelling (27.00±1.68 mm2) showed swelling and pH-dependent controlled montelukast release (92.96±1.05%) after 12 h with longer duration of action.

Conclusion

The prepared montelukast sodium IPN hydrogel beads could be a potent control-released drug delivery vehicle.

© 2025 Bentham Science Publishers
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2024-09-30
2026-01-21

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/content/journals/cdth/10.2174/0115748855319794240910075025
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Modified Release Interpenetrating Polymeric Network Hydrogel Beads of Montelukast Sodium Via Box Behnken Design
Curr Drug Ther 20, 1301 (2025); https://doi.org/10.2174/0115748855319794240910075025
/content/journals/cdth/10.2174/0115748855319794240910075025
/content/journals/cdth/10.2174/0115748855319794240910075025
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  • Article Type:     Research Article
Keyword(s): Chitosan; controlled release; hydrogel beads; interpenetrating polymeric network; montelukast sodium; precipitation method

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