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2000
Volume 20, Issue 4
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903

Abstract

Leishmaniasis represents a pool of debilitating clinical manifestations affecting several individuals globally. The disease remains a serious global health and affects individuals in tropical and subtropical regions. The disease is endemic in several areas of South America, East Africa, the Indian sub-continent and the Mediterranean basin. The bite of female Phlebotomine sand establishes the infection of the parasite within human flies belonging to the family (subfamily: ) of class Diptera. Several species of parasite serve as the infectious trigger associated with varying clinical presentation of the disease. The immune response against the different parasitizing species varies, resulting in a complex response by innate immune cells. The present review summarizes some of the key innate immune effector cells involved during the infection with the parasite in a quest to provide a deeper understanding of -mediated immunobiology. The review also summarizes an up-to-date understanding of several strategies adopted by the parasite to evade immune response mediated by altering the functioning of some key innate immune effector cells. A better understanding of these immuno-biological events within the infected individual would help formulate immune-therapeutical interventions against the disease.

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2025-10-03

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/content/journals/cdth/10.2174/0115748855295089240322081903
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Innate Immune Effectors and Leishmania: An Overview of Complexities
Curr Drug Ther 20, 534 (2025); https://doi.org/10.2174/0115748855295089240322081903
/content/journals/cdth/10.2174/0115748855295089240322081903
/content/journals/cdth/10.2174/0115748855295089240322081903
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  • Article Type:     Review Article
Keyword(s): diptera; innate immune cells; Leishmaniasis; macrophages; phlebotomine sand; T helper cells

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